Long-chain acyl-CoA synthetase 4

AltitudeomicsDB
Protein Official symbol ACSL4
Aliases ACSL4 ACS4 FACL4 LACS4
Chromosomal Location X
Length 711
Uniprot ID O60488
EC number 6.2.1.3; 6.2.1.15
Protein family Information(Pfam) PF00501;
PDB id None
InterPro ID IPR020845;IPR000873;IPR042099;
dbSNP rs753267653 rs122458138

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ACSL4 ACOX1 0.955
ACSL4 ACOX2 0.954
ACSL4 ACADL 0.945
ACSL4 FASN 0.944
ACOX1 ACADL 0.926
ACSL4 AMMECR1 0.921
ACSL4 FADS2 0.918
ELOVL6 ACSL4 0.915
ACOX2 ACOX1 0.911
ELOVL1 ACSL4 0.907
Gene Ontology Semantic Similarity
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# 2182 (ACSL4) 51 (ACOX1) 79071 (ELOVL6) 8309 (ACOX2) 64834 (ELOVL1) 33 (ACADL) 2194 (FASN) 9949 (AMMECR1) 9415 (FADS2)
2182 (ACSL4) 1.00 0.15 0.17 0.17 0.17 0.20 0.17 0.16 0.17
51 (ACOX1) 0.15 1.00 0.46 0.85 0.46 0.63 0.48 0.82 0.29
79071 (ELOVL6) 0.17 0.46 1.00 0.39 1.00 0.20 0.80 1.00 0.15
8309 (ACOX2) 0.17 0.85 0.39 1.00 0.39 0.62 0.42 0.82 0.35
64834 (ELOVL1) 0.17 0.46 1.00 0.39 1.00 0.20 0.80 1.00 0.15
33 (ACADL) 0.20 0.63 0.20 0.62 0.20 1.00 0.24 0.23 0.35
2194 (FASN) 0.17 0.48 0.80 0.42 0.80 0.24 1.00 1.00 0.17
9949 (AMMECR1) 0.16 0.82 1.00 0.82 1.00 0.23 1.00 1.00 0.14
9415 (FADS2) 0.17 0.29 0.15 0.35 0.15 0.35 0.17 0.14 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ACSL4 Toad Liver None 3464 m 33 day upregulated 2.141824257 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EGR1 1958 ACSL4 2182 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT020060 hsa-miR-375 Homo sapiens ACSL4 2182 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT025215 hsa-miR-34a-5p Homo sapiens ACSL4 2182 Homo sapiens Proteomics//Reporter assay;Proteomics Functional MTI 21566225
MIRT028658 hsa-miR-30a-5p Homo sapiens ACSL4 2182 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT043925 hsa-miR-378a-3p Homo sapiens ACSL4 2182 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT054569 hsa-miR-205-5p Homo sapiens ACSL4 2182 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24576478
MIRT108438 hsa-miR-129-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT108447 hsa-miR-200c-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT108448 hsa-miR-429 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT108446 hsa-miR-200b-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT108450 hsa-miR-557 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT108449 hsa-miR-507 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT124869 hsa-miR-190a-3p Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT124869 hsa-miR-190a-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT124873 hsa-miR-5011-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT124873 hsa-miR-5011-5p Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT175300 hsa-miR-4789-3p Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT175328 hsa-miR-448 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175384 hsa-miR-106b-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175379 hsa-miR-20a-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175380 hsa-miR-93-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175400 hsa-miR-519c-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175442 hsa-miR-548az-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175328 hsa-miR-448 Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT175406 hsa-miR-519d-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175381 hsa-miR-106a-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175420 hsa-miR-548t-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175377 hsa-miR-8084 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT175396 hsa-miR-20b-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175408 hsa-miR-519a-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175287 hsa-miR-450b-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175300 hsa-miR-4789-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175378 hsa-miR-17-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175430 hsa-miR-4477a Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175402 hsa-miR-526b-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT175403 hsa-miR-519b-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT441285 hsa-miR-142-3p Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT444495 hsa-miR-369-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT444494 hsa-miR-5692b Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT444491 hsa-miR-374b-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT444489 hsa-miR-578 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT444490 hsa-miR-1298-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT444493 hsa-miR-5692c Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT444492 hsa-miR-374a-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT549456 hsa-miR-186-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549463 hsa-miR-454-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549466 hsa-miR-19a-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549467 hsa-miR-144-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549449 hsa-miR-410-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549442 hsa-miR-33b-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549459 hsa-miR-130b-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549464 hsa-miR-3666 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549445 hsa-miR-518a-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549466 hsa-miR-19a-3p Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT549457 hsa-miR-3662 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549458 hsa-miR-301b-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549446 