Superoxide dismutase

AltitudeomicsDB
Protein Official symbol SOD1
Aliases SOD1
Chromosomal Location 21
Length 154
Uniprot ID P00441
EC number 1.15.1.1
Protein family Information(Pfam) PF00080;
PDB id 1AZV;1BA9;1DSW;1FUN;1HL4;1HL5;1KMG;1L3N;1MFM;1N18;1N19;1OEZ;1OZT;1OZU;1P1V;1PTZ;1PU0;1RK7;1SOS;1SPD;1UXL;1UXM;2AF2;2C9S;2C9U;2C9V;2GBT;2GBU;2GBV;2LU5;2MP3;2NAM;2NNX;2R27;2V0A;2VR6;2VR7;2VR8;2WKO;2WYT;2WYZ;2WZ0;2WZ5;2WZ6;2XJK;2XJL;2ZKW;2ZKX;2ZKY;3CQP;3CQQ;3ECU;3ECV;3ECW;3GQF;3GTV;3GZO;3GZP;3GZQ;3H2P;3H2Q;3HFF;3K91;3KH3;3KH4;3LTV;3QQD;3RE0;3T5W;4A7G;4A7Q;4A7S;4A7T;4A7U;4A7V;4B3E;4BCY;4BCZ;4BD4;4FF9;4MCM;4MCN;4NIN;4NIO;4NIP;4OH2;4SOD;4XCR;5DLI;5IIW;5J07;5J0C;5J0F;5J0G;5K02;5O3Y;5O40;5U9M;5WMJ;5WOR;5YTO;5YTU;5YUL;6A9O;6B79;6DTK;6FFK;6FLH;6FOI;6FOL;6FON;6FP6;6SPA;6SPH;6SPI;6SPJ;6SPK;
InterPro ID IPR036423;IPR024134;IPR018152;IPR001424;
dbSNP rs121912444 rs121912442 rs121912448 rs121912456 rs121912453 rs121912450 rs1169198442 rs121912431 rs121912432 rs121912434 rs121912433 rs121912435 rs121912457 rs121912443 rs986277034 rs121912455 rs1315541036 rs121912452 rs121912436 rs11556620 rs1339283341 rs1280042397 rs80265967 rs121912438 rs121912437 rs121912438 rs121912437 rs121912439 rs121912445 rs1378590183 rs121912440 rs74315452 rs121912441 rs1301635320 rs1235629842 rs121912451 rs1804449 rs1482760341 rs121912446 rs121912447 rs1476760624 rs567511139 rs1424014997 rs121912449

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SOD2 CAT 0.998
SOD2 SOD1 0.998
SOD1 CAT 0.996
SOD2 SOD3 0.995
TXN PRDX1 0.9940000000000001
TXN SOD1 0.993
TXN PRDX2 0.99
CCS SOD1 0.9890000000000001
SOD3 CAT 0.9890000000000001
SOD2 GPX1 0.988
GPX1 SOD1 0.986
SOD1 PRDX1 0.981
SOD2 GPX7 0.977
GPX7 SOD1 0.976
SOD2 GPX3 0.9740000000000001
GPX1 SOD3 0.973
SOD2 GPX2 0.973
GPX3 SOD1 0.973
AKT1 SOD2 0.973
GPX8 SOD1 0.973
AKT1 CAT 0.971
SOD2 GPX8 0.971
GPX5 SOD1 0.97
GPX3 SOD3 0.9690000000000001
PRDX1 CAT 0.968
SOD2 GPX5 0.9670000000000001
GPX6 SOD1 0.966
GPX2 SOD1 0.965
AKT1 SOD1 0.963
GPX2 SOD3 0.963
SOD3 GPX7 0.9620000000000001
SOD2 GPX6 0.961
GPX5 SOD3 0.96
GPX8 SOD3 0.9570000000000001
PRDX2 SOD1 0.956
SOD3 GPX6 0.955
TXN CAT 0.9440000000000001
PARK7 PRDX2 0.943
ATP5H SOD1 0.943
AKT1 SOD3 0.9420000000000001
SOD2 GPX4 0.94
PARK7 SOD1 0.9359999999999999
MDH1 SOD1 0.929
GPX1 CAT 0.9229999999999999
PRDX2 CAT 0.9229999999999999
GPX4 SOD1 0.917
SOD3 SOD1 0.914
SOD2 STAT4 0.909
NEFL SOD1 0.9079999999999999
PPP3CA SOD1 0.9079999999999999
STAT4 SOD1 0.903
Gene Ontology Semantic Similarity
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# 6647 (SOD1) 7295 (TXN) 9973 (CCS) 6649 (SOD3) 2876 (GPX1) 2882 (GPX7) 2878 (GPX3) 207 (AKT1) 493869 (GPX8) 2880 (GPX5) 5052 (PRDX1) 2877 (GPX2) 7001 (PRDX2) 11315 (PARK7) 10476 (ATP5H) 4190 (MDH1) 2879 (GPX4) 4747 (NEFL) 5530 (PPP3CA) 6775 (STAT4) 847 (CAT)
6647 (SOD1) 1.00 0.55 0.84 0.88 0.43 0.60 0.61 0.56 0.59 0.52 0.59 0.28 0.59 0.72 0.17 0.55 0.64 0.60 0.62 0.58 0.62
7295 (TXN) 0.55 1.00 0.47 0.49 0.45 0.54 0.66 0.47 0.19 0.17 0.72 0.26 0.57 0.55 0.18 0.53 0.59 0.65 0.58 0.61 0.55
9973 (CCS) 0.84 0.47 1.00 0.92 0.42 0.56 0.58 0.46 0.59 0.52 0.61 0.31 0.54 0.70 0.17 0.50 0.57 0.52 0.57 0.47 0.52
6649 (SOD3) 0.88 0.49 0.92 1.00 0.43 0.57 0.59 0.46 0.59 0.52 0.56 0.32 0.55 0.69 0.18 0.49 0.57 0.53 0.59 0.48 0.52
2876 (GPX1) 0.43 0.45 0.42 0.43 1.00 0.79 0.72 0.34 0.89 1.00 0.66 0.62 0.66 0.39 0.15 0.47 0.75 0.44 0.40 0.41 0.53
2882 (GPX7) 0.60 0.54 0.56 0.57 0.79 1.00 0.85 0.46 1.00 0.89 0.85 0.65 0.81 0.56 0.19 0.57 0.86 0.57 0.54 0.52 0.72
2878 (GPX3) 0.61 0.66 0.58 0.59 0.72 0.85 1.00 0.49 0.89 1.00 0.77 0.55 0.76 0.58 0.20 0.62 0.85 0.64 0.59 0.61 0.64
