Protein disulfide-isomerase A3

AltitudeomicsDB
Protein Official symbol PDIA3
Aliases PDIA3 ERP57 ERP60 GRP58
Chromosomal Location 15
Length 505
Uniprot ID P30101
EC number 5.3.4.1
Protein family Information(Pfam) PF00085;
PDB id 2ALB;2DMM;2H8L;3F8U;6ENY;
InterPro ID IPR005788;IPR041868;IPR005792;IPR036249;IPR017937;IPR013766;
dbSNP rs6413485

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
B2M HLA-C 0.9990000000000001
SNAP23 VAMP3 0.9990000000000001
CALR HSP90B1 0.9990000000000001
VAMP8 SNAP23 0.9990000000000001
B2M HLA-E 0.9990000000000001
B2M HLA-A 0.9990000000000001
B2M HLA-B 0.9990000000000001
CALR PDIA3 0.9990000000000001
HSPA5 HSP90B1 0.9990000000000001
PRKCSH GANAB 0.9990000000000001
B2M HLA-F 0.998
HSPA5 CANX 0.998
PDIA3 CANX 0.998
B2M HLA-G 0.998
HSPA5 CALR 0.998
TAPBP PDIA3 0.997
HSPA5 PDIA3 0.997
PRKCSH CALR 0.996
GANAB CALR 0.996
HYOU1 HSP90B1 0.995
GANAB CANX 0.995
PRKCSH HSP90B1 0.9940000000000001
B2M TAPBP 0.9940000000000001
B2M CALR 0.993
HLA-A PDIA3 0.992
TAPBP TAP2 0.991
HLA-A CALR 0.991
HYOU1 HSPA5 0.99
PRKCSH CANX 0.9890000000000001
B2M PDIA3 0.9890000000000001
HLA-G HLA-F 0.987
TAPBP TAP1 0.986
HLA-B HLA-A 0.986
HLA-A HLA-C 0.9840000000000001
TAPBP CALR 0.9840000000000001
HLA-G HLA-A 0.982
HLA-G HLA-C 0.981
TAPBP HLA-A 0.981
PDIA3 HSP90B1 0.98
PDIA3 ERP27 0.98
HSP90B1 CANX 0.9790000000000001
HSP90B1 RPN2 0.978
HLA-B HLA-C 0.976
TAPBP HLA-C 0.972
TAPBP CANX 0.971
TAPBP HLA-B 0.97
B2M TAP1 0.9690000000000001
HLA-G HLA-B 0.9690000000000001
HLA-G HLA-E 0.9690000000000001
HLA-E HLA-F 0.9690000000000001
HLA-C HLA-F 0.9690000000000001
HLA-E HLA-C 0.9670000000000001
HLA-B HLA-E 0.966
TAP2 TAP1 0.963
B2M TAP2 0.963
TAPBP HLA-E 0.9620000000000001
HLA-A CANX 0.961
HLA-B TAP1 0.96
CALR CANX 0.9590000000000001
GANAB HSP90B1 0.958
HLA-B PDIA3 0.958
TAPBP HLA-F 0.956
CANX RPN2 0.9540000000000001
HYOU1 CALR 0.9540000000000001
HLA-A TAP2 0.953
HLA-B CALR 0.953
HLA-A TAP1 0.951
TAP1 PDIA3 0.951
HLA-C TAP2 0.951
GANAB PDIA3 0.95
HLA-E CALR 0.9490000000000001
HLA-G TAPBP 0.9490000000000001
TAP1 CALR 0.9470000000000001
PDIA3 PPIB 0.9470000000000001
B2M CANX 0.9470000000000001
HLA-C CALR 0.9470000000000001
HLA-G TAP1 0.9420000000000001
TAP1 HLA-F 0.9420000000000001
TAP1 CANX 0.9420000000000001
HLA-G TAP2 0.941
HLA-A HLA-F 0.941
HLA-B TAP2 0.94
TAP2 CALR 0.9390000000000001
VAMP8 VAMP3 0.9390000000000001
HLA-E TAP2 0.9390000000000001
HLA-B HSPA5 0.938
HLA-A HLA-E 0.9359999999999999
HLA-C HSPA5 0.935
HYOU1 CANX 0.934
HLA-B CANX 0.9309999999999999
HLA-C CANX 0.9309999999999999
HLA-C PDIA3 0.93
PRKCSH PDIA3 0.93
PDIA3 RPN2 0.929
TAP2 HLA-F 0.9259999999999999
HLA-G CANX 0.925
HLA-C TAP1 0.924
HLA-E CANX 0.924
HYOU1 PDIA3 0.924
PDIA3 HLA-F 0.9229999999999999
HLA-E PDIA3 0.9229999999999999
B2M HSPA5 0.9229999999999999
TAPBP HSPA5 0.9209999999999999
HLA-G PDIA3 0.919
CALR HLA-F 0.919
HLA-F CANX 0.919
HLA-E TAP1 0.9179999999999999
HLA-G CALR 0.9179999999999999
