Hypoxia up-regulated protein 1

AltitudeomicsDB
Protein Official symbol HYOU1
Aliases HYOU1 GRP170 ORP150
Chromosomal Location 11
Length 999
Uniprot ID Q9Y4L1
EC number None
Protein family Information(Pfam) PF00012;
PDB id None
InterPro ID IPR043129;IPR018181;IPR029048;IPR029047;IPR013126;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CALR HSP90B1 0.999
P4HB CALR 0.999
CALR PDIA3 0.999
HSPA5 HSP90B1 0.999
SEC63 SEC61A1 0.999
P4HB HSP90B1 0.998
HSPA5 CANX 0.998
PDIA3 CANX 0.998
HSPA5 CALR 0.998
HSPA5 PDIA3 0.997
HSPA5 DNAJC10 0.997
DNAJC3 PDIA6 0.997
PDIA6 HSP90B1 0.997
DNAJC3 HSP90B1 0.995
HYOU1 HSP90B1 0.995
DNAJB11 HSPA5 0.994
PDIA6 P4HB 0.994
HYOU1 PDIA4 0.993
P4HB HSPA5 0.991
HSP90B1 PDIA4 0.991
HSPA5 PDIA4 0.991
HYOU1 HSPA5 0.99
HYOU1 SIL1 0.989
DNAJC3 P4HB 0.986
DNAJC3 HSPA5 0.984
PDIA6 HSPA5 0.983
PDIA3 HSP90B1 0.98
HSP90B1 CANX 0.979
HYOU1 DNAJC10 0.979
CALR PDIA4 0.976
HYOU1 DNAJC3 0.976
DNAJB11 HSP90B1 0.975
MANF HSPA5 0.975
HYOU1 DNAJB11 0.973
HSP90B1 DNAJC10 0.971
MANF CRELD2 0.97
PDIA6 CALR 0.969
MANF HSP90B1 0.963
HYOU1 SEC63 0.962
CALR CANX 0.959
SEC63 HSPA5 0.958
MANF PDIA4 0.955
HYOU1 P4HB 0.954
HYOU1 CALR 0.954
DNAJB11 PDIA6 0.953
HSPA5 SEC61A1 0.951
DNAJC3 PDIA4 0.95
HYOU1 PDIA6 0.95
HYOU1 MANF 0.946
MANF DNAJB11 0.945
DNAJC3 DNAJB11 0.942
HYOU1 CANX 0.934
MANF PDIA6 0.933
HYOU1 PDIA3 0.924
P4HB CANX 0.918
CANX SEC61A1 0.916
PDIA6 PDIA4 0.91
HYOU1 SEC61A1 0.906
CRELD2 PDIA4 0.905
HYOU1 CRELD2 0.901
Gene Ontology Semantic Similarity
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# 811 (CALR) 5034 (P4HB) 3309 (HSPA5) 11231 (SEC63) 2923 (PDIA3) 5611 (DNAJC3) 10130 (PDIA6) 10525 (HYOU1) 51726 (DNAJB11) 7184 (HSP90B1) 7873 (MANF) 821 (CANX) 79174 (CRELD2) 29927 (SEC61A1) 54431 (DNAJC10) 9601 (PDIA4)
811 (CALR) 1.00 0.65 0.73 0.66 0.59 0.56 0.57 1.00 1.00 0.77 0.55 0.72 1.00 0.55 0.56 0.65
5034 (P4HB) 0.65 1.00 0.55 0.51 0.74 0.44 0.63 0.82 1.00 0.56 0.44 0.57 1.00 0.42 0.62 0.81
3309 (HSPA5) 0.73 0.55 1.00 0.59 0.55 0.63 0.62 1.00 1.00 0.69 0.41 0.64 1.00 0.59 0.64 0.59
11231 (SEC63) 0.66 0.51 0.59 1.00 0.50 0.51 0.49 0.82 1.00 0.66 0.60 0.74 1.00 0.58 0.50 0.59
2923 (PDIA3) 0.59 0.74 0.55 0.50 1.00 0.43 0.65 0.82 1.00 0.55 0.44 0.56 1.00 0.41 0.67 0.83
5611 (DNAJC3) 0.56 0.44 0.63 0.51 0.43 1.00 0.59 1.00 0.82 0.56 0.39 0.61 0.82 0.53 0.60 0.50
10130 (PDIA6) 0.57 0.63 0.62 0.49 0.65 0.59 1.00 0.82 1.00 0.58 0.43 0.63 1.00 0.52 0.75 0.76
10525 (HYOU1) 1.00 0.82 1.00 0.82 0.82 1.00 0.82 1.00 0.82 0.82 0.48 0.82 0.82 0.82 1.00 0.82
51726 (DNAJB11) 1.00 1.00 1.00 1.00 1.00 0.82 1.00 0.82 1.00 1.00 0.59 1.00 1.00 1.00 1.00 1.00
7184 (HSP90B1) 0.77 0.56 0.69 0.66 0.55 0.56 0.58 0.82 1.00 1.00 0.61 0.79 1.00 0.54 0.54 0.65
7873 (MANF) 0.55 0.44 0.41 0.60 0.44 0.39 0.43 0.48 0.59 0.61 1.00 0.80 0.59 0.42 0.36 0.58
821 (CANX) 0.72 0.57 0.64 0.74 0.56 0.61 0.63 0.82 1.00 0.79 0.80 1.00 1.00 0.55 0.55 0.72
79174 (CRELD2) 1.00 1.00 1.00 1.00 1.00 0.82 1.00 0.82 1.00 1.00 0.59 1.00 1.00 1.00 1.00 1.00
29927 (SEC61A1) 0.55 0.42 0.59 0.58 0.41 0.53 0.52 0.82 1.00 0.54 0.42 0.55 1.00 1.00 0.51 0.45
54431 (DNAJC10) 0.56 0.62 0.64 0.50 0.67 0.60 0.75 1.00 1.00 0.54 0.36 0.55 1.00 0.51 1.00 0.68
9601 (PDIA4) 0.65 0.81 0.59 0.59 0.83 0.50 0.76 0.82 1.00 0.65 0.58 0.72 1.00 0.45 0.68 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HYOU1 Toad Liver - 3464 m 33 day upregulated 2.341031173 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
USF1 7391 HYOU1 10525 distal 22955619 TRANSFAC
EP300 2033 HYOU1 10525 distal 22955619 TRANSFAC
MAX 4149 HYOU1 10525 distal 22955619 TRANSFAC
USF2 7392 HYOU1 10525 distal 22955619 TRANSFAC
SIRT1 23411 HYOU1 10525 Repression 17507653 TRUSST
FOXO1 2308 HYOU1 10525 Repression 21672318 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT016306 hsa-miR-193b-3p Homo sapiens HYOU1 10525 Homo sapiens Microarray Functional MTI (Weak) 20304954
