Apoptosis inducing factor 2

AltitudeomicsDB
Protein Official symbol AIFM2
Aliases AIFM2 AMID PRG3
Chromosomal Location 10
Length 373
Uniprot ID Q9BRQ8
EC number 1.6.5.-
Protein family Information(Pfam) PF07992;
PDB id None
InterPro ID IPR036188;IPR023753;
dbSNP rs10999147 rs2271694

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SUOX CYCS 0.9890000000000001
CAT GSR 0.987
CAT DAO 0.9740000000000001
ENDOG AIFM1 0.965
CYCS CAT 0.963
PIPOX DAO 0.953
DDO PIPOX 0.951
TYSND1 CAT 0.9390000000000001
DDO CAT 0.938
PIPOX CAT 0.935
PIPOX TYSND1 0.934
DDO TYSND1 0.932
AIFM2 TP53 0.9309999999999999
TYSND1 DAO 0.9209999999999999
DDO DAO 0.9159999999999999
AIFM1 GSR 0.902
TXNRD1 CAT 0.8959999999999999
ENDOG CYCS 0.879
CYCS TP53 0.8390000000000001
CYCS GSR 0.835
AIFM2 GADD45GIP1 0.8
ALAD CAT 0.768
CYCS AIFM1 0.703
EXOG AIFM1 0.703
TP53 CAT 0.68
AIFM2 TYSND1 0.627
TXNRD1 TP53 0.596
IMMP2L MIPEP 0.574
AIFM2 SUOX 0.5720000000000001
ALAD DAO 0.569
AIFM2 GSR 0.564
TXNRD1 CYCS 0.557
HAGHL DHX32 0.556
AIFM2 ETFDH 0.5529999999999999
AIFM2 FASTKD5 0.552
AIFM2 CYCS 0.551
SUOX CAT 0.545
AIFM2 ENDOG 0.544
GADD45GIP1 TP53 0.5379999999999999
AIFM2 CNPY4 0.5329999999999999
AIFM2 AIFM1 0.532
AIFM2 MIPEP 0.527
ETFDH CYCS 0.525
ENDOG TP53 0.516
NDUFV1 CYCS 0.512
ETFDH SUOX 0.498
AIFM1 TP53 0.4970000000000001
AIFM2 PACS2 0.492
ETFDH NDUFV1 0.492
AIFM2 CAT 0.489
TP53 GSR 0.48
AIFM2 NCAN 0.469
CYCS EXOG 0.468
TXNRD1 AIFM1 0.466
AIFM2 SLC25A23 0.465
AIFM2 TOMM20L 0.463
MIPEP SLC25A23 0.461
AIFM2 TXNRD1 0.454
AIFM2 DDO 0.448
AIFM2 DAO 0.448
AIFM2 EXOG 0.445
ALAD GSR 0.444
TXNRD1 SUOX 0.4429999999999999
DDO AIFM1 0.441
AIFM2 CARD14 0.441
AIFM2 DHX32 0.436
AIFM2 HAGHL 0.435
AIFM2 FAM196A 0.433
AIFM2 NDUFV1 0.43
AIFM2 PIPOX 0.424
AIFM1 DAO 0.424
PIPOX AIFM1 0.424
AIFM2 IMMP2L 0.423
AIFM2 PGLYRP2 0.42
AIFM2 ARMC3 0.414
AIFM2 ALAD 0.411
TXNRD1 GSR 0.407
AIFM1 CAT 0.402
Gene Ontology Semantic Similarity
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# 6821 (SUOX) 847 (CAT) 2021 (ENDOG) 54205 (CYCS) 51268 (PIPOX) 8528 (DDO) 219743 (TYSND1) 84883 (AIFM2) 9131 (AIFM1) 7296 (TXNRD1) 210 (ALAD) 9941 (EXOG) 7157 (TP53) 83943 (IMMP2L) 90480 (GADD45GIP1) 2110 (ETFDH) 4723 (NDUFV1) 4285 (MIPEP) 2936 (GSR) 1610 (DAO) 55760 (DHX32) 60493 (FASTKD5) 245812 (CNPY4) 23241 (PACS2) 79085 (SLC25A23) 387990 (TOMM20L) 79092 (CARD14) 114770 (PGLYRP2)
6821 (SUOX) 1.00 0.68 0.40 0.64 0.57 0.59 0.37 0.47 0.57 0.55 0.46 0.15 0.52 0.28 1.00 0.46 0.27 0.16 0.42 0.64 0.55 0.61 0.50 0.82 0.49 0.21 0.69 0.26
847 (CAT) 0.68 1.00 0.45 0.58 0.60 0.60 0.41 0.44 0.59 0.58 0.56 0.18 0.54 0.39 0.82 0.50 0.39 0.23 0.41 0.66 0.52 0.55 0.57 0.66 0.48 0.20 0.56 0.27
2021 (ENDOG) 0.40 0.45 1.00 0.48 0.43 0.44 0.36 0.23 0.43 0.38 0.46 0.88 0.47 0.48 1.00 0.33 0.16 0.27 0.22 0.48 0.38 0.40 0.43 0.82 0.37 0.16 0.69 0.30
