Carbonic anhydrase 1

AltitudeomicsDB
Protein Official symbol CA1
Aliases CA1
Chromosomal Location 8
Length 261
Uniprot ID P00915
EC number 4.2.1.1
Protein family Information(Pfam) PF00194;
PDB id 1AZM;1BZM;1CRM;1CZM;1HCB;1HUG;1HUH;1J9W;1JV0;2CAB;2FOY;2FW4;2IT4;2NMX;2NN1;2NN7;3LXE;3W6H;3W6I;4WR7;4WUP;4WUQ;5E2M;5GMM;6EVR;6EX1;6F3B;6FAF;6FAG;6G3V;6HWZ;6I0J;6I0L;
InterPro ID IPR001148;IPR036398;IPR023561;IPR018338;IPR018442;
dbSNP rs990757234 rs7821248 rs121909577

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CA1 STAT4 0.9
Gene Ontology Semantic Similarity
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# 759 (CA1) 6775 (STAT4)
759 (CA1) 1.00 1.00
6775 (STAT4) 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CA1 Human Serum - 2400 m 0.5 hours upregulated 0.416 2-DE Western Europe Germans 0.298 Healthy adults never had ear surgery or problems with pressure equalization 28858246
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
GATA1 2623 CA1 759 proximal_filtered 22955619 TRANSFAC
TAL1 6886 CA1 759 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT021737 hsa-miR-132-3p Homo sapiens CA1 759 Homo sapiens Microarray Functional MTI (Weak) 17612493
MIRT028780 hsa-miR-26b-5p Homo sapiens CA1 759 Homo sapiens Microarray Functional MTI (Weak) 19088304
Gene Ontology
ID GO ID GO Term GO Type
759 GO:0005737 cytoplasm GOTERM_CC_DIRECT
759 GO:0004064 aminoacylase activity GOTERM_MF_DIRECT
759 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
759 GO:0015701 bicarbonate transport GOTERM_BP_DIRECT
759 GO:0005829 cytosol GOTERM_CC_DIRECT
759 GO:0016836 lyase activity GOTERM_MF_DIRECT
759 GO:0005515 protein binding GOTERM_MF_DIRECT
759 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
759 GO:0006730 one-carbon metabolic process GOTERM_BP_DIRECT
759 GO:0004089 bisphosphoglycerate 2-phosphatase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
759 hsa00910 Nitrogen metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CA1 759 Adenocarcinoma C0001418 Neoplastic Process 0.3 0.672 0.379 group
CA1 759 Adenocarcinoma, Tubular C0205645 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Carcinoma, Cribriform C0205643 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.672 0.379 group
CA1 759 Adenocarcinoma, Basal Cell C0205641 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Adenocarcinoma, Oxyphilic C0205642 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Pneumoconiosis C0032273 Disease or Syndrome 0.3 0.672 0.379 disease
CA1 759 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Squamous cell carcinoma of esophagus C0279626 Neoplastic Process 0.3 0.672 0.379 disease
CA1 759 Bagassosis C0004681 Disease or Syndrome 0.3 0.672 0.379 disease
CA1 759 Carcinoma, Granular Cell C0205644 Neoplastic Process 0.3 0.672 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CA1 759 ACETAZOLAMIDE ACETAZOLAMIDE CHEMBL20 inhibitor
CA1 759 ACETAZOLAMIDE SODIUM ACETAZOLAMIDE SODIUM CHEMBL1200814 inhibitor
CA1 759 ACETAZOLAMIDE ACETAZOLAMIDE CHEMBL20 inhibitor
CA1 759 ACETAZOLAMIDE ACETAZOLAMIDE CHEMBL20 None
CA1 759 ACETAZOLAMIDE ACETAZOLAMIDE CHEMBL20 None
CA1 759 BENZOLAMIDE BENZOLAMIDE CHEMBL73962 inhibitor
CA1 759 BRINZOLAMIDE BRINZOLAMIDE CHEMBL220491 inhibitor
CA1 759 CG100649 POLMACOXIB CHEMBL166863 None
CA1 759 CHLOROTHIAZIDE CHLOROTHIAZIDE CHEMBL842 None
CA1 759 CHLOROTHIAZIDE CHLOROTHIAZIDE CHEMBL842 None
CA1 759 CHLORTHALIDONE CHLORTHALIDONE CHEMBL1055 inhibitor
CA1 759 DICHLORPHENAMIDE DICHLORPHENAMIDE CHEMBL17 None
CA1 759 DICHLORPHENAMIDE DICHLORPHENAMIDE CHEMBL17 None
CA1 759 DICHLORPHENAMIDE DICHLORPHENAMIDE CHEMBL17 inhibitor
CA1 759 DICLOFENAMIDE DICHLORPHENAMIDE CHEMBL17 inhibitor
CA1 759 DORZOLAMIDE DORZOLAMIDE CHEMBL218490 inhibitor
CA1 759 ETHOXZOLAMIDE ETHOXZOLAMIDE CHEMBL18 None
CA1 759 ETHOXZOLAMIDE ETHOXZOLAMIDE CHEMBL18 inhibitor
CA1 759 ETHOXZOLAMIDE ETHOXZOLAMIDE CHEMBL18 inhibitor
CA1 759 ETHOXZOLAMIDE ETHOXZOLAMIDE CHEMBL18 None
CA1 759 GALLIC ACID GALLIC ACID CHEMBL288114 inhibitor
CA1 759 INDISULAM INDISULAM CHEMBL77517 inhibitor
CA1 759 LEVETIRACETAM LEVETIRACETAM CHEMBL1286 None
CA1 759 METHAZOLAMIDE METHAZOLAMIDE CHEMBL19 None
CA1 759 METHAZOLAMIDE METHAZOLAMIDE CHEMBL19 inhibitor
CA1 759 METHOCARBAMOL METHOCARBAMOL CHEMBL1201117 inhibitor
CA1 759 METHAZOLAMIDE METHAZOLAMIDE CHEMBL19 None
CA1 759 METHOCARBAMOL METHOCARBAMOL CHEMBL1201117 inhibitor
CA1 759 METHAZOLAMIDE METHAZOLAMIDE CHEMBL19 inhibitor
CA1 759 POLMACOXIB POLMACOXIB CHEMBL166863 inhibitor
CA1 759 SULPIRIDE SULPIRIDE CHEMBL26 inhibitor
CA1 759 TOPIRAMATE TOPIRAMATE CHEMBL220492 inhibitor
CA1 759 TRICHLORMETHIAZIDE TRICHLORMETHIAZIDE CHEMBL1054 None
CA1 759 TRICHLORMETHIAZIDE TRICHLORMETHIAZIDE CHEMBL1054 None
CA1 759 ZONISAMIDE ZONISAMIDE CHEMBL750 inhibitor
CA1 759 ZONISAMIDE ZONISAMIDE CHEMBL750 None