Cysteine-rich with EGF-like domain protein 2

AltitudeomicsDB
Protein Official symbol CRELD2
Aliases CRELD2 UNQ185/PRO211
Chromosomal Location  22
Length 353
Uniprot ID Q6UXH1
EC number 5.3.4.1
Protein family Information(Pfam) PF07645;
PDB id None
InterPro ID IPR001881;IPR013032;IPR000742;IPR000152;IPR018097;IPR006212;IPR009030;IPR002049;
dbSNP rs8139422 rs11545762 rs11545763

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HYOU1 PDIA4 0.99
CRELD2 SDF2L1 0.975
MANF CRELD2 0.97
MANF PDIA4 0.955
HYOU1 MANF 0.946
CRELD2 PDIA4 0.905
HYOU1 CRELD2 0.901
Gene Ontology Semantic Similarity
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# 10525 (HYOU1) 79174 (CRELD2) 7873 (MANF) 9601 (PDIA4)
10525 (HYOU1) 1.00 0.82 0.48 0.82
79174 (CRELD2) 0.82 1.00 0.59 1.00
7873 (MANF) 0.48 0.59 1.00 0.58
9601 (PDIA4) 0.82 1.00 0.58 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CRELD2 Toad Liver - 3464 m 33 day upregulated 2.096881727 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
YY1 7528 CRELD2 79174 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023504 hsa-miR-1-3p Homo sapiens CRELD2 79174 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT048889 hsa-miR-93-5p Homo sapiens CRELD2 79174 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
79174 GO:0005515 protein binding GOTERM_MF_DIRECT
79174 GO:0005509 calcium ion binding GOTERM_MF_DIRECT
79174 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
79174 GO:0005615 extracellular space GOTERM_CC_DIRECT
79174 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types