207 (AKT1) 0.56 0.47 0.46 0.46 0.34 0.46 0.49 1.00 0.27 0.23 0.47 0.23 0.46 0.58 0.17 0.45 0.51 0.54 0.51 0.49 0.55
493869 (GPX8) 0.59 0.19 0.59 0.59 0.89 1.00 0.89 0.27 1.00 0.89 1.00 0.89 0.82 0.76 0.19 0.38 0.89 0.19 0.19 0.19 0.89
2880 (GPX5) 0.52 0.17 0.52 0.52 1.00 0.89 1.00 0.23 0.89 1.00 0.89 1.00 0.72 0.67 0.17 0.33 1.00 0.17 0.17 0.17 0.78
5052 (PRDX1) 0.59 0.72 0.61 0.56 0.66 0.85 0.77 0.47 1.00 0.89 1.00 0.52 0.80 0.60 0.19 0.56 0.78 0.56 0.54 0.52 0.69
2877 (GPX2) 0.28 0.26 0.31 0.32 0.62 0.65 0.55 0.23 0.89 1.00 0.52 1.00 0.54 0.26 0.22 0.33 0.59 0.28 0.25 0.29 0.41
7001 (PRDX2) 0.59 0.57 0.54 0.55 0.66 0.81 0.76 0.46 0.82 0.72 0.80 0.54 1.00 0.54 0.22 0.54 0.75 0.61 0.55 0.56 0.71
11315 (PARK7) 0.72 0.55 0.70 0.69 0.39 0.56 0.58 0.58 0.76 0.67 0.60 0.26 0.54 1.00 0.19 0.53 0.59 0.56 0.62 0.53 0.62
10476 (ATP5H) 0.17 0.18 0.17 0.18 0.15 0.19 0.20 0.17 0.19 0.17 0.19 0.22 0.22 0.19 1.00 0.18 0.19 0.20 0.20 0.20 0.21
4190 (MDH1) 0.55 0.53 0.50 0.49 0.47 0.57 0.62 0.45 0.38 0.33 0.56 0.33 0.54 0.53 0.18 1.00 0.61 0.57 0.53 0.51 0.55
2879 (GPX4) 0.64 0.59 0.57 0.57 0.75 0.86 0.85 0.51 0.89 1.00 0.78 0.59 0.75 0.59 0.19 0.61 1.00 0.64 0.56 0.60 0.73
4747 (NEFL) 0.60 0.65 0.52 0.53 0.44 0.57 0.64 0.54 0.19 0.17 0.56 0.28 0.61 0.56 0.20 0.57 0.64 1.00 0.59 0.65 0.56
5530 (PPP3CA) 0.62 0.58 0.57 0.59 0.40 0.54 0.59 0.51 0.19 0.17 0.54 0.25 0.55 0.62 0.20 0.53 0.56 0.59 1.00 0.56 0.53
6775 (STAT4) 0.58 0.61 0.47 0.48 0.41 0.52 0.61 0.49 0.19 0.17 0.52 0.29 0.56 0.53 0.20 0.51 0.60 0.65 0.56 1.00 0.55
847 (CAT) 0.62 0.55 0.52 0.52 0.53 0.72 0.64 0.55 0.89 0.78 0.69 0.41 0.71 0.62 0.21 0.55 0.73 0.56 0.53 0.55 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SOD1 Human Skeletal muscle - 4559 m 9 day downregulated -1.53 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
SOD1 Rat Kidney - 7628 m 7 day downregulated -4.2 2-DE Northern indo-australian plate Male sprague-dawley 1 Male SD rats weighing 250-260g 30005088
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
GTF2B 2959 SOD1 6647 proximal_filtered 22955619 TRANSFAC
CEBPD 1052 SOD1 6647 Unknown 10542237 TRUSST
SP1 6667 SOD1 6647 Activation 19059241 TRUSST
KLF4 9314 SOD1 6647 Activation 24242046 TRUSST
MTF1 4520 SOD1 6647 Unknown 17724465 TRUSST
NFE2L2 4780 SOD1 6647 Activation 18625220 TRUSST
PPARD 5467 SOD1 6647 Repression 14708613 TRUSST
EGR1 1958 SOD1 6647 Activation 24242046 TRUSST
MSX2 4488 SOD1 6647 Unknown 19458633 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000992 hsa-miR-377-3p Homo sapiens SOD1 6647 Homo sapiens Luciferase reporter assay// Non-Functional MTI 21203553
MIRT000992 hsa-miR-377-3p Homo sapiens SOD1 6647 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 18716028
MIRT043913 hsa-miR-378a-3p Homo sapiens SOD1 6647 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048056 hsa-miR-197-3p Homo sapiens SOD1 6647 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT735173 hsa-miR-206 Homo sapiens SOD1 6647 Homo sapiens Immunohistochemistry//Luciferase reporter assay//Western blot Functional MTI 25816284
Gene Ontology
ID GO ID GO Term GO Type
6647 GO:0000187 activation of MAPK activity GOTERM_BP_DIRECT
6647 GO:0001890 placenta development GOTERM_BP_DIRECT
6647 GO:0006879 cellular iron ion homeostasis GOTERM_BP_DIRECT
6647 GO:0007568 aging GOTERM_BP_DIRECT
6647 GO:0008089 anterograde axonal transport GOTERM_BP_DIRECT
6647 GO:0008090 retrograde axonal transport GOTERM_BP_DIRECT
6647 GO:0019226 transmission of nerve impulse GOTERM_BP_DIRECT