MIRT016306 hsa-miR-193b-3p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT016902 hsa-miR-335-5p Homo sapiens HYOU1 10525 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT036087 hsa-miR-1296-5p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037898 hsa-miR-455-3p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038859 hsa-miR-93-3p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039029 hsa-miR-766-3p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040395 hsa-miR-615-3p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT041955 hsa-miR-484 Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047102 hsa-miR-183-5p Homo sapiens HYOU1 10525 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT475439 hsa-miR-6130 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475443 hsa-miR-4419a Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475445 hsa-miR-6798-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475434 hsa-miR-6739-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475440 hsa-miR-6129 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475442 hsa-miR-4510 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475446 hsa-miR-3126-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475437 hsa-miR-760 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475438 hsa-miR-6133 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475448 hsa-miR-5584-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475435 hsa-miR-3153 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475444 hsa-miR-6875-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475433 hsa-miR-6834-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475441 hsa-miR-6127 Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475436 hsa-miR-6733-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT475447 hsa-miR-6732-5p Homo sapiens HYOU1 10525 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT727481 hsa-miR-16-5p Homo sapiens HYOU1 10525 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727480 hsa-miR-195-5p Homo sapiens HYOU1 10525 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727482 hsa-miR-15b-5p Homo sapiens HYOU1 10525 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT727483 hsa-miR-15a-5p Homo sapiens HYOU1 10525 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT734106 hsa-miR-193a-3p Homo sapiens HYOU1 10525 Homo sapiens Luciferase reporter assay//Microarray//Western blot Functional MTI 28276476
Gene Ontology
ID GO ID GO Term GO Type
10525 GO:0005524 ATP binding GOTERM_MF_DIRECT
10525 GO:0002931 response to ischemia GOTERM_BP_DIRECT
10525 GO:0051087 chaperone binding GOTERM_MF_DIRECT
10525 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
10525 GO:0071682 endocytic vesicle lumen GOTERM_CC_DIRECT
10525 GO:0006898 receptor-mediated endocytosis GOTERM_BP_DIRECT
10525 GO:0005925 focal adhesion GOTERM_CC_DIRECT
10525 GO:0034663 endoplasmic reticulum chaperone complex GOTERM_CC_DIRECT
10525 GO:0006888 ER to Golgi vesicle-mediated transport GOTERM_BP_DIRECT
10525 GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
10525 GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
10525 GO:0034976 response to endoplasmic reticulum stress GOTERM_BP_DIRECT
10525 GO:0071456 cellular response to hypoxia GOTERM_BP_DIRECT
10525 GO:0005576 extracellular region GOTERM_CC_DIRECT
10525 GO:0016020 membrane GOTERM_CC_DIRECT
10525 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
10525 GO:0005788 endoplasmic reticulum lumen GOTERM_CC_DIRECT
10525 GO:0036498 IRE1-mediated unfolded protein response GOTERM_BP_DIRECT
10525 GO:0005790 smooth endoplasmic reticulum GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
10525 hsa04141 Protein processing in endoplasmic reticulum
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HYOU1 10525 SPINOCEREBELLAR ATAXIA 17 C1846707 Disease or Syndrome 0.3 0.701 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types