PH domain-containing protein 4

AltitudeomicsDB
Protein Official symbol FGD4
Aliases FGD4 FRABP ZFYVE6
Chromosomal Location  12
Length 766
Uniprot ID Q96M96
EC number None
Protein family Information(Pfam) PF01363;PF00169;PF00621;
PDB id None
InterPro ID IPR035899;IPR000219;IPR037742;IPR035941;IPR011993;IPR001849;IPR000306;IPR017455;IPR013083;
dbSNP rs63749871 rs63749871

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CDC42 RHOC 0.972
FGD4 CDC42 0.958
FGD4 RAC2 0.951
RHOBTB2 RHOT1 0.945
RHOBTB2 RHOT2 0.945
RHOT1 RHOBTB1 0.945
RHOBTB1 RHOT2 0.943
RHOA CDC42 0.928
CDC42 RAC2 0.924
FGD4 RAC1 0.921
RHOA RHOC 0.92
RHOG RAC2 0.919
RHOC RAC2 0.918
RHOA FGD4 0.917
RHOBTB2 RHOF 0.917
RHOBTB1 RHOF 0.916
RHOH RHOT1 0.916
RHOT1 RHOF 0.915
RHOT1 RHOQ 0.915
RHOT1 RHOG 0.914
RHOH RAC2 0.914
RHOT1 RAC2 0.914
FGD4 RHOD 0.914
RHOH RHOBTB1 0.914
RHOA RAC2 0.913
RHOH RHOF 0.913
RHOBTB2 RHOU 0.913
RHOD RHOV 0.913
RHOU RHOBTB1 0.913
RHOA RAC1 0.913
RHOT1 RHOC 0.913
RHOBTB2 RHOH 0.913
RHOT1 RAC1 0.912
RHOBTB1 RHOV 0.912
RHOBTB1 RHOD 0.912
RHOT2 RHOD 0.912
RHOH RHOT2 0.912
CDC42 RHOT1 0.912
FGD4 RHOT2 0.912
RHOH RHOD 0.912
RHOH RHOG 0.911
RHOBTB2 RHOD 0.911
RHOT2 RHOC 0.911
RHOT1 RHOB 0.911
FGD4 RAC3 0.911
RHOU RHOT1 0.91
RHOT1 RHOJ 0.91
RHOT1 RHOD 0.91
RHOD RHOC 0.91
CDC42 RHOB 0.91
RHOT1 RHOV 0.91
RHOA RHOT1 0.91
RHOG RHOT2 0.91
RHOT2 RHOQ 0.91
RHOU RHOT2 0.91
RHOF RHOV 0.909
RAC1 RHOC 0.909
RHOT2 RHOB 0.909
RHOT2 RHOF 0.909
RHOJ RHOD 0.909
RHOH RAC1 0.909
RHOBTB2 RHOV 0.909
RHOT2 RHOJ 0.909
RHOU RHOD 0.909
RAC1 RHOB 0.909
RHOB RAC2 0.909
RHOBTB1 RHOJ 0.909
RHOH RHOQ 0.909
CDC42 RHOBTB1 0.908
RHOBTB2 RHOJ 0.908
RHOH RHOV 0.908
CDC42 RHOH 0.908
RHOBTB2 CDC42 0.908
RHOF RAC2 0.908
FGD4 RHOC 0.908
RHOH RHOU 0.908
FGD4 RHOU 0.908
RHOH RAC3 0.908
RAC3 RHOV 0.908
RHOA RAC3 0.908
RHOBTB1 RHOB 0.908
RHOH RHOJ 0.908
RHOA RHOD 0.907
RHOG RHOC 0.907
RHOJ RHOV 0.907
RHOT2 RHOV 0.907
RAC1 RHOBTB1 0.907
RHOH RHOB 0.907
RAC3 RHOC 0.907
RHOA RHOH 0.907
RHOBTB2 RHOB 0.907
FGD4 RHOV 0.907
RHOJ RHOF 0.907
FGD4 RHOT1 0.907
RHOG RHOF 0.907
RAC3 RHOB 0.907
RHOA RHOT2 0.907
RHOC RHOV 0.907
RHOBTB2 RAC1 0.907
RHOH RHOC 0.907
RHOD RHOQ 0.906
RHOC RHOQ 0.906
RHOA RHOJ 0.906
RHOBTB1 RHOC 0.906
RHOA RHOBTB1 0.906
RHOA RHOG 0.906
FGD4 RHOH 0.906
FGD4 RHOG 0.906
CDC42 RAC1 0.906
RHOG RHOD 0.906
CDC42 RAC3 0.906
RAC1 RAC2 0.906
RHOJ RHOB 0.906
RHOJ RHOC 0.906
RHOT2 RAC3 0.906
RHOD RAC3 0.906
FGD4 RHOBTB1 0.906
RAC1 RHOD 0.906
RHOF RHOQ 0.906
RHOB RHOV 0.906
RHOU RHOF 0.906
CDC42 RHOD 0.906
CDC42 RHOT2 0.906
RHOT2 RAC2 0.906
CDC42 RHOG 0.906
FGD4 RHOB 0.906
RHOA RHOV 0.906
RHOBTB1 RHOQ 0.906
