Threonyl-tRNA synthetase 2, mitochondrial

AltitudeomicsDB
Protein Official symbol TARS2
Aliases TARS2 TARSL1
Chromosomal Location 1
Length 718
Uniprot ID Q9BW92
EC number 6.1.1.3
Protein family Information(Pfam) PF03129;PF02824;PF00587;PF07973;
PDB id None
InterPro ID IPR002314;IPR006195;IPR004154;IPR036621;IPR012675;IPR004095;IPR012676;IPR002320;IPR018163;IPR033728;IPR012947;
dbSNP rs587777593

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
IARS EPRS 0.999
EPRS MARS 0.998
IARS MARS 0.997
YARS EPRS 0.995
YARS AARS 0.99
EPRS AARS 0.988
IARS YARS 0.983
MARS AARS 0.975
YARS MARS 0.974
LARS2 YARS 0.972
IARS AARS 0.949
YARS TARS2 0.936
EPRS IARS2 0.936
TARS2 EPRS 0.935
IARS2 MARS 0.93
TARS2 AARS 0.925
YARS IARS2 0.924
LARS2 AARS 0.923
LARS2 EPRS 0.923
TARS2 MARS 0.921
LARS2 MARS 0.917
IARS TARS2 0.91
IARS2 AARS 0.91
TARS2 IARS2 0.907
LARS2 TARS2 0.901
Gene Ontology Semantic Similarity
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# 3376 (IARS) 2058 (EPRS) 8565 (YARS) 4141 (MARS) 23395 (LARS2) 80222 (TARS2) 55699 (IARS2)
3376 (IARS) 1.00 0.76 0.67 0.75 0.75 0.55 1.00
2058 (EPRS) 0.76 1.00 0.74 0.75 0.75 0.60 0.75
8565 (YARS) 0.67 0.74 1.00 0.75 0.75 0.45 0.75
4141 (MARS) 0.75 0.75 0.75 1.00 0.75 0.75 0.75
23395 (LARS2) 0.75 0.75 0.75 0.75 1.00 0.75 0.75
80222 (TARS2) 0.55 0.60 0.45 0.75 0.75 1.00 0.75
55699 (IARS2) 1.00 0.75 0.75 0.75 0.75 0.75 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
TARS2 Rat Blood - 9144 m 1 hour upregulated - 2D- gel Electrophoresis, MALDI India SD rats - Susceptible(<27min )Vs Tolerant(8 min) at 9300 m 25758574
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
FOS 2353 TARS2 80222 proximal_filtered 22955619 TRANSFAC
SP1 6667 TARS2 80222 proximal_filtered 22955619 TRANSFAC
PBX3 5090 TARS2 80222 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT041757 hsa-miR-484 Homo sapiens TARS2 80222 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT761574 hsa-miR-1247-3p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT762431 hsa-miR-1304-3p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT763886 hsa-miR-216a-5p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT763599 hsa-miR-1976 Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT766394 hsa-miR-3653-5p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT768347 hsa-miR-4279 Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT770089 hsa-miR-4532 Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT772210 hsa-miR-4772-3p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT772864 hsa-miR-498 Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT777843 hsa-miR-6722-5p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT778050 hsa-miR-6736-3p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT779209 hsa-miR-6787-3p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT781148 hsa-miR-6890-3p Homo sapiens TARS2 80222 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
Gene Ontology
ID GO ID GO Term GO Type
80222 GO:0070159 mitochondrial threonyl-tRNA aminoacylation GOTERM_BP_DIRECT
80222 GO:0005524 ATP binding GOTERM_MF_DIRECT
80222 GO:0005739 mitochondrion GOTERM_CC_DIRECT
80222 GO:0004829 aminoacyl-tRNA ligase activity GOTERM_MF_DIRECT
80222 GO:0005737 cytoplasm GOTERM_CC_DIRECT
80222 GO:0003723 RNA binding GOTERM_MF_DIRECT
80222 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
80222 GO:0006435 threonyl-tRNA aminoacylation GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
80222 hsa00970 Aminoacyl-tRNA biosynthesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
TARS2 80222 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 21 C4014668 Disease or Syndrome 0.7 0.773 0.345 disease
TARS2 80222 Mitochondrial Diseases C0751651 Disease or Syndrome 0.3 0.773 0.345 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types