Cyclin-G2

AltitudeomicsDB
Protein Official symbol CCNG2
Aliases CCNG2
Chromosomal Location 4
Length 344
Uniprot ID Q16589
EC number None
Protein family Information(Pfam) PF00134;
PDB id None
InterPro ID IPR028895;IPR039361;IPR013763;IPR036915;IPR006671;
dbSNP rs4150050 rs4150051

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CCNG1 TP53 0.994
PPP2CA TP53 0.954
PPP2CA CCNG1 0.951
CCNG1 CCNG2 0.815
ALDH18A1 CCNG1 0.738
ALDH18A1 CCNG2 0.731
CCNG2 CDC6 0.72
CCNG2 TP53 0.708
PPP2CA CCNG2 0.701
Gene Ontology Semantic Similarity
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# 7157 (TP53) 900 (CCNG1) 901 (CCNG2) 990 (CDC6) 5515 (PPP2CA) 5832 (ALDH18A1)
7157 (TP53) 1.00 0.52 0.36 0.59 0.51 0.55
900 (CCNG1) 0.52 1.00 0.94 0.58 0.49 0.54
901 (CCNG2) 0.36 0.94 1.00 0.42 0.32 0.39
990 (CDC6) 0.59 0.58 0.42 1.00 0.53 0.55
5515 (PPP2CA) 0.51 0.49 0.32 0.53 1.00 0.47
5832 (ALDH18A1) 0.55 0.54 0.39 0.55 0.47 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CCNG2 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 13.8 RT-qPCR Western US C57BL/6 mice 1.3 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
CCNG2 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 14.1 RT-qPCR Western US C57BL/6 mice 1.3 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
RFX5 5993 CCNG2 901 proximal_filtered 22955619 TRANSFAC
FOXA1 3169 CCNG2 901 Activation 16103071 TRUSST
AHR 196 CCNG2 901 Unknown 21255642 TRUSST
OTX2 5015 CCNG2 901 Unknown 11278253 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT016825 hsa-miR-335-5p Homo sapiens CCNG2 901 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT027966 hsa-miR-93-5p Homo sapiens CCNG2 901 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT041104 hsa-miR-503-5p Homo sapiens CCNG2 901 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT733281 hsa-miR-340-5p Homo sapiens CCNG2 901 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27374211
MIRT733645 hsa-miR-93-3p Homo sapiens CCNG2 901 Homo sapiens Luciferase reporter assay Functional MTI 25309979
Gene Ontology
ID GO ID GO Term GO Type
901 GO:0000075 cell cycle checkpoint GOTERM_BP_DIRECT
901 GO:0005737 cytoplasm GOTERM_CC_DIRECT
901 GO:0051301 cell division GOTERM_BP_DIRECT
901 GO:0007067 mitotic nuclear division GOTERM_BP_DIRECT
901 GO:0051726 regulation of cell cycle GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
901 hsa04068 FoxO signaling pathway
901 hsa04115 p53 signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types