Actin, g-enteric smooth muscle

AltitudeomicsDB
Protein Official symbol ACTG2
Aliases ACTG2 ACTA3 ACTL3 ACTSG
Chromosomal Location 2
Length 376
Uniprot ID P63267
EC number None
Protein family Information(Pfam) PF00022;
PDB id 6JAT;
InterPro ID IPR004000;IPR020902;IPR004001;IPR043129;
dbSNP rs587777385 rs587777386 rs864309490 rs864309491 rs587777388 rs587777383 rs78001248 rs587777384 rs587777384 rs864309492 rs587777387

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MYL12B MYL6 0.998
PXN VCL 0.997
MYLK MYL9 0.995
MYLK MYL12A 0.992
MYL6B MYLK 0.991
MYL12B MYLK 0.991
MYL5 MYLK 0.991
MYLK MYL10 0.991
MYLK MYL7 0.989
MYL6 MYLK 0.989
MYLK MYLPF 0.989
TLN1 VCL 0.986
ACTA2 MYH11 0.984
CALD1 MYLK 0.984
ACTG2 MYH11 0.98
TPM2 MYL9 0.978
TLN1 PXN 0.976
MYH11 MYL9 0.975
MYH11 MYLK 0.974
MYL12B MYH11 0.971
MYH11 MYL12A 0.971
MYH11 MYL10 0.969
CALD1 MYL9 0.969
MYH11 MYLPF 0.969
SORBS1 VCL 0.969
MYH11 MYL7 0.968
TPM1 VCL 0.968
ACTA2 MYLK 0.968
MYH11 CALD1 0.968
MYL5 MYH11 0.968
MYL6B MYH11 0.968
ACTA2 MYL9 0.966
MYL12B MYL12A 0.966
MYL6 MYH11 0.966
ACTG2 TPM2 0.965
MYL6 TPM3 0.963
SORBS3 VCL 0.962
TPM1 MYL9 0.962
CALD1 TPM1 0.961
ACTA2 TPM2 0.961
ACTA2 CALD1 0.961
ACTG2 TPM4 0.961
MYL12B TPM3 0.96
ACTA2 TPM1 0.96
ACTG2 TPM1 0.96
ACTG2 MYL9 0.959
MYL6 TPM4 0.959
TPM2 MYLPF 0.959
MYL12B TPM2 0.958
ACTG2 TPM3 0.958
CALD1 VCL 0.958
TPM1 MYLPF 0.957
MYLK VCL 0.957
MYL12B TPM4 0.957
MYLK PXN 0.957
ACTG2 CALD1 0.957
TPM4 MYL12A 0.956
ITGB5 ITGA1 0.956
TPM4 MYL9 0.956
ACTA2 TPM4 0.956
PXN SORBS3 0.956
MYH11 LMOD1 0.955
ACTG2 MYLK 0.955
MYL6 TPM2 0.955
TPM2 CALD1 0.955
ACTA2 VCL 0.954
MYL12B TPM1 0.954
TPM4 MYLPF 0.953
ACTG2 VCL 0.953
TPM2 MYL12A 0.953
MYH11 TPM2 0.952
TPM3 VCL 0.952
ACTA2 TPM3 0.952
TPM3 MYL12A 0.952
TPM4 VCL 0.951
TPM4 MYL10 0.951
TPM3 MYLPF 0.951
TPM2 MYL10 0.951
MYH11 TPM1 0.95
MYL6 TPM1 0.95
TPM1 MYL12A 0.95
MYL5 TPM4 0.949
TPM3 MYL9 0.949
MYL6B TPM4 0.949
MYL6 CALD1 0.949
MYL6B TPM2 0.949
MYL12B CALD1 0.948
TPM4 MYL7 0.948
MYL6B TPM3 0.947
MYL6B TPM1 0.947
MYL12B TLN1 0.947
MYL9 PXN 0.946
TPM2 VCL 0.946
TPM2 MYL7 0.946
MYLK TPM1 0.946
MYL5 TPM1 0.946
MYL6 TLN1 0.946
MYL9 VCL 0.946
CALD1 TPM4 0.946
TPM1 MYL10 0.946
MYL5 TPM2 0.946