6647 GO:0032930 positive regulation of superoxide anion generation GOTERM_BP_DIRECT
6647 GO:0001541 ovarian follicle development GOTERM_BP_DIRECT
6647 GO:0001975 response to amphetamine GOTERM_BP_DIRECT
6647 GO:0006801 superoxide metabolic process GOTERM_BP_DIRECT
6647 GO:0007566 embryo implantation GOTERM_BP_DIRECT
6647 GO:0007626 locomotory behavior GOTERM_BP_DIRECT
6647 GO:0019430 removal of superoxide radicals GOTERM_BP_DIRECT
6647 GO:0033081 regulation of T cell differentiation in thymus GOTERM_BP_DIRECT
6647 GO:0042542 response to hydrogen peroxide GOTERM_BP_DIRECT
6647 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
6647 GO:0001819 positive regulation of cytokine production GOTERM_BP_DIRECT
6647 GO:0001895 retina homeostasis GOTERM_BP_DIRECT
6647 GO:0002262 myeloid cell homeostasis GOTERM_BP_DIRECT
6647 GO:0002576 platelet degranulation GOTERM_BP_DIRECT
6647 GO:0007283 spermatogenesis GOTERM_BP_DIRECT
6647 GO:0007569 cell aging GOTERM_BP_DIRECT
6647 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
6647 GO:0009408 response to heat GOTERM_BP_DIRECT
6647 GO:0010033 response to organic substance GOTERM_BP_DIRECT
6647 GO:0031667 response to nutrient levels GOTERM_BP_DIRECT
6647 GO:0032287 peripheral nervous system myelin maintenance GOTERM_BP_DIRECT
6647 GO:0034465 response to carbon monoxide GOTERM_BP_DIRECT
6647 GO:0042493 response to drug GOTERM_BP_DIRECT
6647 GO:0043087 regulation of GTPase activity GOTERM_BP_DIRECT
6647 GO:0045471 response to ethanol GOTERM_BP_DIRECT
6647 GO:0000302 response to reactive oxygen species GOTERM_BP_DIRECT
6647 GO:0000303 response to superoxide GOTERM_BP_DIRECT
6647 GO:0006749 glutathione metabolic process GOTERM_BP_DIRECT
6647 GO:0007605 sensory perception of sound GOTERM_BP_DIRECT
6647 GO:0035865 cellular response to potassium ion GOTERM_BP_DIRECT
6647 GO:0040014 regulation of multicellular organism growth GOTERM_BP_DIRECT
6647 GO:0042554 superoxide anion generation GOTERM_BP_DIRECT
6647 GO:0043085 positive regulation of catalytic activity GOTERM_BP_DIRECT
6647 GO:0043524 negative regulation of neuron apoptotic process GOTERM_BP_DIRECT
6647 GO:0046716 muscle cell cellular homeostasis GOTERM_BP_DIRECT
6647 GO:0050665 hydrogen peroxide biosynthetic process GOTERM_BP_DIRECT
6647 GO:0060087 relaxation of vascular smooth muscle GOTERM_BP_DIRECT
6647 GO:0072593 reactive oxygen species metabolic process GOTERM_BP_DIRECT
6647 GO:0097332 response to antipsychotic drug GOTERM_BP_DIRECT
6647 GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
6647 GO:0005515 protein binding GOTERM_MF_DIRECT
6647 GO:0042802 identical protein binding GOTERM_MF_DIRECT
6647 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
6647 GO:0005764 lysosome GOTERM_CC_DIRECT
6647 GO:0043234 protein complex GOTERM_CC_DIRECT
6647 GO:0045541 negative regulation of cholesterol biosynthetic process GOTERM_BP_DIRECT
6647 GO:0045859 regulation of protein kinase activity GOTERM_BP_DIRECT
6647 GO:0046677 response to antibiotic GOTERM_BP_DIRECT
6647 GO:0046688 response to copper ion GOTERM_BP_DIRECT
6647 GO:0048538 thymus development GOTERM_BP_DIRECT
6647 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
6647 GO:0005507 copper ion binding GOTERM_MF_DIRECT
6647 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
6647 GO:0030346 estrogen receptor binding GOTERM_MF_DIRECT
6647 GO:0046872 metal ion binding GOTERM_MF_DIRECT
6647 GO:0005758 mitochondrial intermembrane space GOTERM_CC_DIRECT
6647 GO:0005886 plasma membrane GOTERM_CC_DIRECT
6647 GO:0031012 extracellular matrix GOTERM_CC_DIRECT
