Dual-specificity tyrosine-(Y)- phosphorylation regulated kinase 1A

AltitudeomicsDB
Protein Official symbol DYRK1A
Aliases DYRK1A DYRK MNB MNBH
Chromosomal Location  21
Length 763
Uniprot ID Q13627
EC number 2.7.12.1
Protein family Information(Pfam) PF00069;
PDB id 2VX3;2WO6;3ANQ;3ANR;4AZE;4MQ1;4MQ2;4NCT;4YLJ;4YLK;4YLL;4YU2;5A3X;5A4E;5A4L;5A4Q;5A4T;5A54;5AIK;6A1F;6A1G;6EIF;6EIJ;6EIL;6EIP;6EIQ;6EIR;6EIS;6EIV;6EJ4;6QU2;6S11;6S14;6S17;6S1B;6S1H;6S1I;6S1J;6T6A;6UIP;6UWY;
InterPro ID IPR028318;IPR011009;IPR000719;IPR017441;IPR008271;
dbSNP rs55720916

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
LIN54 LIN37 0.999
LIN9 LIN37 0.999
LIN54 LIN9 0.999
LIN52 LIN37 0.999
LIN52 LIN9 0.999
RBBP4 LIN9 0.995
LIN52 LIN54 0.995
RBBP4 LIN37 0.991
RBBP4 LIN54 0.991
LIN52 RBBP4 0.985
DCAF7 DYRK1A 0.983
LIN52 DYRK1A 0.974
DYRK1A LIN54 0.945
DYRK1A LIN37 0.94
CCNL2 DYRK1A 0.934
DYRK1A LIN9 0.932
DYRK1A RBBP4 0.93
DYRK1A RCAN1 0.909
Gene Ontology Semantic Similarity
Download Tab separated file
# 132660 (LIN54) 286826 (LIN9) 5928 (RBBP4) 10238 (DCAF7) 1859 (DYRK1A) 81669 (CCNL2) 55957 (LIN37) 1827 (RCAN1)
132660 (LIN54) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
286826 (LIN9) 1.00 1.00 0.57 1.00 0.49 0.63 1.00 0.74
5928 (RBBP4) 1.00 0.57 1.00 1.00 0.43 0.46 1.00 0.51
10238 (DCAF7) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
1859 (DYRK1A) 1.00 0.49 0.43 1.00 1.00 0.46 1.00 0.44
81669 (CCNL2) 1.00 0.63 0.46 1.00 0.46 1.00 1.00 0.55
55957 (LIN37) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
1827 (RCAN1) 1.00 0.74 0.51 1.00 0.44 0.55 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
DYRK1A Human Blood - 3650 m 48 hours downregulated 0.622 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 DYRK1A 1859 distal 22955619 TRANSFAC
REST 5978 DYRK1A 1859 Unknown 12737630 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT017031 hsa-miR-335-5p Homo sapiens DYRK1A 1859 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT024657 hsa-miR-215-5p Homo sapiens DYRK1A 1859 Homo sapiens Microarray Functional MTI (Weak) 19074876
MIRT026006 hsa-miR-148a-3p Homo sapiens DYRK1A 1859 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT026227 hsa-miR-192-5p Homo sapiens DYRK1A 1859 Homo sapiens Microarray Functional MTI (Weak) 19074876
MIRT043199 hsa-miR-324-5p Homo sapiens DYRK1A 1859 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044178 hsa-miR-99b-5p Homo sapiens DYRK1A 1859 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049774 hsa-miR-92a-3p Homo sapiens DYRK1A 1859 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT053774 hsa-miR-1246 Homo sapiens DYRK1A 1859 Homo sapiens ChIP-seq//Flow//Microarray//qRT-PCR//Western blot Functional MTI 24861464
MIRT085345 hsa-miR-224-3p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085346 hsa-miR-522-3p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085350 hsa-miR-1270 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085347 hsa-miR-620 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085346 hsa-miR-522-3p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085355 hsa-miR-6880-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085345 hsa-miR-224-3p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085355 hsa-miR-6880-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085345 hsa-miR-224-3p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085350 hsa-miR-1270 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085353 hsa-miR-5680 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085347 hsa-miR-620 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085349 hsa-miR-298 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085347 hsa-miR-620 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085350 hsa-miR-1270 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085353 hsa-miR-5680 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085355 hsa-miR-6880-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085348 hsa-miR-2113 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT085353 hsa-miR-5680 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085348 hsa-miR-2113 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT085346 hsa-miR-522-3p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT085348 hsa-miR-2113 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT203409 hsa-miR-26b-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT203435 hsa-miR-455-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT203408 hsa-miR-26a-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT351238 hsa-miR-6781-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT351232 hsa-miR-2682-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT351232 hsa-miR-2682-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT351238 hsa-miR-6781-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT507504 hsa-miR-143-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT507503 hsa-miR-3944-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT507504 hsa-miR-143-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT507506 hsa-miR-8071 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT507502 