ALTITUDEOMICSDB

Insulin-like growth factor-binding protein 3

AltitudeomicsDB

Protein Official symbol	IGFBP3
Aliases	IGFBP3 IBP3
Chromosomal Location	7
Length	291
Uniprot ID	P17936
EC number	None
Protein family Information(Pfam)	PF00219;PF00086;
PDB id	None
InterPro ID	IPR009030;IPR012211;IPR000867;IPR009168;IPR022321;IPR017891;IPR000716;IPR036857;
dbSNP	rs2854746 rs34257987 rs9282734 rs35712717 rs538312081

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
AHSG	ALB	0.998
APOA1	APOB	0.998
APOA2	APOA1	0.998
IGF1	IGFBP1	0.997
AHSG	AFP	0.997
IGFBP3	IGF1	0.997
AHSG	APOA1	0.996
APOA2	APOB	0.996
AHSG	APOA2	0.995
APOE	APOB	0.994
IGF2	IGFBP3	0.994
INS	IGF1	0.994
APP	APOE	0.993
IGF1	IGFBP5	0.992
PCSK9	APOB	0.992
MAPK8	TP53	0.991
IGF1	IGFBP4	0.99
ALB	APOA1	0.99
FN1	ALB	0.989
AFP	GPC3	0.989
AFP	APOA2	0.989
IGF2	IGFBP1	0.988
AHSG	APOB	0.987
IGF2	IGFBP5	0.987
APOE	APOA1	0.987
FN1	FBN1	0.986
ALB	APOB	0.986
IGFBP3	TP53	0.985
AFP	APOB	0.984
AFP	IGFBP1	0.984
SERPINA1	ALB	0.983
SERPINA1	AFP	0.983
IL6	ALB	0.983
TP53	EP300	0.983
AHSG	IGFBP1	0.982
IL6	TIMP1	0.982
IGF2	IGFBP4	0.981
APOA2	ALB	0.981
FN1	CDH2	0.981
CYR61	IGFBP7	0.98
FN1	PLG	0.979
APOA2	APOE	0.979
AFP	APOA1	0.979
SPP1	TIMP1	0.978
IL6	SPP1	0.978
SPP1	ALB	0.978
MAPK8	APP	0.978
PLG	ALB	0.978
SPP1	FN1	0.977
IGFBP3	FN1	0.976
IL6	CSF1	0.976
FBN1	VCAN	0.974
SERPINA1	AHSG	0.974
IGF1	ALB	0.974
FN1	IGFBP5	0.973
IGFBP1	APOB	0.973
FN1	TIMP1	0.972
IL6	FN1	0.971
IL6	APOA1	0.971
FN1	SDC2	0.971
SERPINA1	IL6	0.971
IL6	FSTL1	0.97
SERPINA1	APOA1	0.97
FN1	VCAN	0.97
ALB	IGFBP1	0.969
SERPINA1	PLG	0.969
PLG	TIMP1	0.969
IL6	IGFBP1	0.969
IL6	APOE	0.969
ALB	APOE	0.968
FN1	IGF1	0.968
IGFALS	IGFBP3	0.967
FSTL1	FSTL3	0.967
PCSK9	APOE	0.966
AHSG	SPP1	0.966
IGFBP3	IGFBP7	0.966
CDH2	BMP4	0.965
APP	CDH2	0.965
APOA2	IGFBP1	0.965
IGFBP1	APOA1	0.965
IGFBP7	IGFBP5	0.965
ALB	APP	0.965
GPC3	SDC2	0.965
INS	APP	0.965
IGFALS	IGF1	0.964
IGFBP3	PLG	0.962
IGFBP7	IGFBP4	0.962
FN1	BMP4	0.962
FN1	LAMB1	0.961
PCSK9	APOA1	0.96
CDH2	VCAN	0.96
SERPINA1	APOA2	0.96
MMP1	PLG	0.96
LTBP1	FN1	0.96
IGF1	MMP2	0.96
IGF2	ALB	0.958
CYR61	FN1	0.958
AHSG	PLG	0.958
FBN1	FSTL1	0.958
IL6	APP	0.957
INS	ALB	0.957
MMP1	TIMP1	0.957
IL6	APOB	0.957
MMP2	TIMP1	0.957
ALB	CDH2	0.956
PLG	IGF1	0.956
AHSG	GPC3	0.956
IGFBP3	KLK3	0.956
KLK3	IGF1	0.956
IGFBP7	IGFBP1	0.956
ALB	TIMP1	0.956
AFP	ALB	0.956
IGF2	GPC3	0.955
ALB	BMP4	0.955
SPP1	BMP4	0.954
IL6	IGFBP3	0.953
IGF2	FN1	0.953
IGFBP3	SDC2	0.953
IGF1	TIMP1	0.953
IGFALS	IGFBP5	0.953
CSF1	ALB	0.952
AFP	FN1	0.952
SERPINA1	APOB	0.952
FN1	APOE	0.952
MAPK8	EP300	0.951
IGF1	APP	0.95
SPP1	CSF1	0.95
SERPINA1	APOE	0.95
SERPINA1	FN1	0.949
SPP1	APOE	0.949
IGFBP3	TIMP1	0.949
IGFBP3	MMP2	0.948
IGF2	INS	0.948
AFP	BMP4	0.948
FN1	CSF1	0.948
IGFBP3	ALB	0.948
VCAN	BMP4	0.948
AFP	SPP1	0.948
CYR61	IGFBP3	0.948
GPC3	ALB	0.948
SPP1	CDH2	0.947
AHSG	IL6	0.947
IL6	INS	0.947
VCAN	TIMP1	0.946
IL6	AFP	0.946
FN1	APP	0.946
FN1	GAS6	0.946
CSF1	TIMP1	0.946
GPC3	BMP4	0.945
IL6	CDH2	0.945
IL6	BMP4	0.945
MMP1	IGF1	0.945
IGF2	MMP2	0.945
FN1	IGFBP1	0.945
FN1	FSTL1	0.944
IGFALS	IGF2	0.944
APOE	TIMP1	0.944
INS	IGFBP1	0.944
FN1	TNC	0.944
IGFBP4	STC2	0.943
AHSG	APOE	0.942
SPP1	VCAN	0.942
TNC	BMP4	0.941
GPC3	VCAN	0.94
IGFBP1	TIMP1	0.94
IL6	VCAN	0.94
SERPINA1	TIMP1	0.94
CYR61	IL6	0.94
CDH2	TIMP1	0.939
FBN1	TIMP1	0.939
FN1	APOA1	0.939
AFP	LGALS1	0.939
CSF1	APOE	0.939
SDC2	VCAN	0.939
IL6	GAS6	0.939
INS	IGFBP3	0.938
FN1	APOB	0.938
GPC3	IGFBP1	0.938
SPP1	GPC3	0.938
GPC3	APOA1	0.938
FN1	IGFBP7	0.938
PCSK9	ALB	0.938
IGFBP3	MMP1	0.937
CYR61	IGFBP5	0.937
GAS6	ALB	0.937
FN1	IGFBP4	0.937
AFP	CDH2	0.937
LTBP1	FBN1	0.937
IGFBP3	IGFBP1	0.936
CYR61	BMP4	0.936
IGF2	KLK3	0.936
FBN1	LAMB1	0.936
FBN1	BMP4	0.936
CYR61	GAS6	0.936
AHSG	FN1	0.936
SPP1	IGFBP3	0.935
ALB	VCAN	0.935
FSTL1	BMP4	0.935
TIMP1	LGALS1	0.935
IGFBP7	TIMP1	0.935
PLG	APP	0.935
SDC2	MMP2	0.935
CYR61	FSTL1	0.934
IGF2	TIMP1	0.934
IGFBP4	TIMP1	0.934
GPC3	FN1	0.934
LTBP1	VCAN	0.934
IGF2	PLG	0.934
CYR61	TIMP1	0.934
IL6	IGFBP7	0.934
AHSG	IGF1	0.933
IGFBP1	VCAN	0.933
BMP4	FSTL3	0.933
APP	APOA1	0.933
FN1	LGALS1	0.933
GAS6	CSF1	0.933
LAMB2	FN1	0.933
LTBP1	FSTL1	0.933
CYR61	LAMB1	0.933
APOA1	TIMP1	0.932
IGFBP3	STC2	0.932
SPP1	IGFBP1	0.932
