Protein phosphatase 1D

AltitudeomicsDB
Protein Official symbol PPM1D
Aliases PPM1D WIP1
Chromosomal Location 17
Length 605
Uniprot ID O15297
EC number 3.1.3.16
Protein family Information(Pfam) PF00481;
PDB id None
InterPro ID IPR015655;IPR000222;IPR036457;IPR001932;
dbSNP rs17855093

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TP53 MDM2 0.999
ATM TP53 0.999
ATM MDM2 0.99
PPM1D MDM2 0.976
PPM1D ATM 0.939
PPM1D TP53 0.914
CBFB PPM1D 0.9
Gene Ontology Semantic Similarity
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# 7157 (TP53) 472 (ATM) 8493 (PPM1D) 865 (CBFB) 4193 (MDM2)
7157 (TP53) 1.00 0.53 0.51 0.67 0.66
472 (ATM) 0.53 1.00 0.76 0.46 0.58
8493 (PPM1D) 0.51 0.76 1.00 0.42 0.53
865 (CBFB) 0.67 0.46 0.42 1.00 0.50
4193 (MDM2) 0.66 0.58 0.53 0.50 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PPM1D Toad Heart - 3464 m 33 day upregulated 2.002548495 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
BCL11A 53335 PPM1D 8493 distal 22955619 TRANSFAC
EP300 2033 PPM1D 8493 distal 22955619 TRANSFAC
POU2F2 5452 PPM1D 8493 distal 22955619 TRANSFAC
IRF4 3662 PPM1D 8493 distal 22955619 TRANSFAC
MEF2A 4205 PPM1D 8493 distal 22955619 TRANSFAC
BATF 10538 PPM1D 8493 distal 22955619 TRANSFAC
CTCF 10664 PPM1D 8493 proximal_filtered 22955619 TRANSFAC
MYC 4609 PPM1D 8493 proximal_filtered 22955619 TRANSFAC
ZNF263 10127 PPM1D 8493 proximal_filtered 22955619 TRANSFAC
E2F1 1869 PPM1D 8493 proximal_filtered 22955619 TRANSFAC
CREB1 1385 PPM1D 8493 Activation 21411498 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT004044 hsa-miR-29a-3p Homo sapiens PPM1D 8493 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR//Western blot Functional MTI 21175813
MIRT005360 hsa-miR-16-5p Homo sapiens PPM1D 8493 Homo sapiens Northern blot//qRT-PCR//Western blot//Immunoblot//Luciferase reporter assay Functional MTI 20668064
MIRT005683 hsa-miR-145-5p Homo sapiens PPM1D 8493 Homo sapiens Immunoblot//Luciferase reporter assay Non-Functional MTI 20668064
MIRT005684 hsa-miR-203a-3p Homo sapiens PPM1D 8493 Homo sapiens Immunoblot//Luciferase reporter assay Non-Functional MTI 20668064
MIRT005682 hsa-miR-153-3p Homo sapiens PPM1D 8493 Homo sapiens Immunoblot//Luciferase reporter assay Functional MTI (Weak) 20668064
MIRT005685 hsa-miR-217 Homo sapiens PPM1D 8493 Homo sapiens Immunoblot//Luciferase reporter assay Functional MTI (Weak) 20668064
MIRT028938 hsa-miR-26b-5p Homo sapiens PPM1D 8493 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT044244 hsa-miR-29c-3p Homo sapiens PPM1D 8493 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT078311 hsa-miR-450a-1-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT197720 hsa-miR-15b-5p Homo sapiens PPM1D 8493 Homo sapiens Immunofluorescence//Luciferase reporter assay//Western blot Functional MTI 25092292
MIRT637662 hsa-miR-6513-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637675 hsa-miR-30c-1-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637678 hsa-miR-6883-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637666 hsa-miR-6780a-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637671 hsa-miR-30b-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637674 hsa-miR-30c-2-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637682 hsa-miR-149-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637680 hsa-miR-6785-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637677 hsa-miR-6799-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637688 hsa-miR-1228-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637690 hsa-miR-4419b Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637683 hsa-miR-138-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637672 hsa-miR-1273h-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637673 hsa-miR-6788-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637679 hsa-miR-4728-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637691 hsa-miR-3929 Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637664 