TPM1 MYL7 0.946
ACTG2 LMOD1 0.945
ACTA2 MYLPF 0.945
TPM3 MYL10 0.944
MYL5 TPM3 0.944
MYH11 VCL 0.944
TPM3 MYL7 0.944
ACTA2 LMOD1 0.944
TPM3 CALD1 0.942
ACTG2 MYLPF 0.942
MYH11 TPM4 0.942
CALD1 MYL12A 0.941
TPM2 MYLK 0.941
MYL12A VCL 0.941
LMOD1 MYLK 0.94
MYL12B VCL 0.94
MYL6B CALD1 0.939
MYH11 TPM3 0.939
MYL5 CALD1 0.939
CALD1 MYL10 0.939
CALD1 PXN 0.938
SORBS1 PXN 0.938
TPM3 MYLK 0.937
ACTG2 MYL12A 0.937
CALD1 MYLPF 0.937
MYL12B ACTG2 0.937
ACTA2 PXN 0.936
CALD1 MYL7 0.936
ACTA2 MYL7 0.936
MYLK TPM4 0.936
PXN MYL12A 0.935
TPM2 LMOD1 0.934
ACTG2 PXN 0.933
MYL6B ACTG2 0.932
ACTA2 ACTG2 0.932
MYL12B ACTA2 0.931
SORBS1 ITGA1 0.931
MYL6 ACTA2 0.931
ACTA2 MYL12A 0.931
MYL6 ACTG2 0.931
MYL12B PXN 0.931
ACTG2 MYL10 0.931
LMOD1 MYL9 0.93
MYL6 VCL 0.929
CALD1 TLN1 0.929
ITGB5 VCL 0.929
ACTG2 MYL5 0.928
ITGB5 PXN 0.928
MYL6B ACTA2 0.928
TLN1 ITGA1 0.927
TPM1 PXN 0.927
ACTG2 MYL7 0.927
ACTA2 MYL5 0.926
MYLPF VCL 0.926
TLN1 SORBS3 0.925
MYL6 MYL9 0.925
TPM4 TLN1 0.925
SORBS1 MYL9 0.924
ACTA2 MYL10 0.924
MYLK TLN1 0.924
TLN1 ITGB5 0.924
TPM1 TLN1 0.923
MYLPF PXN 0.923
TPM2 PXN 0.923
MYL7 VCL 0.922
MYH11 PXN 0.922
MYL10 VCL 0.922
MYL5 VCL 0.922
TPM4 PXN 0.922
LMOD1 TPM4 0.922
LMOD1 TPM1 0.922
MYL6B VCL 0.921
MYL6 MYL12A 0.921
MYL6 PXN 0.921
PXN MYL10 0.92
MYL5 PXN 0.92
ACTA2 ITGA1 0.92
TPM2 TLN1 0.92
MYL6B PXN 0.919
SORBS1 SORBS3 0.919
TPM3 TLN1 0.919
MYL12B MYL6B 0.919
ACTA2 TLN1 0.919
MYL6B MYL12A 0.918
MYL6B MYL9 0.918
PXN MYL7 0.918
MYLK SORBS3 0.918
MYL12B SORBS1 0.918
TLN1 MYL9 0.918
ITGA1 PXN 0.917
ACTG2 TLN1 0.917
CALD1 ITGB5 0.917
ITGA1 VCL 0.917
TPM2 ITGB5 0.917
TPM3 PXN 0.917
ACTA2 ITGB5 0.916
TPM3 LMOD1 0.916
TLN1 MYL12A 0.915
MYL6 MYL7 0.915
SORBS1 MYL12A 0.915
TPM1 ITGB5 0.915
TPM2 TPM1 0.914
LMOD1 CALD1 0.913
SORBS1 MYLK 0.913
SORBS1 TLN1 0.913
TPM4 ITGB5 0.913
MYL6 MYL10 0.912
MYLPF ITGB5 0.912
CALD1 SORBS3 0.912
MYH11 SORBS1 0.912
MYL6 MYLPF 0.912
ITGB5 MYL9 0.911
MYL9 SORBS3 0.911
CALD1 ITGA1 0.91
MYL6 ITGB5 0.909
SORBS1 TPM3 0.909
MYH11 TLN1 0.909
MYL6 MYL5 0.908
SORBS1 LMOD1 0.908
MYL6B TLN1 0.907
LMOD1 SORBS3 0.907
TPM2 SORBS3 0.907
ACTA2 SORBS1 0.906
MYLK ITGB5 0.906
TPM2 TPM3 0.905
SORBS1 MYLPF 0.905
ITGA1 MYL9 0.905
ITGB5 MYL10 0.905