FN1	PRSS23	0.931
IGFBP4	VCAN	0.931
IGFBP3	IGFBP4	0.931
SPP1	IGFBP5	0.931
CYR61	SPP1	0.931
STC2	IGFBP5	0.931
ALB	TNC	0.93
AHSG	CDH2	0.93
AFP	IGFBP3	0.93
TMEM219	IGFBP3	0.93
FBN1	SDC2	0.93
GPC3	APOB	0.93
FBN1	APP	0.93
GPC3	APOA2	0.93
IGF2	APP	0.93
LTBP1	TIMP1	0.93
IL6	IGFBP5	0.93
IGFBP5	TIMP1	0.93
FSTL1	LAMB1	0.929
IGFBP3	APOA1	0.929
IGFBP7	BMP4	0.929
IL6	PCSK9	0.929
IL6	IGFBP4	0.928
LAMB2	FSTL1	0.928
CYR61	LAMB2	0.928
FBN1	APOE	0.928
CYR61	CDH2	0.927
CYR61	IGFBP4	0.927
FBN1	ALB	0.927
SERPINA1	IGF1	0.927
AHSG	IGF2	0.927
APP	APOB	0.927
IL6	GPC3	0.926
APP	TIMP1	0.926
CSF1	BMP4	0.926
LTBP1	IGFBP3	0.926
PCSK9	CDH2	0.926
IGFBP3	KLK2	0.926
IGFBP3	BMP4	0.926
SPP1	APOA1	0.926
LAMB1	TIMP1	0.926
IL6	APOA2	0.926
SPP1	FBN1	0.926
MAPK8	IGFBP3	0.926
AFP	PCSK9	0.926
FSTL1	IGFBP5	0.925
AHSG	IGFBP3	0.925
SERPINA1	APP	0.925
ALB	IGFBP7	0.925
BMP4	IGFBP5	0.925
SPP1	IGFBP7	0.925
GAS6	IGF1	0.925
IGF2	MMP1	0.925
IGFBP3	CSF1	0.925
IGFBP1	STC2	0.925
CDH2	LAMB1	0.924
LTBP1	ALB	0.924
FBN1	APOB	0.924
SERPINA1	IGFBP1	0.924
APOA2	PCSK9	0.924
CYR61	FBN1	0.923
FN1	PCSK9	0.923
BMP4	TIMP1	0.923
IGFBP1	FSTL3	0.923
IGFBP7	FSTL1	0.923
IGFBP3	LAMB1	0.923
CSF1	APP	0.923
LAMB2	TNC	0.923
IL6	TNC	0.923
IL6	FBN1	0.923
SPP1	GAS6	0.923
IGFBP3	FBN1	0.923
VCAN	APOE	0.923
IGFBP3	CDH2	0.923
ALB	IGFBP4	0.922
CYR61	TNC	0.922
MMP1	MMP2	0.922
LTBP1	BMP4	0.922
IGFBP3	FSTL3	0.922
CSF1	VCAN	0.922
IGF2	IGF1	0.922
IGFBP4	BMP4	0.922
IGFBP5	LAMB1	0.922
IGFBP7	FSTL3	0.922
IGFBP3	IGFBP5	0.922
LAMB2	ALB	0.922
CDH2	TNC	0.922
LTBP1	IGFBP5	0.922
IL6	LGALS1	0.922
CYR61	CSF1	0.921
APP	TNC	0.921
IGFBP3	APOB	0.921
LTBP1	LAMB1	0.921
TNC	APOB	0.921
CSF1	IGFBP4	0.921
VCAN	IGFBP5	0.921
PCSK9	IGFBP1	0.921
IGFBP3	FSTL1	0.921
GAS6	APOE	0.921
TNC	LAMB1	0.921
IGFBP3	EP300	0.921
ALB	IGFBP5	0.921
IGFBP1	LAMB1	0.921
CSF1	IGFBP1	0.921
SPP1	SDC2	0.921
AFP	TIMP1	0.921
IGFBP1	IGFBP4	0.92
GAS6	IGFBP4	0.92
CYR61	IGFBP1	0.92
GPC3	CDH2	0.92
LTBP1	IGFBP4	0.92
TNC	APOA1	0.92
IGFBP4	APOE	0.92
FSTL1	CDH2	0.92
CYR61	VCAN	0.92
CDH2	APOA1	0.92
AFP	APOE	0.92
IGFBP4	IGFBP5	0.92
SDC2	LAMB1	0.92
APOE	BMP4	0.92
IGFBP3	PCSK9	0.92
SDC2	CDH2	0.92
IGFBP3	APOE	0.92
AHSG	TIMP1	0.92
SERPINA1	SPP1	0.92
LTBP1	PRSS23	0.919
IGFBP1	LGALS1	0.919
CYR61	SDC2	0.919
CDH2	IGFBP5	0.919
CYR61	ALB	0.919
FBN1	IGFBP7	0.919
IGF2	KLK2	0.919
APOA1	LGALS1	0.919
GAS6	BMP4	0.919
FSTL1	TIMP1	0.919
SPP1	APOB	0.919
FSTL1	TNC	0.919
FSTL1	IGFBP4	0.919
APOB	TIMP1	0.919
GPC3	APOE	0.919
FBN1	IGFBP5	0.919
CYR61	STC2	0.919
AFP	APP	0.919
PCSK9	APP	0.919
IGFBP4	LAMB1	0.919
LAMB2	LAMB1	0.918
FN1	FSTL3	0.918
SDC2	TIMP1	0.918
IL6	FSTL3	0.918
IGFBP3	TNC	0.918
ALB	LAMB1	0.918
SPP1	APP	0.918
LTBP1	CDH2	0.918
GAS6	CDH2	0.918
SERPINA1	IGFBP4	0.918
AFP	LAMB1	0.918
STC2	FSTL3	0.918
APOA2	APP	0.918
SDC2	APOE	0.918
LAMB2	IGFBP4	0.918
SPP1	IGFBP4	0.917
LAMB1	LGALS1	0.917
CSF1	CDH2	0.917
AFP	TNC	0.917
MAPK8	GPC3	0.917
SERPINA1	FBN1	0.917
CSF1	FSTL1	0.917
IGFBP3	KLK1	0.917
SPP1	LGALS1	0.917
IGFBP1	BMP4	0.917
SERPINA1	VCAN	0.917
FBN1	LGALS1	0.917
SERPINA1	IGFBP3	0.917
TNC	IGFBP5	0.917
IGFBP3	VCAN	0.917
FN1	STC2	0.917
ALB	FSTL1	0.917
CYR61	LTBP1	0.917
LAMB2	CSF1	0.916
SERPINA1	IGF2	0.916
IGFBP7	PRSS23	0.916
FBN1	TNC	0.916
LAMB2	IGFBP3	0.916
IGFBP3	APOA2	0.916
GPC3	IGFBP3	0.916
LAMB2	IGFBP5	0.916
IGFBP1	CDH2	0.916
VCAN	LGALS1	0.916
FBN1	PRSS23	0.916
TIMP1	FSTL3	0.916
IGFBP1	IGFBP5	0.916
LTBP1	SDC2	0.916
FBN1	CDH2	0.916
STC2	VCAN	0.916
ALB	LGALS1	0.916
LTBP1	APP	0.916
MAPK8	SDC2	0.916
IGFBP3	APP	0.915
IGFBP3	GAS6	0.915
IGFBP3	LGALS1	0.915
SDC2	BMP4	0.915
APOE	LGALS1	0.915
SERPINA1	CDH2	0.915
IGFBP3	PRSS23	0.915
AFP	STC2	0.915
VCAN	LAMB1	0.915
SERPINA1	BMP4	0.915
GPC3	IGFBP5	0.915
TNC	APOE	0.915
CDH2	APOE	0.915
SDC2	ALB	0.915
APP	BMP4	0.915
VCAN	APOB	0.915
IGFBP1	APOE	0.915
EP300	APOA1	0.915
KLK2	IGF1	0.915
TNC	VCAN	0.915
CSF1	PCSK9	0.915
STC2	LAMB1	0.915
BMP4	LGALS1	0.915
SDC2	FSTL1	0.914
AHSG	PCSK9	0.914
IGFBP7	LAMB1	0.914
APP	VCAN	0.914
BMP4	LAMB1	0.914
IGFBP7	VCAN	0.914
FSTL1	VCAN	0.914
GPC3	FBN1	0.914
GPC3	TIMP1	0.913
LAMB2	GAS6	0.913
LTBP1	SPP1	0.913
GAS6	APP	0.913
AHSG	APP	0.913
CSF1	APOA1	0.913
LAMB2	SDC2	0.913
SPP1	STC2	0.913
PRSS23	TNC	0.913
SPP1	FSTL3	0.913
SERPINA1	CSF1	0.913
AHSG	IGFBP4	0.913
APOA2	FN1	0.913
