Hexokinase-2

AltitudeomicsDB
Protein Official symbol HK2
Aliases HK2
Chromosomal Location  2
Length 917
Uniprot ID P52789
EC number 2.7.1.1
Protein family Information(Pfam) PF00349;PF03727;
PDB id 2NZT;5HEX;5HFU;5HG1;
InterPro ID IPR043129;IPR001312;IPR019807;IPR022673;IPR022672;
dbSNP rs2229621 rs28363006 rs28363015 rs28363016 rs61748096 rs28363029 rs145124653 rs185927605 rs28363057 rs2229629 rs28363065

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
GPI PGM1 0.995
GPI G6PD 0.994
GPI MPI 0.993
GNPDA1 AMDHD2 0.992
GPI PFKM 0.992
AMDHD2 GNPDA2 0.992
H6PD GPI 0.991
GPI TALDO1 0.991
MPI PMM2 0.987
PGM2 PGM1 0.983
GFPT1 GNPNAT1 0.981
GFPT2 GNPNAT1 0.976
MPI PMM1 0.974
FBP1 TALDO1 0.973
GPI PGM2 0.971
GPI HK2 0.97
PFKM TALDO1 0.97
FBP1 GPI 0.969
FBP2 TALDO1 0.966
GNPDA1 GNPNAT1 0.966
GPI GFPT1 0.964
GPI FBP2 0.961
GLB1 LCT 0.96
GPI GFPT2 0.959
AMDHD2 GFPT2 0.957
SORD KHK 0.956
AMDHD2 GFPT1 0.955
GFPT1 MPI 0.955
G6PD HK2 0.955
GNPDA1 GPI 0.955
GALM LCT 0.951
H6PD TALDO1 0.951
MPI GFPT2 0.948
FBP2 PFKM 0.945
PGM1 HK2 0.944
FBP1 PFKM 0.943
H6PD G6PD 0.942
FBP1 HK2 0.941
GNPDA2 GNPNAT1 0.941
H6PD PGM1 0.941
GPI GNPDA2 0.94
GFPT1 HK2 0.937
MPI HK2 0.935
GNPDA1 MPI 0.935
G6PD TALDO1 0.934
GNPDA1 GFPT2 0.933
HK2 GFPT2 0.933
GNPDA1 GFPT1 0.933
G6PD PGM1 0.933
FBP2 HK2 0.931
HK2 GNPNAT1 0.93
FBP1 MPI 0.93
PGM1 TALDO1 0.929
PGM2 HK2 0.929
HK2 KHK 0.928
GNPDA2 HK2 0.925
GNPDA1 HK2 0.925
H6PD HK2 0.925
HK2 SORD 0.922
GLB1 GALM 0.922
MPI GNPDA2 0.921
PFKM MPI 0.921
FBP2 MPI 0.92
PFKM HK2 0.917
GALM SI 0.917
HK2 GALM 0.915
HK2 PMM1 0.914
GNPDA2 GFPT2 0.914
AMDHD2 HK2 0.912
HK2 PMM2 0.911
SI KHK 0.91
GFPT1 GNPDA2 0.91
TALDO1 HK2 0.905
HK2 SI 0.904
HK2 LCT 0.902
GLB1 HK2 0.9
Gene Ontology Semantic Similarity
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# 2821 (GPI) 10007 (GNPDA1) 51005 (AMDHD2) 4351 (MPI) 55276 (PGM2) 2673 (GFPT1) 9945 (GFPT2) 2203 (FBP1) 5213 (PFKM) 8789 (FBP2) 2720 (GLB1) 6652 (SORD) 2539 (G6PD) 130589 (GALM) 5236 (PGM1) 132789 (GNPDA2) 3099 (HK2) 6476 (SI) 6888 (TALDO1) 3795 (KHK) 3938 (LCT) 64841 (GNPNAT1) 5372 (PMM1) 5373 (PMM2)
2821 (GPI) 1.00 0.56 0.39 0.73 0.59 0.25 0.38 0.48 0.49 0.38 0.36 0.40 0.49 0.48 0.53 0.56 0.32 0.16 0.42 0.38 0.20 0.50 0.57 0.57
10007 (GNPDA1) 0.56 1.00 0.65 0.67 0.64 0.20 0.64 0.59 0.58 0.72 0.59 0.51 0.65 0.34 0.64 1.00 0.46 0.15 0.66 0.57 0.18 0.60 0.70 0.70
51005 (AMDHD2) 0.39 0.65 1.00 0.20 0.52 0.17 0.59 0.54 0.52 0.66 0.58 0.42 0.56 0.20 0.55 0.65 0.40 0.23 0.61 0.51 0.28 0.47 0.60 0.60
4351 (MPI) 0.73 0.67 0.20 1.00 0.34 0.17 0.17 0.16 0.16 0.16 0.17 0.20 0.20 0.34 0.34 0.67 0.17 0.15 0.24 0.20 0.20 0.14 0.34 0.34
55276 (PGM2) 0.59 0.64 0.52 0.34 1.00 0.17 0.50 0.47 0.49 0.55 0.47 0.40 0.52 0.34 0.85 0.64 0.37 0.15 0.54 0.46 0.19 0.41 0.84 0.84
2673 (GFPT1) 0.25 0.20 0.17 0.17 0.17 1.00 1.00 0.14 0.22 0.14 0.15 0.17 0.17 0.17 0.17 0.20 0.25 0.13 0.35 0.29 0.17 0.21 0.17 0.17
9945 (GFPT2) 0.38 0.64 0.59 0.17 0.50 1.00 1.00 0.51 0.53 0.62 0.51 0.41 0.55 0.17 0.54 0.64 0.45 0.13 0.68 0.57 0.16 0.49 0.59 0.59
2203 (FBP1) 0.48 0.59 0.54 0.16 0.47 0.14 0.51 1.00 0.77 0.78 0.51 0.58 0.66 0.16 0.61 0.59 0.40 0.12 0.52 0.47 0.15 0.62 0.51 0.51
5213 (PFKM) 0.49 0.58 0.52 0.16 0.49 0.22 0.53 0.77 1.00 0.57 0.55 0.54 0.70 0.16 0.51 0.58 0.61 0.09 0.54 0.61 0.11 0.62 0.52 0.52