hsa-miR-3653-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549447 hsa-miR-16-1-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549454 hsa-miR-212-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549444 hsa-miR-527 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549452 hsa-miR-580-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549462 hsa-miR-301a-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549465 hsa-miR-19b-3p Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT549448 hsa-miR-586 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549453 hsa-miR-6507-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549440 hsa-miR-3680-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549441 hsa-miR-3658 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549450 hsa-miR-3163 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549451 hsa-miR-8485 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549451 hsa-miR-8485 Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT549461 hsa-miR-4295 Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549443 hsa-miR-33a-5p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549448 hsa-miR-586 Homo sapiens ACSL4 2182 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT549455 hsa-miR-132-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549460 hsa-miR-130a-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT549465 hsa-miR-19b-3p Homo sapiens ACSL4 2182 Homo sapiens PAR-CLIP//HITS-CLIP Functional MTI (Weak) 21572407
MIRT733092 hsa-miR-26a-1-3p Homo sapiens ACSL4 2182 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25961460
Gene Ontology
ID GO ID GO Term GO Type
2182 GO:0006641 triglyceride metabolic process GOTERM_BP_DIRECT
2182 GO:0070672 response to interleukin-15 GOTERM_BP_DIRECT
2182 GO:0005741 mitochondrial outer membrane GOTERM_CC_DIRECT
2182 GO:0030307 positive regulation of cell growth GOTERM_BP_DIRECT
2182 GO:0060136 embryonic process involved in female pregnancy GOTERM_BP_DIRECT
2182 GO:0008152 metabolic process GOTERM_BP_DIRECT
2182 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
2182 GO:0006629 lipid metabolic process GOTERM_BP_DIRECT
2182 GO:0003824 antigen binding GOTERM_MF_DIRECT
2182 GO:0004467 lactose synthase activity GOTERM_MF_DIRECT
2182 GO:0016020 membrane GOTERM_CC_DIRECT
2182 GO:0005737 cytoplasm GOTERM_CC_DIRECT
2182 GO:0047676 15-oxoprostaglandin 13-oxidase activity GOTERM_MF_DIRECT
2182 GO:0044233 ER-mitochondrion membrane contact site GOTERM_CC_DIRECT
2182 GO:0005811 lipid particle GOTERM_CC_DIRECT
2182 GO:0007584 response to nutrient GOTERM_BP_DIRECT
2182 GO:0015908 fatty acid transport GOTERM_BP_DIRECT
2182 GO:0060996 dendritic spine development GOTERM_BP_DIRECT
2182 GO:0005524 ATP binding GOTERM_MF_DIRECT
2182 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
2182 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
2182 GO:0001676 long-chain fatty acid metabolic process GOTERM_BP_DIRECT
2182 GO:0031957 type 2A serotonin receptor binding GOTERM_MF_DIRECT
2182 GO:0005778 peroxisomal membrane GOTERM_CC_DIRECT
2182 GO:0008610 lipid biosynthetic process GOTERM_BP_DIRECT
2182 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2182 GO:0032307 negative regulation of prostaglandin secretion GOTERM_BP_DIRECT
2182 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GOTERM_BP_DIRECT
2182 GO:0102391 cadherin binding involved in cell-cell adhesion GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2182 hsa00061 Fatty acid biosynthesis
2182 hsa00071 Fatty acid degradation
2182 hsa01100 Metabolic pathways
2182 hsa03320 PPAR signaling pathway
2182 hsa01212 Fatty acid metabolism
2182 hsa04146 Peroxisome
2182 hsa04920 Adipocytokine signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ACSL4 2182 Mental Retardation, X-Linked 1 C2931498 Disease or Syndrome 0.52 0.609 0.552 disease
ACSL4 2182 Depressive Syndrome C0086133 Mental or Behavioral Dysfunction 0.3 0.609 0.552 disease
ACSL4 2182 Erythema C0041834 Disease or Syndrome 0.31 0.609 0.552 phenotype
ACSL4 2182 Arthritis, Experimental C0993582 Experimental Model of Disease 0.3 0.609 0.552 disease
ACSL4 2182 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.609 0.552 group
ACSL4 2182 Arthritis, Collagen-Induced C0971858 Experimental Model of Disease 0.3 0.609 0.552 disease
ACSL4 2182 Endogenous depression C0011573 Mental or Behavioral Dysfunction 0.3 0.609 0.552 disease
ACSL4 2182 Melancholia C0025193 Mental or Behavioral Dysfunction 0.3 0.609 0.552 disease
ACSL4 2182 Depression, Neurotic C0282126 Mental or Behavioral Dysfunction 0.3 0.609 0.552 disease
ACSL4 2182 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.31 0.609 0.552 disease
ACSL4 2182 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.3 0.609 0.552 disease
ACSL4 2182 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.31 0.609 0.552 disease
ACSL4 2182 Liver carcinoma C2239176 Neoplastic Process 0.37 0.609 0.552 disease
ACSL4 2182 Arthritis, Adjuvant-Induced C0003865 Experimental Model of Disease 0.3 0.609 0.552 disease
ACSL4 2182 Adenocarcinoma of lung (disorder) C0152013 Neoplastic Process 0.3 0.609 0.552 disease
ACSL4 2182 Mental Retardation, X-Linked 63 C1845672 Disease or Syndrome 0.61 0.609 0.552 disease
ACSL4 2182 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.45 0.609 0.552 group
ACSL4 2182 Alport Syndrome, Mental Retardation, Midface Hypoplasia, and Elliptocytosis C1846242 Disease or Syndrome 0.3 0.609 0.552 disease
ACSL4 2182 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.01 0.609 0.552 disease
ACSL4 2182 Colorectal Cancer C1527249 Neoplastic Process 0.3 0.609 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types