Glutamate DH 1, mitochondrial

AltitudeomicsDB
Protein Official symbol GLUD1
Aliases GLUD1 GLUD
Chromosomal Location 10
Length 558
Uniprot ID P00367
EC number 1.4.1.3
Protein family Information(Pfam) PF00208;PF02812;
PDB id 1L1F;1NR1;6DQG;
InterPro ID IPR006095;IPR033524;IPR006096;IPR006097;IPR036291;IPR033922;
dbSNP rs56275071 rs121909736 rs1554906133 rs121909737 rs121909735 rs121909731 rs121909734 rs121909733 rs121909732 rs121909730

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
OGDH DLD 0.998
CS MDH2 0.997
IDH2 IDH3A 0.997
CS ACLY 0.995
GLUD2 GLUD1 0.994
MDH1 MDH2 0.994
MDH2 GOT2 0.993
PC CS 0.991
PC MDH2 0.99
MDH1 GOT1 0.99
ALDH4A1 ALDH18A1 0.99
IDH1 IDH3A 0.989
OGDHL DLD 0.987
SOD2 SIRT3 0.987
IDH2 OGDH 0.987
IDH1 OGDH 0.987
MDH1 CS 0.986
GLUD1 GOT2 0.986
IDH3A OGDH 0.985
GLUL GLUD1 0.983
GOT1 GPT2 0.983
PC ACLY 0.98
GOT1 GLUD1 0.979
MDH1 GOT2 0.979
SIRT3 IDH2 0.978
GOT1 GLUD2 0.978
GLUD2 GLUL 0.978
IDH1 IDH2 0.976
OGDHL IDH3A 0.974
GLS2 GLUL 0.973
GLUD2 GOT2 0.973
GLS GLUL 0.972
MDH2 DLD 0.971
MDH1 PC 0.971
GPT GOT1 0.97
SOD2 IDH2 0.969
ALDH4A1 GOT1 0.969
CPS1 GLUL 0.966
GPT2 GLUD1 0.966
IDH2 GLUD1 0.965
GPT2 GOT2 0.964
GOT1 MDH2 0.964
ALDH4A1 GLUD1 0.963
SIRT3 ACSS2 0.963
GPT GOT2 0.962
GLUD1 SIRT4 0.961
GLS2 GLUD1 0.96
PC GOT1 0.96
MDH2 ACLY 0.959
GLS GLUD1 0.959
GLUD1 OGDH 0.958
ALDH18A1 GLUD2 0.958
ALDH18A1 GLUD1 0.957
MDH1 ACLY 0.957
CS IDH3A 0.957
ALDH18A1 GLUL 0.956
GAD2 GAD1 0.956
IDH2 GOT2 0.955
GPT2 GLUD2 0.955
GPT GLUD1 0.952
ALDH4A1 GLUL 0.952
IDH2 GLUD2 0.952
IDH1 GOT2 0.95
GAD2 GLUL 0.949
IDH2 ACSS2 0.948
GPT GLUD2 0.948
GAD1 GLUL 0.948
ALDH4A1 GLUD2 0.948
ALDH4A1 GLS2 0.947
MDH2 GLUD1 0.946
PC GOT2 0.943
SIRT3 GLUD1 0.942
SOD2 GLUD1 0.942
CPS1 GLUD1 0.942
GAD1 GLS2 0.941
CS GOT2 0.94
OGDHL IDH2 0.94
IDH1 OGDHL 0.939
GOT1 OGDH 0.939
GLUD2 GLS2 0.939
GAD1 GLS 0.938
PC ACSS2 0.938
GLUD2 OGDH 0.937
GAD2 GLS2 0.937
GLUD1 ACSS2 0.937
GLUD2 MDH2 0.937
NAGS GLUD1 0.935
IDH1 GLUD1 0.934
GAD2 GLS 0.934
GLUD2 SIRT4 0.933
GLUD2 GLS 0.933
SOD2 GLUD2 0.932
MDH1 GLUD1 0.931
GOT1 GOT2 0.931
CPS1 NAGS 0.929
SOD2 ACSS2 0.929
NIT2 GLUD1 0.929
GAD1 GLUD2 0.929
CS OGDH 0.929
ALDH4A1 GOT2 0.928
CS GLUD1 0.928
ALDH4A1 GLS 0.927
GAD2 GLUD2 0.927
GAD1 GLUD1 0.926
CPS1 GLUD2 0.925
GLUD2 NAGS 0.925
GLUD2 ACSS2 0.923
MDH2 IDH3A 0.922
CPS1 GLS2 0.922
GPT OGDH 0.921
PC GLUD1 0.92
GOT2 OGDH 0.92
IDH2 MDH2 0.919
GPT NAGS 0.919
GPT2 NAGS 0.919
SIRT3 GLUD2 0.918
ALDH4A1 GAD1 0.918
OGDHL GLUD2 0.917
GAD2 ALDH4A1 0.917
GAD2 GLUD1 0.917
GPT2 OGDH 0.916
GLUD1 DLD 0.915
IDH1 GOT1 0.915
CPS1 GLS 0.915
