Creatine kinase M-type

AltitudeomicsDB
Protein Official symbol CKM
Aliases CKM CKMM
Chromosomal Location 19
Length 381
Uniprot ID P06732
EC number 2.7.3.2
Protein family Information(Pfam) PF00217;PF02807;
PDB id 1I0E;
InterPro ID IPR000749;IPR022415;IPR022414;IPR022413;IPR036802;IPR014746;
dbSNP rs11559024 rs17875653 rs17357122 rs17875625

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TNNI2 TNNT3 0.9990000000000001
MYL1 TNNT3 0.995
TNNI2 MYL1 0.995
CKB CKM 0.985
ACTN3 TNNT3 0.976
ASB9 CKB 0.97
ACTN3 TNNI2 0.9690000000000001
CKMT2 GAMT 0.96
ACTN3 MYL1 0.9590000000000001
GAMT CKB 0.956
CKMT1A GAMT 0.951
GAMT CKM 0.945
CKMT1A ASB9 0.93
CKMT2 CKM 0.882
CKMT2 MB 0.878
MB CKM 0.8390000000000001
ASB9 CKM 0.8340000000000001
HRC CKM 0.8290000000000001
MB MYL1 0.797
CKMT1A LDHAL6A 0.797
CKMT1A CKM 0.794
ACTN3 MYOZ1 0.785
PGAM2 CKM 0.775
MYOZ1 TNNT3 0.775
CKMT2 LDHAL6A 0.774
MYL1 CKM 0.773
MYOZ1 CKM 0.7559999999999999
CKMT1A LDHAL6B 0.75
CKMT2 LDHAL6B 0.748
TNNI2 MYOZ1 0.748
CKB LDHAL6A 0.747
MB PGAM2 0.747
TNNI2 CKM 0.7440000000000001
LDHAL6B CKB 0.7440000000000001
LDHAL6A CKM 0.738
LDHAL6B CKM 0.722
ACTN3 CKM 0.718
TNNT3 CKM 0.7040000000000001
Gene Ontology Semantic Similarity
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# 7136 (TNNI2) 4632 (MYL1) 1152 (CKB) 89 (ACTN3) 140462 (ASB9) 1160 (CKMT2) 2593 (GAMT) 1159 (CKMT1B) 548596 (CKMT1A) 3270 (HRC) 5224 (PGAM2) 58529 (MYOZ1) 92483 (LDHAL6B) 7140 (TNNT3) 1158 (CKM)
7136 (TNNI2) 1.00 0.26 0.69 0.70 1.00 0.14 0.15 0.14 0.14 0.75 0.13 0.87 0.70 0.73 0.70
4632 (MYL1) 0.26 1.00 0.26 1.00 0.26 0.14 0.18 0.14 0.14 0.26 0.16 0.26 0.26 0.21 0.26
1152 (CKB) 0.69 0.26 1.00 0.62 1.00 1.00 0.25 1.00 1.00 0.66 0.15 0.69 0.59 0.57 0.92
89 (ACTN3) 0.70 1.00 0.62 1.00 1.00 0.14 0.15 0.14 0.14 0.71 0.13 0.69 0.62 0.57 0.62
140462 (ASB9) 1.00 0.26 1.00 1.00 1.00 0.14 0.18 0.14 0.14 1.00 0.16 1.00 1.00 0.82 1.00
1160 (CKMT2) 0.14 0.14 1.00 0.14 0.14 1.00 0.36 1.00 1.00 0.14 0.18 0.14 0.16 0.12 1.00
2593 (GAMT) 0.15 0.18 0.25 0.15 0.18 0.36 1.00 0.36 0.36 0.15 0.21 0.15 0.19 0.13 0.29
1159 (CKMT1B) 0.14 0.14 1.00 0.14 0.14 1.00 0.36 1.00 1.00 0.14 0.18 0.14 0.16 0.12 1.00
548596 (CKMT1A) 0.14 0.14 1.00 0.14 0.14 1.00 0.36 1.00 1.00 0.14 0.18 0.14 0.16 0.12 1.00
3270 (HRC) 0.75 0.26 0.66 0.71 1.00 0.14 0.15 0.14 0.14 1.00 0.13 0.74 0.67 0.60 0.67
5224 (PGAM2) 0.13 0.16 0.15 0.13 0.16 0.18 0.21 0.18 0.18 0.13 1.00 0.13 0.17 0.11 0.17
58529 (MYOZ1) 0.87 0.26 0.69 0.69 1.00 0.14 0.15 0.14 0.14 0.74 0.13 1.00 0.70 0.73 0.70
92483 (LDHAL6B) 0.70 0.26 0.59 0.62 1.00 0.16 0.19 0.16 0.16 0.67 0.17 0.70 1.00 0.58 0.58
7140 (TNNT3) 0.73 0.21 0.57 0.57 0.82 0.12 0.13 0.12 0.12 0.60 0.11 0.73 0.58 1.00 0.58
1158 (CKM) 0.70 0.26 0.92 0.62 1.00 1.00 0.29 1.00 1.00 0.67 0.17 0.70 0.58 0.58 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CKM Human Skeletal muscle - 4559 m 9 day downregulated -1.23 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EGR1 1958 CKM 1158 distal 22955619 TRANSFAC
JUND 3727 CKM 1158 distal 22955619 TRANSFAC
POU5F1 5460 CKM 1158 distal 22955619 TRANSFAC
REST 5978 CKM 1158 distal 22955619 TRANSFAC
CTCF 10664 CKM 1158 distal 22955619 TRANSFAC
EP300 2033 CKM 1158 distal 22955619 TRANSFAC
TAF1 6872 CKM 1158 distal 22955619 TRANSFAC
TCF12 6938 CKM 1158 distal 22955619 TRANSFAC
RAD21 5885 CKM 1158 distal 22955619 TRANSFAC
NANOG 79923 CKM 1158 distal 22955619 TRANSFAC
WT1 7490 CKM 1158 Activation 10878024 TRUSST
TP53 7157 CKM 1158 Unknown 10506225 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
1158 GO:0016301 kinase activity GOTERM_MF_DIRECT
1158 GO:0046314 phosphocreatine biosynthetic process GOTERM_BP_DIRECT
1158 GO:0016310 phosphorylation GOTERM_BP_DIRECT
1158 GO:0006600 creatine metabolic process GOTERM_BP_DIRECT
1158 GO:0004111 carnitine O-palmitoyltransferase activity GOTERM_MF_DIRECT
1158 GO:0005515 protein binding GOTERM_MF_DIRECT
1158 GO:0005524 ATP binding GOTERM_MF_DIRECT
1158 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1158 hsa00330 Arginine and proline metabolism
1158 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CKM 1158 Acute Coronary Syndrome C0948089 Disease or Syndrome 0.3 0.815 0.241 disease
CKM 1158 Ischemia C0022116 Pathologic Function 0.3 0.815 0.241 phenotype
CKM 1158 Left Ventricular Hypertrophy C0149721 Disease or Syndrome 0.3 0.815 0.241 disease
CKM 1158 Malignant tumor of colon C0007102 Neoplastic Process 0.3 0.815 0.241 disease
CKM 1158 Colonic Neoplasms C0009375 Neoplastic Process 0.3 0.815 0.241 group
CKM 1158 Myocardial Infarction C0027051 Disease or Syndrome 0.3 0.815 0.241 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CKM 1158 ADRIAMYCIN None None None
CKM 1158 SALT VOLANESORSEN SODIUM CHEMBL3544989 None