Carbamoyl-phosphate synthase

AltitudeomicsDB
Protein Official symbol CPS1
Aliases CPS1
Chromosomal Location  2
Length 1500
Uniprot ID P31327
EC number 6.3.4.16
Protein family Information(Pfam) PF18302;PF02786;PF02787;PF00988;PF00117;PF02142;
PDB id 2YVQ;4UTR;4UTV;4UTX;4UTZ;4UU7;4UU8;4UUA;4UUB;5DOT;5DOU;5OJO;6UEL;
InterPro ID IPR011761;IPR013815;IPR006275;IPR005480;IPR036897;IPR006274;IPR002474;IPR036480;IPR005479;IPR005483;IPR029062;IPR041557;IPR035686;IPR017926;IPR011607;IPR036914;IPR016185;
dbSNP rs375979196 rs1265394565 rs1553509297 rs1553509661 rs767905306 rs752902711 rs1471393474 rs753751183 rs973321068 rs775920437 rs1273594946 rs28940283 rs1047883 rs1047883 rs1472190012 rs149930500 rs201407486 rs760895692 rs778766382 rs772497399 rs772497399 rs371350538 rs1250316045 rs121912592 rs1242028775 rs1553512642 rs777233486 rs1048119191 rs1553512962 rs1275599086 rs1553512974 rs757205958 rs142693704 rs1248368809 rs369061090 rs752339705 rs758724746 rs1553513429 rs201716417 rs201716417 rs201716417 rs1553513861 rs1553513864 rs772782772 rs1553513870 rs1015051007 rs767694281 rs147062907 rs1388955593 rs754706559 rs765484849 rs760714614 rs537170841 rs1191587211 rs955666400 rs534815243 rs121912595 rs757059355 rs121912595 rs1553516442 rs1553516443 rs990390709 rs1404696893 rs749238466 rs1437651658 rs1241423400 rs770471782 rs1392559810 rs1280211937 rs766125631 rs149518280 rs1319489001 rs141373204 rs778117194 rs750670270 rs1047886 rs1047887 rs372645328 rs140578009 rs1245373037 rs1392934477 rs1047891 rs1202306773 rs933813349 rs1553519513

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ASS1 OTC 0.999
CPS1 ASS1 0.995
GLUD2 GLUD1 0.994
CPS1 OTC 0.991
NAGS OTC 0.99
ASS1 CAD 0.987
ASS1 NAGS 0.987
GLUL GLUD1 0.983
GLUD2 GLUL 0.978
GLS2 GLUL 0.973
GLS GLUL 0.972
CPS1 GLUL 0.966
GLS2 GLUD1 0.96
GLS GLUD1 0.959
GLS CAD 0.951
GLUL CAD 0.943
CPS1 GLUD1 0.942
GLUD2 GLS2 0.939
GLS2 CAD 0.938
NAGS GLUD1 0.935
GLUD2 GLS 0.933
CPS1 NAGS 0.929
GLUD2 NAGS 0.925
CPS1 GLUD2 0.925
CPS1 GLS2 0.922
CPS1 GLS 0.915
CPS1 CAD 0.904
Gene Ontology Semantic Similarity
Download Tab separated file
# 445 (ASS1) 1373 (CPS1) 2747 (GLUD2) 162417 (NAGS) 2752 (GLUL) 27165 (GLS2) 2744 (GLS) 5009 (OTC) 2746 (GLUD1) 790 (CAD)
445 (ASS1) 1.00 0.60 0.37 0.39 0.72 0.56 0.56 0.24 0.60 0.60
1373 (CPS1) 0.60 1.00 0.22 0.22 0.58 0.53 0.53 0.73 0.40 0.75
2747 (GLUD2) 0.37 0.22 1.00 0.38 0.20 0.21 0.21 0.20 0.84 0.43
162417 (NAGS) 0.39 0.22 0.38 1.00 0.20 0.21 0.21 0.24 0.35 0.31
2752 (GLUL) 0.72 0.58 0.20 0.20 1.00 0.63 0.63 0.17 0.49 0.49
27165 (GLS2) 0.56 0.53 0.21 0.21 0.63 1.00 1.00 0.20 0.42 0.42
2744 (GLS) 0.56 0.53 0.21 0.21 0.63 1.00 1.00 0.20 0.42 0.42
5009 (OTC) 0.24 0.73 0.20 0.24 0.17 0.20 0.20 1.00 0.20 0.73
2746 (GLUD1) 0.60 0.40 0.84 0.35 0.49 0.42 0.42 0.20 1.00 0.56
790 (CAD) 0.60 0.75 0.43 0.31 0.49 0.42 0.42 0.73 0.56 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CPS1 Toad Heart - 3464 m 33 day downregulated -2.530414103 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 CPS1 1373 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT051022 hsa-miR-17-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT051022 hsa-miR-17-5p Homo sapiens CPS1 1373 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT205179 hsa-miR-4255 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT205178 hsa-miR-3121-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT478921 hsa-miR-216a-5p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478920 hsa-miR-144-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478916 hsa-miR-1255a Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478923 hsa-miR-224-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478913 hsa-miR-7154-5p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478915 hsa-miR-1255b-5p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478917 hsa-miR-6744-5p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478919 hsa-miR-16-1-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478912 