IDH3A GLUD1 0.914
NIT2 GOT1 0.914
GLUD1 ACLY 0.914
NIT2 GOT2 0.914
CS GLUD2 0.912
IDH1 MDH2 0.91
GLUD2 IDH3A 0.91
NIT2 GLUD2 0.909
NAGS GOT2 0.907
IDH1 GLUD2 0.906
IDH1 NIT2 0.904
GOT1 NAGS 0.903
OGDHL GLUD1 0.902
MDH1 GLUD2 0.902
GOT1 IDH2 0.9
Gene Ontology Semantic Similarity
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# 1738 (DLD) 4191 (MDH2) 3419 (IDH3A) 47 (ACLY) 2746 (GLUD1) 2806 (GOT2) 1431 (CS) 2805 (GOT1) 5832 (ALDH18A1) 23410 (SIRT3) 4967 (OGDH) 84706 (GPT2) 3418 (IDH2) 2747 (GLUD2) 2752 (GLUL) 5091 (PC) 55902 (ACSS2) 23409 (SIRT4) 2571 (GAD1) 27165 (GLS2) 55753 (OGDHL) 2744 (GLS) 162417 (NAGS) 8659 (ALDH4A1) 56954 (NIT2) 4190 (MDH1) 3417 (IDH1) 2875 (GPT) 1373 (CPS1) 2572 (GAD2)
1738 (DLD) 1.00 0.31 0.30 0.45 0.44 0.24 0.24 0.17 0.60 0.39 0.31 0.16 0.39 0.26 0.55 0.57 0.16 0.41 0.51 0.51 0.63 0.51 0.18 0.54 0.18 0.53 0.54 0.16 0.42 0.51
4191 (MDH2) 0.31 1.00 0.39 0.27 0.30 0.51 0.58 0.16 0.47 0.34 0.33 0.16 0.36 0.26 0.27 0.29 0.20 0.24 0.27 0.27 0.34 0.27 0.16 0.29 0.18 0.68 0.36 0.16 0.26 0.27
3419 (IDH3A) 0.30 0.39 1.00 0.24 0.30 0.19 0.18 0.15 0.28 0.32 0.31 0.15 0.74 0.30 0.26 0.28 0.21 0.23 0.26 0.26 0.32 0.26 0.27 0.28 0.17 0.46 0.56 0.15 0.25 0.26
47 (ACLY) 0.45 0.27 0.24 1.00 0.61 0.33 0.45 0.24 0.49 0.46 0.27 0.29 0.35 0.46 0.55 0.57 0.45 0.46 0.51 0.51 0.51 0.51 0.31 0.39 0.20 0.46 0.49 0.29 0.45 0.51
2746 (GLUD1) 0.44 0.30 0.30 0.61 1.00 0.26 0.26 0.13 0.50 0.54 0.39 0.17 0.40 0.84 0.49 0.50 0.42 0.39 0.42 0.42 0.47 0.42 0.35 0.43 0.20 0.45 0.53 0.17 0.40 0.42
2806 (GOT2) 0.24 0.51 0.19 0.33 0.26 1.00 0.58 0.71 0.44 0.33 0.27 0.63 0.20 0.22 0.26 0.29 0.21 0.31 0.27 0.27 0.27 0.27 0.22 0.23 0.20 0.25 0.25 0.63 0.31 0.27
1431 (CS) 0.24 0.58 0.18 0.45 0.26 0.58 1.00 0.24 0.44 0.34 0.27 0.25 0.19 0.21 0.27 0.29 0.20 0.28 0.27 0.27 0.27 0.27 0.25 0.22 0.17 0.25 0.24 0.25 0.28 0.27
2805 (GOT1) 0.17 0.16 0.15 0.24 0.13 0.71 0.24 1.00 0.20 0.14 0.17 0.63 0.14 0.14 0.16 0.20 0.15 0.26 0.19 0.19 0.19 0.19 0.20 0.19 0.20 0.19 0.16 0.63 0.25 0.19
5832 (ALDH18A1) 0.60 0.47 0.28 0.49 0.50 0.44 0.44 0.20 1.00 0.47 0.35 0.25 0.41 0.28 0.56 0.59 0.19 0.46 0.49 0.49 0.61 0.49 0.21 0.62 0.20 0.52 0.57 0.25 0.45 0.49
23410 (SIRT3) 0.39 0.34 0.32 0.46 0.54 0.33 0.34 0.14 0.47 1.00 0.33 0.17 0.38 0.31 0.46 0.48 0.25 0.49 0.43 0.53 0.43 0.53 0.25 0.34 0.51 0.40 0.49 0.17 0.43 0.43
4967 (OGDH) 0.31 0.33 0.31 0.27 0.39 0.27 0.27 0.17 0.35 0.33 1.00 0.17 0.28 0.39 0.19 0.22 0.32 0.21 0.21 0.21 0.61 0.21 0.30 0.32 0.20 0.28 0.27 0.17 0.21 0.21