HLA-B HLA-F 0.9159999999999999
HLA-B VAMP3 0.915
HLA-A VAMP3 0.915
HSPA5 PPIB 0.915
TAP2 CANX 0.912
PDIA3 SNAP23 0.9109999999999999
TAP2 PDIA3 0.91
PDIA3 VAMP8 0.909
B2M SNAP23 0.909
TAP1 HSPA5 0.909
TAP2 HSPA5 0.9079999999999999
PDIA3 VAMP3 0.9079999999999999
B2M VAMP8 0.905
HLA-C VAMP8 0.904
B2M VAMP3 0.903
HLA-B VAMP8 0.903
HLA-E VAMP8 0.903
HLA-A VAMP8 0.902
HLA-A HSPA5 0.902
VAMP8 HLA-F 0.902
HLA-G HSPA5 0.9009999999999999
HLA-E HSPA5 0.9
HLA-E SNAP23 0.9
HLA-F VAMP3 0.9
HLA-B SNAP23 0.9
HLA-G VAMP3 0.9
HLA-G SNAP23 0.9
HLA-F SNAP23 0.9
HLA-C VAMP3 0.9
HLA-E VAMP3 0.9
HLA-C SNAP23 0.9
HLA-G VAMP8 0.9
HLA-A SNAP23 0.9
HSPA5 HLA-F 0.9
Gene Ontology Semantic Similarity
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# 567 (B2M) 8773 (SNAP23) 811 (CALR) 8673 (VAMP8) 3309 (HSPA5) 5589 (PRKCSH) 2923 (PDIA3) 6892 (TAPBP) 23193 (GANAB) 10525 (HYOU1) 3105 (HLA-A) 3135 (HLA-G) 3106 (HLA-B) 7184 (HSP90B1) 3133 (HLA-E) 3107 (HLA-C) 6891 (TAP2) 821 (CANX) 6890 (TAP1) 3134 (HLA-F) 9341 (VAMP3) 121506 (ERP27) 6185 (RPN2) 5479 (PPIB)
567 (B2M) 1.00 0.84 0.65 0.76 0.76 0.70 0.46 0.68 0.37 0.82 0.74 0.68 0.65 0.67 0.66 0.65 0.59 0.78 0.61 0.66 0.86 1.00 0.73 0.69
8773 (SNAP23) 0.84 1.00 0.62 0.83 0.72 0.70 0.46 0.68 0.37 0.82 0.74 0.64 0.65 0.67 0.65 0.65 0.58 0.77 0.58 0.66 0.95 1.00 0.73 0.69
811 (CALR) 0.65 0.62 1.00 0.60 0.77 0.51 0.59 0.60 1.00 1.00 0.72 0.51 0.51 0.76 0.55 0.51 0.55 0.72 0.56 0.53 0.63 1.00 0.58 0.72
8673 (VAMP8) 0.76 0.83 0.60 1.00 0.69 0.63 0.44 0.64 0.37 0.82 0.68 0.58 0.58 0.63 0.61 0.58 0.56 0.69 0.56 0.60 0.88 1.00 0.65 0.65
3309 (HSPA5) 0.76 0.72 0.77 0.69 1.00 0.60 0.55 0.71 0.37 1.00 0.68 0.57 0.56 0.74 0.59 0.56 0.64 0.69 0.61 0.58 0.73 1.00 0.67 0.70
5589 (PRKCSH) 0.70 0.70 0.51 0.63 0.60 1.00 0.39 0.56 0.30 0.66 0.62 0.54 0.55 0.56 0.54 0.55 0.48 0.66 0.49 0.55 0.72 0.82 0.62 0.57
2923 (PDIA3) 0.46 0.46 0.59 0.44 0.55 0.39 1.00 0.46 1.00 0.82 0.56 0.35 0.32 0.53 0.43 0.32 0.42 0.53 0.42 0.39 0.47 1.00 0.38 0.61
6892 (TAPBP) 0.68 0.68 0.60 0.64 0.71 0.56 0.46 1.00 0.37 0.82 0.75 0.68 0.69 0.60 0.73 0.69 0.73 0.62 0.74 0.83 0.69 1.00 0.60 0.65
23193 (GANAB) 0.37 0.37 1.00 0.37 0.37 0.30 1.00 0.37 1.00 0.30 1.00 0.30 0.30 1.00 0.30 0.30 0.37 1.00 0.37 0.30 0.37 0.37 0.37 1.00
10525 (HYOU1) 0.82 0.82 1.00 0.82 1.00 0.66 0.82 0.82 0.30 1.00 0.82 0.66 0.66 0.82 0.66 0.66 0.82 0.82 0.82 0.66 0.82 0.82 0.82 0.82
3105 (HLA-A) 0.74 0.74 0.72 0.68 0.68 0.62 0.56 0.75 1.00 0.82 1.00 0.80 0.83 0.75 0.85 0.83 0.58 0.86 0.67 0.80 0.75 1.00 0.65 0.75
3135 (HLA-G) 0.68 0.64 0.51 0.58 0.57 0.54 0.35 0.68 0.30 0.66 0.80 1.00 0.90 0.54 0.82 0.90 0.47 0.58 0.66 0.80 0.66 0.82 0.55 0.54
3106 (HLA-B) 0.65 0.65 0.51 0.58 0.56 0.55 0.32 0.69 0.30 0.66 0.83 0.90 1.00 0.54 0.87 1.00 0.46 0.58 0.58 0.85 0.67 0.82 0.53 0.53
7184 (HSP90B1) 0.67 0.67 0.76 0.63 0.74 0.56 0.53 0.60 1.00 0.82 0.75 0.54 0.54 1.00 0.58 0.54 0.54 0.77 0.55 0.57 0.68 1.00 0.58 0.71