hsa-miR-4709-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478922 hsa-miR-522-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478924 hsa-miR-4694-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478914 hsa-miR-101-3p Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT478918 hsa-miR-8060 Homo sapiens CPS1 1373 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT688692 hsa-miR-4727-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688694 hsa-miR-142-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688703 hsa-miR-324-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688691 hsa-miR-5001-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688697 hsa-miR-6799-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688699 hsa-miR-7976 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688709 hsa-miR-200b-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688688 hsa-miR-1303 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688693 hsa-miR-1200 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688710 hsa-miR-200a-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688725 hsa-miR-548c-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688690 hsa-miR-1273h-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688705 hsa-miR-4682 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688723 hsa-miR-548k Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688724 hsa-miR-548av-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688689 hsa-miR-3678-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688696 hsa-miR-146b-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688708 hsa-miR-4778-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688714 hsa-miR-519d-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688686 hsa-miR-6516-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688717 hsa-miR-106b-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688711 hsa-miR-4796-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688721 hsa-miR-548l Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688698 hsa-miR-3173-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688712 hsa-miR-93-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688722 hsa-miR-8054 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688701 hsa-miR-302a-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688707 hsa-miR-4324 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688719 hsa-miR-548ah-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688720 hsa-miR-3609 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688687 hsa-miR-6738-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688700 hsa-miR-496 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688715 hsa-miR-20b-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688695 hsa-miR-630 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688716 hsa-miR-20a-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688718 hsa-miR-106a-5p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688702 hsa-miR-18a-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688704 hsa-miR-1913 Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688706 hsa-miR-544b Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT688713 hsa-miR-526b-3p Homo sapiens CPS1 1373 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
Gene Ontology
ID GO ID GO Term GO Type
1373 GO:0006526 arginine biosynthetic process GOTERM_BP_DIRECT
1373 GO:0032094 response to food GOTERM_BP_DIRECT
1373 GO:0000050 urea cycle GOTERM_BP_DIRECT
1373 GO:0043200 response to amino acid GOTERM_BP_DIRECT
1373 GO:0055081 anion homeostasis GOTERM_BP_DIRECT
1373 GO:0070365 hepatocyte differentiation GOTERM_BP_DIRECT
1373 GO:0071400 cellular response to oleic acid GOTERM_BP_DIRECT
1373 GO:0005543 phospholipid binding GOTERM_MF_DIRECT
1373 GO:0006541 glutamine metabolic process GOTERM_BP_DIRECT
1373 GO:0010043 response to zinc ion GOTERM_BP_DIRECT