84706 (GPT2) 0.16 0.16 0.15 0.29 0.17 0.63 0.25 0.63 0.25 0.17 0.17 1.00 0.15 0.17 0.15 0.21 0.16 0.29 0.17 0.17 0.17 0.17 0.21 0.19 0.17 0.17 0.21 1.00 0.29 0.17
3418 (IDH2) 0.39 0.36 0.74 0.35 0.40 0.20 0.19 0.14 0.41 0.38 0.28 0.15 1.00 0.28 0.46 0.48 0.19 0.32 0.38 0.38 0.43 0.38 0.26 0.41 0.17 0.53 0.82 0.15 0.32 0.38
2747 (GLUD2) 0.26 0.26 0.30 0.46 0.84 0.22 0.21 0.14 0.28 0.31 0.39 0.17 0.28 1.00 0.20 0.22 0.49 0.21 0.21 0.21 0.27 0.21 0.38 0.25 0.20 0.27 0.29 0.17 0.22 0.21
2752 (GLUL) 0.55 0.27 0.26 0.55 0.49 0.26 0.27 0.16 0.56 0.46 0.19 0.15 0.46 0.20 1.00 0.78 0.20 0.50 0.63 0.63 0.63 0.63 0.20 0.53 0.17 0.55 0.60 0.15 0.58 0.63
5091 (PC) 0.57 0.29 0.28 0.57 0.50 0.29 0.29 0.20 0.59 0.48 0.22 0.21 0.48 0.22 0.78 1.00 0.24 0.54 0.66 0.66 0.66 0.66 0.22 0.55 0.24 0.58 0.62 0.21 0.58 0.66
55902 (ACSS2) 0.16 0.20 0.21 0.45 0.42 0.21 0.20 0.15 0.19 0.25 0.32 0.16 0.19 0.49 0.20 0.24 1.00 0.17 0.17 0.17 0.17 0.17 0.25 0.17 0.18 0.17 0.18 0.16 0.23 0.17
23409 (SIRT4) 0.41 0.24 0.23 0.46 0.39 0.31 0.28 0.26 0.46 0.49 0.21 0.29 0.32 0.21 0.50 0.54 0.17 1.00 0.47 0.73 0.47 0.73 0.22 0.37 0.73 0.43 0.47 0.29 0.52 0.47
2571 (GAD1) 0.51 0.27 0.26 0.51 0.42 0.27 0.27 0.19 0.49 0.43 0.21 0.17 0.38 0.21 0.63 0.66 0.17 0.47 1.00 0.60 0.60 0.60 0.21 0.43 0.20 0.52 0.53 0.17 0.46 1.00
27165 (GLS2) 0.51 0.27 0.26 0.51 0.42 0.27 0.27 0.19 0.49 0.53 0.21 0.17 0.38 0.21 0.63 0.66 0.17 0.73 0.60 1.00 0.60 1.00 0.21 0.43 0.73 0.52 0.53 0.17 0.53 0.60
55753 (OGDHL) 0.63 0.34 0.32 0.51 0.47 0.27 0.27 0.19 0.61 0.43 0.61 0.17 0.43 0.27 0.63 0.66 0.17 0.47 0.60 0.60 1.00 0.60 0.21 0.56 0.20 0.60 0.58 0.17 0.46 0.60
2744 (GLS) 0.51 0.27 0.26 0.51 0.42 0.27 0.27 0.19 0.49 0.53 0.21 0.17 0.38 0.21 0.63 0.66 0.17 0.73 0.60 1.00 0.60 1.00 0.21 0.43 0.73 0.52 0.53 0.17 0.53 0.60
162417 (NAGS) 0.18 0.16 0.27 0.31 0.35 0.22 0.25 0.20 0.21 0.25 0.30 0.21 0.26 0.38 0.20 0.22 0.25 0.22 0.21 0.21 0.21 0.21 1.00 0.17 0.14 0.19 0.24 0.21 0.22 0.21
8659 (ALDH4A1) 0.54 0.29 0.28 0.39 0.43 0.23 0.22 0.19 0.62 0.34 0.32 0.19 0.41 0.25 0.53 0.55 0.17 0.37 0.43 0.43 0.56 0.43 0.17 1.00 0.21 0.47 0.55 0.19 0.38 0.43
56954 (NIT2) 0.18 0.18 0.17 0.20 0.20 0.20 0.17 0.20 0.20 0.51 0.20 0.17 0.17 0.20 0.17 0.24 0.18 0.73 0.20 0.73 0.20 0.73 0.14 0.21 1.00 0.20 0.24 0.17 0.51 0.20
4190 (MDH1) 0.53 0.68 0.46 0.46 0.45 0.25 0.25 0.19 0.52 0.40 0.28 0.17 0.53 0.27 0.55 0.58 0.17 0.43 0.52 0.52 0.60 0.52 0.19 0.47 0.20 1.00 0.65 0.17 0.43 0.52
3417 (IDH1) 0.54 0.36 0.56 0.49 0.53 0.25 0.24 0.16 0.57 0.49 0.27 0.21 0.82 0.29 0.60 0.62 0.18 0.47 0.53 0.53 0.58 0.53 0.24 0.55 0.24 0.65 1.00 0.21 0.46 0.53
