Complement factor H-related protein 4 (FHR-4)

AltitudeomicsDB
Protein Official symbol CFHR4
Aliases CFHR4 CFHL4 FHR4
Chromosomal Location  1
Length 578
Uniprot ID Q92496
EC number None
Protein family Information(Pfam) PF00084;
PDB id None
InterPro ID IPR035976;IPR000436;
dbSNP rs10801578 rs7417769 rs10494745

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CFB C3 0.99
CD46 C3 0.989
CFB CFI 0.983
CFI C3 0.981
CFHR5 C3 0.98
CFHR4 C3 0.978
CFI CD46 0.977
C2 C3 0.975
CFI C2 0.959
MBL2 C2 0.955
CD46 C2 0.945
CFI C4BPB 0.934
CFB CD46 0.929
CFB C2 0.921
C2 C4BPB 0.905
CFP C3 0.9
ENSG00000244255 C3 0.852
CD46 MYBPH 0.841
ARMS2 CFB 0.835
MBL2 CRP 0.824
ARMS2 C2 0.79
MBL2 C3 0.784
HFL3 C3 0.777
ARMS2 ENSG00000244255 0.736
CFB CFP 0.73
MBL2 CFP 0.728
ENSG00000244255 CFI 0.717
F13B C8A 0.715
CRP C3 0.712
ARMS2 CFI 0.709
DUS2 DDX28 0.705
CD46 CFP 0.698
MBL2 F13B 0.692
MBL2 C8A 0.691
CFHR4 ZBTB41 0.681
CFI CFHR5 0.679
CFI CFP 0.673
CD46 DGKE 0.669
CD46 CFHR5 0.669
CFB CFHR5 0.668
ARMS2 C3 0.668
HFL3 C8A 0.652
PGC F13B 0.649
CFI DGKE 0.645
ENSG00000244255 CFP 0.641
CFHR5 MYBPH 0.641
C8A C3 0.616
CFHR4 CRP 0.615
HFL3 ZBTB41 0.611
CFI CFHR4 0.587
CFB CFHR4 0.585
HFL3 CFHR5 0.583
DGKE CFHR5 0.581
CFB DGKE 0.571
HFL3 F13B 0.571
CFI C8A 0.568
CFI HFL3 0.567
C2 CFP 0.565
C8A CFHR5 0.562
HFL3 RBMS2 0.559
ARMS2 CFHR4 0.559
MBL2 CD46 0.558
CFB HFL3 0.553
DUS2 CFHR4 0.55
CFHR4 DDX28 0.547
ARMS2 ZBTB41 0.543
CD46 RBMS2 0.541
HFL3 MYBPH 0.539
HFL3 C4BPB 0.538
CFHR4 MYBPH 0.537
ARMS2 CFP 0.534
CFI MYBPH 0.534
RBMS2 C3 0.531
CFHR4 CD46 0.53
CFHR4 C4BPB 0.527
MBL2 CFHR5 0.526
C8A C4BPB 0.526
ARMS2 F13B 0.514
ARMS2 CFHR5 0.513
HFL3 CD46 0.511
PGC C4BPB 0.51
CFI MBL2 0.51
CFI F13B 0.5
RBMS2 CFHR5 0.497
CFHR5 CFP 0.491
CFHR4 DGKE 0.489
ARMS2 HFL3 0.474
HFL3 DGKE 0.473
ENSG00000244255 CFHR5 0.47
PGC HFL3 0.47
PGC CFHR4 0.469
PGC CFHR5 0.468
MYBPH C3 0.465
CFB MBL2 0.464
MBL2 HFL3 0.453
ENSG00000244255 MBL2 0.448
HFL3 CRP 0.447
ENSG00000244255 CFHR4 0.444
CFHR4 CFP 0.441
CFHR4 C2 0.441
ENSG00000244255 DGKE 0.44
HFL3 CFP 0.44
CFHR4 C8A 0.437
MBL2 CFHR4 0.432
HFL3 CFHR4 0.431
F13B CFHR5 0.431
DUS2 HFL3 0.426
CRP CFP 0.425
CFHR4 F13B 0.416
F13B ZBTB41 0.416
CFHR4 RBMS2 0.416
CFHR4 CFHR5 0.414
HFL3 DDX28 0.412
OR2A14 CFHR4 0.412
ARMS2 CRP 0.41
CFHR5 CRP 0.408
CFB F13B 0.4
CFHR4 C8orf33 0.4
C3 C4BPB 0.4
Gene Ontology Semantic Similarity
Download Tab separated file
# 718 (C3) 3426 (CFI) 4179 (CD46) 717 (C2) 725 (C4BPB) 4608 (MYBPH) 629 (CFB) 1401 (CRP) 5199 (CFP) 55794 (DDX28) 360023 (ZBTB41) 81494 (CFHR5) 8526 (DGKE) 10877 (CFHR4) 5939 (RBMS2) 4153 (MBL2) 65265 (C8orf33) 54920 (DUS2) 5225 (PGC) 135941 (OR2A14)
718 (C3) 1.00 0.89 0.62 0.89 1.00 0.62 0.88 0.60 0.89 0.27 0.21 0.68 0.16 0.21 0.27 0.82 1.00 0.56 0.59 0.14