IGF1	KLK1	0.913
IGF2	GAS6	0.913
GPC3	LAMB1	0.913
LTBP1	TNC	0.912
CSF1	APOB	0.912
TNC	TIMP1	0.912
CSF1	IGFBP5	0.912
LTBP1	FSTL3	0.912
LAMB2	FSTL3	0.912
AHSG	BMP4	0.912
IGFBP7	CDH2	0.912
SERPINA1	PCSK9	0.912
SDC2	IGFBP5	0.912
IGFBP5	FSTL3	0.912
APOE	IGFBP5	0.912
PCSK9	IGFBP4	0.912
IGFBP4	CDH2	0.912
GPC3	FSTL1	0.912
LAMB2	APP	0.912
LAMB2	LTBP1	0.912
IGFBP7	STC2	0.912
CSF1	LGALS1	0.911
CYR61	PRSS23	0.911
IGFBP4	TNC	0.911
CYR61	APP	0.911
LTBP1	AFP	0.911
SERPINA1	GPC3	0.911
FSTL1	PRSS23	0.911
GAS6	PCSK9	0.911
CSF1	FBN1	0.911
LAMB2	FBN1	0.911
AHSG	STC2	0.911
LGALS1	FSTL3	0.911
CYR61	GPC3	0.911
IGFBP7	APOE	0.911
SPP1	LAMB1	0.911
PRSS23	TIMP1	0.911
APP	LAMB1	0.911
GAS6	FSTL3	0.911
FBN1	IGFBP4	0.911
GAS6	TIMP1	0.91
IL6	STC2	0.91
AFP	CSF1	0.91
AFP	IGFBP4	0.91
CYR61	PCSK9	0.91
GAS6	IGFBP7	0.91
GAS6	FBN1	0.91
AFP	VCAN	0.91
IGF2	KLK1	0.91
GAS6	LGALS1	0.91
LTBP1	IL6	0.91
FSTL1	STC2	0.91
IL6	LAMB1	0.91
SDC2	APP	0.91
IGFBP4	APOA1	0.91
LAMB1	FSTL3	0.91
IGFBP7	LGALS1	0.91
LTBP1	GPC3	0.91
AFP	IGFBP7	0.91
CDH2	STC2	0.91
IGFALS	PLG	0.909
AFP	PRSS23	0.909
IL6	PRSS23	0.909
LTBP1	IGFBP7	0.909
PRSS23	VCAN	0.909
IGFBP4	FSTL3	0.909
FSTL1	LGALS1	0.909
SERPINA1	IGFBP5	0.909
APP	IGFBP5	0.909
CYR61	FSTL3	0.909
IGFBP4	LGALS1	0.909
AHSG	GAS6	0.909
APOA1	IGFBP5	0.909
PCSK9	TNC	0.909
PRSS23	IGFBP5	0.909
SDC2	PRSS23	0.909
PRSS23	LAMB1	0.909
SERPINA1	IGFBP7	0.909
CYR61	APOE	0.909
CSF1	IGFBP7	0.909
CDH2	APOB	0.908
APOA2	TNC	0.908
IGFBP7	APOA1	0.908
GAS6	FSTL1	0.908
SERPINA1	GAS6	0.908
PRSS23	IGFBP4	0.908
LTBP1	APOE	0.908
AHSG	TNC	0.908
SDC2	TNC	0.908
LAMB2	SPP1	0.908
CYR61	LGALS1	0.908
FBN1	FSTL3	0.908
GPC3	STC2	0.908
LAMB2	IGFBP7	0.908
IGFBP5	LGALS1	0.908
AHSG	IGFBP5	0.907
AHSG	LGALS1	0.907
APOA2	TIMP1	0.907
APOE	LAMB1	0.907
TNC	LGALS1	0.907
SPP1	FSTL1	0.907
CDH2	LGALS1	0.907
SPP1	TNC	0.907
GPC3	FSTL3	0.907
FBN1	APOA1	0.907
FSTL1	APP	0.907
GAS6	LAMB1	0.907
BMP4	APOA1	0.907
GPC3	PCSK9	0.907
ALB	PRSS23	0.907
APOA2	IGFBP4	0.907
LAMB2	LGALS1	0.907
IGFBP7	APP	0.907
FBN1	STC2	0.907
LAMB2	IL6	0.907
LAMB2	TIMP1	0.907
ALB	FSTL3	0.907
SERPINA1	LAMB1	0.907
AFP	IGFBP5	0.907
GAS6	IGFBP5	0.907
SDC2	FSTL3	0.907
GAS6	PLG	0.907
IGFBP7	TNC	0.907
BMP4	APOB	0.906
SPP1	APOA2	0.906
IGFBP7	APOB	0.906
IL6	SDC2	0.906
VCAN	APOA1	0.906
PRSS23	LGALS1	0.906
APOA2	CDH2	0.906
AFP	SDC2	0.906
LAMB2	PRSS23	0.906
GPC3	APP	0.906
GPC3	IGFBP4	0.906
SDC2	IGFBP7	0.906
APOE	FSTL3	0.906
LAMB2	BMP4	0.906
IGFBP1	TNC	0.906
FSTL1	APOE	0.906
GPC3	TNC	0.906
CSF1	FSTL3	0.906
STC2	BMP4	0.906
STC2	LGALS1	0.906
IGFBP5	APOB	0.906
GPC3	IGFBP7	0.906
SDC2	IGFBP4	0.905
ALB	STC2	0.905
LTBP1	IGFBP1	0.905
AHSG	LTBP1	0.905
SPP1	PCSK9	0.905
CSF1	TNC	0.905
GPC3	CSF1	0.905
APOA2	STC2	0.905
STC2	TIMP1	0.905
TNC	FSTL3	0.905
APP	IGFBP4	0.905
AHSG	CSF1	0.905
LTBP1	STC2	0.905
TNC	STC2	0.905
LAMB2	STC2	0.905
PCSK9	BMP4	0.905
GAS6	PRSS23	0.905
PRSS23	FSTL3	0.904
LTBP1	LGALS1	0.904
GAS6	SDC2	0.904
LAMB2	APOA1	0.904
AFP	FSTL1	0.904
SERPINA1	LTBP1	0.904
PCSK9	TIMP1	0.904
PCSK9	IGFBP7	0.904
LAMB2	GPC3	0.904
LAMB2	APOE	0.904
APOA2	EP300	0.904
SDC2	STC2	0.904
GPC3	GAS6	0.904
PRSS23	STC2	0.904
APP	LGALS1	0.904
APP	PRSS23	0.904
PCSK9	LAMB1	0.904
CYR61	AFP	0.904
LAMB2	CDH2	0.904
SERPINA1	FSTL1	0.904
GAS6	TNC	0.904
PCSK9	STC2	0.903
APOA2	FSTL3	0.903
CSF1	LAMB1	0.903
APP	STC2	0.903
FBN1	IGFBP1	0.903
AHSG	FBN1	0.903
PRSS23	IGFBP1	0.903
PCSK9	PRSS23	0.903
APP	FSTL3	0.903
SERPINA1	PRSS23	0.903
PRSS23	CDH2	0.903
PCSK9	FSTL1	0.903
GAS6	APOB	0.903
FSTL1	APOB	0.903
FBN1	PCSK9	0.903
SERPINA1	STC2	0.903
APOA2	IGFBP5	0.903
CSF1	SDC2	0.903
AHSG	VCAN	0.903
APOB	LAMB1	0.903
IGFBP4	APOB	0.903
AFP	FBN1	0.903
SDC2	PCSK9	0.903
APP	IGFBP1	0.903
LTBP1	GAS6	0.903
VCAN	FSTL3	0.903
LAMB2	PCSK9	0.902
SDC2	LGALS1	0.902
PRSS23	BMP4	0.902
APOB	LGALS1	0.902
LTBP1	CSF1	0.902
APOA1	LAMB1	0.902
AFP	FSTL3	0.902
PCSK9	FSTL3	0.902
AFP	GAS6	0.902
GAS6	STC2	0.902
LAMB2	VCAN	0.902
AHSG	LAMB1	0.902
IGFALS	MMP1	0.902
AHSG	SDC2	0.902
FSTL1	IGFBP1	0.902
GAS6	VCAN	0.902
PRSS23	APOA1	0.902
SDC2	APOB	0.902
SERPINA1	LGALS1	0.902
CSF1	PRSS23	0.902
FSTL1	APOA1	0.902
IGFALS	KLK1	0.902
PCSK9	IGFBP5	0.901
GAS6	IGFBP1	0.901
IGFALS	KLK2	0.901
APOA2	IGFBP7	0.901
SERPINA1	LAMB2	0.901
APOA2	LGALS1	0.901
LTBP1	APOB	0.901
