Regulatory factor X-associated ankyrin- containing protein

AltitudeomicsDB
Protein Official symbol RFXANK
Aliases RFXANK ANKRA1 RFXB
Chromosomal Location  19
Length 260
Uniprot ID O14593
EC number None
Protein family Information(Pfam) PF12796;PF13606;
PDB id 3UXG;3V30;6MEW;
InterPro ID IPR002110;IPR020683;IPR036770;IPR017362;
dbSNP rs34282046 rs751386365 rs1802498

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
RFXANK RFX5 0.998
RFX5 RFXAP 0.998
RFXANK HDAC4 0.997
CIITA RFX5 0.992
RFX7 RFXANK 0.989
RFXANK HDAC5 0.985
RFXANK RFXAP 0.982
CIITA RFXANK 0.966
CIITA RFXAP 0.948
HDAC4 HDAC5 0.931
Gene Ontology Semantic Similarity
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# 8625 (RFXANK) 5993 (RFX5) 4261 (CIITA) 64864 (RFX7) 9759 (HDAC4) 5994 (RFXAP) 10014 (HDAC5)
8625 (RFXANK) 1.00 0.49 0.37 0.62 0.18 0.77 0.18
5993 (RFX5) 0.49 1.00 0.58 0.80 0.63 0.74 0.62
4261 (CIITA) 0.37 0.58 1.00 0.30 0.65 0.56 0.67
64864 (RFX7) 0.62 0.80 0.30 1.00 0.32 0.64 0.35
9759 (HDAC4) 0.18 0.63 0.65 0.32 1.00 0.34 0.87
5994 (RFXAP) 0.77 0.74 0.56 0.64 0.34 1.00 0.33
10014 (HDAC5) 0.18 0.62 0.67 0.35 0.87 0.33 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
RFXANK Human Blood - 3650 m 48 hours downregulated 0.698 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 RFXANK 8625 distal 22955619 TRANSFAC
GABPA 2551 RFXANK 8625 proximal_filtered 22955619 TRANSFAC
RFXANK 8625 HLA-DMA 3108 Unknown 18339718 TRUSST
RFXANK 8625 HLA-DQA2 3118 Unknown 12364590 TRUSST
RFXANK 8625 HLA-DQB2 3120 Unknown 15358835 TRUSST
RFXANK 8625 HLA-DMB 3109 Unknown 11328853 TRUSST
RFXANK 8625 HLA-DOB 3112 Unknown 9013759 TRUSST
RFXANK 8625 HLA-DRA 3122 Repression 19029285 TRUSST
RFXANK 8625 HLA-DQA1 3117 Activation 15613302 TRUSST
RFXANK 8625 HLA-DPB1 3115 Unknown 20949125 TRUSST
RFXANK 8625 HLA-DRB3 3125 Unknown 12842822 TRUSST
RFXANK 8625 HLA-DRB4 3126 Repression 20679491 TRUSST
RFXANK 8625 HLA-DRB5 3127 Unknown 8683991 TRUSST
RFXANK 8625 HLA-DPA1 3113 Activation 21852362 TRUSST
RFXANK 8625 HLA-DOA 3111 Activation 18191017 TRUSST
RFXANK 8625 HLA-DQB1 3119 Unknown 17075044 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT439777 hsa-miR-106b-5p Homo sapiens RFXANK 8625 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT439776 hsa-miR-20a-5p Homo sapiens RFXANK 8625 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726750 hsa-miR-519d-3p Homo sapiens RFXANK 8625 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726753 hsa-miR-17-5p Homo sapiens RFXANK 8625 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726751 hsa-miR-93-5p Homo sapiens RFXANK 8625 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726752 hsa-miR-20b-5p Homo sapiens RFXANK 8625 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
Gene Ontology
ID GO ID GO Term GO Type
8625 GO:0003712 transcription cofactor activity GOTERM_MF_DIRECT
8625 GO:0007265 Ras protein signal transduction GOTERM_BP_DIRECT
8625 GO:0006357 regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
8625 GO:0003700 transcription factor activity GOTERM_MF_DIRECT
8625 GO:0005634 nucleus GOTERM_CC_DIRECT
8625 GO:0005737 cytoplasm GOTERM_CC_DIRECT
8625 GO:0003677 DNA binding GOTERM_MF_DIRECT
8625 GO:0006351 transcription GOTERM_BP_DIRECT
8625 GO:0045171 intercellular bridge GOTERM_CC_DIRECT
8625 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
8625 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
8625 hsa04612 Antigen processing and presentation
8625 hsa05152 Tuberculosis
8625 hsa05340 Primary immunodeficiency
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
RFXANK 8625 Bare lymphocyte syndrome 2 C2931418 Disease or Syndrome 0.64 0.681 0.483 disease
RFXANK 8625 Bare Lymphocyte Syndrome, Type II, Complementation Group D C1859537 Disease or Syndrome 0.3 0.681 0.483 disease
RFXANK 8625 Bare Lymphocyte Syndrome, Type II, Complementation Group B C1859535 Disease or Syndrome 0.4 0.681 0.483 disease
RFXANK 8625 Bare Lymphocyte Syndrome, Type II, Complementation Group A C1859534 Disease or Syndrome 0.3 0.681 0.483 disease
RFXANK 8625 Bare Lymphocyte Syndrome, Type II, Complementation Group E C1859538 Disease or Syndrome 0.3 0.681 0.483 disease
RFXANK 8625 Bare Lymphocyte Syndrome, Type II, Complementation Group C C1859536 Disease or Syndrome 0.3 0.681 0.483 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types