Protein Official symbol | ACE |
Aliases | ACE DCP DCP1 |
Chromosomal Location | 17 |
Length | 1306 |
Uniprot ID | P12821 |
EC number | 3.2.1.-; 3.4.15.1 |
Protein family Information(Pfam) | PF01401; |
PDB id | 1O86;1O8A;1UZE;1UZF;2C6F;2C6N;2IUL;2IUX;2OC2;2XY9;2XYD;2YDM;3BKK;3BKL;3L3N;3NXQ;4APH;4APJ;4BXK;4BZR;4BZS;4C2N;4C2O;4C2P;4C2Q;4C2R;4CA5;4CA6;4UFA;4UFB;5AM8;5AM9;5AMA;5AMB;5AMC;6EN5;6EN6;6F9R;6F9T;6F9U;6F9V;6H5W;6H5X;6QS1; |
InterPro ID | IPR001548; |
dbSNP | rs13306087 rs12720754 rs3730025 rs4302 rs4303 rs4303 rs989500910 rs2229839 rs56394458 rs13306085 rs12720746 rs4314 rs12709426 rs13306091 rs3730043 rs4976 rs4977 rs12709442 rs121912703 rs4980 rs4364 rs4981 rs4317 rs4318 |
Protein 1 | Protein 2 | Combine Score |
---|---|---|
AGT | REN | 0.999 |
AGTR1 | AGT | 0.996 |
AGT | ACE | 0.996 |
AGTR2 | AGT | 0.993 |
AGT | KNG1 | 0.974 |
AGTR1 | KNG1 | 0.969 |
AGTR2 | KNG1 | 0.966 |
ACE | REN | 0.959 |
AGTR1 | REN | 0.955 |
ACE | KNG1 | 0.95 |
AGTR2 | REN | 0.936 |
AGTR1 | ACE | 0.928 |
AGTR2 | ACE | 0.926 |
AGTR1 | AGTR2 | 0.915 |
REN | KNG1 | 0.904 |
# | 183 (AGT) | 185 (AGTR1) | 186 (AGTR2) | 1636 (ACE) | 5972 (REN) | 3827 (KNG1) |
---|---|---|---|---|---|---|
183 (AGT) | 1.00 | 0.57 | 0.58 | 0.38 | 0.63 | 0.73 |
185 (AGTR1) | 0.57 | 1.00 | 0.83 | 0.37 | 0.53 | 0.52 |
186 (AGTR2) | 0.58 | 0.83 | 1.00 | 0.32 | 0.56 | 0.54 |
1636 (ACE) | 0.38 | 0.37 | 0.32 | 1.00 | 0.62 | 0.44 |
5972 (REN) | 0.63 | 0.53 | 0.56 | 0.62 | 1.00 | 0.57 |
3827 (KNG1) | 0.73 | 0.52 | 0.54 | 0.44 | 0.57 | 1.00 |
Protein Official symbol | Source Organism | Tissue of Expression | Level of hypoxia | Altitude | Duration of experiment | Level of expression | Fold change | Experiment details | geographical location | ethnicity of the patients | Control group | Control (Fold change) | Reference (PMID) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ACE | Toad | Heart | - | 3464 m | 33 day | downregulated | -2.052523659 | RNA-seq | Tibetan Plateau | Asiatic toad | 1 | Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - | 28673260 |
TF | TF Entrez | Gene | Gene Entrez | Type | PMID | Database |
---|---|---|---|---|---|---|
RAD21 | 5885 | ACE | 1636 | distal | 22955619 | TRANSFAC |
RXRA | 6256 | ACE | 1636 | distal | 22955619 | TRANSFAC |
HDAC2 | 3066 | ACE | 1636 | distal | 22955619 | TRANSFAC |
HNF4A | 3172 | ACE | 1636 | distal | 22955619 | TRANSFAC |
EP300 | 2033 | ACE | 1636 | distal | 22955619 | TRANSFAC |
FOXA2 | 3170 | ACE | 1636 | distal | 22955619 | TRANSFAC |
FOXA1 | 3169 | ACE | 1636 | distal | 22955619 | TRANSFAC |
BHLHE40 | 8553 | ACE | 1636 | distal | 22955619 | TRANSFAC |
CEBPB | 1051 | ACE | 1636 | distal | 22955619 | TRANSFAC |
CTCF | 10664 | ACE | 1636 | proximal_filtered | 22955619 | TRANSFAC |
CREM | 1390 | ACE | 1636 | Unknown | 9651321 | TRUSST |
HIF1A | 3091 | ACE | 1636 | Unknown | 11095974 | TRUSST |
EGR1 | 1958 | ACE | 1636 | Unknown | 9651321 | TRUSST |
SP3 | 6670 | ACE | 1636 | Unknown | 23393140 | TRUSST |
miRTarBase ID | miRNA | Species (miRNA) | Protein Official Symbol | Human Entrez ID | Species (Target Gene) | Experiments | Support Type | References (PMID) |
---|---|---|---|---|---|---|---|---|
MIRT018383 | hsa-miR-335-5p | Homo sapiens | ACE | 1636 | Homo sapiens | Microarray | Functional MTI (Weak) | 18185580 |
ID | GO ID | GO Term | GO Type |
---|---|---|---|