AHSG	FSTL3	0.901
APOA2	SDC2	0.901
AHSG	FSTL1	0.901
CYR61	APOA1	0.901
IGFALS	KLK3	0.901
CYR61	AHSG	0.901
LTBP1	APOA1	0.901
AHSG	IGFBP7	0.901
SDC2	IGFBP1	0.9
CDH2	FSTL3	0.9
PRSS23	APOE	0.9
GPC3	PRSS23	0.9
TMEM219	TP53	0.9
STC2	APOE	0.9
LAMB2	IGFBP1	0.9
GPC3	LGALS1	0.9
INS	APOB	0.9
APOA2	LAMB1	0.9
LAMB2	APOB	0.9
CSF1	STC2	0.9
SERPINA1	FSTL3	0.9
LTBP1	PCSK9	0.9
PRSS23	APOB	0.9
LTBP1	APOA2	0.9
LAMB2	APOA2	0.9
GAS6	APOA1	0.9
CYR61	APOB	0.9
LAMB2	AFP	0.9
SDC2	APOA1	0.9
APOA2	PRSS23	0.9
AHSG	LAMB2	0.9
CYR61	APOA2	0.9
APOA2	VCAN	0.9
PCSK9	VCAN	0.9
IGFALS	MMP2	0.9
APOB	FSTL3	0.9
APOA1	FSTL3	0.9
SERPINA1	SDC2	0.9
PCSK9	LGALS1	0.9
SPP1	PRSS23	0.9
AHSG	PRSS23	0.9
APOA2	CSF1	0.9
SERPINA1	TNC	0.9
APOA2	FSTL1	0.9
SERPINA1	CYR61	0.9
STC2	APOA1	0.9
APOA2	GAS6	0.9
APOA2	FBN1	0.9
STC2	APOB	0.9
APOA2	BMP4	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	197 (AHSG)	335 (APOA1)	336 (APOA2)	3479 (IGF1)	3486 (IGFBP3)	348 (APOE)	3481 (IGF2)	3630 (INS)	351 (APP)	255738 (PCSK9)	5599 (MAPK8)	213 (ALB)	2335 (FN1)	174 (AFP)	5265 (SERPINA1)	3569 (IL6)	7157 (TP53)	3491 (CYR61)	6696 (SPP1)	5340 (PLG)	2200 (FBN1)	3484 (IGFBP1)	3483 (IGFALS)	11167 (FSTL1)	1000 (CDH2)	3490 (IGFBP7)	2719 (GPC3)	4312 (MMP1)	4052 (LTBP1)	4313 (MMP2)	354 (KLK3)	1435 (CSF1)	1462 (VCAN)	3487 (IGFBP4)	3371 (TNC)	6383 (SDC2)	2621 (GAS6)	7076 (TIMP1)	652 (BMP4)	3913 (LAMB2)	8614 (STC2)	124446 (TMEM219)	3488 (IGFBP5)	3912 (LAMB1)	338 (APOB)	2033 (EP300)	3817 (KLK2)	3956 (LGALS1)	10272 (FSTL3)	3816 (KLK1)
197 (AHSG)	1.00	0.42	0.63	0.16	0.28	0.42	0.42	0.16	0.42	0.29	0.49	0.20	0.16	0.16	0.42	0.16	0.16	0.09	0.16	0.16	0.16	0.16	0.11	0.16	0.16	0.16	0.50	0.09	0.16	0.16	0.16	0.16	0.16	0.16	0.16	0.16	0.42	0.57	0.20	0.20	0.13	0.16	0.16	0.20	0.16	0.16	0.08	0.16	0.16	0.08
335 (APOA1)	0.42	1.00	0.84	0.59	0.60	0.80	0.59	0.64	0.66	0.60	0.56	0.61	0.65	1.00	0.62	0.59	0.55	0.37	0.58	0.63	0.57	0.62	0.69	1.00	0.63	0.56	0.58	0.13	0.54	0.51	0.49	0.63	0.55	0.62	0.58	0.62	0.59	0.58	0.60	0.27	0.52	1.00	0.59	0.57	0.73	0.45	0.15	0.57	0.60	0.15
336 (APOA2)	0.63	0.84	1.00	0.53	0.55	0.80	0.54	0.55	0.58	0.58	0.49	0.55	0.57	1.00	0.55	0.52	0.51	0.33	0.50	0.55	0.52	0.55	0.69	1.00	0.60	0.49	0.54	0.11	0.48	0.44	0.43	0.58	0.48	0.54	0.50	0.54	0.56	0.55	0.53	0.24	0.47	1.00	0.53	0.49	0.69	0.42	0.12	0.49	0.52	0.12
3479 (IGF1)	0.16	0.59	0.53	1.00	0.64	0.53	0.84	0.93	0.72	0.58	0.52	0.59	0.73	1.00	0.67	0.72	0.52	0.66	0.72	0.68	0.66	0.77	0.69	1.00	0.72	0.67	0.65	0.12	0.60	0.54	0.50	0.72	0.64	0.78	0.69	0.74	0.57	0.59	0.68	0.25	0.57	1.00	0.72	0.63	0.60	0.44	0.12	0.69	0.77	0.12
3486 (IGFBP3)	0.28	0.60	0.55	0.64	1.00	0.58	0.62	0.67	0.64	0.56	0.53	0.62	0.62	1.00	0.64	0.65	0.54	0.35	0.65	0.62	0.62	0.85	1.00	1.00	0.74	0.61	0.62	0.11	0.57	0.51	0.49	0.67	0.59	0.82	0.63	0.67	0.54	0.64	0.64	0.25	0.52	1.00	0.85	0.59	0.58	0.44	0.12	0.62	0.70	0.12
348 (APOE)	0.42	0.80	0.80	0.53	0.58	1.00	0.54	0.57	0.58	0.58	0.50	0.63	0.64	1.00	0.55	0.53	0.55	0.39	0.52	0.56	0.67	0.55	0.69	1.00	0.63	0.55	0.52	0.13	0.53	0.47	0.46	0.59	0.55	0.55	0.56	0.56	0.54	0.54	0.55	0.35	0.48	1.00	0.54	0.59	0.73	0.45	0.15	0.51	0.53	0.15
3481 (IGF2)	0.42	0.59	0.54	0.84	0.62	0.54	1.00	0.79	0.68	0.57	0.52	0.56	0.69	1.00	0.62	0.70	0.51	0.57	0.63	0.65	0.62	0.70	0.69	1.00	0.67	0.59	0.60	0.11	0.55	0.49	0.47	0.71	0.57	0.71	0.61	0.65	0.69	0.58	0.63	0.23	0.51	1.00	0.64	0.57	0.55	0.43	0.12	0.60	0.68	0.12
3630 (INS)	0.16	0.64	0.55	0.93	0.67	0.57	0.79	1.00	0.78	0.60	0.56	0.64	0.76	1.00	0.81	0.74	0.56	0.51	0.75	0.70	0.66	0.78	0.69	1.00	0.75	0.71	0.70	0.12	0.64	0.58	0.55	0.79	0.68	0.79	0.72	0.81	0.59	0.67	0.71	0.26	0.66	1.00	0.75	0.67	0.63	0.46	0.12	0.73	0.79	0.12
351 (APP)	0.42	0.66	0.58	0.72	0.64	0.58	0.68	0.78	1.00	0.65	0.59	0.70	0.71	1.00	0.87	0.73	0.64	0.39	0.69	0.70	0.61	0.73	0.69	1.00	0.71	0.65	0.75	0.12	0.60	0.55	0.52	0.77	0.63	0.73	0.67	0.75	0.65	0.75	0.70	0.26	0.67	1.00	0.70	0.63	0.62	0.53	0.12	0.75	0.71	0.12
255738 (PCSK9)	0.29	0.60	0.58	0.58	0.56	0.58	0.57	0.60	0.65	1.00	0.51	0.58	0.59	1.00	0.57	0.58	0.56	0.35	0.57	0.74	0.53	0.62	0.69	1.00	0.61	0.54	0.55	0.30	0.52	0.65	0.65	0.60	0.54	0.61	0.56	0.59	0.53	0.54	0.58	0.24	0.49	1.00	0.58	0.54	0.58	0.48	1.00	0.64	0.59	1.00
