Insulin-like growth factor-binding protein complex acid labile subunit

AltitudeomicsDB
Protein Official symbol IGFALS
Aliases IGFALS ALS
Chromosomal Location  16
Length 605
Uniprot ID P35858
EC number None
Protein family Information(Pfam) PF13855;PF01462;
PDB id None
InterPro ID IPR000483;IPR001611;IPR003591;IPR032675;IPR000372;
dbSNP rs766004600 rs35947557 rs774634302 rs551618643 rs34297640 rs776840046 rs9282730 rs121909247 rs9282731

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
IGF1 IGFBP5 0.999
IGFBP3 IGF1 0.998
IGF2 IGFBP3 0.996
IGF2 IGFBP5 0.995
PAPPA IGF1 0.978
IGFALS IGFBP3 0.978
IGFALS IGF1 0.976
PAPPA2 IGFBP5 0.975
IGFBP3 PLG 0.975
IGFBP3 KLK3 0.971
IGFALS IGFBP5 0.969
IGFBP3 MMP2 0.966
PAPPA IGFBP5 0.964
MMP1 PLG 0.96
IGF1 MMP2 0.96
IGFBP3 MMP1 0.959
IGF2 PLG 0.957
PLG IGF1 0.956
IGF2 PAPPA 0.956
KLK3 IGF1 0.956
MMP1 IGF1 0.945
IGFBP3 CTSG 0.945
IGF2 MMP2 0.945
IGFBP3 F2 0.944
IGFALS IGF2 0.944
PAPPA2 IGF1 0.937
F2 IGF1 0.937
IGF2 KLK3 0.936
MMP1 CTSG 0.936
IGF2 PAPPA2 0.928
IGFBP3 KLK2 0.926
IGF2 MMP1 0.925
IGF2 F2 0.923
IGF2 IGF1 0.922
IGF2 CTSG 0.922
MMP1 MMP2 0.922
IGFBP3 IGFBP5 0.922
IGF2 KLK2 0.919
IGFALS PAPPA2 0.917
IGFBP3 KLK1 0.917
IGF1 CTSG 0.916
KLK2 IGF1 0.915
IGFALS PLG 0.914
IGFALS F2 0.913
IGF1 KLK1 0.913
IGFALS PAPPA 0.913
IGFALS CTSG 0.912
IGF2 KLK1 0.91
KLK13 IGFBP3 0.908
IGFALS KLK1 0.908
IGFBP3 GZMH 0.907
IGFALS KLK2 0.907
IGFALS GZMH 0.907
IGFALS KLK3 0.907
KLK13 IGF2 0.907
KLK13 IGFALS 0.906
KLK13 IGF1 0.904
IGFALS MMP1 0.902
IGFALS MMP2 0.9
IGF1 GZMH 0.9
IGF2 GZMH 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 3479 (IGF1) 3486 (IGFBP3) 3481 (IGF2) 5069 (PAPPA) 3483 (IGFALS) 60676 (PAPPA2) 4312 (MMP1) 5340 (PLG) 354 (KLK3) 2147 (F2) 3817 (KLK2) 26085 (KLK13) 3488 (IGFBP5) 4313 (MMP2) 1511 (CTSG) 3816 (KLK1) 2999 (GZMH)
3479 (IGF1) 1.00 0.64 0.84 0.21 0.69 0.21 0.12 0.68 0.50 0.63 0.12 0.60 0.72 0.54 0.52 0.12 0.12
3486 (IGFBP3) 0.64 1.00 0.62 0.30 1.00 0.30 0.11 0.62 0.49 0.56 0.12 0.56 0.85 0.51 0.51 0.12 0.12
3481 (IGF2) 0.84 0.62 1.00 0.19 0.69 0.19 0.11 0.65 0.47 0.63 0.12 0.54 0.64 0.49 0.49 0.12 0.12
5069 (PAPPA) 0.21 0.30 0.19 1.00 0.21 1.00 0.71 0.41 0.58 0.34 0.59 0.50 0.22 0.75 0.53 0.59 0.59
3483 (IGFALS) 0.69 1.00 0.69 0.21 1.00 0.21 0.11 0.69 0.69 0.69 0.08 0.69 0.86 0.69 0.69 0.08 0.08
60676 (PAPPA2) 0.21 0.30 0.19 1.00 0.21 1.00 0.71 0.41 0.58 0.34 0.59 0.50 0.22 0.75 0.53 0.59 0.59