54205 (CYCS) 0.64 0.58 0.48 1.00 0.49 0.50 0.37 0.33 0.46 0.42 0.44 0.27 0.51 0.39 1.00 0.41 0.13 0.20 0.41 0.55 0.51 0.57 0.52 0.82 0.47 0.20 0.69 0.27
51268 (PIPOX) 0.57 0.60 0.43 0.49 1.00 0.65 0.40 0.40 0.66 0.59 0.52 0.17 0.50 0.28 1.00 0.45 0.27 0.16 0.28 0.66 0.51 0.55 0.64 0.82 0.54 0.20 0.69 0.27
8528 (DDO) 0.59 0.60 0.44 0.50 0.65 1.00 0.40 0.34 0.64 0.58 0.51 0.16 0.50 0.28 1.00 0.52 0.27 0.16 0.31 0.91 0.52 0.55 0.61 0.82 0.54 0.22 0.69 0.28
219743 (TYSND1) 0.37 0.41 0.36 0.37 0.40 0.40 1.00 0.20 0.40 0.35 0.36 0.22 0.41 0.55 0.69 0.25 0.13 0.59 0.18 0.42 0.37 0.39 0.41 0.56 0.39 0.14 0.47 0.24
84883 (AIFM2) 0.47 0.44 0.23 0.33 0.40 0.34 0.20 1.00 0.38 0.35 0.31 0.15 0.32 0.28 0.37 0.58 0.27 0.16 0.51 0.47 0.41 0.51 0.27 0.30 0.24 0.14 0.25 0.19
9131 (AIFM1) 0.57 0.59 0.43 0.46 0.66 0.64 0.40 0.38 1.00 0.82 0.56 0.23 0.49 0.39 1.00 0.51 0.59 0.23 0.38 0.64 0.48 0.51 0.56 0.82 0.49 0.19 0.69 0.29
7296 (TXNRD1) 0.55 0.58 0.38 0.42 0.59 0.58 0.35 0.35 0.82 1.00 0.52 0.20 0.48 0.33 1.00 0.48 0.49 0.19 0.45 0.60 0.43 0.46 0.50 0.82 0.43 0.18 0.69 0.27
210 (ALAD) 0.46 0.56 0.46 0.44 0.52 0.51 0.36 0.31 0.56 0.52 1.00 0.31 0.48 0.62 0.82 0.44 0.37 0.37 0.30 0.51 0.42 0.43 0.52 0.66 0.42 0.19 0.56 0.31
9941 (EXOG) 0.15 0.18 0.88 0.27 0.17 0.16 0.22 0.15 0.23 0.20 0.31 1.00 0.10 0.48 0.16 0.22 0.16 0.27 0.16 0.15 0.13 0.13 0.23 0.13 0.13 0.08 0.11 0.24
7157 (TP53) 0.52 0.54 0.47 0.51 0.50 0.50 0.41 0.32 0.49 0.48 0.48 0.10 1.00 0.21 1.00 0.31 0.13 0.13 0.25 0.53 0.55 0.57 0.44 0.82 0.50 0.20 0.69 0.23
83943 (IMMP2L) 0.28 0.39 0.48 0.39 0.28 0.28 0.55 0.28 0.39 0.33 0.62 0.48 0.21 1.00 0.21 0.48 0.23 0.58 0.28 0.28 0.21 0.21 0.38 0.17 0.21 0.13 0.15 0.48
90480 (GADD45GIP1) 1.00 0.82 1.00 1.00 1.00 1.00 0.69 0.37 1.00 1.00 0.82 0.16 1.00 0.21 1.00 0.48 0.13 0.13 0.34 1.00 1.00 1.00 0.82 0.82 1.00 0.36 0.69 0.41
2110 (ETFDH) 0.46 0.50 0.33 0.41 0.45 0.52 0.25 0.58 0.51 0.48 0.44 0.22 0.31 0.48 0.48 1.00 0.49 0.28 0.56 0.58 0.33 0.34 0.40 0.39 0.30 0.19 0.33 0.27
4723 (NDUFV1) 0.27 0.39 0.16 0.13 0.27 0.27 0.13 0.27 0.59 0.49 0.37 0.16 0.13 0.23 0.13 0.49 1.00 0.13 0.31 0.27 0.13 0.13 0.23 0.10 0.13 0.07 0.08 0.16
4285 (MIPEP) 0.16 0.23 0.27 0.20 0.16 0.16 0.59 0.16 0.23 0.19 0.37 0.27 0.13 0.58 0.13 0.28 0.13 1.00 0.16 0.16 0.13 0.13 0.22 0.10 0.13 0.07 0.08 0.27
2936 (GSR) 0.42 0.41 0.22 0.41 0.28 0.31 0.18 0.51 0.38 0.45 0.30 0.16 0.25 0.28 0.34 0.56 0.31 0.16 1.00 0.44 0.27 0.30 0.39 0.28 0.23 0.16 0.23 0.20
1610 (DAO) 0.64 0.66 0.48 0.55 0.66 0.91 0.42 0.47 0.64 0.60 0.51 0.15 0.53 0.28 1.00 0.58 0.27 0.16 0.44 1.00 0.57 0.60 0.61 0.82 0.59 0.23 0.69 0.29
55760 (DHX32) 0.55 0.52 0.38 0.51 0.51 0.52 0.37 0.41 0.48 0.43 0.42 0.13 0.55 0.21 1.00 0.33 0.13 0.13 0.27 0.57 1.00 0.83 0.51 0.82 0.50 0.20 0.69 0.25
60493 (FASTKD5) 0.61 0.55 0.40 0.57 0.55 0.55 0.39 0.51 0.51 0.46 0.43 0.13 0.57 0.21 1.00 0.34 0.13 0.13 0.30 0.60 0.83 1.00 0.53 0.82 0.56 0.23 0.69 0.26
