Lanosterol 14-alpha demethylase
AltitudeomicsDB
Protein Official symbol |
CYP51A1 |
Aliases |
CYP51A1 CYP51 |
Chromosomal Location |
7 |
Length |
503 |
Uniprot ID |
Q16850 |
EC number |
1.14.14.154 |
Protein family Information(Pfam) |
PF00067; |
PDB id |
3JUS;3JUV;3LD6;4UHI;4UHL;6Q2T; |
InterPro ID |
IPR001128;IPR017972;IPR002403;IPR036396; |
dbSNP |
rs2229188 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
NSDHL |
MSMO1 |
0.999 |
NFYA |
NFYB |
0.999 |
HMGCS1 |
HMGCR |
0.999 |
NFYC |
NFYA |
0.999 |
LSS |
CYP51A1 |
0.999 |
NFYC |
NFYB |
0.999 |
LSS |
SQLE |
0.998 |
MSMO1 |
CYP51A1 |
0.997 |
SQLE |
MSMO1 |
0.997 |
IDI1 |
MVD |
0.997 |
FDFT1 |
SQLE |
0.997 |
MSMO1 |
HSD17B7 |
0.997 |
FDFT1 |
FDPS |
0.997 |
NSDHL |
HSD17B7 |
0.996 |
FDPS |
MVD |
0.995 |
IDI1 |
FDPS |
0.994 |
HMGCS1 |
SQLE |
0.994 |
HMGCS1 |
MSMO1 |
0.993 |
NSDHL |
SQLE |
0.993 |
SQLE |
CYP51A1 |
0.993 |
FDFT1 |
CYP51A1 |
0.992 |
FDFT1 |
LSS |
0.992 |
LSS |
MSMO1 |
0.992 |
LSS |
NSDHL |
0.992 |
FDFT1 |
MSMO1 |
0.991 |
HMGCR |
SQLE |
0.991 |
TM7SF2 |
CYP51A1 |
0.99 |
SC5D |
CYP51A1 |
0.989 |
FDPS |
HMGCS1 |
0.989 |
IDI1 |
SQLE |
0.989 |
IDI1 |
HMGCS1 |
0.988 |
IDI1 |
MSMO1 |
0.987 |
FDFT1 |
IDI1 |
0.986 |
HMGCS1 |
CYP51A1 |
0.986 |
NSDHL |
CYP51A1 |
0.985 |
TM7SF2 |
MSMO1 |
0.985 |
LBR |
CYP51A1 |
0.981 |
LSS |
DHCR24 |
0.978 |
SREBF2 |
HMGCS1 |
0.978 |
HMGCS1 |
MVD |
0.978 |
LSS |
MVD |
0.978 |
HMGCR |
CYP51A1 |
0.977 |
SC5D |
MSMO1 |
0.977 |
DHCR24 |
SC5D |
0.977 |
IDI1 |
HMGCR |
0.976 |
IDI1 |
CYP51A1 |
0.975 |
LBR |
MSMO1 |
0.975 |
DHCR24 |
CYP51A1 |
0.975 |
FDFT1 |
NSDHL |
0.973 |
DHCR24 |
TM7SF2 |
0.972 |
IDI1 |
NSDHL |
0.972 |
DHCR24 |
MSMO1 |
0.972 |
NSDHL |
HMGCS1 |
0.972 |
FDFT1 |
SC5D |
0.97 |
LSS |
HSD17B7 |
0.97 |
LSS |
IDI1 |
0.97 |
HMGCR |
MSMO1 |
0.97 |
FDFT1 |
MVD |
0.97 |
SREBF2 |
SQLE |
0.969 |
SREBF2 |
CYP51A1 |
0.968 |
FDFT1 |
SREBF2 |
0.967 |
HSD17B7 |
CYP51A1 |
0.966 |
SREBF2 |
FDPS |
0.963 |
SREBF2 |
SC5D |
0.961 |
NFYA |
SP1 |
0.961 |
LSS |
SREBF2 |
0.96 |
DHCR24 |
SQLE |
0.96 |
LSS |
SC5D |
0.959 |
NSDHL |
SC5D |
0.957 |
NFYA |
HMGCS1 |
0.956 |
SQLE |
SC5D |
0.955 |
IDI1 |
SREBF2 |
0.955 |
FDFT1 |
HSD17B7 |
0.954 |
SP1 |
NFYB |
0.953 |
SREBF2 |
HMGCR |
0.953 |
SREBF2 |
SP1 |
0.953 |
FDPS |
HMGCR |
0.952 |
NFYC |
SP1 |
0.949 |
SQLE |
HSD17B7 |
0.949 |
HMGCS1 |
NFYB |
0.947 |
SREBF2 |
MVD |
0.946 |
FDPS |
CYP51A1 |
0.943 |
SREBF2 |
TM7SF2 |
0.94 |
FDFT1 |
HMGCS1 |
0.939 |
LSS |
FDPS |
0.939 |
FDPS |
SQLE |
0.938 |