8789 (FBP2) 0.38 0.72 0.66 0.16 0.55 0.14 0.62 0.78 0.57 1.00 0.59 0.49 0.63 0.16 0.58 0.72 0.43 0.15 0.63 0.54 0.19 0.57 0.62 0.62
2720 (GLB1) 0.36 0.59 0.58 0.17 0.47 0.15 0.51 0.51 0.55 0.59 1.00 0.42 0.60 0.17 0.50 0.59 0.38 0.35 0.54 0.47 0.45 0.45 0.52 0.52
6652 (SORD) 0.40 0.51 0.42 0.20 0.40 0.17 0.41 0.58 0.54 0.49 0.42 1.00 0.74 0.20 0.48 0.51 0.34 0.12 0.44 0.39 0.15 0.49 0.42 0.42
2539 (G6PD) 0.49 0.65 0.56 0.20 0.52 0.17 0.55 0.66 0.70 0.63 0.60 0.74 1.00 0.20 0.53 0.65 0.44 0.11 0.57 0.51 0.14 0.66 0.56 0.56
130589 (GALM) 0.48 0.34 0.20 0.34 0.34 0.17 0.17 0.16 0.16 0.16 0.17 0.20 0.20 1.00 0.34 0.34 0.17 0.15 0.24 0.20 0.20 0.14 0.34 0.34
5236 (PGM1) 0.53 0.64 0.55 0.34 0.85 0.17 0.54 0.61 0.51 0.58 0.50 0.48 0.53 0.34 1.00 0.64 0.39 0.13 0.57 0.49 0.16 0.44 0.76 0.76
132789 (GNPDA2) 0.56 1.00 0.65 0.67 0.64 0.20 0.64 0.59 0.58 0.72 0.59 0.51 0.65 0.34 0.64 1.00 0.46 0.15 0.66 0.57 0.18 0.60 0.70 0.70
3099 (HK2) 0.32 0.46 0.40 0.17 0.37 0.25 0.45 0.40 0.61 0.43 0.38 0.34 0.44 0.17 0.39 0.46 1.00 0.12 0.51 0.82 0.16 0.38 0.40 0.40
6476 (SI) 0.16 0.15 0.23 0.15 0.15 0.13 0.13 0.12 0.09 0.15 0.35 0.12 0.11 0.15 0.13 0.15 0.12 1.00 0.17 0.14 0.62 0.10 0.15 0.15
6888 (TALDO1) 0.42 0.66 0.61 0.24 0.54 0.35 0.68 0.52 0.54 0.63 0.54 0.44 0.57 0.24 0.57 0.66 0.51 0.17 1.00 0.63 0.21 0.53 0.62 0.62
3795 (KHK) 0.38 0.57 0.51 0.20 0.46 0.29 0.57 0.47 0.61 0.54 0.47 0.39 0.51 0.20 0.49 0.57 0.82 0.14 0.63 1.00 0.18 0.46 0.51 0.51
3938 (LCT) 0.20 0.18 0.28 0.20 0.19 0.17 0.16 0.15 0.11 0.19 0.45 0.15 0.14 0.20 0.16 0.18 0.16 0.62 0.21 0.18 1.00 0.13 0.18 0.18
64841 (GNPNAT1) 0.50 0.60 0.47 0.14 0.41 0.21 0.49 0.62 0.62 0.57 0.45 0.49 0.66 0.14 0.44 0.60 0.38 0.10 0.53 0.46 0.13 1.00 0.47 0.47
5372 (PMM1) 0.57 0.70 0.60 0.34 0.84 0.17 0.59 0.51 0.52 0.62 0.52 0.42 0.56 0.34 0.76 0.70 0.40 0.15 0.62 0.51 0.18 0.47 1.00 1.00
5373 (PMM2) 0.57 0.70 0.60 0.34 0.84 0.17 0.59 0.51 0.52 0.62 0.52 0.42 0.56 0.34 0.76 0.70 0.40 0.15 0.62 0.51 0.18 0.47 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HK2 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 4.1 RT-qPCR Western US C57BL/6 mice −1.8 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
HK2 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 2.8 RT-qPCR Western US C57BL/6 mice −1.8 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TCF4 6925 HK2 3099 proximal_filtered 22955619 TRANSFAC
SREBF1 6720 HK2 3099 Repression 16707624 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT006301 hsa-miR-143-3p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay Functional MTI 23376635
MIRT006301 hsa-miR-143-3p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay Functional MTI 22354042
MIRT006301 hsa-miR-143-3p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24033605
MIRT006301 hsa-miR-143-3p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay Functional MTI 22593586
MIRT006301 hsa-miR-143-3p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay Functional MTI 22691140
MIRT006945 hsa-miR-125b-5p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 22593586
MIRT006944 hsa-miR-125a-5p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay Functional MTI 22593586
MIRT019914 hsa-miR-375 Homo sapiens HK2 3099 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT020800 hsa-miR-155-5p Homo sapiens HK2 3099 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT027665 hsa-miR-98-5p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28025745