1636 | GO:0032943 | mononuclear cell proliferation | GOTERM_BP_DIRECT |
1636 | GO:0051019 | actin filament binding | GOTERM_MF_DIRECT |
1636 | GO:0003081 | regulation of systemic arterial blood pressure by renin-angiotensin | GOTERM_BP_DIRECT |
1636 | GO:0001822 | kidney development | GOTERM_BP_DIRECT |
1636 | GO:0010629 | negative regulation of gene expression | GOTERM_BP_DIRECT |
1636 | GO:0032091 | negative regulation of protein binding | GOTERM_BP_DIRECT |
1636 | GO:0050435 | beta-amyloid metabolic process | GOTERM_BP_DIRECT |
1636 | GO:0071838 | cell proliferation in bone marrow | GOTERM_BP_DIRECT |
1636 | GO:0007283 | spermatogenesis | GOTERM_BP_DIRECT |
1636 | GO:0004175 | dopachrome isomerase activity | GOTERM_MF_DIRECT |
1636 | GO:0008238 | metallopeptidase activity | GOTERM_MF_DIRECT |
1636 | GO:0002005 | angiotensin catabolic process in blood | GOTERM_BP_DIRECT |
1636 | GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation | GOTERM_BP_DIRECT |
1636 | GO:1903597 | negative regulation of gap junction assembly | GOTERM_BP_DIRECT |
1636 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation | GOTERM_BP_DIRECT |
1636 | GO:0001974 | blood vessel remodeling | GOTERM_BP_DIRECT |
1636 | GO:0003084 | positive regulation of systemic arterial blood pressure | GOTERM_BP_DIRECT |
1636 | GO:0061098 | positive regulation of protein tyrosine kinase activity | GOTERM_BP_DIRECT |
1636 | GO:0003779 | actin binding | GOTERM_MF_DIRECT |
1636 | GO:0031711 | endothelin A receptor binding | GOTERM_MF_DIRECT |
1636 | GO:0060177 | regulation of angiotensin metabolic process | GOTERM_BP_DIRECT |
1636 | GO:0008237 | serine-type peptidase activity | GOTERM_MF_DIRECT |
1636 | GO:0008241 | dipeptidyl-peptidase activity | GOTERM_MF_DIRECT |
1636 | GO:0008270 | zinc ion binding | GOTERM_MF_DIRECT |
1636 | GO:0031404 | sodium ion binding | GOTERM_MF_DIRECT |
1636 | GO:0070573 | R-SMAD binding | GOTERM_MF_DIRECT |
1636 | GO:0032092 | positive regulation of protein binding | GOTERM_BP_DIRECT |
1636 | GO:0009897 | external side of plasma membrane | GOTERM_CC_DIRECT |
1636 | GO:0016021 | integral component of membrane | GOTERM_CC_DIRECT |
1636 | GO:0070062 | extracellular exosome | GOTERM_CC_DIRECT |
1636 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | GOTERM_BP_DIRECT |
1636 | GO:0010608 | posttranscriptional regulation of gene expression | GOTERM_BP_DIRECT |
1636 | GO:0019229 | regulation of vasoconstriction | GOTERM_BP_DIRECT |
1636 | GO:0042312 | regulation of vasodilation | GOTERM_BP_DIRECT |
1636 | GO:0042447 | hormone catabolic process | GOTERM_BP_DIRECT |
1636 | GO:0050482 | arachidonic acid secretion | GOTERM_BP_DIRECT |
1636 | GO:0005764 | lysosome | GOTERM_CC_DIRECT |
1636 | GO:0005886 | plasma membrane | GOTERM_CC_DIRECT |
1636 | GO:0004180 | aminopeptidase activity | GOTERM_MF_DIRECT |
1636 | GO:0046872 | metal ion binding | GOTERM_MF_DIRECT |
1636 | GO:0005768 | endosome | GOTERM_CC_DIRECT |
1636 | GO:0002019 | regulation of renal output by angiotensin | GOTERM_BP_DIRECT |
1636 | GO:0060047 | heart contraction | GOTERM_BP_DIRECT |
1636 | GO:0008144 | drug binding | GOTERM_MF_DIRECT |
1636 | GO:0005576 | extracellular region | GOTERM_CC_DIRECT |
1636 | GO:0002446 | neutrophil mediated immunity | GOTERM_BP_DIRECT |
1636 | GO:0014910 | regulation of smooth muscle cell migration | GOTERM_BP_DIRECT |