FDFT1 |
HMGCR |
0.936 |
MVD |
HMGCR |
0.936 |
MVD |
CYP51A1 |
0.935 |
NFYC |
SREBF2 |
0.933 |
IDI1 |
HSD17B7 |
0.931 |
SC5D |
HSD17B7 |
0.931 |
LSS |
HMGCS1 |
0.93 |
SREBF2 |
NFYA |
0.929 |
POR |
CYP51A1 |
0.928 |
MVD |
SQLE |
0.928 |
TM7SF2 |
SC5D |
0.923 |
FDFT1 |
NFYC |
0.913 |
NSDHL |
TM7SF2 |
0.912 |
NFYB |
CYP51A1 |
0.91 |
SREBF2 |
NFYB |
0.91 |
FDPS |
NFYB |
0.909 |
NFYC |
FDPS |
0.906 |
FDPS |
NFYA |
0.906 |
NFYA |
SQLE |
0.906 |
NFYC |
CYP51A1 |
0.905 |
SQLE |
NFYB |
0.905 |
IDI1 |
NFYB |
0.905 |
NFYC |
TM7SF2 |
0.904 |
TM7SF2 |
NFYB |
0.902 |
NFYA |
TM7SF2 |
0.902 |
FDFT1 |
SP1 |
0.902 |
SC5D |
NFYB |
0.902 |
FDFT1 |
NFYB |
0.901 |
NSDHL |
FDPS |
0.901 |
SIGMAR1 |
CYP51A1 |
0.901 |
NFYC |
SC5D |
0.901 |
TM7SF2 |
SQLE |
0.901 |
NFYC |
SQLE |
0.901 |
NFYC |
IDI1 |
0.901 |
IDI1 |
NFYA |
0.9 |
NFYA |
SC5D |
0.9 |
SP1 |
CYP51A1 |
0.9 |
NFYC |
HMGCS1 |
0.9 |
FDFT1 |
NFYA |
0.9 |
IDI1 |
SP1 |
0.9 |
NFYA |
CYP51A1 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
50814 (NSDHL) |
4800 (NFYA) |
3157 (HMGCS1) |
4802 (NFYC) |
4047 (LSS) |
6307 (MSMO1) |
6713 (SQLE) |
3422 (IDI1) |
2222 (FDFT1) |
2224 (FDPS) |
3156 (HMGCR) |
7108 (TM7SF2) |
6309 (SC5D) |
3930 (LBR) |
6721 (SREBF2) |
1718 (DHCR24) |
51478 (HSD17B7) |
6667 (SP1) |
4597 (MVD) |
5447 (POR) |
4801 (NFYB) |
10280 (SIGMAR1) |
1595 (CYP51A1) |
50814 (NSDHL)
|
1.00
|
0.18
|
0.26
|
0.17
|
0.36
|
0.55
|
0.55
|
0.36
|
0.27
|
0.28
|
0.56
|
0.41
|
0.53
|
0.35
|
0.18
|
0.48
|
0.86
|
0.17
|
0.25
|
0.54
|
0.19
|
0.26
|
0.37
|
4800 (NFYA)
|
0.18
|
1.00
|
0.25
|
0.93
|
0.16
|
0.14
|
0.14
|
0.16
|
0.37
|
0.37
|
0.38
|
0.24
|
0.14
|
0.57
|
0.88
|
0.31
|
0.16
|
0.86
|
0.31
|
0.38
|
0.96
|
0.59
|
0.31
|
3157 (HMGCS1)
|
0.26
|
0.25
|
1.00
|
0.22
|
0.20
|
0.18
|
0.18
|
0.20
|
0.42
|
0.29
|
0.32
|
0.19
|
0.18
|
0.39
|
0.29
|
0.30
|
0.20
|
0.33
|
0.56
|
0.35
|
0.29
|
0.36
|
0.22
|
4802 (NFYC)
|
0.17
|
0.93
|
0.22
|
1.00
|
0.16
|
0.14
|
0.14
|
0.16
|
0.34
|
0.32
|
0.35
|
0.21
|
0.14
|
0.51
|
0.82
|
0.28
|
0.16
|
0.86
|
0.28
|
0.35
|
0.89
|
0.59
|
0.27
|
4047 (LSS)
|
0.36
|
0.16
|
0.20
|
0.16
|
1.00
|
0.18
|
0.18
|
0.34
|
0.17
|
0.20
|
0.20
|
0.20
|
0.18
|
0.20
|
0.16
|
0.24
|
0.20
|
0.16
|
0.20
|
0.36
|
0.16
|
0.16
|
0.21
|
6307 (MSMO1)
|
0.55
|
0.14
|
0.18
|
0.14
|
0.18
|
1.00
|
0.77
|
0.18
|
0.16
|
0.18
|
0.31
|
0.31
|
0.43
|
0.31
|
0.14
|
0.37
|
0.31
|
0.14
|
0.18
|
0.55
|
0.14
|
0.14
|
0.72
|
6713 (SQLE)
|
0.55
|
0.14
|
0.18
|
0.14
|
0.18
|
0.77
|
1.00
|
0.18
|
0.16
