Adenosine deaminase

AltitudeomicsDB
Protein Official symbol ADA
Aliases ADA ADA1
Chromosomal Location 20
Length 363
Uniprot ID P00813
EC number 3.5.4.4
Protein family Information(Pfam) PF00962;
PDB id 1M7M;3IAR;
InterPro ID IPR006650;IPR001365;IPR028893;IPR006330;IPR032466;
dbSNP rs73598374 rs121908725 rs121908724 rs121908730 rs121908736 rs11555566 rs121908726 rs267606634 rs121908714 rs121908714 rs121908717 rs267606635 rs121908739 rs121908731 rs121908732 rs61732239 rs121908737 rs121908733 rs121908728 rs121908735 rs121908722 rs121908719 rs121908727 rs121908734 rs121908740 rs121908716 rs114025668 rs121908723 rs121908729 rs121908738 rs121908721 rs121908718 rs199422327 rs121908715

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ADA PNP 0.996
ADA ADK 0.995
PNP ADK 0.989
NT5C3A NT5C 0.979
ADA NT5E 0.971
NT5C2 DCK 0.968
ADK NT5E 0.968
PNP DCK 0.963
ADA DCK 0.962
CECR1 PNP 0.957
CECR1 ADK 0.956
NT5C2 NT5C1A 0.956
NT5C3A NT5C2 0.952
CECR1 ADA 0.945
PNP NT5C2 0.945
NT5C3B NT5C1B 0.945
NT5C NT5C1A 0.944
NT5C3A NT5C1A 0.944
NT5C3B NT5C1A 0.944
NT5C3A DCK 0.943
DCK NT5C 0.94
PNP NT5E 0.94
NT5M DCK 0.938
NT5C2 ADK 0.937
ADA NT5C2 0.935
NT5C1B NT5C 0.934
NT5M NT5C1A 0.933
DCK NT5C1A 0.932
NT5C2 NT5C 0.932
NT5C1B NT5C2 0.931
ADA ADAR 0.929
NT5M NT5C1B 0.928
NT5C1B DCK 0.925
NT5M NT5C2 0.923
ADK NT5C1A 0.923
PNP NT5C1A 0.923
NT5C3A NT5C1B 0.921
ADA NT5C1A 0.921
DCK NT5E 0.92
NT5C3B PNP 0.92
NT5C3B NT5C2 0.918
NT5C3A PNP 0.917
NT5C3B ADK 0.917
NT5C3B DCK 0.915
NT5C3B NT5M 0.915
ADA NT5C 0.914
PNP NT5C 0.913
NT5C1B ADK 0.913
NT5C3A ADA 0.912
NT5M NT5E 0.911
NT5M ADK 0.91
NT5M ADA 0.908
NT5C3B ADA 0.907
NT5C3A ADK 0.905
ADA NT5C1B 0.904
RDH14 ADA 0.903
NT5M PNP 0.903
ENSG00000250741 PNP 0.902
PNP NT5C1B 0.902
ADK NT5C 0.902
ENSG00000250741 ADA 0.9
ENSG00000250741 ADK 0.9
CECR1 DCK 0.9
NT5C3A NT5M 0.9
ENSG00000250741 DCK 0.9
NT5C3B NT5C 0.9
Gene Ontology Semantic Similarity
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# 100 (ADA) 103 (ADAR) 132 (ADK) 1633 (DCK) 4860 (PNP) 4907 (NT5E) 22978 (NT5C2) 30833 (NT5C) 51251 (NT5C3A) 51816 (CECR1) 56953 (NT5M) 57665 (RDH14) 84618 (NT5C1A) 93034 (NT5C1B) 115024 (NT5C3B)
100 (ADA) 1.00 0.71 0.26 0.36 0.38 0.27 0.51 0.28 0.40 0.80 0.22 0.18 0.57 0.27 0.57
103 (ADAR) 0.71 1.00 0.53 0.33 0.42 0.24 0.45 0.33 0.25 0.61 0.19 0.15 0.49 0.24 0.49
132 (ADK) 0.26 0.53 1.00 0.56 0.39 0.12 0.47 0.26 0.33 0.22 0.12 0.12 0.25 0.12 0.25
1633 (DCK) 0.36 0.33 0.56 1.00 0.45 0.13 0.56 0.19 0.33 0.42 0.13 0.13 0.33 0.13 0.33
4860 (PNP) 0.38 0.42 0.39 0.45 1.00 0.15 0.37 0.35 0.30 0.33 0.13 0.15 0.37 0.15 0.37
4907 (NT5E) 0.27 0.24 0.12 0.13 0.15 1.00 1.00 1.00 1.00 0.27 1.00 0.11 1.00 1.00 1.00