5599 (MAPK8)	0.49	0.56	0.49	0.52	0.53	0.50	0.52	0.56	0.59	0.51	1.00	0.50	0.57	1.00	0.54	0.51	0.52	0.25	0.49	0.59	0.46	0.54	0.69	1.00	0.57	0.45	0.49	0.16	0.60	0.42	0.42	0.55	0.45	0.52	0.49	0.52	0.47	0.52	0.53	0.24	0.48	1.00	0.52	0.46	0.47	0.47	0.18	0.46	0.52	0.18
213 (ALB)	0.20	0.61	0.55	0.59	0.62	0.63	0.56	0.64	0.70	0.58	0.50	1.00	0.64	1.00	0.60	0.60	0.64	0.36	0.59	0.61	0.61	0.61	0.69	1.00	0.67	0.57	0.56	0.14	0.54	0.50	0.49	0.64	0.56	0.60	0.59	0.64	0.54	0.58	0.60	0.30	0.54	1.00	0.60	0.57	0.59	0.52	0.15	0.64	0.61	0.15
2335 (FN1)	0.16	0.65	0.57	0.73	0.62	0.64	0.69	0.76	0.71	0.59	0.57	0.64	1.00	1.00	0.69	0.68	0.63	0.56	0.65	0.70	0.81	0.69	0.69	1.00	0.68	0.73	0.61	0.11	0.68	0.55	0.53	0.71	0.72	0.69	0.73	0.69	0.59	0.63	0.67	0.38	0.59	1.00	0.66	0.73	0.69	0.49	0.12	0.63	0.69	0.12
174 (AFP)	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.50	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.34	0.82	1.00	1.00	1.00	1.00	1.00	0.12	1.00	1.00	0.12
5265 (SERPINA1)	0.42	0.62	0.55	0.67	0.64	0.55	0.62	0.81	0.87	0.57	0.54	0.60	0.69	1.00	1.00	0.69	0.54	0.36	0.70	0.65	0.58	0.70	0.69	1.00	0.72	0.65	0.80	0.12	0.58	0.50	0.47	0.75	0.62	0.71	0.67	0.79	0.60	0.80	0.66	0.27	0.64	1.00	0.71	0.61	0.58	0.43	0.12	0.67	0.72	0.12
3569 (IL6)	0.16	0.59	0.52	0.72	0.65	0.53	0.70	0.74	0.73	0.58	0.51	0.60	0.68	1.00	0.69	1.00	0.52	0.47	0.75	0.68	0.58	0.79	0.69	1.00	0.74	0.70	0.68	0.12	0.61	0.54	0.50	0.87	0.66	0.80	0.71	0.77	0.56	0.65	0.77	0.27	0.59	1.00	0.74	0.65	0.61	0.44	0.12	0.71	0.76	0.12
7157 (TP53)	0.16	0.55	0.51	0.52	0.54	0.55	0.51	0.56	0.64	0.56	0.52	0.64	0.63	1.00	0.54	0.52	1.00	0.29	0.51	0.58	0.55	0.53	0.69	1.00	0.57	0.50	0.50	0.10	0.50	0.48	0.47	0.54	0.50	0.53	0.51	0.53	0.51	0.56	0.53	0.22	0.52	1.00	0.52	0.51	0.51	0.59	0.12	0.56	0.52	0.12
3491 (CYR61)	0.09	0.37	0.33	0.66	0.35	0.39	0.57	0.51	0.39	0.35	0.25	0.36	0.56	0.50	0.36	0.47	0.29	1.00	0.41	0.38	0.60	0.43	0.35	0.50	0.42	0.36	0.35	0.08	0.31	0.26	0.24	0.45	0.48	0.44	0.37	0.41	0.36	0.33	0.41	0.16	0.32	0.50	0.39	0.32	0.55	0.24	0.07	0.38	0.49	0.07
6696 (SPP1)	0.16	0.58	0.50	0.72	0.65	0.52	0.63	0.75	0.69	0.57	0.49	0.59	0.65	1.00	0.70	0.75	0.51	0.41	1.00	0.65	0.56	0.76	0.69	1.00	0.75	0.71	0.68	0.14	0.59	0.50	0.46	0.75	0.66	0.77	0.73	0.82	0.50	0.57	0.70	0.32	0.62	1.00	0.77	0.64	0.59	0.42	0.12	0.74	0.81	0.12
5340 (PLG)	0.16	0.63	0.55	0.68	0.62	0.56	0.65	0.70	0.70	0.74	0.59	0.61	0.70	1.00	0.65	0.68	0.58	0.38	0.65	1.00	0.59	0.68	0.69	1.00	0.67	0.63	0.62	0.45	0.59	0.83	0.85	0.69	0.61	0.68	0.64	0.68	0.57	0.60	0.67	0.25	0.58	1.00	0.66	0.62	0.61	0.49	1.00	0.64	0.68	1.00
2200 (FBN1)	0.16	0.57	0.52	0.66	0.62	0.67	0.62	0.66	0.61	0.53	0.46	0.61	0.81	1.00	0.58	0.58	0.55	0.60	0.56	0.59	1.00	0.60	0.69	1.00	0.71	0.73	0.52	0.13	0.66	0.45	0.43	0.64	0.70	0.60	0.74	0.63	0.49	0.54	0.58	0.50	0.48	1.00	0.59	0.73	0.62	0.44	0.12	0.54	0.60	0.12
3484 (IGFBP1)	0.16	0.62	0.55	0.77	0.85	0.55	0.70	0.78	0.73	0.62	0.54	0.61	0.69	1.00	0.70	0.79	0.53	0.43	0.76	0.68	0.60	1.00	1.00	1.00	0.74	0.71	0.69	0.12	0.63	0.57	0.53	0.78	0.68	0.98	0.72	0.78	0.59	0.62	0.74	0.27	0.60	1.00	0.94	0.66	0.63	0.46	0.12	0.73	0.77	0.12
3483 (IGFALS)	0.11	0.69	0.69	0.69	1.00	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.69	0.35	0.69	0.69	0.69	1.00	1.00	0.69	0.69	0.69	0.69	0.11	0.69	0.69	0.69	0.69	0.69	0.86	0.69	0.69	0.69	0.69	0.69	0.23	0.56	0.69	0.86	0.69	0.69	0.69	0.08	0.69	0.69	0.08
11167 (FSTL1)	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.50	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.34	0.82	1.00	1.00	1.00	1.00	1.00	0.12	1.00	1.00	0.12
1000 (CDH2)	0.16	0.63	0.60	0.72	0.74	0.63	0.67	0.75	0.71	0.61	0.57	0.67	0.68	1.00	0.72	0.74	0.57	0.42	0.75	0.67	0.71	0.74	0.69	1.00	1.00	0.72	0.71	0.12	0.65	0.61	0.58	0.79	0.69	0.74	0.73	0.78	0.58	0.68	0.71	0.27	0.68	1.00	0.74	0.68	0.65	0.49	0.12	0.73	0.76	0.12
3490 (IGFBP7)	0.16	0.56	0.49	0.67	0.61	0.55	0.59	0.71	0.65	0.54	0.45	0.57	0.73	1.00	0.65	0.70	0.50	0.36	0.71	0.63	0.73	0.71	0.69	1.00	0.72	1.00	0.60	0.14	0.76	0.44	0.41	0.71	0.82	0.71	0.96	0.75	0.47	0.53	0.67	0.78	0.56	1.00	0.71	0.95	0.55	0.41	0.12	0.66	0.74	0.12
2719 (GPC3)	0.50	0.58	0.54	0.65	0.62	0.52	0.60	0.70	0.75	0.55	0.49	0.56	0.61	1.00	0.80	0.68	0.50	0.35	0.68	0.62	0.52	0.69	0.69	1.00	0.71	0.60	1.00	0.13	0.53	0.42	0.39	0.69	0.57	0.69	0.64	0.73	0.55	0.75	0.65	0.28	0.54	1.00	0.69	0.56	0.54	0.40	0.12	0.63	0.72	0.12