1636 | GO:0043171 | peptide catabolic process | GOTERM_BP_DIRECT |
1636 | GO:0060218 | hematopoietic stem cell differentiation | GOTERM_BP_DIRECT |
1636 | GO:1902033 | regulation of hematopoietic stem cell proliferation | GOTERM_BP_DIRECT |
1636 | GO:0008240 | exopeptidase activity | GOTERM_MF_DIRECT |
1636 | GO:0008217 | regulation of blood pressure | GOTERM_BP_DIRECT |
1636 | GO:0016020 | membrane | GOTERM_CC_DIRECT |
1636 | GO:0002003 | angiotensin maturation | GOTERM_BP_DIRECT |
1636 | GO:0031434 | L-ascorbic acid binding | GOTERM_MF_DIRECT |
1636 | GO:0005615 | extracellular space | GOTERM_CC_DIRECT |
Protein Official Symbol | Human Entrez ID | Disease Name | Disease Id | Disease Semantic Type | Semantic score | DSI | DPI | Disease Type |
---|---|---|---|---|---|---|---|---|
ACE | 1636 | Presenile dementia | C0011265 | Mental or Behavioral Dysfunction | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Weight Gain | C0043094 | Finding | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Adenocarcinoma, Basal Cell | C0205641 | Neoplastic Process | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Adenocarcinoma, Oxyphilic | C0205642 | Neoplastic Process | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Cardiac Arrhythmia | C0003811 | Finding | 0.31 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Staphylococcal Infections | C0038160 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | group |
ACE | 1636 | Paroxysmal atrial fibrillation | C0235480 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Coronary Restenosis | C0948480 | Disease or Syndrome | 0.36 | 0.367 | 0.897 | disease |
ACE | 1636 | Cerebral Hemorrhage | C2937358 | Pathologic Function | 0.31 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Nonalcoholic Steatohepatitis | C3241937 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Alzheimer's Disease | C0002395 | Disease or Syndrome | 0.6 | 0.367 | 0.897 | disease |
ACE | 1636 | Coronary Arteriosclerosis | C0010054 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Diabetes Mellitus, Experimental | C0011853 | Experimental Model of Disease | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Drug Allergy | C0013182 | Pathologic Function | 0.31 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Nodular glomerulosclerosis | C0017667 | Disease or Syndrome | 0.33 | 0.367 | 0.897 | disease |
ACE | 1636 | Pneumonia, Viral | C0032310 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Atrial Fibrillation | C0004238 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Sudden death | C0011071 | Pathologic Function | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Hypotension | C0020649 | Finding | 0.4 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Kidney Diseases | C0022658 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | group |
ACE | 1636 | Lung diseases | C0024115 | Disease or Syndrome | 0.54 | 0.367 | 0.897 | group |
ACE | 1636 | Heart failure | C0018801 | Disease or Syndrome | 0.6 | 0.367 | 0.897 | disease |
ACE | 1636 | Cerebrovascular accident | C0038454 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | group |
ACE | 1636 | Left Ventricular Hypertrophy | C0149721 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Brain Ischemia | C0007786 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Glycogen Storage Disease Type V | C0017924 | Disease or Syndrome | 0.34 | 0.367 | 0.897 | disease |
