Protein kinase, interferon-inducible double stranded RNA dependent activator

AltitudeomicsDB
Protein Official symbol PRKRA
Aliases PRKRA PACT RAX HSD-14 HSD14
Chromosomal Location 2
Length 313
Uniprot ID O75569
EC number None
Protein family Information(Pfam) PF00035;PF16482;
PDB id 2DIX;
InterPro ID IPR014720;IPR033363;IPR032478;
dbSNP rs121434410

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
DICER1 AGO2 0.999
DROSHA DGCR8 0.999
DICER1 AGO1 0.999
RAN XPO5 0.999
DICER1 TARBP2 0.999
DICER1 AGO3 0.998
DICER1 XPO5 0.997
TARBP2 AGO2 0.996
DICER1 AGO4 0.996
DICER1 PRKRA 0.995
DICER1 DGCR8 0.992
PRKRA EIF2AK2 0.99
AGO3 TARBP2 0.988
XPO5 AGO2 0.987
AGO1 TARBP2 0.983
TARBP2 XPO5 0.982
DROSHA AGO2 0.981
PRKRA TARBP2 0.98
AGO1 XPO5 0.979
AGO1 AGO3 0.974
PRKRA AGO2 0.974
AGO3 AGO2 0.974
AGO1 AGO2 0.974
DROSHA AGO1 0.971
AGO4 XPO5 0.971
DROSHA XPO5 0.97
PRKRA XPO5 0.968
AGO4 TARBP2 0.968
DROSHA TARBP2 0.968
DGCR8 AGO2 0.963
XPO5 DGCR8 0.96
AGO3 XPO5 0.96
AGO1 PRKRA 0.956
TARBP2 DGCR8 0.954
DROSHA AGO4 0.954
AGO1 DGCR8 0.949
AGO4 PRKRA 0.946
DROSHA AGO3 0.945
DROSHA PRKRA 0.943
AGO3 PRKRA 0.937
RAN DICER1 0.935
PRKRA DGCR8 0.926
AGO4 DGCR8 0.924
AGO4 AGO3 0.924
RAN AGO2 0.923
RAN AGO1 0.916
RAN AGO3 0.909
AGO4 AGO2 0.909
RAN AGO4 0.907
RAN TARBP2 0.905
AGO4 AGO1 0.903
RAN PRKRA 0.903
AGO3 DGCR8 0.901
Gene Ontology Semantic Similarity
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# 23405 (DICER1) 29102 (DROSHA) 5901 (RAN) 6895 (TARBP2) 8575 (PRKRA) 192669 (AGO3) 57510 (XPO5) 26523 (AGO1) 192670 (AGO4) 54487 (DGCR8) 27161 (AGO2) 5610 (EIF2AK2)
23405 (DICER1) 1.00 0.81 0.55 0.76 0.74 0.87 0.65 0.68 0.68 0.81 0.81 0.58
29102 (DROSHA) 0.81 1.00 0.60 0.82 0.84 0.83 0.71 0.76 0.77 0.87 0.79 0.65
5901 (RAN) 0.55 0.60 1.00 0.65 0.64 0.58 0.67 0.61 0.58 0.56 0.60 0.52
6895 (TARBP2) 0.76 0.82 0.65 1.00 0.97 0.77 0.80 0.81 0.84 0.83 0.72 0.73
8575 (PRKRA) 0.74 0.84 0.64 0.97 1.00 0.79 0.82 0.85 0.88 0.86 0.74 0.73
192669 (AGO3) 0.87 0.83 0.58 0.77 0.79 1.00 0.71 0.80 0.83 0.82 0.90 0.63
57510 (XPO5) 0.65 0.71 0.67 0.80 0.82 0.71 1.00 0.76 0.76 0.68 0.68 0.61
26523 (AGO1) 0.68 0.76 0.61 0.81 0.85 0.80 0.76 1.00 0.88 0.73 0.84 0.67
192670 (AGO4) 0.68 0.77 0.58 0.84 0.88 0.83 0.76 0.88 1.00 0.75 0.72 0.67
54487 (DGCR8) 0.81 0.87 0.56 0.83 0.86 0.82 0.68 0.73 0.75 1.00 0.76 0.65
27161 (AGO2) 0.81 0.79 0.60 0.72 0.74 0.90 0.68 0.84 0.72 0.76 1.00 0.63
5610 (EIF2AK2) 0.58 0.65 0.52 0.73 0.73 0.63 0.61 0.67 0.67 0.65 0.63 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PRKRA Human Blood - 3650 m 48 hours downregulated 0.605 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EGR1 1958 PRKRA 8575 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT006128 hsa-miR-125b-5p Homo sapiens PRKRA 8575 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 21935352
MIRT006123 hsa-miR-122-5p Homo sapiens PRKRA 8575 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR//Western blot Functional MTI 21937511
Gene Ontology
ID GO ID GO Term GO Type
8575 GO:0042802 identical protein binding GOTERM_MF_DIRECT
8575 GO:0008047 enzyme activator activity GOTERM_MF_DIRECT
8575 GO:0044822 poly GOTERM_MF_DIRECT
8575 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
8575 GO:0006468 protein phosphorylation GOTERM_BP_DIRECT
8575 GO:0035196 production of miRNAs involved in gene silencing by miRNA GOTERM_BP_DIRECT
8575 GO:0030422 production of siRNA involved in RNA interference GOTERM_BP_DIRECT
8575 GO:0031054 pre-miRNA processing GOTERM_BP_DIRECT
8575 GO:0042474 middle ear morphogenesis GOTERM_BP_DIRECT
8575 GO:0005515 protein binding GOTERM_MF_DIRECT
8575 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
8575 GO:0006955 immune response GOTERM_BP_DIRECT
8575 GO:0042473 outer ear morphogenesis GOTERM_BP_DIRECT
8575 GO:0048705 skeletal system morphogenesis GOTERM_BP_DIRECT
8575 GO:0019899 enzyme binding GOTERM_MF_DIRECT
