Glutathione S-transferase omega-1

AltitudeomicsDB
Protein Official symbol GSTO1
Aliases GSTO1 GSTTLP28
Chromosomal Location  10
Length 241
Uniprot ID P78417
EC number 2.5.1.18; 1.8.5.1; 1.20.4.2
Protein family Information(Pfam) PF14497;PF13417;
PDB id 1EEM;3LFL;3VLN;4IS0;4YQM;4YQU;4YQV;5UEH;5V3Q;5YVN;5YVO;6MHB;6MHC;6MHD;6PNM;6PNN;6PNO;
InterPro ID IPR010987;IPR036282;IPR004045;IPR004046;IPR005442;IPR036249;
dbSNP rs45529437 rs11509436 rs4925 rs11509438 rs11509439

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
STAT4 GSTO1 0.9
Gene Ontology Semantic Similarity
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# 6775 (STAT4) 9446 (GSTO1)
6775 (STAT4) 1.00 0.45
9446 (GSTO1) 0.45 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GSTO1 Human Skeletal muscle - 4559 m 9 day downregulated -1.34 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
GSTO1 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
FOXA1 3169 GSTO1 9446 proximal_filtered 22955619 TRANSFAC
GATA1 2623 GSTO1 9446 proximal_filtered 22955619 TRANSFAC
FOXA2 3170 GSTO1 9446 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023892 hsa-miR-1-3p Homo sapiens GSTO1 9446 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT048048 hsa-miR-197-3p Homo sapiens GSTO1 9446 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT762109 hsa-miR-1275 Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT763451 hsa-miR-193b-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT764552 hsa-miR-30a-3p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT764741 hsa-miR-30d-3p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT764746 hsa-miR-30e-3p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT768196 hsa-miR-4260 Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT768404 hsa-miR-4291 Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT768542 hsa-miR-4310 Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT769871 hsa-miR-450a-2-3p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT770821 hsa-miR-4665-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT774690 hsa-miR-5572 Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT776565 hsa-miR-6503-3p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT778349 hsa-miR-6751-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT778358 hsa-miR-6752-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT779508 hsa-miR-6803-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT780208 hsa-miR-6842-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT780037 hsa-miR-6835-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT781434 hsa-miR-7110-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT781558 hsa-miR-7157-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT781428 hsa-miR-7109-5p Homo sapiens GSTO1 9446 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
Gene Ontology
ID GO ID GO Term GO Type
9446 GO:0019852 L-ascorbic acid metabolic process GOTERM_BP_DIRECT
9446 GO:0006749 glutathione metabolic process GOTERM_BP_DIRECT
9446 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GOTERM_BP_DIRECT
9446 GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion GOTERM_BP_DIRECT
9446 GO:0004364 glutathione transferase activity GOTERM_MF_DIRECT
9446 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity GOTERM_BP_DIRECT
9446 GO:0050610 tau-protein kinase activity GOTERM_MF_DIRECT
9446 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
9446 GO:0045174 poly GOTERM_MF_DIRECT
9446 GO:0098869 cellular oxidant detoxification GOTERM_BP_DIRECT
9446 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
9446 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity GOTERM_BP_DIRECT
9446 GO:0008152 metabolic process GOTERM_BP_DIRECT
9446 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
9446 GO:0042178 xenobiotic catabolic process GOTERM_BP_DIRECT
9446 GO:0032259 methylation GOTERM_BP_DIRECT
9446 GO:1901687 glutathione derivative biosynthetic process GOTERM_BP_DIRECT
9446 GO:0005515 protein binding GOTERM_MF_DIRECT
9446 GO:0005737 cytoplasm GOTERM_CC_DIRECT
9446 GO:0005829 cytosol GOTERM_CC_DIRECT
9446 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GOTERM_BP_DIRECT
9446 GO:0071243 cellular response to arsenic-containing substance GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
9446 hsa00480 Glutathione metabolism
9446 hsa00980 Metabolism of xenobiotics by cytochrome P450
9446 hsa00982 Drug metabolism - cytochrome P450
9446 hsa05204 Chemical carcinogenesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GSTO1 9446 leukemia C0023418 Neoplastic Process 0.3 0.627 0.552 disease
GSTO1 9446 Malignant Neoplasms C0006826 Neoplastic Process 0.3 0.627 0.552 group
GSTO1 9446 Neoplasms C0027651 Neoplastic Process 0.3 0.627 0.552 group
GSTO1 9446 Neurodegenerative Disorders C0524851 Disease or Syndrome 0.31 0.627 0.552 group
GSTO1 9446 Lung diseases C0024115 Disease or Syndrome 0.31 0.627 0.552 group
GSTO1 9446 Benign Neoplasm C0086692 Neoplastic Process 0.3 0.627 0.552 group
GSTO1 9446 Dermatologic disorders C0037274 Disease or Syndrome 0.3 0.627 0.552 group
GSTO1 9446 Squamous cell carcinoma of esophagus C0279626 Neoplastic Process 0.3 0.627 0.552 disease
GSTO1 9446 Degenerative Diseases, Spinal Cord C0751733 Disease or Syndrome 0.3 0.627 0.552 disease
GSTO1 9446 Precancerous Conditions C0032927 Neoplastic Process 0.3 0.627 0.552 group
GSTO1 9446 Condition, Preneoplastic C0282313 Neoplastic Process 0.3 0.627 0.552 phenotype
GSTO1 9446 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.3 0.627 0.552 disease
GSTO1 9446 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.627 0.552 group
GSTO1 9446 Degenerative Diseases, Central Nervous System C0270715 Disease or Syndrome 0.3 0.627 0.552 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
GSTO1 9446 ARSENIC TRIOXIDE ARSENIC TRIOXIDE CHEMBL1200978 None