Cytochrome b5

AltitudeomicsDB
Protein Official symbol CYB5A
Aliases CYB5A CYB5
Chromosomal Location 18
Length 134
Uniprot ID P00167
EC number None
Protein family Information(Pfam) PF00173;
PDB id 2I96;
InterPro ID IPR001199;IPR036400;IPR018506;
dbSNP rs1555688659

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MT-CYB CYCS 0.998
CYB5R3 CYB5A 0.995
POR CYB5A 0.9640000000000001
CYP1A2 CYP3A4 0.9520000000000001
CYP1A1 CYP3A4 0.95
CYP3A4 CYP2A6 0.9490000000000001
CYP2D6 CYP3A4 0.948
CYP3A4 CYP2B6 0.948
CYB5A CYCS 0.9470000000000001
CYP2E1 CYP3A4 0.946
CYP1A1 CYP3A5 0.946
CYP1A2 CYP3A5 0.945
CYP2B6 CYP3A5 0.9440000000000001
CYP1A2 PGRMC1 0.943
CYP2A6 CYP3A5 0.9420000000000001
CYP17A1 CYP3A4 0.935
CYP1A2 CYP2A6 0.932
CYP1A2 CYP2B6 0.93
CYP2E1 CYP1A2 0.93
CYP1A1 CYP2B6 0.9279999999999999
POR CYP51A1 0.9279999999999999
CYP17A1 CYP3A5 0.927
CYP2E1 CYP1A1 0.927
CYP1A1 CYP2A6 0.924
CYP1A1 CYP2D6 0.9229999999999999
CYP2D6 CYP2A6 0.922
CYP1A1 CYP17A1 0.9209999999999999
CYP17A1 CYB5A 0.9209999999999999
CYP2E1 CYP17A1 0.9209999999999999
CYP17A1 CYP1A2 0.92
CYP3A4 CYP3A5 0.9159999999999999
CYP2E1 CYP2A6 0.914
CYP2B6 CYP2A6 0.9109999999999999
CYP2E1 CYP2B6 0.91
NENF CYB5A 0.907
CYP2B6 DECR1 0.9059999999999999
SCD CYB5A 0.905
CYB5A CYP2B6 0.905
POR CYP17A1 0.904
POR CYP2B6 0.8959999999999999
POR DECR1 0.8959999999999999
CYP1A1 CYB5A 0.887
POR CYP3A4 0.883
CYCS DECR1 0.882
CYB5A CYP3A4 0.8759999999999999
PGRMC1 CYP51A1 0.857
CYB5A DECR1 0.851
CYB5RL CYB5A 0.84
CYB5R1 CYB5A 0.836
POR CYCS 0.831
CYB5R2 CYB5A 0.8290000000000001
CYP1A1 CYP1A2 0.813
CYP2E1 CYB5A 0.809
CYP2E1 POR 0.794
CYP2B6 CYCS 0.794
POR CYP1A2 0.792
MT-CYB CYB5A 0.79
POR CYP3A5 0.775
POR CYP2D6 0.77
POR CYP2A6 0.768
CYB5RL POR 0.763
CYB5A PGRMC1 0.7559999999999999
POR CYB5R1 0.7559999999999999
POR CYB5R3 0.752
CYB5A CYB5D2 0.75
CYP1A2 CYB5A 0.746
CYP2E1 DECR1 0.7390000000000001
CYB5R2 POR 0.738
CYP3A4 DECR1 0.736
CYB5A CYP2A6 0.733
POR CYP1A1 0.727
MT-CYB DECR1 0.7170000000000001
CYB5A CYP3A5 0.711
CYP2D6 CYB5A 0.7090000000000001
CYP1A2 DECR1 0.708
CYB5A CYP51A1 0.701
Gene Ontology Semantic Similarity
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# 1727 (CYB5R3) 5447 (POR) 1544 (CYP1A2) 1543 (CYP1A1) 1576 (CYP3A4) 1565 (CYP2D6) 1528 (CYB5A) 1571 (CYP2E1) 1555 (CYP2B6) 1548 (CYP2A6) 1586 (CYP17A1) 6319 (SCD) 54205 (CYCS) 10857 (PGRMC1) 606495 (CYB5RL) 51706 (CYB5R1) 51700 (CYB5R2) 1577 (CYP3A5) 1595 (CYP51A1) 1666 (DECR1) 124936 (CYB5D2)
1727 (CYB5R3) 1.00 0.58 0.56 0.59 0.54 0.59 0.42 0.58 0.51 0.42 0.37 0.66 0.24 0.21 1.00 0.79 0.72 0.61 0.38 0.61 0.16
5447 (POR) 0.58 1.00 0.52 0.60 0.47 0.52 0.51 0.55 0.47 0.50 0.40 0.43 0.49 0.63 0.58 0.76 0.86 0.48 0.34 0.45 0.37
1544 (CYP1A2) 0.56 0.52 1.00 0.74 0.76 0.84 0.51 0.86 0.77 0.69 0.65 0.55 0.55 0.51 0.56 0.70 0.52 0.70 0.56 0.48 1.00
1543 (CYP1A1) 0.59 0.60 0.74 1.00 0.85 0.76 0.52 0.79 0.71 0.57 0.57 0.57 0.43 0.46 0.59 0.73 0.60 0.94 0.41 0.47 0.37
1576 (CYP3A4) 0.54 0.47 0.76 0.85 1.00 0.71 0.47 0.75 0.65 0.55 0.54 0.64 0.34 0.34 0.54 0.64 0.47 0.81 0.40 0.46 0.45
1565 (CYP2D6) 0.59 0.52 0.84 0.76 0.71 1.00 0.46 0.87 0.88 0.70 0.75 0.57 0.50 0.55 0.59 0.66 0.52 0.77 0.64 0.50 1.00
1528 (CYB5A) 0.42 0.51 0.51 0.52 0.47 0.46 1.00 0.55 0.41 0.51 0.34 0.39 0.39 0.44 0.42 0.56 0.51 0.43 0.29 0.33 0.30