245812 (CNPY4) 0.50 0.57 0.43 0.52 0.64 0.61 0.41 0.27 0.56 0.50 0.52 0.23 0.44 0.38 0.82 0.40 0.23 0.22 0.39 0.61 0.51 0.53 1.00 0.66 0.56 0.25 0.56 0.30
23241 (PACS2) 0.82 0.66 0.82 0.82 0.82 0.82 0.56 0.30 0.82 0.82 0.66 0.13 0.82 0.17 0.82 0.39 0.10 0.10 0.28 0.82 0.82 0.82 0.66 1.00 0.82 0.28 0.56 0.33
79085 (SLC25A23) 0.49 0.48 0.37 0.47 0.54 0.54 0.39 0.24 0.49 0.43 0.42 0.13 0.50 0.21 1.00 0.30 0.13 0.13 0.23 0.59 0.50 0.56 0.56 0.82 1.00 0.30 0.69 0.23
387990 (TOMM20L) 0.21 0.20 0.16 0.20 0.20 0.22 0.14 0.14 0.19 0.18 0.19 0.08 0.20 0.13 0.36 0.19 0.07 0.07 0.16 0.23 0.20 0.23 0.25 0.28 0.30 1.00 0.24 0.14
79092 (CARD14) 0.69 0.56 0.69 0.69 0.69 0.69 0.47 0.25 0.69 0.69 0.56 0.11 0.69 0.15 0.69 0.33 0.08 0.08 0.23 0.69 0.69 0.69 0.56 0.56 0.69 0.24 1.00 0.27
114770 (PGLYRP2) 0.26 0.27 0.30 0.27 0.27 0.28 0.24 0.19 0.29 0.27 0.31 0.24 0.23 0.48 0.41 0.27 0.16 0.27 0.20 0.29 0.25 0.26 0.30 0.33 0.23 0.14 0.27 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
AIFM2 Human Saliva - 4175 m 7 day downregulated 1.27 2-DE Himalayas Indians 0.81 Individuals residing at sea level 30219637
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
E2F1 1869 AIFM2 84883 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023966 hsa-miR-1-3p Homo sapiens AIFM2 84883 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT031880 hsa-miR-16-5p Homo sapiens AIFM2 84883 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT038645 hsa-miR-140-3p Homo sapiens AIFM2 84883 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046525 hsa-miR-15b-5p Homo sapiens AIFM2 84883 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT437634 hsa-miR-150-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT437634 hsa-miR-150-5p Homo sapiens AIFM2 84883 Homo sapiens Microarray//qRT-PCR Functional MTI (Weak) 22815788
MIRT660796 hsa-miR-6873-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660805 hsa-miR-6769b-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660810 hsa-miR-6800-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660797 hsa-miR-4713-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660799 hsa-miR-374c-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660800 hsa-miR-6817-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660809 hsa-miR-875-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660798 hsa-miR-655-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660801 hsa-miR-7110-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660807 hsa-miR-3183 Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660806 hsa-miR-4723-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660808 hsa-miR-153-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660803 hsa-miR-2116-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660802 