RHOU RHOB 0.906
RHOG RHOV 0.905
RHOG RHOBTB1 0.905
RHOB RHOF 0.905
RHOBTB2 RHOC 0.905
RHOQ RHOV 0.905
RAC1 RHOG 0.905
CDC42 RHOF 0.905
RHOU RHOJ 0.905
RHOBTB2 RHOG 0.905
RHOBTB2 RHOQ 0.905
RAC1 RHOF 0.905
RHOBTB1 RAC2 0.905
RHOBTB2 RHOA 0.905
RHOG RHOJ 0.905
RHOBTB2 RAC3 0.905
RAC1 RHOV 0.905
RHOBTB1 RAC3 0.905
RHOD RAC2 0.905
RHOU RAC1 0.905
CDC42 RHOU 0.905
RHOD RHOB 0.905
RHOG RHOB 0.905
RHOC RHOB 0.904
RHOU RHOV 0.904
RHOJ RHOQ 0.904
RHOC RHOF 0.904
RHOU RHOG 0.904
RHOG RAC3 0.904
RHOD RHOF 0.904
RHOA RHOU 0.904
RHOG RHOQ 0.904
RHOA RHOQ 0.904
RHOA RHOF 0.904
RHOBTB2 RAC2 0.904
RHOU RHOQ 0.904
RAC1 RHOJ 0.904
CDC42 RHOV 0.904
RHOU RAC2 0.904
RHOB RHOQ 0.904
RAC2 RHOV 0.903
CDC42 RHOJ 0.903
RHOT1 RHOT2 0.903
FGD4 RHOQ 0.903
RHOJ RAC2 0.903
RHOU RHOC 0.903
RAC1 RHOQ 0.903
FGD4 RHOF 0.903
RHOU RAC3 0.903
RAC1 RHOT2 0.902
RAC2 RHOQ 0.902
RHOA RHOB 0.902
CDC42 RHOQ 0.902
RHOBTB2 RHOBTB1 0.902
RHOT1 RAC3 0.902
RAC3 RHOF 0.902
RHOJ RAC3 0.902
RHOBTB2 FGD4 0.902
RAC3 RHOQ 0.902
RAC1 RAC3 0.901
RAC3 RAC2 0.901
FGD4 RHOJ 0.901
Gene Ontology Semantic Similarity
Download Tab separated file
# 998 (CDC42) 121512 (FGD4) 23221 (RHOBTB2) 55288 (RHOT1) 9886 (RHOBTB1) 387 (RHOA) 391 (RHOG) 389 (RHOC) 399 (RHOH) 29984 (RHOD) 58480 (RHOU) 89941 (RHOT2) 54509 (RHOF) 5879 (RAC1) 57381 (RHOJ) 388 (RHOB) 5881 (RAC3) 23433 (RHOQ) 5880 (RAC2)
998 (CDC42) 1.00 0.34 0.79 0.74 0.67 0.78 0.79 0.79 0.70 0.67 0.79 0.74 0.67 0.88 0.79 0.79 0.79 0.78 0.74
121512 (FGD4) 0.34 1.00 0.34 0.39 0.25 0.35 0.34 0.34 0.42 0.25 0.34 0.31 0.25 0.40 0.34 0.34 0.36 0.31 0.31
23221 (RHOBTB2) 0.79 0.34 1.00 0.89 0.94 0.97 1.00 1.00 0.80 0.94 1.00 0.94 0.94 0.86 1.00 1.00 0.98 0.92 0.94
55288 (RHOT1) 0.74 0.39 0.89 1.00 0.78 0.86 0.89 0.89 0.74 0.78 0.89 0.93 0.78 0.79 0.89 0.89 0.88 0.81 0.93
9886 (RHOBTB1) 0.67 0.25 0.94 0.78 1.00 0.88 0.94 0.94 0.72 1.00 0.94 0.87 1.00 0.77 0.94 0.94 0.89 0.86 0.87
387 (RHOA) 0.78 0.35 0.97 0.86 0.88 1.00 0.97 0.97 0.79 0.88 0.97 0.91 0.88 0.85 0.97 0.97 0.95 0.89 0.91
391 (RHOG) 0.79 0.34 1.00 0.89 0.94 0.97 1.00 1.00 0.80 0.94 1.00 0.94 0.94 0.86 1.00 1.00 0.98 0.92 0.94
389 (RHOC) 0.79 0.34 1.00 0.89 0.94 0.97 1.00 1.00 0.80 0.94 1.00 0.94 0.94 0.86 1.00 1.00 0.98 0.92 0.94
399 (RHOH) 0.70 0.42 0.80 0.74 0.72 0.79 0.80 0.80 1.00 0.72 0.80 0.74 0.72 0.75 0.80 0.80 0.80 0.75 0.74
29984 (RHOD) 0.67 0.25 0.94 0.78 1.00 0.88 0.94 0.94 0.72 1.00 0.94 0.87 1.00 0.77 0.94 0.94 0.89 0.86 0.87
58480 (RHOU) 0.79 0.34 1.00 0.89 0.94 0.97 1.00 1.00 0.80 0.94 1.00 0.94 0.94 0.86 1.00 1.00 0.98 0.92 0.94
89941 (RHOT2) 0.74 0.31 0.94 0.93 0.87 0.91 0.94 0.94 0.74 0.87 0.94 1.00 0.87 0.81 0.94 0.94 0.93 0.87 1.00