2875 (GPT) 0.16 0.16 0.15 0.29 0.17 0.63 0.25 0.63 0.25 0.17 0.17 1.00 0.15 0.17 0.15 0.21 0.16 0.29 0.17 0.17 0.17 0.17 0.21 0.19 0.17 0.17 0.21 1.00 0.29 0.17
1373 (CPS1) 0.42 0.26 0.25 0.45 0.40 0.31 0.28 0.25 0.45 0.43 0.21 0.29 0.32 0.22 0.58 0.58 0.23 0.52 0.46 0.53 0.46 0.53 0.22 0.38 0.51 0.43 0.46 0.29 1.00 0.46
2572 (GAD2) 0.51 0.27 0.26 0.51 0.42 0.27 0.27 0.19 0.49 0.43 0.21 0.17 0.38 0.21 0.63 0.66 0.17 0.47 1.00 0.60 0.60 0.60 0.21 0.43 0.20 0.52 0.53 0.17 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GLUD1 Rat Left brain cortices 300hPa 9144 m 1 hour upregulated 1.39±0.4 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
E2F1 1869 GLUD1 2746 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT038802 hsa-miR-93-3p Homo sapiens GLUD1 2746 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT041407 hsa-miR-193b-3p Homo sapiens GLUD1 2746 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045359 hsa-miR-185-5p Homo sapiens GLUD1 2746 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048701 hsa-miR-99a-5p Homo sapiens GLUD1 2746 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT490447 hsa-miR-3152-3p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490450 hsa-miR-4424 Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490446 hsa-miR-6864-5p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490449 hsa-miR-609 Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490445 hsa-miR-4762-3p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490453 hsa-miR-513c-3p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490448 hsa-miR-4694-5p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490454 hsa-miR-513a-3p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490455 hsa-miR-3606-3p Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490452 hsa-miR-7515 Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490451 hsa-miR-3179 Homo sapiens GLUD1 2746 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT724254 hsa-miR-580-3p Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT724259 hsa-miR-7151-5p Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT724255 hsa-miR-4477a Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT724257 hsa-miR-885-5p Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT724256 hsa-miR-4790-3p Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT724258 hsa-miR-126-5p Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT724253 hsa-miR-653-5p Homo sapiens GLUD1 2746 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
