Protein deglycase

AltitudeomicsDB
Protein Official symbol PARK7
Aliases PARK7
Chromosomal Location 1
Length 189
Uniprot ID Q99497
EC number 3.1.2.-; 3.5.1.-; 3.5.1.124
Protein family Information(Pfam) PF01965;
PDB id 1J42;1P5F;1PDV;1PDW;1PE0;1Q2U;1SOA;1UCF;2OR3;2R1T;2R1U;2R1V;2RK3;2RK4;2RK6;3B36;3B38;3B3A;3BWE;3CY6;3CYF;3CZ9;3CZA;3EZG;3F71;3SF8;4BTE;4MNT;4MTC;4N0M;4N12;4OGF;4OQ4;4P2G;4P34;4P35;4P36;4RKW;4RKY;4S0Z;4ZGG;5IP5;5SY6;5SY9;5SYA;6AF5;6AF7;6AF9;6AFA;6AFB;6AFC;6AFD;6AFE;6AFF;6AFG;6AFH;6AFI;6AFJ;6AFL;6E5Z;6M8Z;
InterPro ID IPR029062;IPR006287;IPR002818;
dbSNP rs74315351 rs137853051 rs74315353 rs71653619 rs774005786 rs74315352 rs368420490 rs74315354 rs28938172 rs777026628

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PINK1 PARK2 0.9990000000000001
SUMO1 UBE2I 0.9990000000000001
PARK2 SNCA 0.992
PARK7 SNCA 0.99
PARK7 PINK1 0.988
PARK7 PARK2 0.9790000000000001
PARK2 LRRK2 0.978
PRDX2 PRDX5 0.976
SNCA LRRK2 0.971
PINK1 LRRK2 0.966
PARK7 SUMO1 0.9620000000000001
PARK7 LRRK2 0.958
PRDX2 SOD1 0.956
PARK7 UBE2I 0.945
PARK7 PRDX2 0.943
PARK7 SOD1 0.9359999999999999
PARK7 PTEN 0.9229999999999999
PINK1 SNCA 0.922
PARK7 PRDX5 0.9209999999999999
PARK7 MIF 0.905
Gene Ontology Semantic Similarity
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# 65018 (PINK1) 7341 (SUMO1) 5071 (PARK2) 11315 (PARK7) 7001 (PRDX2) 6622 (SNCA) 7329 (UBE2I) 120892 (LRRK2) 25824 (PRDX5) 6647 (SOD1) 5728 (PTEN)
65018 (PINK1) 1.00 0.58 0.65 0.59 0.21 0.61 0.57 0.73 0.41 0.53 0.45
7341 (SUMO1) 0.58 1.00 0.68 0.66 0.27 0.58 0.76 0.58 0.52 0.62 0.57
5071 (PARK2) 0.65 0.68 1.00 0.68 0.24 0.70 0.72 0.64 0.53 0.69 0.63
11315 (PARK7) 0.59 0.66 0.68 1.00 0.25 0.69 0.62 0.59 0.51 0.69 0.58
7001 (PRDX2) 0.21 0.27 0.24 0.25 1.00 0.25 0.25 0.22 0.52 0.30 0.21
6622 (SNCA) 0.61 0.58 0.70 0.69 0.25 1.00 0.57 0.59 0.58 0.72 0.53
7329 (UBE2I) 0.57 0.76 0.72 0.62 0.25 0.57 1.00 0.58 0.50 0.60 0.53
120892 (LRRK2) 0.73 0.58 0.64 0.59 0.22 0.59 0.58 1.00 0.47 0.60 0.52
25824 (PRDX5) 0.41 0.52 0.53 0.51 0.52 0.58 0.50 0.47 1.00 0.52 0.39
6647 (SOD1) 0.53 0.62 0.69 0.69 0.30 0.72 0.60 0.60 0.52 1.00 0.53
5728 (PTEN) 0.45 0.57 0.63 0.58 0.21 0.53 0.53 0.52 0.39 0.53 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PARK7 Human Skeletal muscle - 4559 m 9 day downregulated -1.37 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
NRF1 4899 PARK7 11315 proximal_filtered 22955619 TRANSFAC
EP300 2033 PARK7 11315 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT029955 hsa-miR-26b-5p Homo sapiens PARK7 11315 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT040717 hsa-miR-92b-3p Homo sapiens PARK7 11315 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046823 hsa-miR-222-3p Homo sapiens PARK7 11315 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049137 hsa-miR-92a-3p Homo sapiens PARK7 11315 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT290040 hsa-miR-5680 Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562981 hsa-miR-4478 Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562976 hsa-miR-4438 Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562983 hsa-miR-3929 Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562979 hsa-miR-6806-5p Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562978 hsa-miR-135b-3p Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562982 hsa-miR-4419b Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562980 hsa-miR-203a-3p Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT562977 hsa-miR-3674 Homo sapiens PARK7 11315 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
Gene Ontology
ID GO ID GO Term GO Type
11315 GO:0010273 detoxification of copper ion GOTERM_BP_DIRECT