4312 (MMP1)	0.09	0.13	0.11	0.12	0.11	0.13	0.11	0.12	0.12	0.30	0.16	0.14	0.11	0.16	0.12	0.12	0.10	0.08	0.14	0.45	0.13	0.12	0.11	0.16	0.12	0.14	0.13	1.00	0.14	0.82	0.77	0.12	0.14	0.12	0.14	0.13	0.11	0.11	0.14	0.18	0.11	0.16	0.12	0.17	0.12	0.12	1.00	0.13	0.13	1.00
4052 (LTBP1)	0.16	0.54	0.48	0.60	0.57	0.53	0.55	0.64	0.60	0.52	0.60	0.54	0.68	1.00	0.58	0.61	0.50	0.31	0.59	0.59	0.66	0.63	0.69	1.00	0.65	0.76	0.53	0.14	1.00	0.44	0.42	0.63	0.67	0.62	0.76	0.63	0.47	0.50	0.60	0.54	0.48	1.00	0.62	0.76	0.52	0.42	0.12	0.56	0.62	0.12
4313 (MMP2)	0.16	0.51	0.44	0.54	0.51	0.47	0.49	0.58	0.55	0.65	0.42	0.50	0.55	1.00	0.50	0.54	0.48	0.26	0.50	0.83	0.45	0.57	0.69	1.00	0.61	0.44	0.42	0.82	0.44	1.00	0.84	0.58	0.44	0.55	0.50	0.56	0.41	0.44	0.55	0.24	0.42	1.00	0.55	0.45	0.45	0.40	1.00	0.46	0.55	1.00
354 (KLK3)	0.16	0.49	0.43	0.50	0.49	0.46	0.47	0.55	0.52	0.65	0.42	0.49	0.53	1.00	0.47	0.50	0.47	0.24	0.46	0.85	0.43	0.53	0.69	1.00	0.58	0.41	0.39	0.77	0.42	0.84	1.00	0.55	0.41	0.51	0.46	0.51	0.39	0.42	0.52	0.25	0.39	1.00	0.51	0.42	0.43	0.41	1.00	0.42	0.51	1.00
1435 (CSF1)	0.16	0.63	0.58	0.72	0.67	0.59	0.71	0.79	0.77	0.60	0.55	0.64	0.71	1.00	0.75	0.87	0.54	0.45	0.75	0.69	0.64	0.78	0.69	1.00	0.79	0.71	0.69	0.12	0.63	0.58	0.55	1.00	0.68	0.79	0.72	0.82	0.59	0.67	0.77	0.26	0.70	1.00	0.74	0.67	0.63	0.46	0.12	0.72	0.76	0.12
1462 (VCAN)	0.16	0.55	0.48	0.64	0.59	0.55	0.57	0.68	0.63	0.54	0.45	0.56	0.72	1.00	0.62	0.66	0.50	0.48	0.66	0.61	0.70	0.68	0.69	1.00	0.69	0.82	0.57	0.14	0.67	0.44	0.41	0.68	1.00	0.67	0.82	0.70	0.48	0.52	0.64	0.57	0.53	1.00	0.67	0.79	0.59	0.41	0.12	0.61	0.69	0.12
3487 (IGFBP4)	0.16	0.62	0.54	0.78	0.82	0.55	0.71	0.79	0.73	0.61	0.52	0.60	0.69	1.00	0.71	0.80	0.53	0.44	0.77	0.68	0.60	0.98	0.86	1.00	0.74	0.71	0.69	0.12	0.62	0.55	0.51	0.79	0.67	1.00	0.73	0.79	0.58	0.62	0.74	0.27	0.60	1.00	0.95	0.66	0.63	0.45	0.12	0.73	0.78	0.12
3371 (TNC)	0.16	0.58	0.50	0.69	0.63	0.56	0.61	0.72	0.67	0.56	0.49	0.59	0.73	1.00	0.67	0.71	0.51	0.37	0.73	0.64	0.74	0.72	0.69	1.00	0.73	0.96	0.64	0.14	0.76	0.50	0.46	0.72	0.82	0.73	1.00	0.76	0.50	0.56	0.68	0.68	0.58	1.00	0.73	0.93	0.58	0.42	0.12	0.69	0.75	0.12
6383 (SDC2)	0.16	0.62	0.54	0.74	0.67	0.56	0.65	0.81	0.75	0.59	0.52	0.64	0.69	1.00	0.79	0.77	0.53	0.41	0.82	0.68	0.63	0.78	0.69	1.00	0.78	0.75	0.73	0.13	0.63	0.56	0.51	0.82	0.70	0.79	0.76	1.00	0.53	0.61	0.72	0.29	0.68	1.00	0.79	0.68	0.63	0.44	0.12	0.77	0.82	0.12
2621 (GAS6)	0.42	0.59	0.56	0.57	0.54	0.54	0.69	0.59	0.65	0.53	0.47	0.54	0.59	1.00	0.60	0.56	0.51	0.36	0.50	0.57	0.49	0.59	0.69	1.00	0.58	0.47	0.55	0.11	0.47	0.41	0.39	0.59	0.48	0.58	0.50	0.53	1.00	0.59	0.56	0.22	0.43	1.00	0.53	0.47	0.53	0.41	0.12	0.48	0.53	0.12
7076 (TIMP1)	0.57	0.58	0.55	0.59	0.64	0.54	0.58	0.67	0.75	0.54	0.52	0.58	0.63	1.00	0.80	0.65	0.56	0.33	0.57	0.60	0.54	0.62	0.69	1.00	0.68	0.53	0.75	0.11	0.50	0.44	0.42	0.67	0.52	0.62	0.56	0.61	0.59	1.00	0.64	0.24	0.50	1.00	0.60	0.52	0.51	0.41	0.12	0.54	0.60	0.12
652 (BMP4)	0.20	0.60	0.53	0.68	0.64	0.55	0.63	0.71	0.70	0.58	0.53	0.60	0.67	1.00	0.66	0.77	0.53	0.41	0.70	0.67	0.58	0.74	0.69	1.00	0.71	0.67	0.65	0.14	0.60	0.55	0.52	0.77	0.64	0.74	0.68	0.72	0.56	0.64	1.00	0.31	0.56	1.00	0.70	0.65	0.60	0.46	0.15	0.67	0.71	0.15
3913 (LAMB2)	0.20	0.27	0.24	0.25	0.25	0.35	0.23	0.26	0.26	0.24	0.24	0.30	0.38	0.34	0.27	0.27	0.22	0.16	0.32	0.25	0.50	0.27	0.23	0.34	0.27	0.78	0.28	0.18	0.54	0.24	0.25	0.26	0.57	0.27	0.68	0.29	0.22	0.24	0.31	1.00	0.24	0.34	0.27	0.87	0.25	0.20	0.15	0.29	0.29	0.15
8614 (STC2)	0.13	0.52	0.47	0.57	0.52	0.48	0.51	0.66	0.67	0.49	0.48	0.54	0.59	0.82	0.64	0.59	0.52	0.32	0.62	0.58	0.48	0.60	0.56	0.82	0.68	0.56	0.54	0.11	0.48	0.42	0.39	0.70	0.53	0.60	0.58	0.68	0.43	0.50	0.56	0.24	1.00	0.82	0.60	0.52	0.52	0.38	0.10	0.67	0.63	0.10
124446 (TMEM219)	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.50	1.00	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.34	0.82	1.00	1.00	1.00	1.00	1.00	0.12	1.00	1.00	0.12
3488 (IGFBP5)	0.16	0.59	0.53	0.72	0.85	0.54	0.64	0.75	0.70	0.58	0.52	0.60	0.66	1.00	0.71	0.74	0.52	0.39	0.77	0.66	0.59	0.94	0.86	1.00	0.74	0.71	0.69	0.12	0.62	0.55	0.51	0.74	0.67	0.95	0.73	0.79	0.53	0.60	0.70	0.27	0.60	1.00	1.00	0.66	0.62	0.44	0.12	0.73	0.83	0.12