hsa-miR-6844 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT507503 hsa-miR-3944-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT507504 hsa-miR-143-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT507505 hsa-miR-3165 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT507507 hsa-miR-4683 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT507505 hsa-miR-3165 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT507503 hsa-miR-3944-5p Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT507502 hsa-miR-6844 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT507502 hsa-miR-6844 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT507505 hsa-miR-3165 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT507506 hsa-miR-8071 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT507507 hsa-miR-4683 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT507506 hsa-miR-8071 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT507507 hsa-miR-4683 Homo sapiens DYRK1A 1859 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT642126 hsa-miR-5692a Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT642124 hsa-miR-3152-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT642126 hsa-miR-5692a Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT642125 hsa-miR-6836-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT642124 hsa-miR-3152-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT642125 hsa-miR-6836-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668629 hsa-miR-550b-2-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668634 hsa-miR-3135a Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668636 hsa-miR-5685 Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668637 hsa-miR-4690-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668638 hsa-miR-7151-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668635 hsa-miR-4716-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668630 hsa-miR-3157-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668626 hsa-miR-30e-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668628 hsa-miR-30a-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668625 hsa-miR-335-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668633 hsa-miR-1271-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668632 hsa-miR-550a-3-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668627 hsa-miR-30d-3p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT668631 hsa-miR-550a-5p Homo sapiens DYRK1A 1859 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
1859 GO:0018108 peptidyl-tyrosine phosphorylation GOTERM_BP_DIRECT
1859 GO:0005524 ATP binding GOTERM_MF_DIRECT
1859 GO:0000381 regulation of alternative mRNA splicing GOTERM_BP_DIRECT
1859 GO:0043621 sequence-specific DNA binding GOTERM_MF_DIRECT
1859 GO:0004713 protein tyrosine kinase activity GOTERM_MF_DIRECT
1859 GO:0030529 intracellular ribonucleoprotein complex GOTERM_CC_DIRECT
1859 GO:0006468 protein phosphorylation GOTERM_BP_DIRECT
1859 GO:0048025 negative regulation of mRNA splicing GOTERM_BP_DIRECT
1859 GO:0004672 protein kinase activity GOTERM_MF_DIRECT
1859 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
1859 GO:0018107 peptidyl-threonine phosphorylation GOTERM_BP_DIRECT
1859 GO:0046777 protein autophosphorylation GOTERM_BP_DIRECT
1859 GO:0090312 positive regulation of protein deacetylation GOTERM_BP_DIRECT
1859 GO:0004715 transmembrane receptor protein tyrosine kinase activity GOTERM_MF_DIRECT
1859 GO:0018105 peptidyl-serine phosphorylation GOTERM_BP_DIRECT
1859 GO:0004674 protein serine/threonine kinase activity GOTERM_MF_DIRECT
1859 GO:0005634 nucleus GOTERM_CC_DIRECT
1859 GO:0005515 protein binding GOTERM_MF_DIRECT
1859 GO:0043518 negative regulation of DNA damage response GOTERM_BP_DIRECT
1859 GO:0007623 circadian rhythm GOTERM_BP_DIRECT
1859 GO:0004712 MAP kinase kinase kinase activity GOTERM_MF_DIRECT
1859 GO:0048156 cofactor binding GOTERM_MF_DIRECT
1859 GO:0042802 identical protein binding GOTERM_MF_DIRECT
1859 GO:0016607 nuclear speck GOTERM_CC_DIRECT
1859 GO:0007399 nervous system development GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
DYRK1A 1859 MENTAL RETARDATION, AUTOSOMAL DOMINANT 7 C3279839 Disease or Syndrome 0.4 0.607 0.483 disease
DYRK1A 1859 Neurodevelopmental Disorders C1535926 Mental or Behavioral Dysfunction 0.31 0.607 0.483 group
DYRK1A 1859 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.607 0.483 group
DYRK1A 1859 Microcephaly C0025958 Congenital Abnormality 0.36 0.607 0.483 disease
DYRK1A 1859 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.607 0.483 disease
DYRK1A 1859 Primary microcephaly C0431350 Congenital Abnormality 0.3 0.607 0.483 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
DYRK1A 1859 COMPOUND 17 [PMID: 23642479] None None inhibitor
DYRK1A 1859 COMPOUND 3B [PMID: 23454515] None None inhibitor
DYRK1A 1859 COMPOUND 68 [PMID: 24900699] None None inhibitor
DYRK1A 1859 COMPOUND 72 [WO2013026806] None None inhibitor
DYRK1A 1859 HARMINE HARMINE CHEMBL269538 inhibitor
DYRK1A 1859 KH-CB19 None None inhibitor
DYRK1A 1859 ML315 None None inhibitor