| Protein Official symbol | FBLN2 |
| Aliases | FBLN2 |
| Chromosomal Location | 3 |
| Length | 1184 |
| Uniprot ID | P98095 |
| EC number | None |
| Protein family Information(Pfam) | PF01821;PF12662;PF07645; |
| PDB id | None |
| InterPro ID | IPR000020;IPR026823;IPR001881;IPR013032;IPR000742;IPR000152;IPR018097;IPR037286;IPR009030; |
| dbSNP | rs60850813 rs28587534 rs3732666 rs3796318 rs9843344 rs1061375 |
| Protein 1 | Protein 2 | Combine Score |
|---|---|---|
| MFAP2 | MFAP3 | 0.979 |
| MFAP2 | MFAP1 | 0.979 |
| MFAP5 | FBLN1 | 0.967 |
| MFAP2 | FBLN5 | 0.96 |
| MFAP4 | FBLN5 | 0.956 |
| MFAP2 | EFEMP2 | 0.956 |
| MFAP2 | FBLN1 | 0.956 |
| MFAP4 | MFAP2 | 0.955 |
| FBLN2 | MFAP2 | 0.953 |
| FBLN2 | MFAP5 | 0.948 |
| MFAP5 | EFEMP2 | 0.946 |
| MFAP4 | FBLN1 | 0.943 |
| FBLN5 | EFEMP2 | 0.941 |
| FBLN1 | VTN | 0.938 |
| FBLN2 | MFAP4 | 0.937 |
| MFAP5 | FBLN5 | 0.935 |
| EFEMP1 | FBLN1 | 0.935 |
| MFAP2 | VTN | 0.933 |
| EFEMP1 | MFAP2 | 0.933 |
| FBLN2 | VTN | 0.932 |
| MFAP4 | MFAP5 | 0.931 |
| EFEMP1 | VTN | 0.931 |
| FBLN5 | VTN | 0.931 |
| MFAP5 | MFAP3 | 0.927 |
| FBLN5 | FBLN1 | 0.925 |
| FBLN2 | FBLN1 | 0.925 |
| FBLN2 | FBLN5 | 0.924 |
| FBLN2 | EFEMP2 | 0.924 |
| MFAP2 | MFAP5 | 0.922 |
| FBLN2 | EFEMP1 | 0.922 |
| EFEMP2 | VTN | 0.921 |
| FBLN1 | EFEMP2 | 0.92 |
| MFAP5 | MFAP1 | 0.919 |
| FBLN2 | MFAP1 | 0.918 |
| MFAP4 | EFEMP2 | 0.917 |
| FBLN1 | MFAP1 | 0.914 |
| EFEMP1 | FBLN5 | 0.913 |
| MFAP4 | EFEMP1 | 0.912 |
| EFEMP1 | EFEMP2 | 0.911 |
| EFEMP1 | MFAP5 | 0.911 |
| MFAP5 | VTN | 0.908 |
| FBLN5 | MFAP1 | 0.908 |
| FBLN2 | MFAP3 | 0.9 |
| EFEMP2 | MFAP1 | 0.9 |
| FBLN5 | MFAP3 | 0.9 |
| MFAP3 | EFEMP2 | 0.9 |
| EFEMP1 | MFAP1 | 0.9 |
| FBLN1 | MFAP3 | 0.9 |
| EFEMP1 | MFAP3 | 0.9 |
| # | 4237 (MFAP2) | 8076 (MFAP5) | 4239 (MFAP4) | 2199 (FBLN2) | 10516 (FBLN5) | 2192 (FBLN1) | 2202 (EFEMP1) | 30008 (EFEMP2) | 4236 (MFAP1) | 7448 (VTN) |
|---|---|---|---|---|---|---|---|---|---|---|
| 4237 (MFAP2) | 1.00 | 1.00 | 1.00 | 1.00 | 0.71 | 1.00 | 1.00 | 1.00 | 0.26 | 1.00 |
| 8076 (MFAP5) | 1.00 | 1.00 | 1.00 | 1.00 | 0.71 | 1.00 | 1.00 | 1.00 | 0.26 | 1.00 |
| 4239 (MFAP4) | 1.00 | 1.00 | 1.00 | 0.78 | 0.76 | 0.76 | 0.78 | 1.00 | 0.66 | 0.90 |
| 2199 (FBLN2) | 1.00 | 1.00 | 0.78 | 1.00 | 0.63 | 0.61 | 0.62 | 0.78 | 0.40 | 0.70 |
| 10516 (FBLN5) | 0.71 | 0.71 | 0.76 | 0.63 | 1.00 | 0.73 | 0.67 | 0.76 | 0.64 | 0.86 |
| 2192 (FBLN1) | 1.00 | 1.00 | 0.76 | 0.61 | 0.73 | 1.00 | 0.67 | 0.76 | 0.61 | 0.75 |
| 2202 (EFEMP1) | 1.00 | 1.00 | 0.78 | 0.62 | 0.67 | 0.67 | 1.00 | 0.78 | 0.55 | 0.74 |
| 30008 (EFEMP2) | 1.00 | 1.00 | 1.00 | 0.78 | 0.76 | 0.76 | 0.78 | 1.00 | 0.66 | 0.90 |
| 4236 (MFAP1) | 0.26 | 0.26 | 0.66 | 0.40 | 0.64 | 0.61 | 0.55 | 0.66 | 1.00 | 0.63 |
| 7448 (VTN) | 1.00 | 1.00 | 0.90 | 0.70 | 0.86 | 0.75 | 0.74 | 0.90 | 0.63 | 1.00 |
| Protein Official symbol | Source Organism | Tissue of Expression | Level of hypoxia | Altitude | Duration of experiment | Level of expression | Fold change | Experiment details | geographical location | ethnicity of the patients | Control group | Control (Fold change) | Reference (PMID) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FBLN2 | Human | Blood | - | 3650 m | 48 hours | downregulated | 0.613 | Microarray | Himalayas | Indians | 1 | HAPE Pateints Vs Normal | http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf |
| TF | TF Entrez | Gene | Gene Entrez | Type | PMID | Database |
|---|