MIRT027665 hsa-miR-98-5p Homo sapiens HK2 3099 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT041885 hsa-miR-484 Homo sapiens HK2 3099 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT731381 hsa-miR-199a-5p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26054020
MIRT731659 hsa-miR-181b-5p Homo sapiens HK2 3099 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27314295
MIRT731659 hsa-miR-181b-5p Homo sapiens HK2 3099 Homo sapiens Immunohistochemistry//In situ hybridization//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28184935
Gene Ontology
ID GO ID GO Term GO Type
3099 GO:0015758 glucose transport GOTERM_BP_DIRECT
3099 GO:0004340 exo-alpha-sialidase activity GOTERM_MF_DIRECT
3099 GO:0072655 establishment of protein localization to mitochondrion GOTERM_BP_DIRECT
3099 GO:0005524 ATP binding GOTERM_MF_DIRECT
3099 GO:0005623 cell GOTERM_CC_DIRECT
3099 GO:0016020 membrane GOTERM_CC_DIRECT
3099 GO:0007595 lactation GOTERM_BP_DIRECT
3099 GO:0051156 glucose 6-phosphate metabolic process GOTERM_BP_DIRECT
3099 GO:0061621 canonical glycolysis GOTERM_BP_DIRECT
3099 GO:0005536 FK506 binding GOTERM_MF_DIRECT
3099 GO:0005741 mitochondrial outer membrane GOTERM_CC_DIRECT
3099 GO:0008865 cysteine-type endopeptidase activator activity involved in apoptotic process GOTERM_MF_DIRECT
3099 GO:0019158 GDP binding GOTERM_MF_DIRECT
3099 GO:0002931 response to ischemia GOTERM_BP_DIRECT
3099 GO:0001678 cellular glucose homeostasis GOTERM_BP_DIRECT
3099 GO:0035795 negative regulation of mitochondrial membrane permeability GOTERM_BP_DIRECT
3099 GO:0046835 carbohydrate phosphorylation GOTERM_BP_DIRECT
3099 GO:1904925 positive regulation of mitophagy in response to mitochondrial depolarization GOTERM_BP_DIRECT
3099 GO:0005829 cytosol GOTERM_CC_DIRECT
3099 GO:0072656 maintenance of protein location in mitochondrion GOTERM_BP_DIRECT
3099 GO:2000378 negative regulation of reactive oxygen species metabolic process GOTERM_BP_DIRECT
3099 GO:0005515 protein binding GOTERM_MF_DIRECT
3099 GO:0008637 apoptotic mitochondrial changes GOTERM_BP_DIRECT
3099 GO:0006096 glycolytic process GOTERM_BP_DIRECT
3099 GO:0004396 helicase activity GOTERM_MF_DIRECT
3099 GO:0046324 regulation of glucose import GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3099 hsa00010 Glycolysis / Gluconeogenesis
3099 hsa00052 Galactose metabolism
3099 hsa00051 Fructose and mannose metabolism
3099 hsa00524 Butirosin and neomycin biosynthesis
3099 hsa00520 Amino sugar and nucleotide sugar metabolism
3099 hsa00500 Starch and sucrose metabolism
3099 hsa01100 Metabolic pathways
3099 hsa01130 Biosynthesis of antibiotics
3099 hsa01200 Carbon metabolism
3099 hsa04066 HIF-1 signaling pathway
3099 hsa04910 Insulin signaling pathway
3099 hsa04930 Type II diabetes mellitus
3099 hsa04973 Carbohydrate digestion and absorption
3099 hsa05230 Central carbon metabolism in cancer
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HK2 3099 Obesity C0028754 Disease or Syndrome 0.52 0.584 0.552 disease
HK2 3099 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.584 0.552 disease
HK2 3099 Adenocarcinoma of lung (disorder) C0152013 Neoplastic Process 0.3 0.584 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types