SH2 domain containing 2A

AltitudeomicsDB
Protein Official symbol SH2D2A
Aliases SH2D2A SCAP TSAD VRAP
Chromosomal Location 1
Length 389
Uniprot ID Q9NP31
EC number None
Protein family Information(Pfam) PF00017;
PDB id None
InterPro ID IPR000980;IPR036860;IPR035884;
dbSNP rs926103 rs12072861

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
VEGFA KDR 0.9990000000000001
PIK3R1 PIK3CA 0.9990000000000001
PIK3CB PIK3R2 0.998
PIK3CA PIK3R2 0.995
PIK3R1 PIK3CB 0.995
VEGFA SRC 0.987
PIK3R1 SRC 0.985
PIK3R1 PIK3R2 0.983
SH2D2A SRC 0.98
KDR PLCG1 0.973
SH2D2A KDR 0.9690000000000001
PIK3CA KDR 0.966
SRC PLCG1 0.965
SRC PIK3R2 0.9620000000000001
SRC KDR 0.96
SRC PIK3CA 0.96
VAV1 PLCG1 0.958
MAP3K2 SH2D2A 0.951
VEGFA PIK3CA 0.951
PIK3R1 SH2D2A 0.95
AXL PIK3CA 0.948
PIK3R1 AXL 0.945
PIK3R1 PLCG1 0.943
SRC PIK3CB 0.9420000000000001
VAV1 PIK3R1 0.941
SRC VAV2 0.94
AXL PIK3R2 0.94
PIK3CA PLCG1 0.9390000000000001
PIK3CB KDR 0.937
PIK3R1 VAV3 0.9359999999999999
VAV3 PLCG1 0.9359999999999999
VEGFA PLCG1 0.935
VAV2 KDR 0.9329999999999999
VEGFA SH2D2A 0.932
VAV1 KDR 0.9309999999999999
PIK3R1 KDR 0.9309999999999999
VAV1 AXL 0.93
VEGFA PIK3R1 0.9279999999999999
AXL KDR 0.9279999999999999
MAP3K2 SRC 0.927
KDR PIK3R2 0.9259999999999999
PIK3CB PLCG1 0.9229999999999999
VAV3 KDR 0.919
PLCG1 PIK3R2 0.919
VAV1 SH2D2A 0.9179999999999999
VAV3 AXL 0.914
VAV2 AXL 0.914
VAV2 PLCG1 0.914
AXL PIK3CB 0.9129999999999999
PIK3CB PIK3CA 0.9109999999999999
VAV1 PIK3CA 0.909
VAV2 PIK3R2 0.909
VAV3 PIK3CA 0.909
VAV1 PIK3CB 0.9079999999999999
VAV3 PIK3CB 0.907
VAV1 VAV2 0.905
VAV1 VAV3 0.905
VAV2 PIK3CB 0.905
VAV2 PIK3CA 0.904
SH2D2A PLCG1 0.904
SH2D2A AXL 0.903
VAV2 VAV3 0.903
VAV1 PIK3R2 0.903
VAV3 PIK3R2 0.903
PIK3R1 VAV2 0.903
SH2D2A VAV2 0.902
SH2D2A PIK3R2 0.9009999999999999
SH2D2A PIK3CB 0.9009999999999999
SH2D2A PIK3CA 0.9
SH2D2A VAV3 0.9
Gene Ontology Semantic Similarity
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# 7422 (VEGFA) 5295 (PIK3R1) 5291 (PIK3CB) 5290 (PIK3CA) 9047 (SH2D2A) 3791 (KDR) 6714 (SRC) 7409 (VAV1) 10746 (MAP3K2) 558 (AXL) 10451 (VAV3) 7410 (VAV2) 5335 (PLCG1) 5296 (PIK3R2)
7422 (VEGFA) 1.00 0.58 0.53 0.53 0.63 0.56 0.65 0.56 0.57 0.60 0.57 0.60 0.57 0.58
5295 (PIK3R1) 0.58 1.00 0.70 0.70 0.57 0.61 0.69 0.67 0.62 0.59 0.56 0.60 0.56 0.83
5291 (PIK3CB) 0.53 0.70 1.00 1.00 0.41 0.65 0.74 0.67 0.72 0.65 0.35 0.37 0.36 0.71
5290 (PIK3CA) 0.53 0.70 1.00 1.00 0.41 0.65 0.74 0.67 0.72 0.65 0.35 0.37 0.36 0.71
9047 (SH2D2A) 0.63 0.57 0.41 0.41 1.00 0.50 0.66 0.50 0.51 0.58 0.66 0.60 0.52 0.50
3791 (KDR) 0.56 0.61 0.65 0.65 0.50 1.00 0.79 0.54 0.75 0.75 0.43 0.46 0.49 0.56
6714 (SRC) 0.65 0.69 0.74 0.74 0.66 0.79 1.00 0.65 0.78 0.75 0.60 0.59 0.59 0.66
7409 (VAV1) 0.56 0.67 0.67 0.67 0.50 0.54 0.65 1.00 0.56 0.52 0.71 0.84 0.42 0.67
10746 (MAP3K2) 0.57 0.62 0.72 0.72 0.51 0.75 0.78 0.56 1.00 0.75 0.41 0.45 0.55 0.61
558 (AXL) 0.60 0.59 0.65 0.65 0.58 0.75 0.75 0.52 0.75 1.00 0.44 0.49 0.44 0.55
10451 (VAV3) 0.57 0.56 0.35 0.35 0.66 0.43 0.60 0.71 0.41 0.44 1.00 0.83 0.43 0.58
7410 (VAV2) 0.60 0.60 0.37 0.37 0.60 0.46 0.59 0.84 0.45 0.49 0.83 1.00 0.46 0.56
5335 (PLCG1) 0.57 0.56 0.36 0.36 0.52 0.49 0.59 0.42 0.55 0.44 0.43 0.46 1.00 0.46
5296 (PIK3R2) 0.58 0.83 0.71 0.71 0.50 0.56 0.66 0.67 0.61 0.55 0.58 0.56 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SH2D2A Human Blood - 3250 m 4 day upregulated 3.0366 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
9047 GO:0009967 positive regulation of signal transduction GOTERM_BP_DIRECT
9047 GO:0001525 angiogenesis GOTERM_BP_DIRECT
9047 GO:0017124 nucleoside-diphosphatase activity GOTERM_MF_DIRECT
9047 GO:0005737 cytoplasm GOTERM_CC_DIRECT
9047 GO:0005829 cytosol GOTERM_CC_DIRECT
9047 GO:0005515 protein binding GOTERM_MF_DIRECT
9047 GO:0008283 cell proliferation GOTERM_BP_DIRECT
9047 GO:0007165 signal transduction GOTERM_BP_DIRECT
9047 GO:0048010 vascular endothelial growth factor receptor signaling pathway GOTERM_BP_DIRECT
9047 GO:0005070 laminin receptor activity GOTERM_MF_DIRECT
9047 GO:0030154 cell differentiation GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
9047 hsa04370 VEGF signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types