4312 (MMP1) 0.12 0.11 0.11 0.71 0.11 0.71 1.00 0.45 0.77 0.40 1.00 0.68 0.12 0.82 0.64 1.00 1.00
5340 (PLG) 0.68 0.62 0.65 0.41 0.69 0.41 0.45 1.00 0.85 0.77 1.00 0.82 0.66 0.83 0.82 1.00 1.00
354 (KLK3) 0.50 0.49 0.47 0.58 0.69 0.58 0.77 0.85 1.00 0.69 1.00 0.87 0.51 0.84 0.83 1.00 1.00
2147 (F2) 0.63 0.56 0.63 0.34 0.69 0.34 0.40 0.77 0.69 1.00 1.00 0.69 0.60 0.69 0.79 1.00 1.00
3817 (KLK2) 0.12 0.12 0.12 0.59 0.08 0.59 1.00 1.00 1.00 1.00 1.00 1.00 0.12 1.00 1.00 1.00 1.00
26085 (KLK13) 0.60 0.56 0.54 0.50 0.69 0.50 0.68 0.82 0.87 0.69 1.00 1.00 0.63 0.83 0.85 1.00 1.00
3488 (IGFBP5) 0.72 0.85 0.64 0.22 0.86 0.22 0.12 0.66 0.51 0.60 0.12 0.63 1.00 0.55 0.54 0.12 0.12
4313 (MMP2) 0.54 0.51 0.49 0.75 0.69 0.75 0.82 0.83 0.84 0.69 1.00 0.83 0.55 1.00 0.80 1.00 1.00
1511 (CTSG) 0.52 0.51 0.49 0.53 0.69 0.53 0.64 0.82 0.83 0.79 1.00 0.85 0.54 0.80 1.00 1.00 1.00
3816 (KLK1) 0.12 0.12 0.12 0.59 0.08 0.59 1.00 1.00 1.00 1.00 1.00 1.00 0.12 1.00 1.00 1.00 1.00
2999 (GZMH) 0.12 0.12 0.12 0.59 0.08 0.59 1.00 1.00 1.00 1.00 1.00 1.00 0.12 1.00 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
IGFALS Toad Heart - 3464 m 33 day downregulated -3.552936701 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
3483 GO:0042567 insulin-like growth factor ternary complex GOTERM_CC_DIRECT
3483 GO:0007155 cell adhesion GOTERM_BP_DIRECT
3483 GO:0044267 cellular protein metabolic process GOTERM_BP_DIRECT
3483 GO:0005576 extracellular region GOTERM_CC_DIRECT
3483 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
3483 GO:0007165 signal transduction GOTERM_BP_DIRECT
3483 GO:0005520 insulin-like growth factor binding GOTERM_MF_DIRECT
3483 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3483 GO:0005615 extracellular space GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
IGFALS 3483 Delayed Puberty C0034012 Pathologic Function 0.4 0.565 0.69 phenotype
IGFALS 3483 Growth Disorders C0018273 Pathologic Function 0.3 0.565 0.69 group
IGFALS 3483 Insulin Resistance C0021655 Pathologic Function 0.4 0.565 0.69 phenotype
IGFALS 3483 Insulin Sensitivity C0920563 Pathologic Function 0.3 0.565 0.69 phenotype
IGFALS 3483 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.565 0.69 disease
IGFALS 3483 Acid-Labile Subunit Deficiency C3900122 Laboratory or Test Result 0.61 0.565 0.69 phenotype
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types