2746 GO:0021762 substantia nigra development GOTERM_BP_DIRECT
2746 GO:0005525 GTP binding GOTERM_MF_DIRECT
2746 GO:0032024 positive regulation of insulin secretion GOTERM_BP_DIRECT
2746 GO:0006541 glutamine metabolic process GOTERM_BP_DIRECT
2746 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
2746 GO:0006520 cellular amino acid metabolic process GOTERM_BP_DIRECT
2746 GO:0005515 protein binding GOTERM_MF_DIRECT
2746 GO:0042802 identical protein binding GOTERM_MF_DIRECT
2746 GO:0070403 lipoprotein particle receptor binding GOTERM_MF_DIRECT
2746 GO:0005524 ATP binding GOTERM_MF_DIRECT
2746 GO:0004352 gluconolactonase activity GOTERM_MF_DIRECT
2746 GO:0004353 glucose-6-phosphate dehydrogenase activity GOTERM_MF_DIRECT
2746 GO:0006537 glutamate biosynthetic process GOTERM_BP_DIRECT
2746 GO:0006538 glutamate catabolic process GOTERM_BP_DIRECT
2746 GO:0008652 cellular amino acid biosynthetic process GOTERM_BP_DIRECT
2746 GO:0072350 tricarboxylic acid metabolic process GOTERM_BP_DIRECT
2746 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
2746 GO:0043531 ADP binding GOTERM_MF_DIRECT
2746 GO:0070728 None GOTERM_MF_DIRECT
2746 GO:0005737 cytoplasm GOTERM_CC_DIRECT
2746 GO:0005739 mitochondrion GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2746 hsa00220 Arginine biosynthesis
2746 hsa00250 Alanine
2746 hsa00471 D-Glutamine and D-glutamate metabolism
2746 hsa01200 Carbon metabolism
2746 hsa00910 Nitrogen metabolism
2746 hsa01100 Metabolic pathways
2746 hsa04964 Proximal tubule bicarbonate reclamation
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GLUD1 2746 Endogenous Hyperinsulinism C1257963 Disease or Syndrome 0.3 0.636 0.552 disease
GLUD1 2746 Fetal Growth Retardation C0015934 Pathologic Function 0.3 0.636 0.552 phenotype
GLUD1 2746 Compensatory Hyperinsulinemia C1257965 Disease or Syndrome 0.3 0.636 0.552 disease
GLUD1 2746 Exogenous Hyperinsulinism C1257964 Disease or Syndrome 0.3 0.636 0.552 disease
GLUD1 2746 Hyperinsulinism C0020459 Disease or Syndrome 0.59 0.636 0.552 disease
GLUD1 2746 Hyperammonemia C0220994 Disease or Syndrome 0.59 0.636 0.552 phenotype
GLUD1 2746 Hyperinsulinemic hypoglycemia, familial, 6 C1847555 Disease or Syndrome 0.75 0.636 0.552 disease
GLUD1 2746 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.636 0.552 group
GLUD1 2746 Mitochondrial Diseases C0751651 Disease or Syndrome 0.3 0.636 0.552 group
GLUD1 2746 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.636 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types