Glutathione peroxidase 1

AltitudeomicsDB
Protein Official symbol GPX1
Aliases GPX1
Chromosomal Location  3
Length 203
Uniprot ID P07203
EC number 1.11.1.9
Protein family Information(Pfam) PF00255;
PDB id 2F8A;
InterPro ID IPR000889;IPR029759;IPR029760;IPR036249;
dbSNP rs8179169 rs6446261 rs1050450

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SOD2 CAT 0.996
SOD2 SOD1 0.996
SOD1 CAT 0.994
SOD2 SOD3 0.993
SOD2 GPX1 0.988
SOD3 CAT 0.988
GPX1 GSR 0.987
GPX1 SOD1 0.986
GSR GSS 0.985
CAT GSR 0.977
GPX1 SOD3 0.973
GPX1 GSS 0.954
GPX1 ALOX5 0.919
SOD2 GSR 0.916
GPX1 CAT 0.915
SOD3 SOD1 0.914
Gene Ontology Semantic Similarity
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# 6648 (SOD2) 6647 (SOD1) 6649 (SOD3) 2876 (GPX1) 2936 (GSR) 847 (CAT) 2937 (GSS) 240 (ALOX5)
6648 (SOD2) 1.00 0.75 0.79 0.44 0.31 0.56 0.63 0.66
6647 (SOD1) 0.75 1.00 0.88 0.43 0.27 0.62 0.65 0.66
6649 (SOD3) 0.79 0.88 1.00 0.43 0.29 0.52 0.55 0.68
2876 (GPX1) 0.44 0.43 0.43 1.00 0.28 0.53 0.37 0.44
2936 (GSR) 0.31 0.27 0.29 0.28 1.00 0.41 0.31 0.27
847 (CAT) 0.56 0.62 0.52 0.53 0.41 1.00 0.58 0.52
2937 (GSS) 0.63 0.65 0.55 0.37 0.31 0.58 1.00 0.55
240 (ALOX5) 0.66 0.66 0.68 0.44 0.27 0.52 0.55 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GPX1 Bird Cardiac muscle - 4000 m Native downregulated -4.83 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TFAP2C 7022 GPX1 2876 proximal_filtered 22955619 TRANSFAC
ZNF263 10127 GPX1 2876 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT040633 hsa-miR-92b-3p Homo sapiens GPX1 2876 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT486917 hsa-miR-4537 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT486919 hsa-miR-634 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT486919 hsa-miR-634 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT486916 hsa-miR-505-5p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT486916 hsa-miR-505-5p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT486917 hsa-miR-4537 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT486918 hsa-miR-1226-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT486918 hsa-miR-1226-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT512626 hsa-miR-4674 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512627 hsa-miR-3147 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512630 hsa-miR-4733-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512625 hsa-miR-1587 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512626 hsa-miR-4674 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512628 hsa-miR-4437 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512624 hsa-miR-3620-5p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512628 hsa-miR-4437 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512631 hsa-miR-1911-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512627 hsa-miR-3147 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT512625 hsa-miR-1587 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512629 hsa-miR-4259 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512630 hsa-miR-4733-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512631 hsa-miR-1911-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512624 hsa-miR-3620-5p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT512629 hsa-miR-4259 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT568883 hsa-miR-4670-3p Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT568884 hsa-miR-8060 Homo sapiens GPX1 2876 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
Gene Ontology
ID GO ID GO Term GO Type
2876 GO:0033599 regulation of mammary gland epithelial cell proliferation GOTERM_BP_DIRECT
2876 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GOTERM_BP_DIRECT
2876 GO:0009650 UV protection GOTERM_BP_DIRECT
2876 GO:0033194 response to hydroperoxide GOTERM_BP_DIRECT
2876 GO:0005829 cytosol GOTERM_CC_DIRECT
2876 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GOTERM_BP_DIRECT
2876 GO:0043523 regulation of neuron apoptotic process GOTERM_BP_DIRECT