22978 (NT5C2) 0.51 0.45 0.47 0.56 0.37 1.00 1.00 0.61 0.64 0.47 0.63 0.13 0.83 1.00 0.83
30833 (NT5C) 0.28 0.33 0.26 0.19 0.35 1.00 0.61 1.00 0.57 0.23 0.82 0.13 0.70 1.00 0.70
51251 (NT5C3A) 0.40 0.25 0.33 0.33 0.30 1.00 0.64 0.57 1.00 0.32 0.63 0.16 0.57 1.00 0.57
51816 (CECR1) 0.80 0.61 0.22 0.42 0.33 0.27 0.47 0.23 0.32 1.00 0.16 0.18 0.51 0.27 0.51
56953 (NT5M) 0.22 0.19 0.12 0.13 0.13 1.00 0.63 0.82 0.63 0.16 1.00 0.13 0.75 1.00 0.75
57665 (RDH14) 0.18 0.15 0.12 0.13 0.15 0.11 0.13 0.13 0.16 0.18 0.13 1.00 0.13 0.11 0.13
84618 (NT5C1A) 0.57 0.49 0.25 0.33 0.37 1.00 0.83 0.70 0.57 0.51 0.75 0.13 1.00 1.00 1.00
93034 (NT5C1B) 0.27 0.24 0.12 0.13 0.15 1.00 1.00 1.00 1.00 0.27 1.00 0.11 1.00 1.00 1.00
115024 (NT5C3B) 0.57 0.49 0.25 0.33 0.37 1.00 0.83 0.70 0.57 0.51 0.75 0.13 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ADA Bird Kidney - 4000 m Native downregulated -2.05 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
SP1 6667 ADA 100 Repression 16980305 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT027685 hsa-miR-98-5p Homo sapiens ADA 100 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT041891 hsa-miR-484 Homo sapiens ADA 100 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT438367 hsa-miR-140-5p Homo sapiens ADA 100 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 24530397
Gene Ontology
ID GO ID GO Term GO Type
100 GO:0001829 trophectodermal cell differentiation GOTERM_BP_DIRECT
100 GO:0001890 placenta development GOTERM_BP_DIRECT
100 GO:0032261 purine nucleotide salvage GOTERM_BP_DIRECT
100 GO:0033089 positive regulation of T cell differentiation in thymus GOTERM_BP_DIRECT
100 GO:0043278 response to morphine GOTERM_BP_DIRECT
100 GO:0045987 positive regulation of smooth muscle contraction GOTERM_BP_DIRECT
100 GO:0046101 hypoxanthine biosynthetic process GOTERM_BP_DIRECT
100 GO:0005886 plasma membrane GOTERM_CC_DIRECT
100 GO:0016020 membrane GOTERM_CC_DIRECT
100 GO:0030054 cell junction GOTERM_CC_DIRECT
100 GO:0001889 liver development GOTERM_BP_DIRECT
100 GO:0002906 negative regulation of mature B cell apoptotic process GOTERM_BP_DIRECT
100 GO:0006154 adenosine catabolic process GOTERM_BP_DIRECT
100 GO:0042542 response to hydrogen peroxide GOTERM_BP_DIRECT
100 GO:0043103 hypoxanthine salvage GOTERM_BP_DIRECT
100 GO:0046638 positive regulation of alpha-beta T cell differentiation GOTERM_BP_DIRECT
100 GO:0048541 Peyer's patch development GOTERM_BP_DIRECT
100 GO:0048566 embryonic digestive tract development GOTERM_BP_DIRECT
100 GO:0060407 negative regulation of penile erection GOTERM_BP_DIRECT
100 GO:0070244 negative regulation of thymocyte apoptotic process GOTERM_BP_DIRECT
