Acyl-CoA 6-desaturase

AltitudeomicsDB
Protein Official symbol FADS2
Aliases FADS2
Chromosomal Location  11
Length 444
Uniprot ID O95864
EC number 1.14.19.3
Protein family Information(Pfam) PF00173;PF00487;
PDB id None
InterPro ID IPR001199;IPR036400;IPR005804;IPR012171;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ELOVL5 FADS2 0.986
ACSL1 FADS2 0.952
FADS2 SLC27A2 0.936
ACSL3 FADS2 0.933
ACSL5 FADS2 0.928
ACSL6 FADS2 0.922
ACSM5 FADS2 0.92
ACSL4 FADS2 0.918
FADS2 ACSBG1 0.916
ACSBG2 FADS2 0.912
ACSM1 FADS2 0.907
ACSM3 FADS2 0.903
ACSM6 FADS2 0.902
ACSM4 FADS2 0.902
PLA2G16 FADS2 0.9
Gene Ontology Semantic Similarity
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# 60481 (ELOVL5) 2180 (ACSL1) 9415 (FADS2) 2181 (ACSL3) 51703 (ACSL5) 23305 (ACSL6) 54988 (ACSM5) 2182 (ACSL4) 81616 (ACSBG2) 116285 (ACSM1) 6296 (ACSM3) 142827 (ACSM6) 341392 (ACSM4) 11145 (PLA2G16) 11001 (SLC27A2) 23205 (ACSBG1)
60481 (ELOVL5) 1.00 0.17 0.15 0.52 0.17 0.39 0.33 0.17 0.17 0.29 0.40 0.33 0.33 0.60 0.37 0.17
2180 (ACSL1) 0.17 1.00 0.17 1.00 1.00 1.00 0.86 1.00 1.00 0.86 0.86 0.86 0.86 0.28 1.00 1.00
9415 (FADS2) 0.15 0.17 1.00 0.17 0.17 0.17 0.21 0.17 0.17 0.21 0.26 0.21 0.21 0.25 0.17 0.17
2181 (ACSL3) 0.52 1.00 0.17 1.00 1.00 0.67 0.43 0.58 0.52 0.47 0.49 0.43 0.43 0.45 0.62 0.59
51703 (ACSL5) 0.17 1.00 0.17 1.00 1.00 1.00 0.86 1.00 1.00 0.86 0.86 0.86 0.86 0.28 1.00 1.00
23305 (ACSL6) 0.39 1.00 0.17 0.67 1.00 1.00 0.49 0.67 0.60 0.51 0.49 0.49 0.49 0.35 0.54 0.71
54988 (ACSM5) 0.33 0.86 0.21 0.43 0.86 0.49 1.00 0.68 0.57 0.93 0.90 1.00 1.00 0.35 0.48 0.64
2182 (ACSL4) 0.17 1.00 0.17 0.58 1.00 0.67 0.68 1.00 0.78 0.68 0.62 0.68 0.68 0.23 0.60 0.90
81616 (ACSBG2) 0.17 1.00 0.17 0.52 1.00 0.60 0.57 0.78 1.00 0.57 0.54 0.57 0.57 0.31 0.51 0.84
116285 (ACSM1) 0.29 0.86 0.21 0.47 0.86 0.51 0.93 0.68 0.57 1.00 0.86 0.93 0.93 0.34 0.52 0.62
6296 (ACSM3) 0.40 0.86 0.26 0.49 0.86 0.49 0.90 0.62 0.54 0.86 1.00 0.90 0.90 0.41 0.54 0.58
142827 (ACSM6) 0.33 0.86 0.21 0.43 0.86 0.49 1.00 0.68 0.57 0.93 0.90 1.00 1.00 0.35 0.48 0.64
341392 (ACSM4) 0.33 0.86 0.21 0.43 0.86 0.49 1.00 0.68 0.57 0.93 0.90 1.00 1.00 0.35 0.48 0.64
11145 (PLA2G16) 0.60 0.28 0.25 0.45 0.28 0.35 0.35 0.23 0.31 0.34 0.41 0.35 0.35 1.00 0.38 0.22
11001 (SLC27A2) 0.37 1.00 0.17 0.62 1.00 0.54 0.48 0.60 0.51 0.52 0.54 0.48 0.48 0.38 1.00 0.55
23205 (ACSBG1) 0.17 1.00 0.17 0.59 1.00 0.71 0.64 0.90 0.84 0.62 0.58 0.64 0.64 0.22 0.55 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
FADS2 Toad Heart - 3464 m 33 day downregulated -2.836246766 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
FADS2 Toad Liver - 3464 m 33 day downregulated -2.913856595 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
SREBF1 6720 FADS2 9415 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT001634 hsa-let-7b-5p Homo sapiens FADS2 9415 Homo sapiens pSILAC//Proteomics;Other Functional MTI (Weak) 18668040
MIRT001634 hsa-let-7b-5p Homo sapiens FADS2 9415 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT017360 hsa-miR-335-5p Homo sapiens FADS2 9415 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT029144 hsa-miR-26b-5p Homo sapiens FADS2 9415 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT040802 hsa-miR-18a-3p Homo sapiens FADS2 9415 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT041155 hsa-miR-500a-3p Homo sapiens FADS2 9415 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042511 hsa-miR-423-3p Homo sapiens FADS2 9415 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042871 hsa-miR-324-3p Homo sapiens FADS2 9415 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT440695 hsa-miR-218-5p Homo sapiens FADS2 9415 Homo sapiens HITS-CLIP Functional MTI (Weak) 23212916
Gene Ontology
ID GO ID GO Term GO Type
9415 GO:0006629 lipid metabolic process GOTERM_BP_DIRECT
9415 GO:0006636 unsaturated fatty acid biosynthetic process GOTERM_BP_DIRECT
9415 GO:0004768 retinol dehydrogenase activity GOTERM_MF_DIRECT
9415 GO:0036109 alpha-linolenic acid metabolic process GOTERM_BP_DIRECT
9415 GO:0016213 antioxidant activity GOTERM_MF_DIRECT
9415 GO:0016020 membrane GOTERM_CC_DIRECT
9415 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
9415 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
9415 GO:0005887 integral component of plasma membrane GOTERM_CC_DIRECT
9415 GO:0043651 linoleic acid metabolic process GOTERM_BP_DIRECT
9415 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
9415 hsa00592 alpha-Linolenic acid metabolism
9415 hsa01040 Biosynthesis of unsaturated fatty acids
9415 hsa01212 Fatty acid metabolism
9415 hsa03320 PPAR signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
FADS2 9415 Colorectal Neoplasms C0009404 Neoplastic Process 0.3 0.627 0.552 group
FADS2 9415 Colorectal Carcinoma C0009402 Neoplastic Process 0.3 0.627 0.552 disease
FADS2 9415 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.627 0.552 disease
FADS2 9415 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.627 0.552 disease
FADS2 9415 Lipoidosis C0023794 Disease or Syndrome 0.3 0.627 0.552 disease
FADS2 9415 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.627 0.552 disease
FADS2 9415 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.627 0.552 disease
FADS2 9415 Colorectal Cancer C1527249 Neoplastic Process 0.4 0.627 0.552 disease
FADS2 9415 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.627 0.552 disease
FADS2 9415 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.627 0.552 disease
FADS2 9415 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.31 0.627 0.552 disease
FADS2 9415 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.41 0.627 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types