Peroxiredoxin-5, mitochondrial=Homo sapiens GN=PRDX5

AltitudeomicsDB
Protein Official symbol PRDX5
Aliases PRDX5 ACR1 SBBI10
Chromosomal Location  11
Length 214
Uniprot ID P30044
EC number 1.11.1.24
Protein family Information(Pfam) PF08534;
PDB id 1H4O;1HD2;1OC3;1URM;2VL2;2VL3;2VL9;3MNG;4K7I;4K7N;4K7O;4MMM;
InterPro ID IPR037944;IPR013740;IPR036249;IPR013766;
dbSNP rs7938623

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TXNRD1 TXN 0.999
SOD2 CAT 0.998
SOD2 SOD1 0.998
SOD1 CAT 0.996
TXN PRDX1 0.994
TXN SOD1 0.993
TXN PRDX2 0.99
SOD2 GPX1 0.988
GPX1 GSR 0.987
CAT GSR 0.987
GPX1 SOD1 0.986
GPX4 GSR 0.985
PRDX3 TXN2 0.985
TXN GSR 0.984
SRXN1 PRDX1 0.982
SOD1 PRDX1 0.981
PRDX5 PRDX1 0.978
PRDX2 PRDX5 0.976
PRDX1 CAT 0.968
PRDX5 CAT 0.967
PARK7 SUMO1 0.962
PRDX2 SOD1 0.956
TXN CAT 0.944
PARK7 PRDX2 0.943
SOD2 GPX4 0.94
PARK7 SOD1 0.936
PRDX6 PRDX5 0.934
TXN PRDX6 0.933
TXN TXN2 0.93
PRDX2 CAT 0.923
GPX1 CAT 0.923
SOD2 PRDX5 0.922
PARK7 PRDX5 0.921
GPX4 SOD1 0.917
SOD2 GSR 0.916
PRDX6 CAT 0.91
PRDX3 PRDX5 0.902
TXNRD1 CAT 0.896
SOD2 TXN 0.896
GPX4 CAT 0.892
SRXN1 TXN 0.891
PRDX6 PRDX2 0.89
PRDX3 CAT 0.89
TXN GPX4 0.889
TXNRD1 GPX1 0.889
PRDX3 PRDX1 0.885
SOD1 GSR 0.884
SOD2 TXNRD1 0.884
TXNRD1 GPX4 0.879
TXN PRDX3 0.876
PRDX4 PRDX5 0.874
GPX4 PRDX6 0.871
PRDX2 PRDX1 0.869
TXNRD1 PRDX1 0.869
PRDX4 TXN 0.865
SOD1 PRDX5 0.863
PARK7 NIT2 0.86
CAT TXN2 0.858
TXNRD1 TXN2 0.855
URM1 PRDX2 0.851
SOD2 PARK7 0.842
SRXN1 PRDX6 0.84
SOD2 PRDX6 0.838
NIT2 PRDX5 0.838
PRDX5 SPR 0.835
PRDX1 GSR 0.834
TXNRD1 PRDX6 0.831
GPX4 TXN2 0.829
SOD2 PRDX3 0.829
NME1 PRDX5 0.827
PRDX4 CAT 0.827
GSR TXN2 0.824
TXN PRDX5 0.823
TXNRD1 SRXN1 0.82
URM1 PRDX1 0.82
PRDX5 GSR 0.82
GPX4 PRDX2 0.813
SRXN1 CAT 0.813
TXNRD1 PRDX3 0.81
TXNRD1 PRDX4 0.805
TXNRD1 PRDX2 0.804
GPX1 TXN 0.801
SRXN1 GSR 0.8
SUMO1 PRDX5 0.792
NIT2 PRDX6 0.792
SOD2 PRDX1 0.786
TXNRD1 PRDX5 0.785
PRDX3 SOD1 0.785
TXNRD1 SOD1 0.78
PRDX6 SOD1 0.771
PRDX2 GSR 0.765
SOD1 TXN2 0.764
SRXN1 PRDX3 0.763
NME1 SOD1 0.759
GPX4 PRDX3 0.753
SRXN1 PRDX2 0.751
SOD2 PRDX2 0.751
PRDX6 GSR 0.75
PRDX5 DSTN 0.746
PARK7 CAT 0.745
PRDX1 TXN2 0.745
PRDX5 TRAP1 0.743
PRDX5 TXN2 0.739
PRDX4 SOD1 0.736
PARK7 PRDX1 0.729
URM1 PRDX5 0.727
GPX1 TXN2 0.718
SRXN1 PRDX4 0.717
PRDX3 GSR 0.716
GPX4 PRDX1 0.715
SOD2 TXN2 0.711
GPX1 PRDX5 0.707
GPX1 PRDX1 0.705
GPX4 PRDX5 0.703
GPX1 PRDX3 0.702
SRXN1 PRDX5 0.7
Gene Ontology Semantic Similarity
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# 7296 (TXNRD1) 6647 (SOD1) 7295 (TXN) 2876 (GPX1) 847 (CAT) 2879 (GPX4) 10935 (PRDX3) 140809 (SRXN1) 25824 (PRDX5) 7001 (PRDX2) 5052 (PRDX1) 11315 (PARK7) 9588 (PRDX6) 10549 (PRDX4) 81605 (URM1) 56954 (NIT2) 4830 (NME1) 2936 (GSR) 7341 (SUMO1) 25828 (TXN2) 6697 (SPR) 11034 (DSTN)
7296 (TXNRD1) 1.00 0.57 0.48 0.51 0.58 0.64 0.67 0.72 0.57 0.57 0.59 0.54 0.58 0.59 0.51 0.24 0.41 0.45 0.56 1.00 0.35 0.51
6647 (SOD1) 0.57 1.00 0.55 0.43 0.62 0.64 0.62 0.60 0.59 0.59 0.59 0.72 0.63 0.59 0.55 0.23 0.56 0.27 0.58 1.00 0.23 0.57
7295 (TXN) 0.48 0.55 1.00 0.45 0.55 0.59 0.57 0.55 0.57 0.57 0.72 0.55 0.53 0.63 0.64 0.16 0.58 0.30 0.69 1.00 0.28 0.72
2876 (GPX1) 0.51 0.43 0.45 1.00 0.53 0.75 0.52 0.58 0.58 0.66 0.66 0.39 0.63 0.70 0.46 0.20 0.32 0.28 0.42 0.69 0.27 0.48
