double C2-like domains, alpha
AltitudeomicsDB
| Protein Official symbol |
DOC2A |
| Aliases |
DOC2A |
| Chromosomal Location |
16 |
| Length |
400 |
| Uniprot ID |
Q14183 |
| EC number |
None |
| Protein family Information(Pfam) |
PF00168; |
| PDB id |
4MJJ; |
| InterPro ID |
IPR000008;IPR035892;IPR014638;IPR030535;IPR001565; |
| dbSNP |
rs1140239 |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| UNC13B |
SNAP25 |
0.984 |
| UNC13A |
UNC13B |
0.958 |
| SEZ6L2 |
ASPHD1 |
0.911 |
| DOC2A |
SNAP25 |
0.852 |
| UNC13A |
SNAP25 |
0.831 |
| FAM57B |
ASPHD1 |
0.817 |
| SEZ6L2 |
DOC2A |
0.782 |
| DOC2A |
ASPHD1 |
0.772 |
| SEZ6L2 |
HIRIP3 |
0.746 |
| UNC13A |
DOC2A |
0.745 |
| FAM57B |
DOC2A |
0.738 |
| SEZ6L2 |
FAM57B |
0.724 |
| DOC2A |
HIRIP3 |
0.715 |
| UNC13B |
DOC2A |
0.708 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
10497 (UNC13B) |
23025 (UNC13A) |
8448 (DOC2A) |
6616 (SNAP25) |
8479 (HIRIP3) |
|
10497 (UNC13B)
|
1.00
|
0.78
|
1.00
|
0.83
|
1.00
|
|
23025 (UNC13A)
|
0.78
|
1.00
|
0.82
|
0.83
|
0.82
|
|
8448 (DOC2A)
|
1.00
|
0.82
|
1.00
|
1.00
|
1.00
|
|
6616 (SNAP25)
|
0.83
|
0.83
|
1.00
|
1.00
|
1.00
|
|
8479 (HIRIP3)
|
1.00
|
0.82
|
1.00
|
1.00
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| DOC2A |
Human |
Blood |
- |
3650 m |
48 hours |
downregulated |
0.673 |
Microarray |
Himalayas |
Indians |
1 |
HAPE Pateints Vs Normal |
http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 8448 |
GO:0030672 |
synaptic vesicle membrane |
GOTERM_CC_DIRECT |
| 8448 |
GO:0007268 |
chemical synaptic transmission |
GOTERM_BP_DIRECT |
| 8448 |
GO:0005509 |
calcium ion binding |
GOTERM_MF_DIRECT |
| 8448 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
| 8448 |
GO:0005764 |
lysosome |
GOTERM_CC_DIRECT |
| 8448 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
| 8448 |
GO:0030276 |
carbohydrate binding |
GOTERM_MF_DIRECT |
| 8448 |
GO:0006906 |
vesicle fusion |
GOTERM_BP_DIRECT |
| 8448 |
GO:0016020 |
membrane |
GOTERM_CC_DIRECT |
| 8448 |
GO:0017158 |
regulation of calcium ion-dependent exocytosis |
GOTERM_BP_DIRECT |
| 8448 |
GO:0048791 |
calcium ion-regulated exocytosis of neurotransmitter |
GOTERM_BP_DIRECT |
| 8448 |
GO:0030054 |
cell junction |
GOTERM_CC_DIRECT |
| 8448 |
GO:0043005 |
neuron projection |
GOTERM_CC_DIRECT |
| 8448 |
GO:0005544 |
calcium-dependent phospholipid binding |
GOTERM_MF_DIRECT |
| 8448 |
GO:0019905 |
protein domain specific binding |
GOTERM_MF_DIRECT |
| 8448 |
GO:0007399 |
nervous system development |
GOTERM_BP_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |