Mesencephalic astrocyte-derived neurotrophic factor

AltitudeomicsDB
Protein Official symbol MANF
Aliases MANF ARMET ARP
Chromosomal Location 3
Length 182
Uniprot ID P55145
EC number None
Protein family Information(Pfam) PF10208;
PDB id 2KVD;2KVE;2W51;
InterPro ID IPR019345;IPR036361;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HSPA5 HSP90B1 0.999
PDIA6 HSP90B1 0.997
HYOU1 HSP90B1 0.995
DNAJB11 HSPA5 0.994
HYOU1 PDIA4 0.993
HSPA5 PDIA4 0.991
HSP90B1 PDIA4 0.991
HYOU1 HSPA5 0.99
PDIA6 HSPA5 0.983
DNAJB11 HSP90B1 0.975
MANF HSPA5 0.975
HYOU1 DNAJB11 0.973
MANF CRELD2 0.97
MANF HSP90B1 0.963
MANF PDIA4 0.955
DNAJB11 PDIA6 0.953
HYOU1 PDIA6 0.95
HYOU1 MANF 0.946
MANF DNAJB11 0.945
MANF PDIA6 0.933
PDIA6 PDIA4 0.91
CRELD2 PDIA4 0.905
HYOU1 CRELD2 0.901
Gene Ontology Semantic Similarity
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# 3309 (HSPA5) 10130 (PDIA6) 10525 (HYOU1) 51726 (DNAJB11) 7184 (HSP90B1) 7873 (MANF) 79174 (CRELD2) 9601 (PDIA4)
3309 (HSPA5) 1.00 0.62 1.00 1.00 0.69 0.41 1.00 0.59
10130 (PDIA6) 0.62 1.00 0.82 1.00 0.58 0.43 1.00 0.76
10525 (HYOU1) 1.00 0.82 1.00 0.82 0.82 0.48 0.82 0.82
51726 (DNAJB11) 1.00 1.00 0.82 1.00 1.00 0.59 1.00 1.00
7184 (HSP90B1) 0.69 0.58 0.82 1.00 1.00 0.61 1.00 0.65
7873 (MANF) 0.41 0.43 0.48 0.59 0.61 1.00 0.59 0.58
79174 (CRELD2) 1.00 1.00 0.82 1.00 1.00 0.59 1.00 1.00
9601 (PDIA4) 0.59 0.76 0.82 1.00 0.65 0.58 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MANF Toad Liver - 3464 m 33 day upregulated 2.264394091 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT024847 hsa-miR-215-5p Homo sapiens MANF 7873 Homo sapiens Microarray Functional MTI (Weak) 19074876
MIRT026482 hsa-miR-192-5p Homo sapiens MANF 7873 Homo sapiens Microarray Functional MTI (Weak) 19074876
MIRT050039 hsa-miR-26b-5p Homo sapiens MANF 7873 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
7873 GO:0005615 extracellular space GOTERM_CC_DIRECT
7873 GO:0005634 nucleus GOTERM_CC_DIRECT
7873 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
7873 GO:0006986 response to unfolded protein GOTERM_BP_DIRECT
7873 GO:0008083 growth factor activity GOTERM_MF_DIRECT
7873 GO:0031175 neuron projection development GOTERM_BP_DIRECT
7873 GO:0044822 poly(A) RNA binding GOTERM_MF_DIRECT
7873 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
7873 GO:0071542 dopaminergic neuron differentiation GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types