TPM3 ITGB5 0.905
MYLK ITGA1 0.905
MYL6B MYLPF 0.905
MYH11 SORBS3 0.905
TPM1 ITGA1 0.905
SORBS1 TPM1 0.905
MYL9 MYL12A 0.905
LMOD1 ITGA1 0.905
ACTG2 ITGA1 0.905
TPM3 SORBS3 0.905
ITGB5 SORBS3 0.905
TPM2 TPM4 0.905
MYH11 ITGA1 0.904
TPM2 SORBS1 0.904
LMOD1 ITGB5 0.904
MYL5 MYL9 0.904
MYLPF MYL7 0.904
MYL6B SORBS3 0.904
SORBS1 TPM4 0.904
SORBS1 CALD1 0.904
TPM3 TPM4 0.904
LMOD1 PXN 0.903
MYL5 SORBS1 0.903
MYL6B MYL7 0.903
MYL12B LMOD1 0.903
SORBS3 MYL12A 0.903
MYL6B MYL5 0.903
MYL6B SORBS1 0.903
MYL12B MYL9 0.903
LMOD1 MYL12A 0.903
ACTG2 ITGB5 0.903
ITGA1 MYL10 0.903
MYL6 SORBS3 0.903
SORBS3 MYL10 0.903
MYL5 SORBS3 0.903
SORBS1 MYL10 0.903
TPM1 SORBS3 0.903
MYL6 SORBS1 0.903
MYLPF SORBS3 0.902
MYLPF MYL10 0.902
MYLPF ITGA1 0.902
MYL6 LMOD1 0.902
ITGA1 SORBS3 0.902
TPM4 ITGA1 0.902
TPM3 TPM1 0.902
TLN1 MYL7 0.902
ACTA2 SORBS3 0.902
MYLPF TLN1 0.902
MYL6B MYL6 0.902
MYL6B LMOD1 0.902
MYL12B SORBS3 0.902
ITGA1 MYL7 0.902
TLN1 MYL10 0.902
MYL5 MYL10 0.902
MYL6 ITGA1 0.902
MYH11 ITGB5 0.902
SORBS3 MYL7 0.902
TPM2 ITGA1 0.902
MYLPF MYL9 0.902
TPM3 ITGA1 0.902
ACTG2 SORBS1 0.902
TPM4 SORBS3 0.902
MYL6B ITGA1 0.902
LMOD1 VCL 0.902
MYL5 TLN1 0.902
SORBS1 MYL7 0.902
MYL7 MYL10 0.901
MYLPF MYL12A 0.901
ITGA1 MYL12A 0.901
TPM1 TPM4 0.901
MYL6B ITGB5 0.901
MYL9 MYL7 0.901
MYL12B MYL7 0.901
MYL5 ITGA1 0.901
MYL10 MYL12A 0.901
MYL12B ITGA1 0.901
MYL12B MYL10 0.901
ACTG2 SORBS3 0.901
MYL6B MYL10 0.901
LMOD1 TLN1 0.901
MYL7 MYL12A 0.901
LMOD1 MYL10 0.9
MYL5 MYLPF 0.9
MYL9 MYL10 0.9
ITGB5 MYL7 0.9
MYL12B ITGB5 0.9
MYL12B MYLPF 0.9
MYL5 MYL7 0.9
ITGB5 MYL12A 0.9
LMOD1 MYL7 0.9
MYL5 LMOD1 0.9
MYL5 MYL12A 0.9
MYL5 ITGB5 0.9
LMOD1 MYLPF 0.9
SORBS1 ITGB5 0.9
MYL12B MYL5 0.9
Gene Ontology Semantic Similarity
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# 4638 (MYLK) 7170 (TPM3) 7169 (TPM2) 4629 (MYH11) 7168 (TPM1) 7171 (TPM4) 10398 (MYL9) 29895 (MYLPF) 7414 (VCL)
4638 (MYLK) 1.00 0.58 0.45 0.60 0.58 0.54 0.26 0.26 0.71
7170 (TPM3) 0.58 1.00 0.84 0.83 0.86 0.85 1.00 1.00 0.70
7169 (TPM2) 0.45 0.84 1.00 0.78 0.90 0.81 1.00 1.00 0.61
4629 (MYH11) 0.60 0.83 0.78 1.00 0.83 0.81 1.00 1.00 0.72
7168 (TPM1) 0.58 0.86 0.90 0.83 1.00 0.85 1.00 1.00 0.74
