Hemopexin

AltitudeomicsDB
Protein Official symbol HPX
Aliases HPX
Chromosomal Location  11
Length 462
Uniprot ID P02790
EC number None
Protein family Information(Pfam) PF00045;
PDB id None
InterPro ID IPR016358;IPR000585;IPR036375;IPR018487;IPR018486;
dbSNP rs10839564 rs12117

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ALB HPX 0.976
HPX LRP1 0.965
ALB LRP1 0.945
HBB HPX 0.937
HBB LRP1 0.901
Gene Ontology Semantic Similarity
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# 213 (ALB) 3263 (HPX) 3043 (HBB) 4035 (LRP1)
213 (ALB) 1.00 1.00 0.67 0.56
3263 (HPX) 1.00 1.00 1.00 1.00
3043 (HBB) 0.67 1.00 1.00 0.54
4035 (LRP1) 0.56 1.00 0.54 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HPX Rat Lungs - 7600 m 12 hours downregulated 1.4 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
HPX Human Plasma - 3500-4000m Native upregulated 1.92 2-DE Northern indo-australian plate Ladakhi 1 Sea level healthy individuals 23844025
HPX Rat Lungs - 7600 m 6 hours upregulated 1.2 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
HPX Rat Lungs - 7600 m 24 hours upregulated 1.9 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
HPX Rat Plasma - 7619 m 24 hours upregulated 0.51 2-DE Northern indo-australian plate Male sprague-dawley 1 8 weeks old male SD rats kept at standard conditions 26882918
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
FOXA2 3170 HPX 3263 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
3263 GO:0015232 L-serine transmembrane transporter activity GOTERM_MF_DIRECT
3263 GO:0006879 cellular iron ion homeostasis GOTERM_BP_DIRECT
3263 GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway GOTERM_BP_DIRECT
3263 GO:0005615 extracellular space GOTERM_CC_DIRECT
3263 GO:0042168 heme metabolic process GOTERM_BP_DIRECT
3263 GO:0046872 metal ion binding GOTERM_MF_DIRECT
3263 GO:0002639 positive regulation of immunoglobulin production GOTERM_BP_DIRECT
3263 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin GOTERM_BP_DIRECT
3263 GO:0016032 viral process GOTERM_BP_DIRECT
3263 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3263 GO:0072562 blood microparticle GOTERM_CC_DIRECT
3263 GO:0006898 receptor-mediated endocytosis GOTERM_BP_DIRECT
3263 GO:0015886 heme transport GOTERM_BP_DIRECT
3263 GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein GOTERM_BP_DIRECT
3263 GO:0005576 extracellular region GOTERM_CC_DIRECT
3263 GO:0005515 protein binding GOTERM_MF_DIRECT
3263 GO:0071682 endocytic vesicle lumen GOTERM_CC_DIRECT
3263 GO:0020027 hemoglobin metabolic process GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HPX 3263 Acute Kidney Insufficiency C1565662 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Autoimmune Diseases C0004364 Disease or Syndrome 0.3 0.648 0.621 group
HPX 3263 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Compartment syndromes C0009492 Disease or Syndrome 0.3 0.648 0.621 group
HPX 3263 Kidney Failure, Acute C0022660 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Acute kidney injury C2609414 Injury or Poisoning 0.3 0.648 0.621 disease
HPX 3263 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Adverse reaction to drug C0041755 Pathologic Function 0.3 0.648 0.621 group
HPX 3263 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.648 0.621 disease
HPX 3263 Diabetes Mellitus, Non-Insulin-Dependent C0011860 Disease or Syndrome 0.3 0.648 0.621 disease
HPX 3263 Drug toxicity C0013221 Injury or Poisoning 0.3 0.648 0.621 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types