3133 (HLA-E) 0.66 0.65 0.55 0.61 0.59 0.54 0.43 0.73 0.30 0.66 0.85 0.82 0.87 0.58 1.00 0.87 0.53 0.62 0.61 0.80 0.67 0.82 0.60 0.62
3107 (HLA-C) 0.65 0.65 0.51 0.58 0.56 0.55 0.32 0.69 0.30 0.66 0.83 0.90 1.00 0.54 0.87 1.00 0.46 0.58 0.58 0.85 0.67 0.82 0.53 0.53
6891 (TAP2) 0.59 0.58 0.55 0.56 0.64 0.48 0.42 0.73 0.37 0.82 0.58 0.47 0.46 0.54 0.53 0.46 1.00 0.53 0.84 0.56 0.59 1.00 0.51 0.56
821 (CANX) 0.78 0.77 0.72 0.69 0.69 0.66 0.53 0.62 1.00 0.82 0.86 0.58 0.58 0.77 0.62 0.58 0.53 1.00 0.55 0.61 0.80 1.00 0.63 0.78
6890 (TAP1) 0.61 0.58 0.56 0.56 0.61 0.49 0.42 0.74 0.37 0.82 0.67 0.66 0.58 0.55 0.61 0.58 0.84 0.55 1.00 0.72 0.59 1.00 0.51 0.57
3134 (HLA-F) 0.66 0.66 0.53 0.60 0.58 0.55 0.39 0.83 0.30 0.66 0.80 0.80 0.85 0.57 0.80 0.85 0.56 0.61 0.72 1.00 0.67 0.82 0.58 0.56
9341 (VAMP3) 0.86 0.95 0.63 0.88 0.73 0.72 0.47 0.69 0.37 0.82 0.75 0.66 0.67 0.68 0.67 0.67 0.59 0.80 0.59 0.67 1.00 1.00 0.75 0.70
121506 (ERP27) 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 0.37 0.82 1.00 0.82 0.82 1.00 0.82 0.82 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00
6185 (RPN2) 0.73 0.73 0.58 0.65 0.67 0.62 0.38 0.60 0.37 0.82 0.65 0.55 0.53 0.58 0.60 0.53 0.51 0.63 0.51 0.58 0.75 1.00 1.00 0.62
5479 (PPIB) 0.69 0.69 0.72 0.65 0.70 0.57 0.61 0.65 1.00 0.82 0.75 0.54 0.53 0.71 0.62 0.53 0.56 0.78 0.57 0.56 0.70 1.00 0.62 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PDIA3 Rat Lungs - 7600 m 24 hours upregulated 1.7 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
PDIA3 Rat Lungs - 7600 m 6 hours upregulated 1.3 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
PDIA3 Rat Lungs - 7600 m 12 hours upregulated 1.2 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TAF1 6872 PDIA3 2923 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023749 hsa-miR-1-3p Homo sapiens PDIA3 2923 Homo sapiens Proteomics;Microarray Non-Functional MTI (Weak) 18668037
MIRT025802 hsa-miR-7-5p Homo sapiens PDIA3 2923 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT025802 hsa-miR-7-5p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT054720 hsa-miR-494-3p Homo sapiens PDIA3 2923 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 24823364
MIRT281136 hsa-miR-148a-3p Homo sapiens PDIA3 2923 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26004124
MIRT342364 hsa-miR-524-5p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT342365 hsa-miR-520d-5p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT342370 hsa-miR-6077 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718875 hsa-miR-3134 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718879 hsa-miR-4653-5p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718880 hsa-miR-3921 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718882 hsa-miR-301a-5p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718874 hsa-miR-4273 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718881 