ACE | 1636 | Meningococcal Infections | C0025303 | Disease or Syndrome | 0.32 | 0.367 | 0.897 | group |
ACE | 1636 | Familial Alzheimer Disease (FAD) | C0276496 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Acute Confusional Senile Dementia | C0546126 | Mental or Behavioral Dysfunction | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Severe Acute Respiratory Syndrome | C1175175 | Disease or Syndrome | 0.32 | 0.367 | 0.897 | disease |
ACE | 1636 | Persistent atrial fibrillation | C2585653 | Pathologic Function | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Berylliosis | C0005138 | Injury or Poisoning | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Coughing | C0010200 | Sign or Symptom | 0.4 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Kidney Failure, Chronic | C0022661 | Disease or Syndrome | 0.6 | 0.367 | 0.897 | disease |
ACE | 1636 | Pre-Eclampsia | C0032914 | Pathologic Function | 0.34 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Staphylococcus aureus infection | C1318973 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Hereditary Diffuse Gastric Cancer | C1708349 | Neoplastic Process | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Coronary Artery Disease | C1956346 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Left-Sided Heart Failure | C0023212 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Myocardial Infarction | C0027051 | Disease or Syndrome | 0.6 | 0.367 | 0.897 | disease |
ACE | 1636 | Streptozotocin Diabetes | C0038433 | Experimental Model of Disease | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Malignant neoplasm of lung | C0242379 | Neoplastic Process | 0.31 | 0.367 | 0.897 | disease |
ACE | 1636 | Gaucher Disease, Type 2 (disorder) | C0268250 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Malignant neoplasm of prostate | C0376358 | Neoplastic Process | 0.34 | 0.367 | 0.897 | disease |
ACE | 1636 | Gaucher Disease, Type 3 (disorder) | C0268251 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Alzheimer Disease, Early Onset | C0750901 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Adenocarcinoma | C0001418 | Neoplastic Process | 0.3 | 0.367 | 0.897 | group |
ACE | 1636 | IGA Glomerulonephritis | C0017661 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Hypertensive disease | C0020538 | Disease or Syndrome | 0.6 | 0.367 | 0.897 | group |
ACE | 1636 | Infant, Premature, Diseases | C0021295 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | group |
ACE | 1636 | Lung Neoplasms | C0024121 | Neoplastic Process | 0.31 | 0.367 | 0.897 | group |
ACE | 1636 | Heart Decompensation | C1961112 | Pathologic Function | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Liver carcinoma | C2239176 | Neoplastic Process | 0.37 | 0.367 | 0.897 | disease |
ACE | 1636 | Acute Cerebrovascular Accidents | C0751956 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Cardiovascular Diseases | C0007222 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | group |
ACE | 1636 | Congestive heart failure | C0018802 | Disease or Syndrome | 0.6 | 0.367 | 0.897 | disease |
ACE | 1636 | Prostatic Neoplasms | C0033578 | Neoplastic Process | 0.31 | 0.367 | 0.897 | group |
ACE | 1636 | Respiratory Tract Diseases | C0035242 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | group |