847 (CAT) 0.58 0.62 0.55 0.53 1.00 0.73 0.65 0.62 0.68 0.71 0.69 0.62 0.70 0.63 0.52 0.28 0.52 0.41 0.60 0.82 0.43 0.51
2879 (GPX4) 0.64 0.64 0.59 0.75 0.73 1.00 0.71 0.71 0.72 0.75 0.78 0.59 0.78 0.79 0.60 0.24 0.48 0.32 0.59 1.00 0.33 0.61
10935 (PRDX3) 0.67 0.62 0.57 0.52 0.65 0.71 1.00 0.67 0.80 0.71 0.71 0.61 0.66 0.73 0.57 0.18 0.49 0.33 0.62 1.00 0.24 0.58
140809 (SRXN1) 0.72 0.60 0.55 0.58 0.62 0.71 0.67 1.00 0.62 0.66 0.65 0.55 0.63 0.67 0.59 0.28 0.44 0.42 0.59 1.00 0.39 0.58
25824 (PRDX5) 0.57 0.59 0.57 0.58 0.68 0.72 0.80 0.62 1.00 0.74 0.79 0.59 0.71 0.76 0.53 0.23 0.47 0.30 0.59 1.00 0.27 0.54
7001 (PRDX2) 0.57 0.59 0.57 0.66 0.71 0.75 0.71 0.66 0.74 1.00 0.80 0.54 0.69 0.88 0.56 0.21 0.43 0.36 0.60 1.00 0.27 0.60
5052 (PRDX1) 0.59 0.59 0.72 0.66 0.69 0.78 0.71 0.65 0.79 0.80 1.00 0.60 0.79 0.84 0.54 0.23 0.54 0.35 0.64 1.00 0.33 0.56
11315 (PARK7) 0.54 0.72 0.55 0.39 0.62 0.59 0.61 0.55 0.59 0.54 0.60 1.00 0.61 0.54 0.53 0.48 0.59 0.24 0.65 1.00 0.21 0.53
9588 (PRDX6) 0.58 0.63 0.53 0.63 0.70 0.78 0.66 0.63 0.71 0.69 0.79 0.61 1.00 0.71 0.54 0.26 0.48 0.29 0.61 1.00 0.27 0.54
10549 (PRDX4) 0.59 0.59 0.63 0.70 0.63 0.79 0.73 0.67 0.76 0.88 0.84 0.54 0.71 1.00 0.61 0.18 0.43 0.32 0.59 1.00 0.29 0.66
81605 (URM1) 0.51 0.55 0.64 0.46 0.52 0.60 0.57 0.59 0.53 0.56 0.54 0.53 0.54 0.61 1.00 0.24 0.47 0.27 0.63 1.00 0.25 0.67
56954 (NIT2) 0.24 0.23 0.16 0.20 0.28 0.24 0.18 0.28 0.23 0.21 0.23 0.48 0.26 0.18 0.24 1.00 0.34 0.21 0.24 0.16 0.20 0.16
4830 (NME1) 0.41 0.56 0.58 0.32 0.52 0.48 0.49 0.44 0.47 0.43 0.54 0.59 0.48 0.43 0.47 0.34 1.00 0.31 0.59 1.00 0.26 0.46
2936 (GSR) 0.45 0.27 0.30 0.28 0.41 0.32 0.33 0.42 0.30 0.36 0.35 0.24 0.29 0.32 0.27 0.21 0.31 1.00 0.28 0.34 0.42 0.24
7341 (SUMO1) 0.56 0.58 0.69 0.42 0.60 0.59 0.62 0.59 0.59 0.60 0.64 0.65 0.61 0.59 0.63 0.24 0.59 0.28 1.00 1.00 0.23 0.61
25828 (TXN2) 1.00 1.00 1.00 0.69 0.82 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.16 1.00 0.34 1.00 1.00 0.27 1.00
6697 (SPR) 0.35 0.23 0.28 0.27 0.43 0.33 0.24 0.39 0.27 0.27 0.33 0.21 0.27 0.29 0.25 0.20 0.26 0.42 0.23 0.27 1.00 0.20
11034 (DSTN) 0.51 0.57 0.72 0.48 0.51 0.61 0.58 0.58 0.54 0.60 0.56 0.53 0.54 0.66 0.67 0.16 0.46 0.24 0.61 1.00 0.20 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PRDX5 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
ELK4 2005 PRDX5 25824 proximal_filtered 22955619 TRANSFAC
NRF1 4899 PRDX5 25824 Unknown 16237091 TRUSST
DEK 7913 PRDX5 25824 Unknown 21272048 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT037717 hsa-miR-744-5p Homo sapiens PRDX5 25824 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT470285 hsa-miR-873-5p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470286 hsa-miR-219b-3p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470289 hsa-miR-4733-3p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470290 hsa-miR-3688-3p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470282 hsa-miR-4722-5p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470288 hsa-miR-1205 Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470292 hsa-miR-302f Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470287 hsa-miR-570-3p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470283 hsa-miR-4764-5p Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470284 hsa-miR-1286 Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT470291 hsa-miR-1265 Homo sapiens PRDX5 25824 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