hsa-miR-301b-5p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718877 hsa-miR-4534 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718883 hsa-miR-146a-3p Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718876 hsa-miR-8082 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT718878 hsa-miR-4502 Homo sapiens PDIA3 2923 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT735383 hsa-miR-330-5p Homo sapiens PDIA3 2923 Homo sapiens Western blot Functional MTI 27363653
Gene Ontology
ID GO ID GO Term GO Type
2923 GO:0042470 melanosome GOTERM_CC_DIRECT
2923 GO:0006621 protein retention in ER lumen GOTERM_BP_DIRECT
2923 GO:0005623 cell GOTERM_CC_DIRECT
2923 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
2923 GO:0007165 signal transduction GOTERM_BP_DIRECT
2923 GO:0006457 protein folding GOTERM_BP_DIRECT
2923 GO:0034975 protein folding in endoplasmic reticulum GOTERM_BP_DIRECT
2923 GO:0015036 protein disulfide oxidoreductase activity GOTERM_MF_DIRECT
2923 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GOTERM_BP_DIRECT
2923 GO:0034976 response to endoplasmic reticulum stress GOTERM_BP_DIRECT
2923 GO:0004629 lysophospholipase activity GOTERM_MF_DIRECT
2923 GO:0003756 peptidyl-prolyl cis-trans isomerase activity GOTERM_MF_DIRECT
2923 GO:0005634 nucleus GOTERM_CC_DIRECT
2923 GO:0006606 protein import into nucleus GOTERM_BP_DIRECT
2923 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
2923 GO:0009986 cell surface GOTERM_CC_DIRECT
2923 GO:0006508 proteolysis GOTERM_BP_DIRECT
2923 GO:0016853 isomerase activity GOTERM_MF_DIRECT
2923 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2923 GO:0005515 protein binding GOTERM_MF_DIRECT
2923 GO:0005788 endoplasmic reticulum lumen GOTERM_CC_DIRECT
2923 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
2923 GO:0044822 poly GOTERM_MF_DIRECT
2923 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
2923 GO:0004197 aspartic-type endopeptidase activity GOTERM_MF_DIRECT
2923 GO:0005925 focal adhesion GOTERM_CC_DIRECT
2923 GO:0043209 myelin sheath GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2923 hsa04141 Protein processing in endoplasmic reticulum
2923 hsa04612 Antigen processing and presentation
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PDIA3 2923 Neoplasms C0027651 Neoplastic Process 0.3 0.633 0.552 group
PDIA3 2923 Acute Coronary Syndrome C0948089 Disease or Syndrome 0.3 0.633 0.552 disease
PDIA3 2923 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.633 0.552 group
PDIA3 2923 Benign Neoplasm C0086692 Neoplastic Process 0.3 0.633 0.552 group
PDIA3 2923 SPINOCEREBELLAR ATAXIA 17 C1846707 Disease or Syndrome 0.3 0.633 0.552 disease
PDIA3 2923 Malignant Neoplasms C0006826 Neoplastic Process 0.3 0.633 0.552 group
PDIA3 2923 Liver carcinoma C2239176 Neoplastic Process 0.32 0.633 0.552 disease
PDIA3 2923 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.32 0.633 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types