100 GO:0001883 complement component C1q binding GOTERM_MF_DIRECT
100 GO:0005615 extracellular space GOTERM_CC_DIRECT
100 GO:0005764 lysosome GOTERM_CC_DIRECT
100 GO:0005829 cytosol GOTERM_CC_DIRECT
100 GO:0009897 external side of plasma membrane GOTERM_CC_DIRECT
100 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
100 GO:0002314 germinal center B cell differentiation GOTERM_BP_DIRECT
100 GO:0002636 positive regulation of germinal center formation GOTERM_BP_DIRECT
100 GO:0002686 negative regulation of leukocyte migration GOTERM_BP_DIRECT
100 GO:0006157 deoxyadenosine catabolic process GOTERM_BP_DIRECT
100 GO:0009168 purine ribonucleoside monophosphate biosynthetic process GOTERM_BP_DIRECT
100 GO:0010460 positive regulation of heart rate GOTERM_BP_DIRECT
100 GO:0033197 response to vitamin E GOTERM_BP_DIRECT
100 GO:0042110 T cell activation GOTERM_BP_DIRECT
100 GO:0042323 negative regulation of circadian sleep/wake cycle GOTERM_BP_DIRECT
100 GO:0043101 purine-containing compound salvage GOTERM_BP_DIRECT
100 GO:0046103 inosine biosynthetic process GOTERM_BP_DIRECT
100 GO:0050728 negative regulation of inflammatory response GOTERM_BP_DIRECT
100 GO:0050862 positive regulation of T cell receptor signaling pathway GOTERM_BP_DIRECT
100 GO:0004000 acyl-CoA dehydrogenase activity GOTERM_MF_DIRECT
100 GO:0005515 protein binding GOTERM_MF_DIRECT
100 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
100 GO:0019239 kinase regulator activity GOTERM_MF_DIRECT
100 GO:0009986 cell surface GOTERM_CC_DIRECT
100 GO:0032839 dendrite cytoplasm GOTERM_CC_DIRECT
100 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
100 GO:0060205 cytoplasmic membrane-bounded vesicle lumen GOTERM_CC_DIRECT
100 GO:0001821 histamine secretion GOTERM_BP_DIRECT
100 GO:0007568 aging GOTERM_BP_DIRECT
100 GO:0030890 positive regulation of B cell proliferation GOTERM_BP_DIRECT
100 GO:0033632 regulation of cell-cell adhesion mediated by integrin GOTERM_BP_DIRECT
100 GO:0042493 response to drug GOTERM_BP_DIRECT
100 GO:0046061 dATP catabolic process GOTERM_BP_DIRECT
100 GO:0046111 xanthine biosynthetic process GOTERM_BP_DIRECT
100 GO:0048286 lung alveolus development GOTERM_BP_DIRECT
100 GO:0050850 positive regulation of calcium-mediated signaling GOTERM_BP_DIRECT
100 GO:0060169 negative regulation of adenosine receptor signaling pathway GOTERM_BP_DIRECT
100 GO:0070256 negative regulation of mucus secretion GOTERM_BP_DIRECT
100 GO:0005737 cytoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
100 hsa00230 Purine metabolism
100 hsa01100 Metabolic pathways
100 hsa05340 Primary immunodeficiency
