CA-III

AltitudeomicsDB
Protein Official symbol CA3
Aliases CA3
Chromosomal Location 8
Length 260
Uniprot ID P07451
EC number 4.2.1.1
Protein family Information(Pfam) PF00194;
PDB id 1Z93;1Z97;2HFW;3UYN;3UYQ;
InterPro ID IPR001148;IPR036398;IPR023561;IPR018338;IPR018441;
dbSNP rs20571

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TTC3 CA3 0.794
CA3 CYP24A1 0.738
Gene Ontology Semantic Similarity
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# 7267 (TTC3) 761 (CA3) 1591 (CYP24A1)
7267 (TTC3) 1.00 0.24 0.36
761 (CA3) 0.24 1.00 0.36
1591 (CYP24A1) 0.36 0.36 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CA3 Human Skeletal muscle - 4559 m 9 day downregulated -1.29 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT018185 hsa-miR-335-5p Homo sapiens CA3 761 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT023831 hsa-miR-1-3p Homo sapiens CA3 761 Homo sapiens Microarray Functional MTI (Weak) 18668037
Gene Ontology
ID GO ID GO Term GO Type
761 GO:0006730 one-carbon metabolic process GOTERM_BP_DIRECT
761 GO:0006979 response to oxidative stress GOTERM_BP_DIRECT
761 GO:0016311 dephosphorylation GOTERM_BP_DIRECT
761 GO:0016151 mannosidase activity GOTERM_MF_DIRECT
761 GO:0016791 hydrolase activity GOTERM_MF_DIRECT
761 GO:0005737 cytoplasm GOTERM_CC_DIRECT
761 GO:0015701 bicarbonate transport GOTERM_BP_DIRECT
761 GO:0045471 response to ethanol GOTERM_BP_DIRECT
761 GO:0004089 carbonate dehydratase activity GOTERM_MF_DIRECT
761 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
761 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
761 hsa00910 Nitrogen metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CA3 761 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.5 0.69 0.379 disease
CA3 761 Pneumoconiosis C0032273 Disease or Syndrome 0.3 0.69 0.379 disease
CA3 761 Bagassosis C0004681 Disease or Syndrome 0.3 0.69 0.379 disease
CA3 761 Obesity C0028754 Disease or Syndrome 0.3 0.69 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CA3 761 ACETAZOLAMIDE ACETAZOLAMIDE CHEMBL20 None
CA3 761 ETHOXZOLAMIDE ETHOXZOLAMIDE CHEMBL18 inhibitor
CA3 761 ISOTRETINOIN ISOTRETINOIN CHEMBL547 None