54509 (RHOF) 0.67 0.25 0.94 0.78 1.00 0.88 0.94 0.94 0.72 1.00 0.94 0.87 1.00 0.77 0.94 0.94 0.89 0.86 0.87
5879 (RAC1) 0.88 0.40 0.86 0.79 0.77 0.85 0.86 0.86 0.75 0.77 0.86 0.81 0.77 1.00 0.86 0.86 0.86 0.80 0.81
57381 (RHOJ) 0.79 0.34 1.00 0.89 0.94 0.97 1.00 1.00 0.80 0.94 1.00 0.94 0.94 0.86 1.00 1.00 0.98 0.92 0.94
388 (RHOB) 0.79 0.34 1.00 0.89 0.94 0.97 1.00 1.00 0.80 0.94 1.00 0.94 0.94 0.86 1.00 1.00 0.98 0.92 0.94
5881 (RAC3) 0.79 0.36 0.98 0.88 0.89 0.95 0.98 0.98 0.80 0.89 0.98 0.93 0.89 0.86 0.98 0.98 1.00 0.90 0.93
23433 (RHOQ) 0.78 0.31 0.92 0.81 0.86 0.89 0.92 0.92 0.75 0.86 0.92 0.87 0.86 0.80 0.92 0.92 0.90 1.00 0.87
5880 (RAC2) 0.74 0.31 0.94 0.93 0.87 0.91 0.94 0.94 0.74 0.87 0.94 1.00 0.87 0.81 0.94 0.94 0.93 0.87 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
FGD4 Bird Liver - 4000 m Native downregulated -2.68 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT272324 hsa-miR-4487 Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448833 hsa-miR-558 Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448838 hsa-miR-206 Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448839 hsa-miR-613 Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448830 hsa-miR-526b-5p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448832 hsa-miR-6716-5p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448836 hsa-miR-204-3p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448837 hsa-miR-1-3p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448834 hsa-miR-3160-3p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448835 hsa-miR-4646-5p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT448831 hsa-miR-431-5p Homo sapiens FGD4 121512 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT668360 hsa-miR-3152-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668364 hsa-miR-5100 Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668366 hsa-miR-545-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668361 hsa-miR-4774-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668363 hsa-miR-6836-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668362 hsa-miR-3942-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668367 hsa-miR-10b-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668365 hsa-miR-4797-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668359 hsa-miR-129-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT703562 hsa-miR-499a-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT703561 hsa-miR-4266 Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT703567 