11315 GO:0032757 positive regulation of interleukin-8 production GOTERM_BP_DIRECT
11315 GO:0042177 negative regulation of protein catabolic process GOTERM_BP_DIRECT
11315 GO:0007265 Ras protein signal transduction GOTERM_BP_DIRECT
11315 GO:0018323 enzyme active site formation via L-cysteine sulfinic acid GOTERM_BP_DIRECT
11315 GO:0032091 negative regulation of protein binding GOTERM_BP_DIRECT
11315 GO:0032148 activation of protein kinase B activity GOTERM_BP_DIRECT
11315 GO:0033138 positive regulation of peptidyl-serine phosphorylation GOTERM_BP_DIRECT
11315 GO:0034599 cellular response to oxidative stress GOTERM_BP_DIRECT
11315 GO:1903094 negative regulation of protein K48-linked deubiquitination GOTERM_BP_DIRECT
11315 GO:1903202 negative regulation of oxidative stress-induced cell death GOTERM_BP_DIRECT
11315 GO:0098793 presynapse GOTERM_CC_DIRECT
11315 GO:0051881 regulation of mitochondrial membrane potential GOTERM_BP_DIRECT
11315 GO:0045560 regulation of TRAIL receptor biosynthetic process GOTERM_BP_DIRECT
11315 GO:0005515 protein binding GOTERM_MF_DIRECT
11315 GO:0036470 peptidyl-asparagine 3-dioxygenase activity GOTERM_MF_DIRECT
11315 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
11315 GO:0005737 cytoplasm GOTERM_CC_DIRECT
11315 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
11315 GO:0050787 detoxification of mercury ion GOTERM_BP_DIRECT
11315 GO:0050821 protein stabilization GOTERM_BP_DIRECT
11315 GO:0051897 positive regulation of protein kinase B signaling GOTERM_BP_DIRECT
11315 GO:1902903 regulation of fibril organization GOTERM_BP_DIRECT
11315 GO:1903206 negative regulation of hydrogen peroxide-induced cell death GOTERM_BP_DIRECT
11315 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:0036478 annealing helicase activity GOTERM_MF_DIRECT
11315 GO:0044390 ion channel binding GOTERM_MF_DIRECT
11315 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
11315 GO:0060765 regulation of androgen receptor signaling pathway GOTERM_BP_DIRECT
11315 GO:0098609 cell-cell adhesion GOTERM_BP_DIRECT
11315 GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:0003697 double-stranded telomeric DNA binding GOTERM_MF_DIRECT
11315 GO:0016684 oxidoreductase activity GOTERM_MF_DIRECT
11315 GO:0042802 identical protein binding GOTERM_MF_DIRECT
11315 GO:0006954 inflammatory response GOTERM_BP_DIRECT
11315 GO:1902958 positive regulation of mitochondrial electron transport GOTERM_BP_DIRECT
11315 GO:0019900 enzyme binding GOTERM_MF_DIRECT
11315 GO:0001933 negative regulation of protein phosphorylation GOTERM_BP_DIRECT
11315 GO:0036471 cellular response to glyoxal GOTERM_BP_DIRECT
11315 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
11315 GO:0051444 negative regulation of ubiquitin-protein transferase activity GOTERM_BP_DIRECT
11315 GO:2000679 positive regulation of transcription regulatory region DNA binding GOTERM_BP_DIRECT
11315 GO:2000825 positive regulation of androgen receptor activity GOTERM_BP_DIRECT
11315 GO:0016532 peptidase activator activity GOTERM_MF_DIRECT
11315 GO:0019955 protein domain specific binding GOTERM_MF_DIRECT
11315 GO:0006914 autophagy GOTERM_BP_DIRECT
11315 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GOTERM_BP_DIRECT
11315 GO:0070301 cellular response to hydrogen peroxide GOTERM_BP_DIRECT
11315 GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:0003713 transcription coactivator activity GOTERM_MF_DIRECT
11315 GO:0008233 heparin binding GOTERM_MF_DIRECT
11315 GO:0044388 ion channel binding GOTERM_MF_DIRECT
11315 GO:0009438 methylglyoxal metabolic process GOTERM_BP_DIRECT
11315 GO:0043523 regulation of neuron apoptotic process GOTERM_BP_DIRECT