3912 (LAMB1)	0.20	0.57	0.49	0.63	0.59	0.59	0.57	0.67	0.63	0.54	0.46	0.57	0.73	1.00	0.61	0.65	0.51	0.32	0.64	0.62	0.73	0.66	0.69	1.00	0.68	0.95	0.56	0.17	0.76	0.45	0.42	0.67	0.79	0.66	0.93	0.68	0.47	0.52	0.65	0.87	0.52	1.00	0.66	1.00	0.53	0.42	0.15	0.59	0.67	0.15
338 (APOB)	0.16	0.73	0.69	0.60	0.58	0.73	0.55	0.63	0.62	0.58	0.47	0.59	0.69	1.00	0.58	0.61	0.51	0.55	0.59	0.61	0.62	0.63	0.69	1.00	0.65	0.55	0.54	0.12	0.52	0.45	0.43	0.63	0.59	0.63	0.58	0.63	0.53	0.51	0.60	0.25	0.52	1.00	0.62	0.53	1.00	0.42	0.12	0.56	0.62	0.12
2033 (EP300)	0.16	0.45	0.42	0.44	0.44	0.45	0.43	0.46	0.53	0.48	0.47	0.52	0.49	1.00	0.43	0.44	0.59	0.24	0.42	0.49	0.44	0.46	0.69	1.00	0.49	0.41	0.40	0.12	0.42	0.40	0.41	0.46	0.41	0.45	0.42	0.44	0.41	0.41	0.46	0.20	0.38	1.00	0.44	0.42	0.42	1.00	0.22	0.46	0.44	0.22
3817 (KLK2)	0.08	0.15	0.12	0.12	0.12	0.15	0.12	0.12	0.12	1.00	0.18	0.15	0.12	0.12	0.12	0.12	0.12	0.07	0.12	1.00	0.12	0.12	0.08	0.12	0.12	0.12	0.12	1.00	0.12	1.00	1.00	0.12	0.12	0.12	0.12	0.12	0.12	0.12	0.15	0.15	0.10	0.12	0.12	0.15	0.12	0.22	1.00	0.12	0.12	1.00
3956 (LGALS1)	0.16	0.57	0.49	0.69	0.62	0.51	0.60	0.73	0.75	0.64	0.46	0.64	0.63	1.00	0.67	0.71	0.56	0.38	0.74	0.64	0.54	0.73	0.69	1.00	0.73	0.66	0.63	0.13	0.56	0.46	0.42	0.72	0.61	0.73	0.69	0.77	0.48	0.54	0.67	0.29	0.67	1.00	0.73	0.59	0.56	0.46	0.12	1.00	0.76	0.12
10272 (FSTL3)	0.16	0.60	0.52	0.77	0.70	0.53	0.68	0.79	0.71	0.59	0.52	0.61	0.69	1.00	0.72	0.76	0.52	0.49	0.81	0.68	0.60	0.77	0.69	1.00	0.76	0.74	0.72	0.13	0.62	0.55	0.51	0.76	0.69	0.78	0.75	0.82	0.53	0.60	0.71	0.29	0.63	1.00	0.83	0.67	0.62	0.44	0.12	0.76	1.00	0.12
3816 (KLK1)	0.08	0.15	0.12	0.12	0.12	0.15	0.12	0.12	0.12	1.00	0.18	0.15	0.12	0.12	0.12	0.12	0.12	0.07	0.12	1.00	0.12	0.12	0.08	0.12	0.12	0.12	0.12	1.00	0.12	1.00	1.00	0.12	0.12	0.12	0.12	0.12	0.12	0.12	0.15	0.15	0.10	0.12	0.12	0.15	0.12	0.22	1.00	0.12	0.12	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
IGFBP3	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	3.3	RT-qPCR	Western US	C57BL/6 mice	–3.7	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
IGFBP3	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	9	RT-qPCR	Western US	C57BL/6 mice	–3.7	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
TBP	6908	IGFBP3	3486	distal	22955619	TRANSFAC
RAD21	5885	IGFBP3	3486	proximal_filtered	22955619	TRANSFAC
CTCF	10664	IGFBP3	3486	proximal_filtered	22955619	TRANSFAC
NCOR1	9611	IGFBP3	3486	Unknown	19288057	TRUSST
EP300	2033	IGFBP3	3486	Unknown	8895520	TRUSST
DNMT3A	1788	IGFBP3	3486	Activation	8206526	TRUSST
FLI1	2313	IGFBP3	3486	Unknown	11137218	TRUSST
VDR	7421	IGFBP3	3486	Unknown	22389255	TRUSST
AR	367	IGFBP3	3486	Unknown	1409593	TRUSST
HOXC6	3223	IGFBP3	3486	Activation	11245470	TRUSST
MECP2	4204	IGFBP3	3486	Activation	17448444	TRUSST
HDAC1	3065	IGFBP3	3486	Repression	17068183	TRUSST
DLX5	1749	IGFBP3	3486	Unknown	11087747	TRUSST
CDX2	1045	IGFBP3	3486	Unknown	11005379	TRUSST
SP1	6667	IGFBP3	3486	Unknown	12626711	TRUSST
SP3	6670	IGFBP3	3486	Activation	22389255	TRUSST
TP53	7157	IGFBP3	3486	Activation	17510387	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT019713	hsa-miR-375	Homo sapiens	IGFBP3	3486	Homo sapiens	Microarray	Functional MTI (Weak)	20215506
MIRT022363	hsa-miR-124-3p	Homo sapiens	IGFBP3	3486	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT054206	hsa-miR-210-3p	Homo sapiens	IGFBP3	3486	Homo sapiens	Luciferase reporter assay//Microarray//qRT-PCR//Western blot	Functional MTI	23028679
MIRT702744	hsa-miR-7977	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702743	hsa-miR-3157-3p	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702746	hsa-miR-1909-5p	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702745	hsa-miR-18b-3p	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702747	hsa-miR-759	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702749	hsa-miR-4773	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702748	hsa-miR-371b-3p	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT702750	hsa-miR-5580-3p	Homo sapiens	IGFBP3	3486	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23313552