6647 GO:0031410 cytoplasmic vesicle GOTERM_CC_DIRECT
6647 GO:0032839 dendrite cytoplasm GOTERM_CC_DIRECT
6647 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
6647 GO:0043209 myelin sheath GOTERM_CC_DIRECT
6647 GO:0051881 regulation of mitochondrial membrane potential GOTERM_BP_DIRECT
6647 GO:0060047 heart contraction GOTERM_BP_DIRECT
6647 GO:0060052 neurofilament cytoskeleton organization GOTERM_BP_DIRECT
6647 GO:0071318 cellular response to ATP GOTERM_BP_DIRECT
6647 GO:0004784 stearoyl-CoA 9-desaturase activity GOTERM_MF_DIRECT
6647 GO:0005634 nucleus GOTERM_CC_DIRECT
6647 GO:0005739 mitochondrion GOTERM_CC_DIRECT
6647 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
6647 GO:0031045 dense core granule GOTERM_CC_DIRECT
6647 GO:1904115 axon cytoplasm GOTERM_CC_DIRECT
6647 GO:0046620 regulation of organ growth GOTERM_BP_DIRECT
6647 GO:0048678 response to axon injury GOTERM_BP_DIRECT
6647 GO:0060088 auditory receptor cell stereocilium organization GOTERM_BP_DIRECT
6647 GO:0071276 cellular response to cadmium ion GOTERM_BP_DIRECT
6647 GO:0048365 Rac GTPase binding GOTERM_MF_DIRECT
6647 GO:0051087 chaperone binding GOTERM_MF_DIRECT
6647 GO:0005576 extracellular region GOTERM_CC_DIRECT
6647 GO:0005615 extracellular space GOTERM_CC_DIRECT
6647 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
6647 GO:0005737 cytoplasm GOTERM_CC_DIRECT
6647 GO:0005777 peroxisome GOTERM_CC_DIRECT
6647 GO:0005829 cytosol GOTERM_CC_DIRECT
6647 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
6647 hsa04146 Peroxisome
6647 hsa05020 Prion diseases
6647 hsa05016 Huntington's disease
6647 hsa05014 Amyotrophic lateral sclerosis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
SOD1 6647 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.406 0.931 disease
SOD1 6647 Diabetic Retinopathy C0011884 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Fetal Growth Retardation C0015934 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 Congestive heart failure C0018802 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Obesity C0028754 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Radiation Injuries, Experimental C0034531 Injury or Poisoning 0.3 0.406 0.931 group
SOD1 6647 Reperfusion Injury C0035126 Injury or Poisoning 0.31 0.406 0.931 disease
SOD1 6647 Scrapie C0036457 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.406 0.931 disease
SOD1 6647 Cerebrovascular accident C0038454 Disease or Syndrome 0.31 0.406 0.931 group
SOD1 6647 Adverse reaction to drug C0041755 Pathologic Function 0.3 0.406 0.931 group
SOD1 6647 Motor Neuron Disease C0085084 Disease or Syndrome 0.7 0.406 0.931 disease
SOD1 6647 Gait, Shuffling C0231688 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Charcot Gait C0231693 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Intravascular hemolysis C0235574 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Hypothermia, Accidental C0274285 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Marche a Petit Pas C0427169 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Chronic active hepatitis C0520463 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Cryptogenic Chronic Hepatitis C0524611 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Trisomy 21, Mitotic Nondisjunction C0751081 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Acquired Meningomyelocele C0751316 Acquired Abnormality 0.3 0.406 0.931 phenotype
SOD1 6647 Gait Disorder, Sensorimotor C0751829 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Deficiency Diseases C0011156 Disease or Syndrome 0.5 0.406 0.931 group