11315 GO:0005829 cytosol GOTERM_CC_DIRECT
11315 GO:0097110 sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential GOTERM_MF_DIRECT
11315 GO:0005886 plasma membrane GOTERM_CC_DIRECT
11315 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
11315 GO:0016605 PML body GOTERM_CC_DIRECT
11315 GO:0005913 cell-cell adherens junction GOTERM_CC_DIRECT
11315 GO:0045340 cadherin binding GOTERM_MF_DIRECT
11315 GO:0005758 mitochondrial intermembrane space GOTERM_CC_DIRECT
11315 GO:0006469 negative regulation of protein kinase activity GOTERM_BP_DIRECT
11315 GO:0060081 membrane hyperpolarization GOTERM_BP_DIRECT
11315 GO:0060548 negative regulation of cell death GOTERM_BP_DIRECT
11315 GO:0090073 positive regulation of protein homodimerization activity GOTERM_BP_DIRECT
11315 GO:1900182 positive regulation of protein localization to nucleus GOTERM_BP_DIRECT
11315 GO:1903073 negative regulation of death-inducing signaling complex assembly GOTERM_BP_DIRECT
11315 GO:1903178 positive regulation of tyrosine 3-monooxygenase activity GOTERM_BP_DIRECT
11315 GO:1903190 glyoxal catabolic process GOTERM_BP_DIRECT
11315 GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:1990381 N6-methyladenosine-containing RNA binding GOTERM_MF_DIRECT
11315 GO:1990422 ubiquitin-specific protease binding GOTERM_MF_DIRECT
11315 GO:0005634 nucleus GOTERM_CC_DIRECT
11315 GO:0005747 mitochondrial respiratory chain complex I GOTERM_CC_DIRECT
11315 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
11315 GO:0043524 negative regulation of neuron apoptotic process GOTERM_BP_DIRECT
11315 GO:0051583 dopamine uptake involved in synaptic transmission GOTERM_BP_DIRECT
11315 GO:1901671 positive regulation of superoxide dismutase activity GOTERM_BP_DIRECT
11315 GO:0051920 Hsp90 protein binding GOTERM_MF_DIRECT
11315 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
11315 GO:0006508 proteolysis GOTERM_BP_DIRECT
11315 GO:0010629 negative regulation of gene expression GOTERM_BP_DIRECT
11315 GO:0031397 negative regulation of protein ubiquitination GOTERM_BP_DIRECT
11315 GO:0050727 regulation of inflammatory response GOTERM_BP_DIRECT
11315 GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity GOTERM_BP_DIRECT
11315 GO:0005102 GTPase activator activity GOTERM_MF_DIRECT
11315 GO:1903136 phosphatidylinositol phosphate binding GOTERM_MF_DIRECT
11315 GO:0005739 mitochondrion GOTERM_CC_DIRECT
11315 GO:0007005 mitochondrion organization GOTERM_BP_DIRECT
11315 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GOTERM_BP_DIRECT
11315 GO:1903181 positive regulation of dopamine biosynthetic process GOTERM_BP_DIRECT
11315 GO:1903200 positive regulation of L-dopa decarboxylase activity GOTERM_BP_DIRECT
11315 GO:1903599 positive regulation of mitophagy GOTERM_BP_DIRECT
11315 GO:1903135 decanoate--CoA ligase activity GOTERM_MF_DIRECT
11315 GO:0006517 protein deglycosylation GOTERM_BP_DIRECT
11315 GO:0008344 adult locomotory behavior GOTERM_BP_DIRECT
11315 GO:0019249 lactate biosynthetic process GOTERM_BP_DIRECT
11315 GO:0042743 hydrogen peroxide metabolic process GOTERM_BP_DIRECT
11315 GO:0051899 membrane depolarization GOTERM_BP_DIRECT
11315 GO:1903428 positive regulation of reactive oxygen species biosynthetic process GOTERM_BP_DIRECT
11315 GO:2000157 negative regulation of ubiquitin-specific protease activity GOTERM_BP_DIRECT
11315 GO:0003729 double-stranded RNA binding GOTERM_MF_DIRECT
11315 GO:0050681 NADP binding GOTERM_MF_DIRECT
11315 GO:0098641 cadherin binding involved in cell-cell adhesion GOTERM_MF_DIRECT
11315 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GOTERM_BP_DIRECT
11315 GO:0098869 cellular oxidant detoxification GOTERM_BP_DIRECT