ACE | 1636 | Vascular System Injuries | C0178324 | Injury or Poisoning | 0.3 | 0.367 | 0.897 | group |
ACE | 1636 | Alzheimer's Disease, Focal Onset | C0750900 | Mental or Behavioral Dysfunction | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Alzheimer Disease, Late Onset | C0494463 | Mental or Behavioral Dysfunction | 0.35 | 0.367 | 0.897 | disease |
ACE | 1636 | Renal Insufficiency | C1565489 | Disease or Syndrome | 0.39 | 0.367 | 0.897 | disease |
ACE | 1636 | Beryllium Disease | C2350873 | Disease or Syndrome | 0.31 | 0.367 | 0.897 | disease |
ACE | 1636 | MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding) | C2675470 | Finding | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Albuminuria | C0001925 | Finding | 0.31 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Gaucher Disease | C0017205 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Malignant neoplasm of stomach | C0024623 | Neoplastic Process | 0.36 | 0.367 | 0.897 | disease |
ACE | 1636 | Psychoses, Substance-Induced | C0033941 | Mental or Behavioral Dysfunction | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Kidney Failure | C0035078 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Adenocarcinoma, Tubular | C0205645 | Neoplastic Process | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | familial atrial fibrillation | C3468561 | Pathologic Function | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Autistic Disorder | C0004352 | Mental or Behavioral Dysfunction | 0.31 | 0.367 | 0.897 | group |
ACE | 1636 | Pulmonary Hypertension | C0020542 | Pathologic Function | 0.32 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Neoplasm Metastasis | C0027627 | Neoplastic Process | 0.33 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Diabetic Nephropathy | C0011881 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Male infertility | C0021364 | Disease or Syndrome | 0.32 | 0.367 | 0.897 | disease |
ACE | 1636 | Stomach Neoplasms | C0038356 | Neoplastic Process | 0.32 | 0.367 | 0.897 | group |
ACE | 1636 | Carcinoma, Cribriform | C0205643 | Neoplastic Process | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Non-alcoholic Fatty Liver Disease | C0400966 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Male sterility | C0917731 | Finding | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Cerebral Ischemia | C0917798 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Myocardial Failure | C1959583 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Gaucher Disease, Type 1 | C1961835 | Disease or Syndrome | 0.31 | 0.367 | 0.897 | disease |
ACE | 1636 | Alloxan Diabetes | C0002152 | Experimental Model of Disease | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Coronary heart disease | C0010068 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Psychoses, Drug | C0033937 | Mental or Behavioral Dysfunction | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Carcinoma, Granular Cell | C0205644 | Neoplastic Process | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Heart Failure, Right-Sided | C0235527 | Disease or Syndrome | 0.3 | 0.367 | 0.897 | disease |
ACE | 1636 | Subfertility, Male | C0848676 | Sign or Symptom | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Allanson Pantzar McLeod syndrome | C0266313 | Disease or Syndrome | 0.64 | 0.367 | 0.897 | disease |