2876 GO:0000302 response to reactive oxygen species GOTERM_BP_DIRECT
2876 GO:0001659 temperature homeostasis GOTERM_BP_DIRECT
2876 GO:0042311 vasodilation GOTERM_BP_DIRECT
2876 GO:0060055 angiogenesis involved in wound healing GOTERM_BP_DIRECT
2876 GO:0001885 endothelial cell development GOTERM_BP_DIRECT
2876 GO:0006195 purine nucleotide catabolic process GOTERM_BP_DIRECT
2876 GO:0017124 SH3 domain binding GOTERM_MF_DIRECT
2876 GO:0019372 lipoxygenase pathway GOTERM_BP_DIRECT
2876 GO:0061136 regulation of proteasomal protein catabolic process GOTERM_BP_DIRECT
2876 GO:0006641 triglyceride metabolic process GOTERM_BP_DIRECT
2876 GO:0018158 protein oxidation GOTERM_BP_DIRECT
2876 GO:0043403 skeletal muscle tissue regeneration GOTERM_BP_DIRECT
2876 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2876 GO:0043534 blood vessel endothelial cell migration GOTERM_BP_DIRECT
2876 GO:0090201 negative regulation of release of cytochrome c from mitochondria GOTERM_BP_DIRECT
2876 GO:0009410 response to xenobiotic stimulus GOTERM_BP_DIRECT
2876 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
2876 GO:1902905 positive regulation of fibril organization GOTERM_BP_DIRECT
2876 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
2876 GO:0006749 glutathione metabolic process GOTERM_BP_DIRECT
2876 GO:0034599 cellular response to oxidative stress GOTERM_BP_DIRECT
2876 GO:0005737 cytoplasm GOTERM_CC_DIRECT
2876 GO:0007605 sensory perception of sound GOTERM_BP_DIRECT
2876 GO:0040029 regulation of gene expression GOTERM_BP_DIRECT
2876 GO:0042744 hydrogen peroxide catabolic process GOTERM_BP_DIRECT
2876 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
2876 GO:0048741 skeletal muscle fiber development GOTERM_BP_DIRECT
2876 GO:0002862 negative regulation of inflammatory response to antigenic stimulus GOTERM_BP_DIRECT
2876 GO:0042542 response to hydrogen peroxide GOTERM_BP_DIRECT
2876 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GOTERM_BP_DIRECT
2876 GO:0010332 response to gamma radiation GOTERM_BP_DIRECT
2876 GO:0045444 fat cell differentiation GOTERM_BP_DIRECT
2876 GO:0051450 myoblast proliferation GOTERM_BP_DIRECT
2876 GO:0051897 positive regulation of protein kinase B signaling GOTERM_BP_DIRECT
2876 GO:0004602 glutathione peroxidase activity GOTERM_MF_DIRECT
2876 GO:0009609 response to symbiotic bacterium GOTERM_BP_DIRECT
2876 GO:0051702 interaction with symbiont GOTERM_BP_DIRECT
2876 GO:0005739 mitochondrion GOTERM_CC_DIRECT
2876 GO:0006979 response to oxidative stress GOTERM_BP_DIRECT
2876 GO:0060047 heart contraction GOTERM_BP_DIRECT
2876 GO:0098869 cellular oxidant detoxification GOTERM_BP_DIRECT
2876 GO:0097413 Lewy body GOTERM_CC_DIRECT
2876 GO:0010269 response to selenium ion GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2876 hsa00480 Glutathione metabolism
2876 hsa00590 Arachidonic acid metabolism
2876 hsa04918 Thyroid hormone synthesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GPX1 2876 Brain Ischemia C0007786 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Osteoporosis C0029456 Disease or Syndrome 0.31 0.498 0.759 disease
GPX1 2876 Cryptogenic Chronic Hepatitis C0524611 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Carcinoma, Transitional Cell C0007138 Neoplastic Process 0.3 0.498 0.759 disease
GPX1 2876 Hyperthyroidism C0020550 Disease or Syndrome 0.5 0.498 0.759 disease
GPX1 2876 Cerebral Ischemia C0917798 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.498 0.759 disease
GPX1 2876 Osteoporosis, Age-Related C0001787 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Bladder Neoplasm C0005695 Neoplastic Process 0.39 0.498 0.759 group
GPX1 2876 Hepatitis, Chronic C0019189 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Parkinson Disease C0030567 Disease or Syndrome 0.32 0.498 0.759 disease
GPX1 2876 Awakening Epilepsy C0751111 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.498 0.759 group
GPX1 2876 Hypertensive disease C0020538 Disease or Syndrome 0.5 0.498 0.759 group