11315 GO:1901215 negative regulation of neuron death GOTERM_BP_DIRECT
11315 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity GOTERM_BP_DIRECT
11315 GO:1903189 glyoxal metabolic process GOTERM_BP_DIRECT
11315 GO:0001047 RNA polymerase III regulatory region DNA binding GOTERM_MF_DIRECT
11315 GO:0008134 transcription factor binding GOTERM_MF_DIRECT
11315 GO:0019899 enzyme binding GOTERM_MF_DIRECT
11315 GO:0070491 NAD+ binding GOTERM_MF_DIRECT
11315 GO:0043005 neuron projection GOTERM_CC_DIRECT
11315 GO:0007338 single fertilization GOTERM_BP_DIRECT
11315 GO:0005507 iron ion binding GOTERM_MF_DIRECT
11315 GO:0019172 protein-disulfide reductase GOTERM_MF_DIRECT
11315 GO:0000785 chromatin GOTERM_CC_DIRECT
11315 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
11315 GO:0033234 negative regulation of protein sumoylation GOTERM_BP_DIRECT
11315 GO:0046295 glycolate biosynthetic process GOTERM_BP_DIRECT
11315 GO:0046826 negative regulation of protein export from nucleus GOTERM_BP_DIRECT
11315 GO:1901984 negative regulation of protein acetylation GOTERM_BP_DIRECT
11315 GO:1903197 positive regulation of L-dopa biosynthetic process GOTERM_BP_DIRECT
11315 GO:1903208 negative regulation of hydrogen peroxide-induced neuron death GOTERM_BP_DIRECT
11315 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
11315 GO:0003690 DNA replication origin binding GOTERM_MF_DIRECT
11315 GO:0030424 axon GOTERM_CC_DIRECT
11315 GO:0044297 cell body GOTERM_CC_DIRECT
11315 GO:0045121 membrane raft GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
11315 hsa05012 Parkinson's disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PARK7 11315 Parkinsonian Disorders C0242422 Disease or Syndrome 0.4 0.586 0.552 group
PARK7 11315 Familial Juvenile Parkinsonism C0752104 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Necrotizing Enterocolitis C0520459 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Liver carcinoma C2239176 Neoplastic Process 0.31 0.586 0.552 disease
PARK7 11315 Osteoporosis, Age-Related C0001787 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Parkinsonism, Juvenile C0752105 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Osteoporosis C0029456 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Ramsay Hunt Paralysis Syndrome C0242423 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Autosomal Dominant Juvenile Parkinson Disease C0752097 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Reticulocytosis C0206160 Finding 0.3 0.586 0.552 phenotype
PARK7 11315 Osteoporosis, Senile C0029459 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Autosomal Dominant Parkinsonism C0752098 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Post-Traumatic Osteoporosis C0751406 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Autosomal Recessive Parkinsonism C0752100 Disease or Syndrome 0.31 0.586 0.552 disease
PARK7 11315 Parkinsonism, Experimental C0752101 Experimental Model of Disease 0.3 0.586 0.552 disease
PARK7 11315 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE C1868675 Disease or Syndrome 0.5 0.586 0.552 disease
PARK7 11315 Parkinson Disease C0030567 Disease or Syndrome 0.8 0.586 0.552 disease
PARK7 11315 PARKINSON DISEASE 7, AUTOSOMAL RECESSIVE EARLY-ONSET C1853445 Disease or Syndrome 0.83 0.586 0.552 disease
PARK7 11315 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.586 0.552 group
PARK7 11315 Amyotrophic Lateral Sclerosis, Guam Form C0543859 Disease or Syndrome 0.3 0.586 0.552 disease
PARK7 11315 Young onset Parkinson disease C4275179 Disease or Syndrome 0.4 0.586 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types