|
0.18
|
0.31
|
0.31
|
0.43
|
0.31
|
0.14
|
0.37
|
0.31
|
0.14
|
0.18
|
0.55
|
0.14
|
0.14
|
0.72
|
3422 (IDI1)
|
0.36
|
0.16
|
0.20
|
0.16
|
0.34
|
0.18
|
0.18
|
1.00
|
0.17
|
0.20
|
0.20
|
0.20
|
0.18
|
0.20
|
0.16
|
0.24
|
0.20
|
0.16
|
0.20
|
0.36
|
0.16
|
0.16
|
0.21
|
2222 (FDFT1)
|
0.27
|
0.37
|
0.42
|
0.34
|
0.17
|
0.16
|
0.16
|
0.17
|
1.00
|
0.55
|
0.43
|
0.21
|
0.16
|
0.55
|
0.43
|
0.37
|
0.17
|
0.45
|
0.42
|
0.45
|
0.43
|
0.59
|
0.26
|
2224 (FDPS)
|
0.28
|
0.37
|
0.29
|
0.32
|
0.20
|
0.18
|
0.18
|
0.20
|
0.55
|
1.00
|
0.27
|
0.28
|
0.18
|
0.44
|
0.28
|
0.24
|
0.20
|
0.33
|
0.22
|
0.33
|
0.36
|
0.37
|
0.34
|
3156 (HMGCR)
|
0.56
|
0.38
|
0.32
|
0.35
|
0.20
|
0.31
|
0.31
|
0.20
|
0.43
|
0.27
|
1.00
|
0.50
|
0.31
|
0.57
|
0.42
|
0.45
|
0.73
|
0.45
|
0.39
|
0.70
|
0.43
|
0.59
|
0.33
|
7108 (TM7SF2)
|
0.41
|
0.24
|
0.19
|
0.21
|
0.20
|
0.31
|
0.31
|
0.20
|
0.21
|
0.28
|
0.50
|
1.00
|
0.31
|
0.50
|
0.20
|
0.54
|
0.34
|
0.22
|
0.19
|
0.57
|
0.24
|
0.27
|
0.36
|
6309 (SC5D)
|
0.53
|
0.14
|
0.18
|
0.14
|
0.18
|
0.43
|
0.43
|
0.18
|
0.16
|
0.18
|
0.31
|
0.31
|
1.00
|
0.31
|
0.14
|
0.36
|
0.31
|
0.14
|
0.18
|
0.53
|
0.14
|
0.14
|
0.42
|
3930 (LBR)
|
0.35
|
0.57
|
0.39
|
0.51
|
0.20
|
0.31
|
0.31
|
0.20
|
0.55
|
0.44
|
0.57
|
0.50
|
0.31
|
1.00
|
0.56
|
0.67
|
0.34
|
0.58
|
0.46
|
0.61
|
0.60
|
0.59
|
0.38
|
6721 (SREBF2)
|
0.18
|
0.88
|
0.29
|
0.82
|
0.16
|
0.14
|
0.14
|
0.16
|
0.43
|
0.28
|
0.42
|
0.20
|
0.14
|
0.56
|
1.00
|
0.34
|
0.16
|
0.81
|
0.36
|
0.41
|
0.84
|
0.59
|
0.25
|
1718 (DHCR24)
|
0.48
|
0.31
|
0.30
|
0.28
|
0.24
|
0.37
|
0.37
|
0.24
|
0.37
|
0.24
|
0.45
|
0.54
|
0.36
|
0.67
|
0.34
|
1.00
|
0.40
|
0.38
|
0.34
|
0.54
|
0.34
|
0.48
|
0.31
|
51478 (HSD17B7)
|
0.86
|
0.16
|
0.20
|
0.16
|
0.20
|
0.31
|
0.31
|
0.20
|
0.17
|
0.20
|
0.73
|
0.34
|
0.31
|
0.34
|
0.16
|
0.40
|
1.00
|
0.16
|
0.20
|
0.60
|
0.16
|
0.16
|
0.32
|
6667 (SP1)
|
0.17
|
0.86
|
0.33
|
0.86
|
0.16
|
0.14
|
0.14
|
0.16
|
0.45
|
0.33
|
0.45
|
0.22
|
0.14
|
0.58
|
0.81
|
0.38
|
0.16
|
1.00
|
0.38
|
0.45
|
0.87
|
0.59
|
0.29
|
4597 (MVD)
|
0.25
|
0.31
|
0.56
|
0.28
|
0.20
|
0.18
|
0.18
|
0.20
|
0.42
|
0.22
|
0.39
|
0.19
|
0.18
|
0.46
|
0.36
|
0.34
|
0.20
|
0.38
|
1.00
|
0.40
|
0.35
|
0.41
|
0.23
|
5447 (POR)
|
0.54
|
0.38
|
0.35
|
0.35
|
0.36
|
0.55
|
0.55
|
0.36
|
0.45
|
0.33
|
0.70
|
0.57
|
0.53
|
0.61
|
0.41
|
0.54
|
0.60
|
0.45
|
0.40
|
1.00
|
0.42
|
0.59
|
0.39
|
4801 (NFYB)
|
0.19
|
0.96
|
0.29
|
0.89
|
0.16
|
0.14
|
0.14
|
0.16