SOD1 6647 Diabetes Mellitus C0011849 Disease or Syndrome 0.35 0.406 0.931 group
SOD1 6647 Diabetes Mellitus, Non-Insulin-Dependent C0011860 Disease or Syndrome 0.37 0.406 0.931 disease
SOD1 6647 Down Syndrome C0013080 Disease or Syndrome 0.4 0.406 0.931 disease
SOD1 6647 Drug toxicity C0013221 Injury or Poisoning 0.3 0.406 0.931 group
SOD1 6647 Fatty Liver C0015695 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Heart failure C0018801 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Hypotension C0020649 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Hypothermia, natural C0020672 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Ischemia C0022116 Pathologic Function 0.31 0.406 0.931 phenotype
SOD1 6647 Kidney Failure, Acute C0022660 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Marfan Syndrome C0024796 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Melancholia C0025193 Mental or Behavioral Dysfunction 0.3 0.406 0.931 disease
SOD1 6647 Muscular Atrophy C0026846 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 nervous system disorder C0027765 Disease or Syndrome 0.34 0.406 0.931 group
SOD1 6647 Spinal Cord Injuries C0037929 Injury or Poisoning 0.3 0.406 0.931 group
SOD1 6647 Turner Syndrome C0041408 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Chronic Persistent Hepatitis C0149519 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Gait, Unsteady C0231686 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Spastic gait C0231687 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Hemiplegic C0231696 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Scissors C0231698 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Waddling gait C0231712 Sign or Symptom 0.3 0.406 0.931 phenotype
SOD1 6647 Gonadal Dysgenesis, 45,X C0242526 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 mixed gliomas C0259783 Neoplastic Process 0.3 0.406 0.931 disease
SOD1 6647 Extravascular Hemolysis C0312854 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Rapid Fatigue of Gait C0427128 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Drop Foot C0427149 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Hysterical C0427177 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Spinal Cord Laceration C0433900 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Spinal Cord transection injury C0433905 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Motor Neuron Disease, Upper C0521659 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Malignant Glioma C0555198 Neoplastic Process 0.3 0.406 0.931 disease
SOD1 6647 Carotid Circulation Transient Ischemic Attack C0751019 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Post-Traumatic Myelopathy C0751515 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Gait Disorders, Neurologic C0751830 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Gait, Frontal C0751831 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.406 0.931 disease
SOD1 6647 Asphyxia Neonatorum C0004045 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Atherosclerosis C0004153 Disease or Syndrome 0.35 0.406 0.931 disease
SOD1 6647 Neoplastic Cell Transformation C0007621 Neoplastic Process 0.3 0.406 0.931 phenotype
SOD1 6647 Endogenous depression C0011573 Mental or Behavioral Dysfunction 0.3 0.406 0.931 disease
SOD1 6647 Contact Dermatitis C0011616 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Fatty Liver, Alcoholic C0015696 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Glioma C0017638 Neoplastic Process 0.36 0.406 0.931 disease
