Alanine aminotransferase 1

AltitudeomicsDB
Protein Official symbol GPT
Aliases GPT AAT1 GPT1
Chromosomal Location  16
Length 496
Uniprot ID P24298
EC number 2.6.1.2
Protein family Information(Pfam) PF00155;
PDB id None
InterPro ID IPR004839;IPR015424;IPR015422;IPR015421;
dbSNP rs1063739 rs141505249 rs147998249

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
GLUD2 GLUD1 0.994
GLUD1 GOT2 0.986
GOT1 GLUD1 0.979
GOT1 GLUD2 0.978
GLUD2 GOT2 0.973
GPT GOT1 0.97
GPT GOT2 0.962
F2 ALB 0.96
GLUD1 OGDH 0.958
GPT GLUD1 0.952
GPT GLUD2 0.948
GOT1 OGDH 0.939
GLUD2 OGDH 0.937
NAGS GLUD1 0.935
GOT1 GOT2 0.931
GPT AGXT 0.927
GLUD2 NAGS 0.925
GPT ALB 0.924
GPT OGDH 0.921
GOT2 OGDH 0.92
GPT NAGS 0.919
NAGS GOT2 0.907
GOT1 NAGS 0.903
GPT F2 0.902
Gene Ontology Semantic Similarity
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# 2747 (GLUD2) 2746 (GLUD1) 2805 (GOT1) 2875 (GPT) 2147 (F2) 162417 (NAGS) 2806 (GOT2) 213 (ALB) 4967 (OGDH) 189 (AGXT)
2747 (GLUD2) 1.00 0.84 0.14 0.17 0.24 0.38 0.22 0.32 0.39 0.34
2746 (GLUD1) 0.84 1.00 0.13 0.17 0.48 0.35 0.26 0.60 0.39 0.62
2805 (GOT1) 0.14 0.13 1.00 0.63 0.13 0.20 0.71 0.14 0.17 0.40
2875 (GPT) 0.17 0.17 0.63 1.00 0.14 0.21 0.63 0.19 0.17 0.75
2147 (F2) 0.24 0.48 0.13 0.14 1.00 0.22 0.24 0.56 0.23 0.57
162417 (NAGS) 0.38 0.35 0.20 0.21 0.22 1.00 0.22 0.30 0.30 0.35
2806 (GOT2) 0.22 0.26 0.71 0.63 0.24 0.22 1.00 0.36 0.27 0.52
213 (ALB) 0.32 0.60 0.14 0.19 0.56 0.30 0.36 1.00 0.30 0.67
4967 (OGDH) 0.39 0.39 0.17 0.17 0.23 0.30 0.27 0.30 1.00 0.29
189 (AGXT) 0.34 0.62 0.40 0.75 0.57 0.35 0.52 0.67 0.29 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GPT Toad Heart - 3464 m 33 day upregulated 2.270195598 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
ESRRA 2101 GPT 2875 proximal_filtered 22955619 TRANSFAC
HNF4A 3172 GPT 2875 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
2875 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2875 GO:0030170 pyridoxal phosphate binding GOTERM_MF_DIRECT
2875 GO:0008652 cellular amino acid biosynthetic process GOTERM_BP_DIRECT
2875 GO:0005829 cytosol GOTERM_CC_DIRECT
2875 GO:0042853 L-alanine catabolic process GOTERM_BP_DIRECT
2875 GO:0004021 ATP-dependent RNA helicase activity GOTERM_MF_DIRECT
2875 GO:0005615 extracellular space GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2875 hsa00250 Alanine
2875 hsa00220 Arginine biosynthesis
2875 hsa01100 Metabolic pathways
2875 hsa01200 Carbon metabolism
2875 hsa01210 2-Oxocarboxylic acid metabolism
2875 hsa01230 Biosynthesis of amino acids
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GPT 2875 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.32 0.51 0.828 disease
GPT 2875 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.51 0.828 disease
GPT 2875 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.51 0.828 disease
GPT 2875 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.51 0.828 disease
GPT 2875 Reperfusion Injury C0035126 Injury or Poisoning 0.3 0.51 0.828 disease
GPT 2875 Steatohepatitis C2711227 Disease or Syndrome 0.4 0.51 0.828 disease
GPT 2875 Fatty Liver C0015695 Disease or Syndrome 0.4 0.51 0.828 disease
GPT 2875 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.51 0.828 disease
GPT 2875 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.51 0.828 disease
GPT 2875 Liver diseases C0023895 Disease or Syndrome 0.4 0.51 0.828 group
GPT 2875 Liver Dysfunction C0086565 Finding 0.3 0.51 0.828 phenotype
GPT 2875 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.51 0.828 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
GPT 2875 GLUCAGON GLUCAGON CHEMBL266481 None
GPT 2875 PROTEASE INHIBITOR None None None
GPT 2875 TACROLIMUS TACROLIMUS CHEMBL269732 None