MIRT734603	hsa-miR-17-5p	Homo sapiens	IGFBP3	3486	Homo sapiens	Luciferase reporter assay//qRT-PCR	Functional MTI	27621763

Gene Ontology

ID	GO ID	GO Term	GO Type
3486	GO:0001558	regulation of cell growth	GOTERM_BP_DIRECT
3486	GO:0043085	positive regulation of catalytic activity	GOTERM_BP_DIRECT
3486	GO:0001649	osteoblast differentiation	GOTERM_BP_DIRECT
3486	GO:0006468	protein phosphorylation	GOTERM_BP_DIRECT
3486	GO:0014912	negative regulation of smooth muscle cell migration	GOTERM_BP_DIRECT
3486	GO:0044267	cellular protein metabolic process	GOTERM_BP_DIRECT
3486	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	GOTERM_BP_DIRECT
3486	GO:0016942	insulin-like growth factor binding protein complex	GOTERM_CC_DIRECT
3486	GO:0042981	regulation of apoptotic process	GOTERM_BP_DIRECT
3486	GO:0045663	positive regulation of myoblast differentiation	GOTERM_BP_DIRECT
3486	GO:0001933	negative regulation of protein phosphorylation	GOTERM_BP_DIRECT
3486	GO:0043410	positive regulation of MAPK cascade	GOTERM_BP_DIRECT
3486	GO:0005515	protein binding	GOTERM_MF_DIRECT
3486	GO:0005520	collagen binding	GOTERM_MF_DIRECT
3486	GO:0044342	type B pancreatic cell proliferation	GOTERM_BP_DIRECT
3486	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
3486	GO:0005576	extracellular region	GOTERM_CC_DIRECT
3486	GO:0042567	insulin-like growth factor ternary complex	GOTERM_CC_DIRECT
3486	GO:0006915	apoptotic process	GOTERM_BP_DIRECT
3486	GO:0043065	positive regulation of apoptotic process	GOTERM_BP_DIRECT
3486	GO:0005615	extracellular space	GOTERM_CC_DIRECT
3486	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
3486	GO:0005634	nucleus	GOTERM_CC_DIRECT
3486	GO:0008285	negative regulation of cell proliferation	GOTERM_BP_DIRECT
3486	GO:0048662	negative regulation of smooth muscle cell proliferation	GOTERM_BP_DIRECT
3486	GO:0010906	regulation of glucose metabolic process	GOTERM_BP_DIRECT
3486	GO:0031995	insulin-like growth factor I binding	GOTERM_MF_DIRECT
3486	GO:0001968	glycoprotein binding	GOTERM_MF_DIRECT
3486	GO:0009968	negative regulation of signal transduction	GOTERM_BP_DIRECT
3486	GO:0031994	very long-chain fatty acid-CoA ligase activity	GOTERM_MF_DIRECT
3486	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	GOTERM_BP_DIRECT
3486	GO:0008160	drug binding	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
3486	hsa04115	p53 signaling pathway
3486	hsa05202	Transcriptional misregulation in cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
IGFBP3	3486	Malignant neoplasm of urinary bladder	C0005684	Neoplastic Process	0.33	0.464	0.759	disease
IGFBP3	3486	Bladder Neoplasm	C0005695	Neoplastic Process	0.34	0.464	0.759	group
IGFBP3	3486	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.35	0.464	0.759	disease
IGFBP3	3486	Carcinoma, Transitional Cell	C0007138	Neoplastic Process	0.31	0.464	0.759	disease
IGFBP3	3486	Spontaneous abortion	C0000786	Pathologic Function	0.3	0.464	0.759	phenotype
IGFBP3	3486	Autistic Disorder	C0004352	Mental or Behavioral Dysfunction	0.3	0.464	0.759	group
IGFBP3	3486	Colorectal Neoplasms	C0009404	Neoplastic Process	0.32	0.464	0.759	group
IGFBP3	3486	Prostatic Neoplasms	C0033578	Neoplastic Process	0.4	0.464	0.759	group
IGFBP3	3486	Abortion, Tubal	C0000822	Pathologic Function	0.3	0.464	0.759	disease
IGFBP3	3486	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.4	0.464	0.759	disease
IGFBP3	3486	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.464	0.759	disease
IGFBP3	3486	Rheumatoid Arthritis	C0003873	Disease or Syndrome	0.32	0.464	0.759	disease
IGFBP3	3486	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.464	0.759	disease
IGFBP3	3486	Stomach Neoplasms	C0038356	Neoplastic Process	0.33	0.464	0.759	group
IGFBP3	3486	Myocardial Ischemia	C0151744	Disease or Syndrome	0.32	0.464	0.759	disease
IGFBP3	3486	Colorectal Carcinoma	C0009402	Neoplastic Process	0.4	0.464	0.759	disease
IGFBP3	3486	Colorectal Cancer	C1527249	Neoplastic Process	0.6	0.464	0.759	disease
IGFBP3	3486	Russell-Silver syndrome	C0175693	Disease or Syndrome	0.32	0.464	0.759	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types