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ADA 100 Autistic Disorder C0004352 Mental or Behavioral Dysfunction 0.34 0.494 0.793 group
ADA 100 Spinal Cord Diseases C0037928 Disease or Syndrome 0.3 0.494 0.793 group
ADA 100 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.494 0.793 disease
ADA 100 Lung Neoplasms C0024121 Neoplastic Process 0.3 0.494 0.793 group
ADA 100 Reactive Hyperemia C0178824 Pathologic Function 0.3 0.494 0.793 phenotype
ADA 100 Malignant neoplasm of lung C0242379 Neoplastic Process 0.3 0.494 0.793 disease
ADA 100 Active Hyperemia C0333233 Pathologic Function 0.3 0.494 0.793 phenotype
ADA 100 Venous Engorgement C0042484 Pathologic Function 0.3 0.494 0.793 phenotype
ADA 100 Hyperemia C0020452 Disease or Syndrome 0.31 0.494 0.793 disease
ADA 100 Severe combined immunodeficiency due to adenosine deaminase deficiency C0392607 Disease or Syndrome 0.7 0.494 0.793 disease
ADA 100 Partial adenosine deaminase deficiency C1863239 Disease or Syndrome 0.63 0.494 0.793 disease
ADA 100 Adenosine deaminase deficiency C0268124 Disease or Syndrome 0.6 0.494 0.793 disease
ADA 100 Omenn Syndrome C2700553 Disease or Syndrome 0.31 0.494 0.793 disease
ADA 100 Pancreatic Ductal Adenocarcinoma C1335302 Neoplastic Process 0.3 0.494 0.793 disease
ADA 100 SCID Due to ADA Deficiency, Early-Onset C1863236 Disease or Syndrome 0.4 0.494 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ADA 100 2,3-DIDEOXYADENOSINE CHEMBL23094 CHEMBL23094 None
ADA 100 6-METHYLMERCAPTOPURINE RIBOSIDE None None None
ADA 100 AMITRIPTYLINE AMITRIPTYLINE CHEMBL629 None
ADA 100 ANTIMALARIALS CHEMBL1255648 CHEMBL1255648 None
ADA 100 CLADRIBINE CLADRIBINE CHEMBL1619 inhibitor
ADA 100 CHELATORS None None None
ADA 100 COBALT None None None
ADA 100 DIFFERENTIATING AGENTS None None None
ADA 100 DIPYRIDAMOLE DIPYRIDAMOLE CHEMBL932 None
ADA 100 DIPYRIDAMOLE DIPYRIDAMOLE CHEMBL932 inhibitor
ADA 100 DIPYRIDAMOLE DIPYRIDAMOLE CHEMBL932 None
ADA 100 EHNA EHNA CHEMBL50378 inhibitor
ADA 100 FLUDARABINE FLUDARABINE CHEMBL1568 inhibitor
ADA 100 GARLIC GARLIC CHEMBL2108463 None
ADA 100 H2O2 HYDROGEN PEROXIDE CHEMBL71595 None
ADA 100 HYDROCORTISONE HYDROCORTISONE CHEMBL389621 None
ADA 100 L-DOPA LEVODOPA CHEMBL1009 None
ADA 100 METHOTREXATE METHOTREXATE CHEMBL34259 None
ADA 100 NG-MONOMETHYL-L-ARGININE TARGININE CHEMBL256147 None
ADA 100 PENTOSTATIN PENTOSTATIN CHEMBL1580 inhibitor
ADA 100 PENTOSTATIN PENTOSTATIN CHEMBL1580 inhibitor
ADA 100 PENTOSTATIN PENTOSTATIN CHEMBL1580 None
ADA 100 PENTOSTATIN PENTOSTATIN CHEMBL1580 inhibitor
ADA 100 PENTOSTATIN PENTOSTATIN CHEMBL1580 None
ADA 100 PROTHYMOSIN ALPHA None None None
ADA 100 RECOMBINANT INTERLEUKIN None None None
ADA 100 SELENIUM None None None