Microfibril-associated glycoprotein 4

AltitudeomicsDB
Protein Official symbol MFAP4
Aliases MFAP4
Chromosomal Location :17
Length 255
Uniprot ID P55083
EC number None
Protein family Information(Pfam) PF00147;
PDB id None
InterPro ID IPR036056;IPR002181;
dbSNP rs17855749

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MFAP2 FBLN5 0.96
MFAP2 EFEMP2 0.956
MFAP5 FBLN1 0.956
MFAP2 FBLN1 0.956
MFAP4 FBLN5 0.955
MFAP4 MFAP2 0.955
FBLN2 MFAP2 0.953
FBLN2 MFAP5 0.948
MFAP5 EFEMP2 0.946
MFAP4 FBLN1 0.942
FBLN2 MFAP4 0.936
MFAP5 FBLN5 0.935
EFEMP1 MFAP2 0.933
MFAP4 MFAP5 0.931
EFEMP1 FBLN1 0.929
FBLN2 FBLN1 0.925
FBLN5 FBLN1 0.925
FBLN2 FBLN5 0.924
FBLN2 EFEMP2 0.924
FBLN2 EFEMP1 0.922
MFAP2 MFAP5 0.922
FBLN1 EFEMP2 0.92
MFAP4 EFEMP2 0.915
EFEMP1 FBLN5 0.913
FBLN5 EFEMP2 0.913
EFEMP1 EFEMP2 0.911
EFEMP1 MFAP5 0.911
MFAP4 EFEMP1 0.91
Gene Ontology Semantic Similarity
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# 10516 (FBLN5) 30008 (EFEMP2) 2192 (FBLN1) 4237 (MFAP2) 8076 (MFAP5) 4239 (MFAP4) 2202 (EFEMP1) 2199 (FBLN2)
10516 (FBLN5) 1.00 0.76 0.73 0.71 0.71 0.76 0.67 0.63
30008 (EFEMP2) 0.76 1.00 0.76 1.00 1.00 1.00 0.78 0.78
2192 (FBLN1) 0.73 0.76 1.00 1.00 1.00 0.76 0.67 0.61
4237 (MFAP2) 0.71 1.00 1.00 1.00 1.00 1.00 1.00 1.00
8076 (MFAP5) 0.71 1.00 1.00 1.00 1.00 1.00 1.00 1.00
4239 (MFAP4) 0.76 1.00 0.76 1.00 1.00 1.00 0.78 0.78
2202 (EFEMP1) 0.67 0.78 0.67 1.00 1.00 0.78 1.00 0.62
2199 (FBLN2) 0.63 0.78 0.61 1.00 1.00 0.78 0.62 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MFAP4 Toad Brain - 3464 m 33 day downregulated -3.283941787 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT022137 hsa-miR-124-3p Homo sapiens MFAP4 4239 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT734959 hsa-miR-449a Homo sapiens MFAP4 4239 Homo sapiens Luciferase reporter assay Functional MTI 25760387
Gene Ontology
ID GO ID GO Term GO Type
4239 GO:0071953 elastic fiber GOTERM_CC_DIRECT
4239 GO:0071493 cellular response to UV-B GOTERM_BP_DIRECT
4239 GO:0001527 microfibril GOTERM_CC_DIRECT
4239 GO:0048251 elastic fiber assembly GOTERM_BP_DIRECT
4239 GO:0031012 extracellular matrix GOTERM_CC_DIRECT
4239 GO:0043206 extracellular fibril organization GOTERM_BP_DIRECT
4239 GO:0005576 extracellular region GOTERM_CC_DIRECT
4239 GO:0010712 regulation of collagen metabolic process GOTERM_BP_DIRECT
4239 GO:0009650 UV protection GOTERM_BP_DIRECT
4239 GO:0005515 protein binding GOTERM_MF_DIRECT
4239 GO:0007155 cell adhesion GOTERM_BP_DIRECT
4239 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MFAP4 4239 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.773 0.241 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types