SOD1 6647 Hemolysis (disorder) C0019054 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 Hepatitis, Chronic C0019189 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Hypertensive disease C0020538 Disease or Syndrome 0.55 0.406 0.931 group
SOD1 6647 Hyperthyroidism C0020550 Disease or Syndrome 0.5 0.406 0.931 disease
SOD1 6647 Kidney Calculi C0022650 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Liver diseases C0023895 Disease or Syndrome 0.3 0.406 0.931 group
SOD1 6647 Myocardial Infarction C0027051 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Necrosis C0027540 Organ or Tissue Function 0.3 0.406 0.931 phenotype
SOD1 6647 Nephrosis C0027720 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Nerve Degeneration C0027746 Cell or Molecular Dysfunction 0.43 0.406 0.931 phenotype
SOD1 6647 Protein Deficiency C0033626 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Proteinuria C0033687 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.3 0.406 0.931 disease
SOD1 6647 Hamman-Rich syndrome C0085786 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Depressive Syndrome C0086133 Mental or Behavioral Dysfunction 0.3 0.406 0.931 disease
SOD1 6647 Myelocele C0086664 Congenital Abnormality 0.3 0.406 0.931 disease
SOD1 6647 Iron deficiency anemia C0162316 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Contact hypersensitivity C0162351 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 MELAS Syndrome C0162671 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Gait, Athetotic C0231689 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Festinating C0231694 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Intestinal schistosomiasis C0242497 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Motor Neuron Disease, Lower C0270764 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Gait, Stumbling C0337210 Sign or Symptom 0.3 0.406 0.931 phenotype
SOD1 6647 Spinal Cord Contusion C0433895 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Motor Neuron Disease, Secondary C0543858 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Transient Ischemic Attack, Vertebrobasilar Circulation C0751020 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Aortic Diseases C0003493 Disease or Syndrome 0.3 0.406 0.931 group
SOD1 6647 Asthma C0004096 Disease or Syndrome 0.34 0.406 0.931 disease
SOD1 6647 Brain Ischemia C0007786 Disease or Syndrome 0.34 0.406 0.931 disease
SOD1 6647 Transient Ischemic Attack C0007787 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Inflammation C0021368 Pathologic Function 0.33 0.406 0.931 phenotype
SOD1 6647 Meningomyelocele C0025312 Congenital Abnormality 0.32 0.406 0.931 disease
SOD1 6647 Parkinson Disease C0030567 Disease or Syndrome 0.4 0.406 0.931 disease
SOD1 6647 Pulmonary Fibrosis C0034069 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Retinal Degeneration C0035304 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 Schistosomiasis mansoni C0036330 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Liver Dysfunction C0086565 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Anterior Horn Cell Disease C0154681 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Lateral Sclerosis C0154682 Disease or Syndrome 0.32 0.406 0.931 disease
SOD1 6647 Chronic progressive external ophthalmoplegia C0162674 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Cerebellar ataxic gait C0231695 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Rigid C0234996 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Gait, Broadened C0235000 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Familial Motor Neuron Disease C0270763 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Neurogenic Muscular Atrophy C0270948 Pathologic Function 0.4 0.406 0.931 phenotype
