Neuromodulin

AltitudeomicsDB
Protein Official symbol GAP43
Aliases GAP43
Chromosomal Location 3
Length 238.0
Uniprot ID P17677
EC number None
Protein family Information(Pfam) PF00612;PF06614;PF10580;
PDB id None
InterPro ID IPR000048;IPR001422;IPR017454;IPR018947;IPR033137;IPR018243;
dbSNP rs6291 rs11557762

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SYN1 SNAP25 0.983
GAP43 LYPLA2 0.927
BDNF NGF 0.92
SYP SNAP25 0.883
SYN1 SYP 0.88
GFAP SYP 0.857
GFAP MAP2 0.835
MAP2 SYP 0.83
BDNF SYN1 0.825
GAP43 MAP2 0.785
NGF SYP 0.783
GAP43 SYP 0.773
GFAP BDNF 0.77
STMN2 GAP43 0.766
GFAP MAG 0.757
MAP2 SYN1 0.749
BDNF SYP 0.748
GFAP GAP43 0.732
NEFL GAP43 0.731
GAP43 SYN1 0.722
GFAP SYN1 0.722
GAP43 SNAP25 0.712
GAP43 BASP1 0.711
OMP GAP43 0.706
GAP43 NRGN 0.706
NEFL MAP2 0.705
BDNF MAP2 0.703
GAP43 NGF 0.702
BDNF GAP43 0.701
GAP43 UCHL1 0.701
GAP43 MAG 0.701
Gene Ontology Semantic Similarity
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# 6616 (SNAP25) 11313 (LYPLA2) 4803 (NGF) 6855 (SYP) 4133 (MAP2) 6853 (SYN1) 627 (BDNF) 2596 (GAP43) 4099 (MAG) 10409 (BASP1) 4900 (NRGN) 7345 (UCHL1) 2670 (GFAP) 11075 (STMN2) 4747 (NEFL)
6616 (SNAP25) 1.00 0.46 0.68 0.61 0.71 0.67 0.69 0.65 0.22 0.69 0.58 0.56 0.82 0.85 0.70
11313 (LYPLA2) 0.46 1.00 0.36 0.31 0.40 0.36 0.47 0.35 0.13 0.37 0.30 0.42 0.45 0.46 0.41
4803 (NGF) 0.68 0.36 1.00 0.48 0.59 0.54 1.00 0.54 0.17 0.56 0.46 0.47 0.67 0.68 0.61
6855 (SYP) 0.61 0.31 0.48 1.00 0.52 0.48 0.56 0.48 0.19 0.49 0.42 0.38 0.64 0.63 0.53
4133 (MAP2) 0.71 0.40 0.59 0.52 1.00 0.60 0.69 0.57 0.23 0.60 0.49 0.50 0.71 0.75 0.73
6853 (SYN1) 0.67 0.36 0.54 0.48 0.60 1.00 0.69 0.55 0.23 0.56 0.46 0.47 0.65 0.66 0.60
627 (BDNF) 0.69 0.47 1.00 0.56 0.69 0.69 1.00 0.69 0.22 0.69 0.56 0.69 0.69 0.69 0.69
2596 (GAP43) 0.65 0.35 0.54 0.48 0.57 0.55 0.69 1.00 0.41 0.54 0.80 0.46 0.63 0.64 0.58
4099 (MAG) 0.22 0.13 0.17 0.19 0.23 0.23 0.22 0.41 1.00 0.19 0.28 0.15 0.22 0.22 0.20
10409 (BASP1) 0.69 0.37 0.56 0.49 0.60 0.56 0.69 0.54 0.19 1.00 0.47 0.47 0.68 0.68 0.61
4900 (NRGN) 0.58 0.30 0.46 0.42 0.49 0.46 0.56 0.80 0.28 0.47 1.00 0.38 0.58 0.58 0.51
7345 (UCHL1) 0.56 0.42 0.47 0.38 0.50 0.47 0.69 0.46 0.15 0.47 0.38 1.00 0.52 0.53 0.51
2670 (GFAP) 0.82 0.45 0.67 0.64 0.71 0.65 0.69 0.63 0.22 0.68 0.58 0.52 1.00 0.86 0.75
11075 (STMN2) 0.85 0.46 0.68 0.63 0.75 0.66 0.69 0.64 0.22 0.68 0.58 0.53 0.86 1.00 0.70
4747 (NEFL) 0.70 0.41 0.61 0.53 0.73 0.60 0.69 0.58 0.20 0.61 0.51 0.51 0.75 0.70 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GAP43 Rat Left brain cortices 300hPa 9144 m 1 hour upregulated 1.62±0.3 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT489926 hsa-miR-3614-5p Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT489927 hsa-miR-6859-5p Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT489928 hsa-miR-3916 Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT489929 hsa-miR-3125 Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT489930 hsa-miR-6856-5p Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT489931 hsa-miR-6758-5p Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT489932 hsa-miR-890 Homo sapiens GAP43 2596 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT735469 hsa-miR-363-3p Homo sapiens GAP43 2596 Homo sapiens Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27495233
Gene Ontology
ID GO ID GO Term GO Type
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GAP43 2596 Malignant tumor of colon C0007102 Neoplastic Process 0.3 0.624 0.517 disease
GAP43 2596 Colonic Neoplasms C0009375 Neoplastic Process 0.3 0.624 0.517 group
GAP43 2596 Status Epilepticus C0038220 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Petit mal status C0270823 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Grand Mal Status Epilepticus C0311335 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Complex Partial Status Epilepticus C0393734 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Status Epilepticus, Subclinical C0751522 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Non-Convulsive Status Epilepticus C0751523 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Simple Partial Status Epilepticus C0751524 Disease or Syndrome 0.3 0.624 0.517 disease
GAP43 2596 Alcoholic Intoxication, Chronic C0001973 Mental or Behavioral Dysfunction 0.31 0.624 0.517 disease
GAP43 2596 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.3 0.624 0.517 disease
GAP43 2596 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.31 0.624 0.517 disease
GAP43 2596 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.31 0.624 0.517 disease
GAP43 2596 Dysthymic Disorder C0013415 Mental or Behavioral Dysfunction 0.31 0.624 0.517 disease
GAP43 2596 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.35 0.624 0.517 disease
GAP43 2596 Mood Disorders C0525045 Mental or Behavioral Dysfunction 0.3 0.624 0.517 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types