GPX1 2876 Osteoporosis, Senile C0029459 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Malignant Head and Neck Neoplasm C0278996 Neoplastic Process 0.31 0.498 0.759 disease
GPX1 2876 Cardiomyopathy, Familial Idiopathic C1449563 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Primary Hyperthyroidism C3714618 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Cardiovascular Diseases C0007222 Disease or Syndrome 0.34 0.498 0.759 group
GPX1 2876 Obesity C0028754 Disease or Syndrome 0.31 0.498 0.759 disease
GPX1 2876 Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due to C3501647 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Malignant neoplasm of breast C0006142 Neoplastic Process 0.39 0.498 0.759 disease
GPX1 2876 Squamous cell carcinoma C0007137 Neoplastic Process 0.34 0.498 0.759 disease
GPX1 2876 Diabetes Mellitus, Non-Insulin-Dependent C0011860 Disease or Syndrome 0.36 0.498 0.759 disease
GPX1 2876 Reperfusion Injury C0035126 Injury or Poisoning 0.3 0.498 0.759 disease
GPX1 2876 Aura C0236018 Finding 0.3 0.498 0.759 phenotype
GPX1 2876 Breast Carcinoma C0678222 Neoplastic Process 0.4 0.498 0.759 disease
GPX1 2876 Mammary Neoplasms C1458155 Neoplastic Process 0.34 0.498 0.759 group
GPX1 2876 Autistic Disorder C0004352 Mental or Behavioral Dysfunction 0.31 0.498 0.759 group
GPX1 2876 Endogenous Hyperinsulinism C1257963 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Hyperglycemia, Postprandial C1855520 Finding 0.3 0.498 0.759 phenotype
GPX1 2876 Malignant neoplasm of urinary bladder C0005684 Neoplastic Process 0.37 0.498 0.759 disease
GPX1 2876 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.498 0.759 disease
GPX1 2876 Hyperinsulinism C0020459 Disease or Syndrome 0.31 0.498 0.759 disease
GPX1 2876 Chronic active hepatitis C0520463 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Cancer of Head C0751177 Neoplastic Process 0.3 0.498 0.759 disease
GPX1 2876 Exogenous Hyperinsulinism C1257964 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Lung Neoplasms C0024121 Neoplastic Process 0.35 0.498 0.759 group
GPX1 2876 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.498 0.759 disease
GPX1 2876 Cardiomyopathy, Dilated C0007193 Disease or Syndrome 0.33 0.498 0.759 group
GPX1 2876 Epilepsy C0014544 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Fatty Liver C0015695 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Hyperglycemia C0020456 Disease or Syndrome 0.31 0.498 0.759 disease
GPX1 2876 Neck Neoplasms C0027533 Neoplastic Process 0.3 0.498 0.759 group
GPX1 2876 Epilepsy, Cryptogenic C0086237 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Chronic Persistent Hepatitis C0149519 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Cancer of Neck C0746787 Neoplastic Process 0.3 0.498 0.759 disease
GPX1 2876 Post-Traumatic Osteoporosis C0751406 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Upper Aerodigestive Tract Neoplasms C0887900 Neoplastic Process 0.3 0.498 0.759 group
GPX1 2876 Head Neoplasms C0018675 Neoplastic Process 0.3 0.498 0.759 group
GPX1 2876 Malignant neoplasm of lung C0242379 Neoplastic Process 0.38 0.498 0.759 disease
GPX1 2876 Head and Neck Neoplasms C0018671 Neoplastic Process 0.3 0.498 0.759 group
GPX1 2876 Compensatory Hyperinsulinemia C1257965 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Steatohepatitis C2711227 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Congenital anemia C0158995 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Cytopenia C0010828 Pathologic Function 0.3 0.498 0.759 phenotype
GPX1 2876 Familial Ménière disease C4302111 Disease or Syndrome 0.3 0.498 0.759 disease
GPX1 2876 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.31 0.498 0.759 disease
GPX1 2876 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.04 0.498 0.759 disease
GPX1 2876 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.31 0.498 0.759 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
GPX1 2876 GP-120 None None None