SOD1 6647 Depression, Neurotic C0282126 Mental or Behavioral Dysfunction 0.3 0.406 0.931 disease
SOD1 6647 Amyotrophic Lateral Sclerosis With Dementia C0393554 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Down Syndrome, Partial Trisomy 21 C0432416 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Trisomy 21, Meiotic Nondisjunction C0432417 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Posterior Circulation Transient Ischemic Attack C0472381 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Amyotrophic Lateral Sclerosis, Guam Form C0543859 Disease or Syndrome 0.32 0.406 0.931 disease
SOD1 6647 Crescendo Transient Ischemic Attacks C0751021 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Brain Stem Ischemia, Transient C0751022 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Gait, Widebased C0751832 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Malignant neoplasm of ovary C1140680 Neoplastic Process 0.3 0.406 0.931 disease
SOD1 6647 Weight decreased C1262477 Finding 0.3 0.406 0.931 phenotype
SOD1 6647 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Ureteral Calculi C1456865 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Acute Kidney Insufficiency C1565662 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Heart Decompensation C1961112 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 Acute kidney injury C2609414 Injury or Poisoning 0.3 0.406 0.931 disease
SOD1 6647 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Acute Cerebrovascular Accidents C0751956 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 ovarian neoplasm C0919267 Neoplastic Process 0.3 0.406 0.931 disease
SOD1 6647 hearing impairment C1384666 Disease or Syndrome 0.3 0.406 0.931 phenotype
SOD1 6647 Bonnevie-Ullrich Syndrome C1527168 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Cerebral Ischemia C0917798 Disease or Syndrome 0.34 0.406 0.931 disease
SOD1 6647 Transient Ischemic Attack, Anterior Circulation C1527335 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Steatohepatitis C2711227 Disease or Syndrome 0.31 0.406 0.931 disease
SOD1 6647 Primary Hyperthyroidism C3714618 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Transient Cerebral Ischemia C0917805 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Atherogenesis C1563937 Pathologic Function 0.3 0.406 0.931 phenotype
SOD1 6647 Alcoholic Steatohepatitis C2718067 Disease or Syndrome 0.3 0.406 0.931 disease
SOD1 6647 Amyotrophic Lateral Sclerosis C0002736 Disease or Syndrome 0.7 0.406 0.931 disease
SOD1 6647 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.6 0.406 0.931 disease
SOD1 6647 Amyotrophic Lateral Sclerosis, Sporadic C1862941 Disease or Syndrome 0.8 0.406 0.931 disease
SOD1 6647 AMYOTROPHIC LATERAL SCLEROSIS 1 C1862939 Disease or Syndrome 0.9 0.406 0.931 disease
SOD1 6647 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.02 0.406 0.931 disease
SOD1 6647 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.3 0.406 0.931 disease
SOD1 6647 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.02 0.406 0.931 disease
SOD1 6647 AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE C3542025 Disease or Syndrome 0.6 0.406 0.931 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
SOD1 6647 ISIS-SOD1 None None antisense
SOD1 6647 ISIS-SOD1RX BIIB067 CHEMBL3833346 None