ACE | 1636 | Renal Tubular Dysgenesis With Choanal Atresia And Athelia | C2678367 | Disease or Syndrome | 0.5 | 0.367 | 0.897 | disease |
ACE | 1636 | Hypercholesterolemia, Familial | C0020445 | Disease or Syndrome | 0.32 | 0.367 | 0.897 | disease |
ACE | 1636 | Cerebrovascular Disorders | C0007820 | Disease or Syndrome | 0.4 | 0.367 | 0.897 | group |
ACE | 1636 | Bipolar Disorder | C0005586 | Mental or Behavioral Dysfunction | 0.55 | 0.367 | 0.897 | disease |
ACE | 1636 | Alcoholic Intoxication, Chronic | C0001973 | Mental or Behavioral Dysfunction | 0.32 | 0.367 | 0.897 | disease |
ACE | 1636 | Depressed mood | C0344315 | Finding | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Schizophrenia | C0036341 | Mental or Behavioral Dysfunction | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Depressive Symptoms | C0086132 | Sign or Symptom | 0.32 | 0.367 | 0.897 | phenotype |
ACE | 1636 | Chronic schizophrenia | C0221765 | Mental or Behavioral Dysfunction | 0.33 | 0.367 | 0.897 | disease |
ACE | 1636 | Depressive disorder | C0011581 | Mental or Behavioral Dysfunction | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | Major Depressive Disorder | C1269683 | Mental or Behavioral Dysfunction | 0.4 | 0.367 | 0.897 | disease |
ACE | 1636 | H/O: depression | C0455503 | Finding | 0.3 | 0.367 | 0.897 | phenotype |
ACE | 1636 | MAJOR AFFECTIVE DISORDER 2 | C1839839 | Mental or Behavioral Dysfunction | 0.01 | 0.367 | 0.897 | disease |
ACE | 1636 | Unipolar Depression | C0041696 | Mental or Behavioral Dysfunction | 0.4 | 0.367 | 0.897 | disease |
Protein Official Symbol | Human Entrez ID | drug_claim_primary_name | drug_name | drug_chembl_id | interaction_types |
---|---|---|---|---|---|
ACE | 1636 | BENAZEPRIL HYDROCHLORIDE | BENAZEPRIL HYDROCHLORIDE | CHEMBL1694 | inhibitor |
ACE | 1636 | BENAZEPRIL | BENAZEPRIL | CHEMBL838 | inhibitor |
ACE | 1636 | BENAZEPRIL | BENAZEPRIL | CHEMBL838 | None |
ACE | 1636 | BENAZEPRIL | BENAZEPRIL | CHEMBL838 | None |
ACE | 1636 | BENAZEPRILAT | BENAZEPRILAT | CHEMBL1192519 | inhibitor |
ACE | 1636 | CANDOXATRIL | CANDOXATRIL | CHEMBL35084 | None |
ACE | 1636 | CANDOXATRIL | CANDOXATRIL | CHEMBL35084 | None |
ACE | 1636 | CAPTOPRIL | CAPTOPRIL | CHEMBL1560 | None |
ACE | 1636 | CAPTOPRIL | CAPTOPRIL | CHEMBL1560 | None |
ACE | 1636 | CAPTOPRIL | CAPTOPRIL | CHEMBL1560 | inhibitor |
ACE | 1636 | CAPTOPRIL | CAPTOPRIL | CHEMBL1560 | inhibitor |
ACE | 1636 | CAPTOPRIL | CAPTOPRIL | CHEMBL1560 | None |
ACE | 1636 | CILAZAPRIL | CILAZAPRIL | CHEMBL515606 | inhibitor |
ACE | 1636 | CILAZAPRIL | CILAZAPRIL | CHEMBL515606 | None |
ACE | 1636 | CILAZAPRIL | CILAZAPRIL | CHEMBL515606 | None |
ACE | 1636 | DESERPIDINE | DESERPIDINE | CHEMBL1200515 | None |
ACE | 1636 | DESERPIDINE | DESERPIDINE | CHEMBL1200515 | None |
ACE | 1636 | ENALAPRIL | ENALAPRIL | CHEMBL578 | inhibitor |
ACE | 1636 | ENALAPRIL MALEATE | ENALAPRIL MALEATE | CHEMBL1200659 | inhibitor |
ACE | 1636 | ENALAPRIL | ENALAPRIL | CHEMBL578 | None |
ACE | 1636 | ENALAPRILAT | ENALAPRILAT | CHEMBL577 | inhibitor |
ACE | 1636 | ENALAPRIL MALEATE | ENALAPRIL MALEATE | CHEMBL1200659 | None |
ACE | 1636 | ENALAPRILAT HYDRATE | ENALAPRILAT HYDRATE | CHEMBL1200697 | inhibitor |
ACE | 1636 | ENALAPRIL | ENALAPRIL | CHEMBL578 | None |