7171 (TPM4) 0.54 0.85 0.81 0.81 0.85 1.00 1.00 1.00 0.69
10398 (MYL9) 0.26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.26
29895 (MYLPF) 0.26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.26
7414 (VCL) 0.71 0.70 0.61 0.72 0.74 0.69 0.26 0.26 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ACTG2 Human Skeletal muscle - 4559 m 9 day upregulated 1.31 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
ACTG2 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MYOCD 93649 ACTG2 72 Repression 18239137 TRUSST
NKX3-1 4824 ACTG2 72 Repression 18239137 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
72 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
72 GO:0072562 blood microparticle GOTERM_CC_DIRECT
72 GO:0030175 filopodium GOTERM_CC_DIRECT
72 GO:0005737 cytoplasm GOTERM_CC_DIRECT
72 GO:0032982 myosin filament GOTERM_CC_DIRECT
72 GO:0005524 ATP binding GOTERM_MF_DIRECT
72 GO:0005615 extracellular space GOTERM_CC_DIRECT
72 GO:0030027 lamellipodium GOTERM_CC_DIRECT
72 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
72 GO:0005829 cytosol GOTERM_CC_DIRECT
72 GO:0006936 muscle contraction GOTERM_BP_DIRECT
72 GO:0044297 cell body GOTERM_CC_DIRECT
72 GO:0071944 cell periphery GOTERM_CC_DIRECT
72 GO:0090131 mesenchyme migration GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
72 hsa04270 Vascular smooth muscle contraction
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ACTG2 72 Colonic Neoplasms C0009375 Neoplastic Process 0.3 0.639 0.379 group
ACTG2 72 Malignant tumor of colon C0007102 Neoplastic Process 0.3 0.639 0.379 disease
ACTG2 72 Visceral Myopathy, Familial C0266833 Disease or Syndrome 0.52 0.639 0.379 disease
ACTG2 72 Megacystis microcolon intestinal hypoperistalsis syndrome C1608393 Disease or Syndrome 0.65 0.639 0.379 disease
ACTG2 72 Cakut C1968949 Disease or Syndrome 0.3 0.639 0.379 disease
ACTG2 72 Megaduodenum and-or Megacystis C1835084 Disease or Syndrome 0.6 0.639 0.379 disease
ACTG2 72 Visceral Neuropathy, Familial, Autosomal Dominant C1864996 Disease or Syndrome 0.3 0.639 0.379 disease
ACTG2 72 Visceral Myopathy C0042781 Disease or Syndrome 0.31 0.639 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types