hsa-miR-3617-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT703565 hsa-miR-302f Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT703566 hsa-miR-641 Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT703564 hsa-miR-208a-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT703563 hsa-miR-208b-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT709060 hsa-miR-335-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709061 hsa-miR-5096 Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709062 hsa-miR-197-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709063 hsa-miR-4742-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709065 hsa-miR-490-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709066 hsa-miR-7153-3p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709064 hsa-miR-339-5p Homo sapiens FGD4 121512 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
121512 GO:0043087 regulation of GTPase activity GOTERM_BP_DIRECT
121512 GO:0005737 cytoplasm GOTERM_CC_DIRECT
121512 GO:0030035 microspike assembly GOTERM_BP_DIRECT
121512 GO:0007010 cytoskeleton organization GOTERM_BP_DIRECT
121512 GO:0008360 regulation of cell shape GOTERM_BP_DIRECT
121512 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
121512 GO:0030036 actin cytoskeleton organization GOTERM_BP_DIRECT
121512 GO:0046847 filopodium assembly GOTERM_BP_DIRECT
121512 GO:0001726 ruffle GOTERM_CC_DIRECT
121512 GO:0030032 lamellipodium assembly GOTERM_BP_DIRECT
121512 GO:0035023 regulation of Rho protein signal transduction GOTERM_BP_DIRECT
121512 GO:0043547 positive regulation of GTPase activity GOTERM_BP_DIRECT
121512 GO:0031267 phosphatidylcholine binding GOTERM_MF_DIRECT
121512 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
121512 GO:0005829 cytosol GOTERM_CC_DIRECT
121512 GO:0030027 lamellipodium GOTERM_CC_DIRECT
121512 GO:0015629 actin cytoskeleton GOTERM_CC_DIRECT
121512 GO:0030175 filopodium GOTERM_CC_DIRECT
121512 GO:0051056 regulation of small GTPase mediated signal transduction GOTERM_BP_DIRECT
121512 GO:0003779 motor activity GOTERM_MF_DIRECT
121512 GO:0046872 metal ion binding GOTERM_MF_DIRECT
121512 GO:0005085 protein kinase C binding GOTERM_MF_DIRECT
121512 GO:0005089 Ras guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
FGD4 121512 CHARCOT-MARIE-TOOTH DISEASE, TYPE 4H C1836336 Disease or Syndrome 0.95 0.735 0.276 disease
FGD4 121512 Charcot-Marie-Tooth Disease C0007959 Disease or Syndrome 0.52 0.735 0.276 disease
FGD4 121512 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.735 0.276 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types