CBFA2/RUNX1 Partner Transcriptional Co-Repressor 2

AltitudeomicsDB
Protein Official symbol CCNB3
Aliases CCNB3 CYCB3
Chromosomal Location  X
Length 1395
Uniprot ID Q8WWL7
EC number None
Protein family Information(Pfam) PF02984;PF00134;
PDB id None
InterPro ID IPR039361;IPR013763;IPR036915;IPR015452;IPR004367;IPR006671;
dbSNP rs6614336

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CDC20 CCNB2 0.999
CDC20 PLK1 0.999
CDK1 CCNB1 0.999
CDK1 CCNB2 0.999
CDC20 CCNB1 0.999
CDK1 MAD2L1 0.999
PLK1 CCNB1 0.999
CDC20 MAD2L1 0.999
CDK1 CDC20 0.999
MAD2L1 CCNB1 0.998
MAD2L1 CCNB2 0.998
PLK1 MAD2L1 0.998
PLK1 CCNB2 0.998
CDK1 PLK1 0.997
NUSAP1 CDK1 0.997
CCNB2 CCNB1 0.995
CDK1 CCNB3 0.995
NUSAP1 CDC20 0.991
CDK2 CCNB1 0.991
CDK1 PCNA 0.99
CCNB3 PLK1 0.989
PCNA CDK2 0.981
CCNB2 CDK2 0.981
CDK1 MCM7 0.98
NUSAP1 CCNB2 0.978
NUSAP1 MAD2L1 0.976
MCM7 CDK2 0.975
NUSAP1 PLK1 0.975
PCNA MCM7 0.972
CCNB3 CCNB2 0.968
CDK1 CDK2 0.968
CCNB3 CCNB1 0.967
CDC20 MCM7 0.963
PCNA MAD2L1 0.961
CCNB3 CDC20 0.944
MCM7 PLK1 0.939
NUSAP1 CCNB1 0.933
CCNB3 MCM7 0.933
MCM7 MAD2L1 0.933
MCM7 CCNB2 0.929
NUSAP1 CCNB3 0.926
PCNA CCNB3 0.92
CCNB3 CDK2 0.916
MCM7 CCNB1 0.908
CCNB3 MAD2L1 0.907
Gene Ontology Semantic Similarity
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# 991 (CDC20) 983 (CDK1) 5347 (PLK1) 4085 (MAD2L1) 51203 (NUSAP1) 9133 (CCNB2) 1017 (CDK2) 85417 (CCNB3) 5111 (PCNA) 4176 (MCM7)
991 (CDC20) 1.00 0.47 0.56 0.89 0.75 0.61 0.58 0.67 0.66 0.68
983 (CDK1) 0.47 1.00 0.79 0.48 0.40 0.84 0.97 0.82 0.45 0.37
5347 (PLK1) 0.56 0.79 1.00 0.59 0.57 0.74 0.76 0.73 0.55 0.47
4085 (MAD2L1) 0.89 0.48 0.59 1.00 0.73 0.59 0.58 0.64 0.64 0.67
51203 (NUSAP1) 0.75 0.40 0.57 0.73 1.00 0.51 0.50 0.54 0.62 0.68
9133 (CCNB2) 0.61 0.84 0.74 0.59 0.51 1.00 0.82 0.94 0.56 0.46
1017 (CDK2) 0.58 0.97 0.76 0.58 0.50 0.82 1.00 0.79 0.51 0.46
85417 (CCNB3) 0.67 0.82 0.73 0.64 0.54 0.94 0.79 1.00 0.58 0.48
5111 (PCNA) 0.66 0.45 0.55 0.64 0.62 0.56 0.51 0.58 1.00 0.63
4176 (MCM7) 0.68 0.37 0.47 0.67 0.68 0.46 0.46 0.48 0.63 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CCNB3 Toad Liver - 3464 m 33 day downregulated -2.163742189 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
CCNB3 Toad Heart - 3464 m 33 day downregulated -2.671268804 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
85417 GO:0010389 regulation of G2/M transition of mitotic cell cycle GOTERM_BP_DIRECT
85417 GO:0051321 meiotic cell cycle GOTERM_BP_DIRECT
85417 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GOTERM_BP_DIRECT
85417 GO:0005515 protein binding GOTERM_MF_DIRECT
85417 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
85417 GO:0019901 protein kinase binding GOTERM_MF_DIRECT
85417 GO:0051301 cell division GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
85417 hsa04068 FoxO signaling pathway
85417 hsa04110 Cell cycle
85417 hsa04115 p53 signaling pathway
85417 hsa04914 Progesterone-mediated oocyte maturation
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CCNB3 85417 Osteosarcoma C0029463 Neoplastic Process 0.31 0.785 0.069 disease
CCNB3 85417 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.785 0.069 group
CCNB3 85417 Colorectal Cancer C1527249 Neoplastic Process 0.3 0.785 0.069 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types