3426 (CFI) 0.89 1.00 0.60 1.00 1.00 0.60 0.96 0.57 1.00 0.29 0.21 0.68 0.17 0.21 0.27 0.79 1.00 0.52 0.59 0.14
4179 (CD46) 0.62 0.60 1.00 0.60 1.00 0.63 0.64 0.59 0.60 0.29 0.21 0.70 0.15 0.21 0.28 0.60 1.00 0.56 0.13 0.72
717 (C2) 0.89 1.00 0.60 1.00 1.00 0.60 0.96 0.57 1.00 0.29 0.21 0.68 0.17 0.21 0.27 0.79 1.00 0.52 0.59 0.14
725 (C4BPB) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.37 0.21 1.00 0.18 0.21 0.37 1.00 1.00 1.00 0.13 0.14
4608 (MYBPH) 0.62 0.60 0.63 0.60 1.00 1.00 0.64 0.59 0.60 0.31 0.21 0.71 0.17 0.21 0.29 0.59 1.00 0.54 0.13 0.14
629 (CFB) 0.88 0.96 0.64 0.96 1.00 0.64 1.00 0.61 0.96 0.29 0.21 0.71 0.17 0.21 0.28 0.80 1.00 0.57 0.59 0.14
1401 (CRP) 0.60 0.57 0.59 0.57 1.00 0.59 0.61 1.00 0.57 0.27 0.21 0.65 0.13 0.21 0.27 0.70 1.00 0.55 0.13 0.14
5199 (CFP) 0.89 1.00 0.60 1.00 1.00 0.60 0.96 0.57 1.00 0.29 0.21 0.68 0.17 0.21 0.27 0.79 1.00 0.52 0.59 0.14
55794 (DDX28) 0.27 0.29 0.29 0.29 0.37 0.31 0.29 0.27 0.29 1.00 0.13 0.31 0.10 0.13 0.84 0.27 0.37 0.59 0.08 0.09
360023 (ZBTB41) 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.13 1.00 0.21 0.15 0.17 0.13 0.21 0.21 0.21 0.10 0.12
81494 (CFHR5) 0.68 0.68 0.70 0.68 1.00 0.71 0.71 0.65 0.68 0.31 0.21 1.00 0.15 0.21 0.29 0.64 1.00 0.63 0.13 0.14
8526 (DGKE) 0.16 0.17 0.15 0.17 0.18 0.17 0.17 0.13 0.17 0.10 0.15 0.15 1.00 0.15 0.09 0.15 0.18 0.14 0.19 0.10
10877 (CFHR4) 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.13 0.17 0.21 0.15 1.00 0.13 0.21 0.21 0.21 0.10 0.12
5939 (RBMS2) 0.27 0.27 0.28 0.27 0.37 0.29 0.28 0.27 0.27 0.84 0.13 0.29 0.09 0.13 1.00 0.27 0.37 0.57 0.08 0.09
4153 (MBL2) 0.82 0.79 0.60 0.79 1.00 0.59 0.80 0.70 0.79 0.27 0.21 0.64 0.15 0.21 0.27 1.00 1.00 0.55 0.59 0.14
65265 (C8orf33) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.37 0.21 1.00 0.18 0.21 0.37 1.00 1.00 1.00 0.13 0.14
54920 (DUS2) 0.56 0.52 0.56 0.52 1.00 0.54 0.57 0.55 0.52 0.59 0.21 0.63 0.14 0.21 0.57 0.55 1.00 1.00 0.13 0.14
5225 (PGC) 0.59 0.59 0.13 0.59 0.13 0.13 0.59 0.13 0.59 0.08 0.10 0.13 0.19 0.10 0.08 0.59 0.13 0.13 1.00 0.07
135941 (OR2A14) 0.14 0.14 0.72 0.14 0.14 0.14 0.14 0.14 0.14 0.09 0.12 0.14 0.10 0.12 0.09 0.14 0.14 0.14 0.07 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CFHR4 Toad Brain - 3464 m 33 day upregulated 2.525820877 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
10877 GO:0006869 lipid transport GOTERM_BP_DIRECT
10877 GO:0005576 extracellular region GOTERM_CC_DIRECT
10877 GO:0005319 lipid transporter activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CFHR4 10877 Atypical Hemolytic Uremic Syndrome C2931788 Disease or Syndrome 0.3 0.886 0.207 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types