Mucosal vascular addressin cell adhesion molecule 1

AltitudeomicsDB
Protein Official symbol MADCAM1
Aliases MADCAM1
Chromosomal Location 19
Length 382
Uniprot ID Q13477
EC number None
Protein family Information(Pfam) PF09085;
PDB id 1BQS;1GSM;4HBQ;4HC1;4HCR;4HD9;
InterPro ID IPR015169;IPR007110;IPR036179;IPR013783;IPR003599;IPR037413;
dbSNP rs3745925

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ITGA4 ITGB7 0.971
SELL MADCAM1 0.962
ITGA4 MADCAM1 0.955
ITGB7 MADCAM1 0.951
RHOA ITGA4 0.918
RHOA ITGB7 0.907
RHOA MADCAM1 0.906
Gene Ontology Semantic Similarity
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# 3695 (ITGB7) 8174 (MADCAM1) 3676 (ITGA4) 6402 (SELL) 387 (RHOA)
3695 (ITGB7) 1.00 0.81 0.77 0.61 0.61
8174 (MADCAM1) 0.81 1.00 0.49 0.39 0.39
3676 (ITGA4) 0.77 0.49 1.00 0.58 0.57
6402 (SELL) 0.61 0.39 0.58 1.00 0.54
387 (RHOA) 0.61 0.39 0.57 0.54 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MADCAM1 Human Blood - 3250 m 4 day upregulated 2.43 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
BTF3 689 MADCAM1 8174 Unknown 11027556 TRUSST
RELA 5970 MADCAM1 8174 Unknown 18499083 TRUSST
NFKB1 4790 MADCAM1 8174 Unknown 18194454 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
8174 GO:0034113 heterotypic cell-cell adhesion GOTERM_BP_DIRECT
8174 GO:0030198 extracellular matrix organization GOTERM_BP_DIRECT
8174 GO:0002687 positive regulation of leukocyte migration GOTERM_BP_DIRECT
8174 GO:0007165 signal transduction GOTERM_BP_DIRECT
8174 GO:0098640 cullin family protein binding GOTERM_MF_DIRECT
8174 GO:0005886 plasma membrane GOTERM_CC_DIRECT
8174 GO:0050901 leukocyte tethering or rolling GOTERM_BP_DIRECT
8174 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
8174 GO:0007160 cell-matrix adhesion GOTERM_BP_DIRECT
8174 GO:0007229 integrin-mediated signaling pathway GOTERM_BP_DIRECT
8174 GO:0050776 regulation of immune response GOTERM_BP_DIRECT
8174 GO:0007155 cell adhesion GOTERM_BP_DIRECT
8174 GO:0016020 membrane GOTERM_CC_DIRECT
8174 GO:0006955 immune response GOTERM_BP_DIRECT
8174 GO:0007568 aging GOTERM_BP_DIRECT
8174 GO:0043113 receptor clustering GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
8174 hsa04514 Cell adhesion molecules
8174 hsa04672 Intestinal immune network for IgA production
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MADCAM1 8174 Corpus Luteum Cyst C0010093 Disease or Syndrome 0.3 0.696 0.345 disease
MADCAM1 8174 Colitis C0009319 Disease or Syndrome 0.32 0.696 0.345 disease
MADCAM1 8174 Ovarian Cysts C0029927 Disease or Syndrome 0.3 0.696 0.345 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
MADCAM1 8174 PF-00547659 PF-00547659 CHEMBL2109511 inhibitor
MADCAM1 8174 PF-00547659 PF-00547659 CHEMBL2109511 antibody