ACE | 1636 | ENZYME INHIBITOR | None | None | None |
ACE | 1636 | FASIDOTRIL | FASIDOTRIL | CHEMBL2106226 | inhibitor |
ACE | 1636 | FASIDOTRILAT | FASIDOTRILAT | CHEMBL325055 | inhibitor |
ACE | 1636 | FOSINOPRIL | FOSINOPRIL | CHEMBL3039598 | None |
ACE | 1636 | FOSINOPRIL | FOSINOPRIL | CHEMBL3039598 | inhibitor |
ACE | 1636 | FOSINOPRIL | FOSINOPRIL | CHEMBL3039598 | None |
ACE | 1636 | FOSINOPRIL SODIUM | FOSINOPRIL SODIUM | CHEMBL3039596 | inhibitor |
ACE | 1636 | GLUCOCORTICOID | None | None | None |
ACE | 1636 | ILEPATRIL | CHEMBL3187812 | CHEMBL3187812 | None |
ACE | 1636 | IMIDAPRIL | IMIDAPRIL | CHEMBL317094 | inhibitor |
ACE | 1636 | IMIDAPRILAT | IMIDAPRILAT | CHEMBL99701 | inhibitor |
ACE | 1636 | INDOMETHACIN | INDOMETHACIN | CHEMBL6 | None |
ACE | 1636 | LISINOPRIL | LISINOPRIL | CHEMBL1237 | None |
ACE | 1636 | LISINOPRIL-TRYPTOPHAN | None | None | inhibitor |
ACE | 1636 | LISINOPRIL | LISINOPRIL | CHEMBL1237 | inhibitor |
ACE | 1636 | LISINOPRIL | LISINOPRIL | CHEMBL1237 | None |
ACE | 1636 | LISINOPRIL HYDRATE | LISINOPRIL HYDRATE | CHEMBL1729579 | inhibitor |
ACE | 1636 | MOEXIPRIL HYDROCHLORIDE | MOEXIPRIL HYDROCHLORIDE | CHEMBL1200534 | inhibitor |
ACE | 1636 | MOEXIPRIL | MOEXIPRIL | CHEMBL1165 | None |
ACE | 1636 | MOEXIPRIL | MOEXIPRIL | CHEMBL1165 | None |
ACE | 1636 | MOEXIPRIL | MOEXIPRIL | CHEMBL1165 | inhibitor |
ACE | 1636 | PERINDOPRIL | PERINDOPRIL | CHEMBL1581 | None |
ACE | 1636 | PERINDOPRIL ARGININE | PERINDOPRIL ARGININE | CHEMBL3544986 | inhibitor |
ACE | 1636 | PERINDOPRIL | PERINDOPRIL | CHEMBL1581 | None |
ACE | 1636 | PERINDOPRIL ERBUMINE | PERINDOPRIL ERBUMINE | CHEMBL1200343 | inhibitor |
ACE | 1636 | PERINDOPRILAT | PERINDOPRILAT | CHEMBL1201368 | inhibitor |
ACE | 1636 | PERINDOPRIL | PERINDOPRIL | CHEMBL1581 | inhibitor |
ACE | 1636 | QUINAPRIL HYDROCHLORIDE | QUINAPRIL HYDROCHLORIDE | CHEMBL1201011 | inhibitor |
ACE | 1636 | QUINAPRIL | QUINAPRIL | CHEMBL1592 | None |
ACE | 1636 | QUINAPRIL | QUINAPRIL | CHEMBL1592 | None |
ACE | 1636 | QUINAPRILAT | QUINAPRILAT | CHEMBL1733 | inhibitor |
ACE | 1636 | RAMIPRIL | RAMIPRIL | CHEMBL1168 | None |
ACE | 1636 | RAMIPRIL | RAMIPRIL | CHEMBL1168 | inhibitor |
ACE | 1636 | RAMIPRILAT | RAMIPRILAT | CHEMBL1201365 | inhibitor |
ACE | 1636 | RAMIPRIL | RAMIPRIL | CHEMBL1168 | inhibitor |
ACE | 1636 | RAMIPRIL | RAMIPRIL | CHEMBL1168 | None |
ACE | 1636 | RESCINNAMINE | RESCINNAMINE | CHEMBL1668 | None |
ACE | 1636 | RESCINNAMINE | RESCINNAMINE | CHEMBL1668 | None |
ACE | 1636 | RXP-407 | CHEMBL1235767 | CHEMBL1235767 | inhibitor |
ACE | 1636 | SPIRAPRIL HYDROCHLORIDE | SPIRAPRIL HYDROCHLORIDE | CHEMBL1200831 | inhibitor |
ACE | 1636 | SPIRAPRILAT | SPIRAPRILAT | CHEMBL579 | inhibitor |
ACE | 1636 | SPIRAPRIL | SPIRAPRIL | CHEMBL431 | None |
ACE | 1636 | SPIRAPRIL | SPIRAPRIL | CHEMBL431 | None |
ACE | 1636 | SPIRAPRIL | SPIRAPRIL | CHEMBL431 | inhibitor |
ACE | 1636 | TRANDOLAPRIL | TRANDOLAPRIL | CHEMBL1519 | inhibitor |
ACE | 1636 | TRANDOLAPRIL | TRANDOLAPRIL | CHEMBL1519 | None |
ACE | 1636 | TRANDOLAPRIL | TRANDOLAPRIL | CHEMBL1519 | inhibitor |
ACE | 1636 | TRANDOLAPRILAT | TRANDOLAPRILAT | CHEMBL1201387 | inhibitor |
ACE | 1636 | TRANDOLAPRIL | TRANDOLAPRIL | CHEMBL1519 | None |
ACE | 1636 | VASOPRESSIN | VASOPRESSIN | CHEMBL373742 | None |
ACE | 1636 | ZOFENOPRIL | ZOFENOPRIL | CHEMBL331378 | inhibitor |