Cyclin-L2

AltitudeomicsDB
Protein Official symbol CCNL2
Aliases CCNL2 SB138
Chromosomal Location  1
Length 520
Uniprot ID Q96S94
EC number None
Protein family Information(Pfam) PF02984;PF00134;
PDB id None
InterPro ID IPR013763;IPR036915;IPR043198;IPR004367;IPR006671;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CCNL2 DYRK1A 0.934
CCNL2 SRSF7 0.846
CDK11A CCNL2 0.844
CCNL2 CDK7 0.836
CDK11B CCNL2 0.833
DYRK1A SRSF7 0.813
CCNL2 CDK13 0.802
Gene Ontology Semantic Similarity
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# 81669 (CCNL2) 728642 (CDK11A) 984 (CDK11B) 1859 (DYRK1A) 6432 (SRSF7) 1022 (CDK7) 8621 (CDK13)
81669 (CCNL2) 1.00 0.13 0.38 0.46 0.67 0.37 0.48
728642 (CDK11A) 0.13 1.00 0.84 0.64 0.16 0.60 0.57
984 (CDK11B) 0.38 0.84 1.00 0.81 0.60 0.74 0.87
1859 (DYRK1A) 0.46 0.64 0.81 1.00 0.52 0.78 0.81
6432 (SRSF7) 0.67 0.16 0.60 0.52 1.00 0.42 0.67
1022 (CDK7) 0.37 0.60 0.74 0.78 0.42 1.00 0.75
8621 (CDK13) 0.48 0.57 0.87 0.81 0.67 0.75 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CCNL2 Toad Heart - 3464 m 33 day upregulated 2.100915598 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
FOS 2353 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
SP2 6668 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
NFYA 4800 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
ELF1 1997 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
CTCFL 140690 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
NFYB 4801 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
PBX3 5090 CCNL2 81669 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT030118 hsa-miR-26b-5p Homo sapiens CCNL2 81669 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT053433 hsa-miR-512-5p Homo sapiens CCNL2 81669 Homo sapiens Microarray Functional MTI (Weak) 23807165
MIRT440983 hsa-miR-218-5p Homo sapiens CCNL2 81669 Homo sapiens HITS-CLIP Functional MTI (Weak) 23212916
MIRT527217 hsa-miR-548f-5p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527212 hsa-miR-548aw Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527219 hsa-miR-8063 Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527221 hsa-miR-4668-3p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527215 hsa-miR-548x-5p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527218 hsa-miR-548aj-5p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527220 hsa-miR-3120-3p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527222 hsa-miR-5582-3p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527216 hsa-miR-548g-5p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527214 hsa-miR-1468-3p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT527213 hsa-miR-222-5p Homo sapiens CCNL2 81669 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT728027 hsa-miR-27b-3p Homo sapiens CCNL2 81669 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT728028 hsa-miR-27a-3p Homo sapiens CCNL2 81669 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
Gene Ontology
ID GO ID GO Term GO Type
81669 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain GOTERM_BP_DIRECT
81669 GO:0016607 nuclear speck GOTERM_CC_DIRECT
81669 GO:0000307 cyclin-dependent protein kinase holoenzyme complex GOTERM_CC_DIRECT
81669 GO:0005515 protein binding GOTERM_MF_DIRECT
81669 GO:0019901 protein kinase binding GOTERM_MF_DIRECT
81669 GO:0006351 transcription GOTERM_BP_DIRECT
81669 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
81669 GO:0006355 regulation of transcription GOTERM_BP_DIRECT
81669 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
81669 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GOTERM_BP_DIRECT
81669 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GOTERM_BP_DIRECT
81669 GO:0005634 nucleus GOTERM_CC_DIRECT
81669 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
81669 GO:0016538 long-chain-enoyl-CoA hydratase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types