|
0.43
|
0.36
|
0.43
|
0.24
|
0.14
|
0.60
|
0.84
|
0.34
|
0.16
|
0.87
|
0.35
|
0.42
|
1.00
|
0.59
|
0.31
|
10280 (SIGMAR1)
|
0.26
|
0.59
|
0.36
|
0.59
|
0.16
|
0.14
|
0.14
|
0.16
|
0.59
|
0.37
|
0.59
|
0.27
|
0.14
|
0.59
|
0.59
|
0.48
|
0.16
|
0.59
|
0.41
|
0.59
|
0.59
|
1.00
|
0.37
|
1595 (CYP51A1)
|
0.37
|
0.31
|
0.22
|
0.27
|
0.21
|
0.72
|
0.72
|
0.21
|
0.26
|
0.34
|
0.33
|
0.36
|
0.42
|
0.38
|
0.25
|
0.31
|
0.32
|
0.29
|
0.23
|
0.39
|
0.31
|
0.37
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
CYP51A1 |
Toad |
Liver |
- |
3464 m |
33 day |
downregulated |
-2.375992441 |
RNA-seq |
Tibetan Plateau |
Asiatic toad |
1 |
Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - |
28673260 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
1595 |
GO:0004497 |
methylcrotonoyl-CoA carboxylase activity |
GOTERM_MF_DIRECT |
1595 |
GO:0008398 |
thioredoxin peroxidase activity |
GOTERM_MF_DIRECT |
1595 |
GO:0020037 |
heme binding |
GOTERM_MF_DIRECT |
1595 |
GO:0016705 |
oxidoreductase activity |
GOTERM_MF_DIRECT |
1595 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
1595 |
GO:0055114 |
oxidation-reduction process |
GOTERM_BP_DIRECT |
1595 |
GO:0043231 |
intracellular membrane-bounded organelle |
GOTERM_CC_DIRECT |
1595 |
GO:0006695 |
cholesterol biosynthetic process |
GOTERM_BP_DIRECT |
1595 |
GO:0033488 |
cholesterol biosynthetic process via 24 |
GOTERM_BP_DIRECT |
1595 |
GO:0016020 |
membrane |
GOTERM_CC_DIRECT |
1595 |
GO:0006694 |
steroid biosynthetic process |
GOTERM_BP_DIRECT |
1595 |
GO:0016125 |
sterol metabolic process |
GOTERM_BP_DIRECT |
1595 |
GO:0070988 |
demethylation |
GOTERM_BP_DIRECT |
1595 |
GO:0005789 |
endoplasmic reticulum membrane |
GOTERM_CC_DIRECT |
1595 |
GO:0005783 |
endoplasmic reticulum |
GOTERM_CC_DIRECT |
1595 |
GO:0016021 |
integral component of membrane |
GOTERM_CC_DIRECT |
1595 |
GO:0031090 |
organelle membrane |
GOTERM_CC_DIRECT |
1595 |
GO:0005506 |
iron ion binding |
GOTERM_MF_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
1595 |
hsa00100 |
Steroid biosynthesis |
1595 |
hsa01100 |
Metabolic pathways |
1595 |
hsa01130 |
Biosynthesis of antibiotics |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
CYP51A1 |
1595 |
Cataract |
C0086543 |
Acquired Abnormality |
0.3 |
0.773 |
0.31 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
CYP51A1 |
1595 |
AZALANSTAT |
AZALANSTAT |
CHEMBL70611 |
inhibitor |
CYP51A1 |
1595 |
FLUCONAZOLE |
FLUCONAZOLE |
CHEMBL106 |
None |