hsa-miR-6845-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660797 hsa-miR-4713-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT660804 hsa-miR-532-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT705820 hsa-miR-1260b Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705822 hsa-miR-188-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705819 hsa-miR-3156-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705821 hsa-miR-1260a Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705834 hsa-miR-603 Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705825 hsa-miR-4493 Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705833 hsa-miR-6757-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705824 hsa-miR-6735-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705827 hsa-miR-6506-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705835 hsa-miR-214-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705830 hsa-miR-1224-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705832 hsa-miR-5197-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705823 hsa-miR-377-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705826 hsa-miR-3185 Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705831 hsa-miR-6826-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705828 hsa-miR-619-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705818 hsa-miR-5089-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705829 hsa-miR-342-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT723746 hsa-miR-6867-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723747 hsa-miR-5584-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723748 hsa-miR-6874-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723750 hsa-miR-3168 Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723745 hsa-miR-629-3p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723749 hsa-miR-148b-5p Homo sapiens AIFM2 84883 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
84883 GO:0005737 cytoplasm GOTERM_CC_DIRECT
84883 GO:0005741 mitochondrial outer membrane GOTERM_CC_DIRECT
84883 GO:0004174 dodecenoyl-CoA delta-isomerase activity GOTERM_MF_DIRECT
84883 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
84883 GO:0042981 regulation of apoptotic process GOTERM_BP_DIRECT
84883 GO:0003677 DNA binding GOTERM_MF_DIRECT
84883 GO:0050660 arachidonic acid binding GOTERM_MF_DIRECT
84883 GO:0008637 apoptotic mitochondrial changes GOTERM_BP_DIRECT
84883 GO:0005829 cytosol GOTERM_CC_DIRECT
84883 GO:0005615 extracellular space GOTERM_CC_DIRECT
84883 GO:0005739 mitochondrion GOTERM_CC_DIRECT
84883 GO:0005811 lipid particle GOTERM_CC_DIRECT
84883 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
84883 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types