1571 (CYP2E1) 0.58 0.55 0.86 0.79 0.75 0.87 0.55 1.00 0.91 0.85 0.73 0.56 0.51 0.56 0.58 0.69 0.55 0.75 0.67 0.49 1.00
1555 (CYP2B6) 0.51 0.47 0.77 0.71 0.65 0.88 0.41 0.91 1.00 0.81 0.78 0.49 0.51 0.59 0.51 0.59 0.47 0.73 0.69 0.45 1.00
1548 (CYP2A6) 0.42 0.50 0.69 0.57 0.55 0.70 0.51 0.85 0.81 1.00 0.64 0.42 0.54 0.66 0.42 0.56 0.50 0.51 0.69 0.38 1.00
1586 (CYP17A1) 0.37 0.40 0.65 0.57 0.54 0.75 0.34 0.73 0.78 0.64 1.00 0.39 0.49 0.58 0.37 0.48 0.40 0.58 0.62 0.35 1.00
6319 (SCD) 0.66 0.43 0.55 0.57 0.64 0.57 0.39 0.56 0.49 0.42 0.39 1.00 0.26 0.25 0.66 0.61 0.43 0.57 0.36 0.52 0.19
54205 (CYCS) 0.24 0.49 0.55 0.43 0.34 0.50 0.39 0.51 0.51 0.54 0.49 0.26 1.00 0.73 0.24 0.51 0.49 0.33 0.48 0.25 1.00
10857 (PGRMC1) 0.21 0.63 0.51 0.46 0.34 0.55 0.44 0.56 0.59 0.66 0.58 0.25 0.73 1.00 0.21 0.54 0.63 0.34 0.63 0.25 1.00
606495 (CYB5RL) 1.00 0.58 0.56 0.59 0.54 0.59 0.42 0.58 0.51 0.42 0.37 0.66 0.24 0.21 1.00 0.79 0.72 0.61 0.38 0.61 0.16
51706 (CYB5R1) 0.79 0.76 0.70 0.73 0.64 0.66 0.56 0.69 0.59 0.56 0.48 0.61 0.51 0.54 0.79 1.00 0.85 0.63 0.39 0.54 0.37
51700 (CYB5R2) 0.72 0.86 0.52 0.60 0.47 0.52 0.51 0.55 0.47 0.50 0.40 0.43 0.49 0.63 0.72 0.85 1.00 0.48 0.34 0.45 0.37
1577 (CYP3A5) 0.61 0.48 0.70 0.94 0.81 0.77 0.43 0.75 0.73 0.51 0.58 0.57 0.33 0.34 0.61 0.63 0.48 1.00 0.41 0.48 0.37
1595 (CYP51A1) 0.38 0.34 0.56 0.41 0.40 0.64 0.29 0.67 0.69 0.69 0.62 0.36 0.48 0.63 0.38 0.39 0.34 0.41 1.00 0.37 1.00
1666 (DECR1) 0.61 0.45 0.48 0.47 0.46 0.50 0.33 0.49 0.45 0.38 0.35 0.52 0.25 0.25 0.61 0.54 0.45 0.48 0.37 1.00 0.33
124936 (CYB5D2) 0.16 0.37 1.00 0.37 0.45 1.00 0.30 1.00 1.00 1.00 1.00 0.19 1.00 1.00 0.16 0.37 0.37 0.37 1.00 0.33 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CYB5A Rat Lungs - 7600 m 24 hours upregulated 3.5 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
CYB5A Rat Lungs - 7600 m 6 hours upregulated 1.4 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
PBX3 5090 CYB5A 1528 proximal_filtered 22955619 TRANSFAC
ZEB1 6935 CYB5A 1528 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023043 hsa-miR-124-3p Homo sapiens CYB5A 1528 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT054659 hsa-miR-223-3p Homo sapiens CYB5A 1528 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24078287
MIRT648371 hsa-miR-562 Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT648367 hsa-miR-619-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT648370 hsa-miR-5697 Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT648368 hsa-miR-150-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT648369 hsa-miR-6814-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664371 hsa-miR-27a-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664372 hsa-miR-5589-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664374 hsa-miR-6778-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664375 hsa-miR-378g Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664373 hsa-miR-4731-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664376 hsa-miR-600 Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664370 hsa-miR-640 Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664377 hsa-miR-1224-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664384 hsa-miR-520c-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664392 hsa-miR-302b-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664399 