8575 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
8575 GO:0016301 kinase activity GOTERM_MF_DIRECT
8575 GO:0016020 membrane GOTERM_CC_DIRECT
8575 GO:0008285 negative regulation of cell proliferation GOTERM_BP_DIRECT
8575 GO:0031047 gene silencing by RNA GOTERM_BP_DIRECT
8575 GO:0034599 cellular response to oxidative stress GOTERM_BP_DIRECT
8575 GO:0005829 cytosol GOTERM_CC_DIRECT
8575 GO:0009615 response to virus GOTERM_BP_DIRECT
8575 GO:0005737 cytoplasm GOTERM_CC_DIRECT
8575 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
8575 GO:0003725 double-stranded RNA binding GOTERM_MF_DIRECT
8575 GO:0043085 positive regulation of catalytic activity GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PRKRA 8575 Profound Mental Retardation C0020796 Mental or Behavioral Dysfunction 0.3 0.6 0.448 disease
PRKRA 8575 Autosomal Dominant Familial Dystonia C0752200 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Dystonia C0013421 Sign or Symptom 0.39 0.6 0.448 phenotype
PRKRA 8575 Dystonia, Limb C0751093 Sign or Symptom 0.4 0.6 0.448 phenotype
PRKRA 8575 Mental deficiency C0917816 Mental or Behavioral Dysfunction 0.3 0.6 0.448 disease
PRKRA 8575 Parkinsonism, Experimental C0752101 Experimental Model of Disease 0.3 0.6 0.448 disease
PRKRA 8575 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE C1868675 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Pseudodystonia C0752208 Mental or Behavioral Dysfunction 0.3 0.6 0.448 disease
PRKRA 8575 Autosomal Dominant Parkinsonism C0752098 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Adult-Onset Idiopathic Torsion Dystonias C0752199 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Autosomal Recessive Familial Dystonia C0752201 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Writer's Cramp C4316810 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Parkinsonian Disorders C0242422 Disease or Syndrome 0.45 0.6 0.448 group
PRKRA 8575 Ramsay Hunt Paralysis Syndrome C0242423 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Dystonia, Diurnal C0393610 Sign or Symptom 0.3 0.6 0.448 phenotype
PRKRA 8575 Autosomal Recessive Parkinsonism C0752100 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Parkinsonism, Juvenile C0752105 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Dystonia, Paroxysmal C0393588 Sign or Symptom 0.3 0.6 0.448 phenotype
PRKRA 8575 Dystonia Disorders C0393593 Disease or Syndrome 0.38 0.6 0.448 group
PRKRA 8575 Childhood Onset Dystonias C0752202 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Idiopathic familial dystonia C0393598 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Autosomal Dominant Juvenile Parkinson Disease C0752097 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Focal Dystonia C0743332 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Dystonia, Secondary C0752205 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Mental Retardation, Psychosocial C0025363 Mental or Behavioral Dysfunction 0.3 0.6 0.448 disease
PRKRA 8575 Craniofacial Abnormalities C0376634 Congenital Abnormality 0.3 0.6 0.448 group
PRKRA 8575 Familial Juvenile Parkinsonism C0752104 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Adult-Onset Dystonias C0752197 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Dystonias, Sporadic C0752206 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Familial Dystonia C0752207 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Adult-Onset Idiopathic Focal Dystonias C0752198 Disease or Syndrome 0.3 0.6 0.448 disease
PRKRA 8575 Dystonia, Primary C0752203 Disease or Syndrome 0.31 0.6 0.448 disease
PRKRA 8575 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.5 0.6 0.448 group
PRKRA 8575 Parkinson Disease C0030567 Disease or Syndrome 0.31 0.6 0.448 disease
PRKRA 8575 DYSTONIA 16 (disorder) C2677567 Disease or Syndrome 0.61 0.6 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types