hsa-miR-3913-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637670 hsa-miR-3689a-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637685 hsa-miR-342-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637668 hsa-miR-3689c Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637676 hsa-miR-7977 Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637681 hsa-miR-7106-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637689 hsa-miR-4478 Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637686 hsa-miR-645 Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637687 hsa-miR-383-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637663 hsa-miR-887-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637665 hsa-miR-3122 Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637667 hsa-miR-6779-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637669 hsa-miR-3689b-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT637684 hsa-miR-3135a Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673631 hsa-miR-4746-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673629 hsa-miR-24-3p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673633 hsa-miR-4712-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673630 hsa-miR-4284 Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673632 hsa-miR-770-5p Homo sapiens PPM1D 8493 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT746996 hsa-miR-4687-5p Homo sapiens PPM1D 8493 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT751596 hsa-miR-593-5p Homo sapiens PPM1D 8493 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
Gene Ontology
ID GO ID GO Term GO Type
8493 GO:0005515 protein binding GOTERM_MF_DIRECT
8493 GO:0000086 G2/M transition of mitotic cell cycle GOTERM_BP_DIRECT
8493 GO:0005634 nucleus GOTERM_CC_DIRECT
8493 GO:0004722 protein serine/threonine phosphatase activity GOTERM_MF_DIRECT
8493 GO:0051019 mitogen-activated protein kinase binding GOTERM_MF_DIRECT
8493 GO:0035970 peptidyl-threonine dephosphorylation GOTERM_BP_DIRECT
8493 GO:0009267 cellular response to starvation GOTERM_BP_DIRECT
8493 GO:0009314 response to radiation GOTERM_BP_DIRECT
8493 GO:0043169 ATP-dependent 5'-3' DNA helicase activity GOTERM_MF_DIRECT
8493 GO:0006470 protein dephosphorylation GOTERM_BP_DIRECT
8493 GO:0008285 negative regulation of cell proliferation GOTERM_BP_DIRECT
8493 GO:0009617 response to bacterium GOTERM_BP_DIRECT
8493 GO:0046872 metal ion binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
8493 hsa04115 p53 signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PPM1D 8493 Breast Carcinoma C0678222 Neoplastic Process 0.5 0.573 0.724 disease
PPM1D 8493 INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLD C4479517 Disease or Syndrome 0.4 0.573 0.724 disease
PPM1D 8493 Glioma C0017638 Neoplastic Process 0.33 0.573 0.724 disease
PPM1D 8493 Brain Stem Neoplasms, Primary C0751886 Neoplastic Process 0.3 0.573 0.724 group
PPM1D 8493 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.573 0.724 group
PPM1D 8493 Pontine Tumors C0751889 Neoplastic Process 0.3 0.573 0.724 group
PPM1D 8493 Mammary Neoplasms C1458155 Neoplastic Process 0.4 0.573 0.724 group
PPM1D 8493 Mesencephalic Neoplasms C0751888 Neoplastic Process 0.3 0.573 0.724 group
PPM1D 8493 Malignant neoplasm of breast C0006142 Neoplastic Process 0.4 0.573 0.724 disease
PPM1D 8493 mixed gliomas C0259783 Neoplastic Process 0.3 0.573 0.724 disease
PPM1D 8493 Malignant Glioma C0555198 Neoplastic Process 0.31 0.573 0.724 disease
PPM1D 8493 Medullary Neoplasms C0751887 Neoplastic Process 0.3 0.573 0.724 disease
PPM1D 8493 Neurodevelopmental Disorders C1535926 Mental or Behavioral Dysfunction 0.3 0.573 0.724 group
PPM1D 8493 Brain Stem Neoplasms C0677866 Neoplastic Process 0.3 0.573 0.724 group
PPM1D 8493 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.41 0.573 0.724 group
PPM1D 8493 Breast Cancer, Familial C0346153 Neoplastic Process 0.5 0.573 0.724 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types