hsa-miR-17-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664401 hsa-miR-106a-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664378 hsa-miR-520h Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664379 hsa-miR-520g-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664388 hsa-miR-372-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664391 hsa-miR-302c-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664383 hsa-miR-520d-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664387 hsa-miR-373-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664381 hsa-miR-552-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664385 hsa-miR-520b Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664386 hsa-miR-520a-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664389 hsa-miR-302e Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664380 hsa-miR-512-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664394 hsa-miR-93-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664395 hsa-miR-526b-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664397 hsa-miR-20b-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664382 hsa-miR-520e Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664393 hsa-miR-302a-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664390 hsa-miR-302d-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664396 hsa-miR-519d-3p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664398 hsa-miR-20a-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT664400 hsa-miR-106b-5p Homo sapiens CYB5A 1528 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
1528 GO:0004129 creatine kinase activity GOTERM_MF_DIRECT
1528 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
1528 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
1528 GO:0019852 L-ascorbic acid metabolic process GOTERM_BP_DIRECT
1528 GO:0046686 response to cadmium ion GOTERM_BP_DIRECT
1528 GO:0016020 membrane GOTERM_CC_DIRECT
1528 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
1528 GO:0004033 alcohol dehydrogenase activity GOTERM_MF_DIRECT
1528 GO:0019899 enzyme binding GOTERM_MF_DIRECT
1528 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
1528 GO:0005737 cytoplasm GOTERM_CC_DIRECT
1528 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
1528 GO:0005741 mitochondrial outer membrane GOTERM_CC_DIRECT
1528 GO:1902600 hydrogen ion transmembrane transport GOTERM_BP_DIRECT
1528 GO:0020037 heme binding GOTERM_MF_DIRECT
1528 GO:0046872 metal ion binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CYB5A 1528 Endometriosis C0014175 Disease or Syndrome 0.3 0.633 0.448 disease
CYB5A 1528 Respiratory Distress Syndrome, Adult C0035222 Disease or Syndrome 0.3 0.633 0.448 disease
CYB5A 1528 Endometrioma C0269102 Neoplastic Process 0.3 0.633 0.448 disease
CYB5A 1528 Obesity C0028754 Disease or Syndrome 0.3 0.633 0.448 disease
CYB5A 1528 METHEMOGLOBINEMIA TYPE IV C2673427 Disease or Syndrome 0.4 0.633 0.448 disease
CYB5A 1528 Disorders of Sex Development C0036875 Congenital Abnormality 0.3 0.633 0.448 group
CYB5A 1528 Congenital Methemoglobinemia C0272087 Disease or Syndrome 0.31 0.633 0.448 disease
CYB5A 1528 Adrenal hyperplasia, congenital, type 5 C0268285 Disease or Syndrome 0.3 0.633 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types