Gene Ontology
ID GO ID GO Term GO Type
25824 GO:0000302 response to reactive oxygen species GOTERM_BP_DIRECT
25824 GO:0006979 response to oxidative stress GOTERM_BP_DIRECT
25824 GO:0016480 negative regulation of transcription from RNA polymerase III promoter GOTERM_BP_DIRECT
25824 GO:0005739 mitochondrion GOTERM_CC_DIRECT
25824 GO:0034614 cellular response to reactive oxygen species GOTERM_BP_DIRECT
25824 GO:0043027 ribosome binding GOTERM_MF_DIRECT
25824 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
25824 GO:0004601 peroxidase activity GOTERM_MF_DIRECT
25824 GO:0031410 cytoplasmic vesicle GOTERM_CC_DIRECT
25824 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
25824 GO:0016209 antioxidant activity GOTERM_MF_DIRECT
25824 GO:0046983 protein dimerization activity GOTERM_MF_DIRECT
25824 GO:0098869 cellular oxidant detoxification GOTERM_BP_DIRECT
25824 GO:0005829 cytosol GOTERM_CC_DIRECT
25824 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
25824 GO:0005102 receptor binding GOTERM_MF_DIRECT
25824 GO:0070995 NADPH oxidation GOTERM_BP_DIRECT
25824 GO:0042744 hydrogen peroxide catabolic process GOTERM_BP_DIRECT
25824 GO:0060785 regulation of apoptosis involved in tissue homeostasis GOTERM_BP_DIRECT
25824 GO:0072541 Arp2/3 complex binding GOTERM_MF_DIRECT
25824 GO:0005782 peroxisomal matrix GOTERM_CC_DIRECT
25824 GO:2001057 reactive nitrogen species metabolic process GOTERM_BP_DIRECT
25824 GO:0005737 cytoplasm GOTERM_CC_DIRECT
25824 GO:0051354 negative regulation of oxidoreductase activity GOTERM_BP_DIRECT
25824 GO:0051920 G-quadruplex DNA binding GOTERM_MF_DIRECT
25824 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
25824 GO:0006915 apoptotic process GOTERM_BP_DIRECT
25824 GO:0032967 positive regulation of collagen biosynthetic process GOTERM_BP_DIRECT
25824 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
25824 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GOTERM_BP_DIRECT
25824 GO:0005777 peroxisome GOTERM_CC_DIRECT
25824 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
25824 GO:0006954 inflammatory response GOTERM_BP_DIRECT
25824 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
25824 GO:0001016 transcription factor activity GOTERM_MF_DIRECT
25824 GO:0008379 galactosyltransferase activity GOTERM_MF_DIRECT
25824 GO:0005615 extracellular space GOTERM_CC_DIRECT
25824 GO:0005634 nucleus GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
25824 hsa04146 Peroxisome
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PRDX5 25824 Alopecia Areata C0002171 Disease or Syndrome 0.3 0.577 0.655 disease
PRDX5 25824 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.3 0.577 0.655 disease
PRDX5 25824 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.577 0.655 disease
PRDX5 25824 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.577 0.655 group
PRDX5 25824 Malignant neoplasm of breast C0006142 Neoplastic Process 0.32 0.577 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types