1373 GO:0004175 dopachrome isomerase activity GOTERM_MF_DIRECT
1373 GO:0005524 ATP binding GOTERM_MF_DIRECT
1373 GO:0032403 protein complex binding GOTERM_MF_DIRECT
1373 GO:0042493 response to drug GOTERM_BP_DIRECT
1373 GO:0005743 mitochondrial inner membrane GOTERM_CC_DIRECT
1373 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
1373 GO:0032496 response to lipopolysaccharide GOTERM_BP_DIRECT
1373 GO:0060416 response to growth hormone GOTERM_BP_DIRECT
1373 GO:0043234 protein complex GOTERM_CC_DIRECT
1373 GO:0009636 response to toxic substance GOTERM_BP_DIRECT
1373 GO:0042594 response to starvation GOTERM_BP_DIRECT
1373 GO:0070409 carbamoyl phosphate biosynthetic process GOTERM_BP_DIRECT
1373 GO:0046872 metal ion binding GOTERM_MF_DIRECT
1373 GO:0019433 triglyceride catabolic process GOTERM_BP_DIRECT
1373 GO:0071377 cellular response to glucagon stimulus GOTERM_BP_DIRECT
1373 GO:0072341 14-3-3 protein binding GOTERM_MF_DIRECT
1373 GO:0014075 response to amine GOTERM_BP_DIRECT
1373 GO:0004087 biotin carboxylase activity GOTERM_MF_DIRECT
1373 GO:0046209 nitric oxide metabolic process GOTERM_BP_DIRECT
1373 GO:0005509 calcium ion binding GOTERM_MF_DIRECT
1373 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process GOTERM_BP_DIRECT
1373 GO:0004151 cytochrome-c oxidase activity GOTERM_MF_DIRECT
1373 GO:0005980 glycogen catabolic process GOTERM_BP_DIRECT
1373 GO:0006508 proteolysis GOTERM_BP_DIRECT
1373 GO:0042645 mitochondrial nucleoid GOTERM_CC_DIRECT
1373 GO:0050667 homocysteine metabolic process GOTERM_BP_DIRECT
1373 GO:0005515 protein binding GOTERM_MF_DIRECT
1373 GO:0044344 cellular response to fibroblast growth factor stimulus GOTERM_BP_DIRECT
1373 GO:0071320 cellular response to cAMP GOTERM_BP_DIRECT
1373 GO:0006807 nitrogen compound metabolic process GOTERM_BP_DIRECT
1373 GO:0007494 midgut development GOTERM_BP_DIRECT
1373 GO:0019240 citrulline biosynthetic process GOTERM_BP_DIRECT
1373 GO:0045909 positive regulation of vasodilation GOTERM_BP_DIRECT
1373 GO:0004088 bisphosphoglycerate mutase activity GOTERM_MF_DIRECT
1373 GO:0071548 response to dexamethasone GOTERM_BP_DIRECT
1373 GO:0004070 arylesterase activity GOTERM_MF_DIRECT
1373 GO:0016595 long-chain-3-hydroxyacyl-CoA dehydrogenase activity GOTERM_MF_DIRECT
1373 GO:0005730 nucleolus GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1373 hsa00220 Arginine biosynthesis
1373 hsa00250 Alanine
1373 hsa00910 Nitrogen metabolism
1373 hsa01100 Metabolic pathways
1373 hsa01200 Carbon metabolism
1373 hsa01230 Biosynthesis of amino acids
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CPS1 1373 Condition, Preneoplastic C0282313 Neoplastic Process 0.3 0.645 0.379 phenotype
CPS1 1373 Comatose C0009421 Disease or Syndrome 0.4 0.645 0.379 phenotype
CPS1 1373 Psychogenic coma C0860634 Mental or Behavioral Dysfunction 0.3 0.645 0.379 disease
CPS1 1373 Endotoxemia C0376618 Finding 0.3 0.645 0.379 phenotype
CPS1 1373 Carbamoyl Phosphate Synthase 1 Deficiency C4085580 Disease or Syndrome 0.31 0.645 0.379 disease
CPS1 1373 Precancerous Conditions C0032927 Neoplastic Process 0.3 0.645 0.379 group
CPS1 1373 Persistent Fetal Circulation Syndrome C0031190 Disease or Syndrome 0.3 0.645 0.379 disease
CPS1 1373 PULMONARY HYPERTENSION, NEONATAL, SUSCEPTIBILITY TO C3714958 Finding 0.3 0.645 0.379 phenotype
CPS1 1373 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.645 0.379 disease
CPS1 1373 Hyperammonemia C0220994 Disease or Syndrome 0.7 0.645 0.379 phenotype
CPS1 1373 Carbamoyl-Phosphate Synthase I Deficiency Disease C0751753 Disease or Syndrome 0.92 0.645 0.379 disease
CPS1 1373 Hyperammonemia Due to Carbamoyl Phosphate Synthetase 1 Deficiency C4082171 Disease or Syndrome 0.51 0.645 0.379 disease
CPS1 1373 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.645 0.379 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CPS1 1373 CARGLUMIC ACID CARGLUMIC ACID CHEMBL1201780 activator
CPS1 1373 CARGLUMIC ACID CARGLUMIC ACID CHEMBL1201780 positive allosteric modulator