| miRTarBase ID | miRNA | Species (miRNA) | Protein Official Symbol | Human Entrez ID | Species (Target Gene) | Experiments | Support Type | References (PMID) |
|---|---|---|---|---|---|---|---|---|
| MIRT002753 | hsa-miR-1-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| MIRT018315 | hsa-miR-335-5p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | Microarray | Functional MTI (Weak) | 18185580 |
| MIRT527267 | hsa-miR-4775 | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527268 | hsa-miR-32-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527272 | hsa-miR-548ap-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527276 | hsa-miR-548aq-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527281 | hsa-miR-548z | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527273 | hsa-miR-548aa | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527275 | hsa-miR-548j-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527280 | hsa-miR-548ae-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527278 | hsa-miR-548aj-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527269 | hsa-miR-548at-5p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527274 | hsa-miR-548x-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527277 | hsa-miR-548am-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527266 | hsa-miR-520d-5p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527270 | hsa-miR-497-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527271 | hsa-miR-548t-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527279 | hsa-miR-548ah-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527285 | hsa-miR-548ac | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527265 | hsa-miR-524-5p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527283 | hsa-miR-548d-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527284 | hsa-miR-548bb-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| MIRT527282 | hsa-miR-548h-3p | Homo sapiens | FBLN2 | 2199 | Homo sapiens | PAR-CLIP | Functional MTI (Weak) | 22012620 |
| ID | GO ID | GO Term | GO Type |
|---|---|---|---|
| 2199 | GO:0005201 | structural constituent of cytoskeleton | GOTERM_MF_DIRECT |
| 2199 | GO:1903561 | extracellular vesicle | GOTERM_CC_DIRECT |
| 2199 | GO:0010811 | positive regulation of cell-substrate adhesion | GOTERM_BP_DIRECT |
| 2199 | GO:0005578 | proteinaceous extracellular matrix | GOTERM_CC_DIRECT |
| 2199 | GO:0005509 | calcium ion binding | GOTERM_MF_DIRECT |
| 2199 | GO:0031012 | extracellular matrix | GOTERM_CC_DIRECT |
| 2199 | GO:0050840 | cell adhesion molecule binding | GOTERM_MF_DIRECT |
| 2199 | GO:0005576 | extracellular region | GOTERM_CC_DIRECT |
| 2199 | GO:0070062 | extracellular exosome | GOTERM_CC_DIRECT |
| Human Entrez ID | KEGG ID | KEGG Term |
|---|
| Protein Official Symbol | Human Entrez ID | Disease Name | Disease Id | Disease Semantic Type | Semantic score | DSI | DPI | Disease Type |
|---|---|---|---|---|---|---|---|---|
| FBLN2 | 2199 | Colorectal Neoplasms | C0009404 | Neoplastic Process | 0.3 | 0.735 | 0.448 | group |
| FBLN2 | 2199 | Colorectal Carcinoma | C0009402 | Neoplastic Process | 0.3 | 0.735 | 0.448 | disease |
| FBLN2 | 2199 | Weight Gain | C0043094 | Finding | 0.3 | 0.735 | 0.448 | phenotype |
| FBLN2 | 2199 | Colorectal Cancer | C1527249 | Neoplastic Process | 0.3 | 0.735 | 0.448 | disease |
| Protein Official Symbol | Human Entrez ID | drug_claim_primary_name | drug_name | drug_chembl_id | interaction_types |
|---|