Cytochrome c oxidase subunit 2

AltitudeomicsDB
Protein Official symbol MT-CO2
Aliases MT-CO2 COII COX2 COXII MTCO2
Chromosomal Location MT(non-nuclear)NC
Length 227
Uniprot ID P00403
EC number 7.1.1.9
Protein family Information(Pfam) PF00116;PF02790;
PDB id 3VRJ;5Z62;
InterPro ID IPR002429;IPR034210;IPR001505;IPR008972;IPR014222;IPR011759;IPR036257;
dbSNP rs199474827 rs199474826 rs1116904

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
COX5A COX5B 0.999
COX7C COX5B 0.999
MT-CO3 MT-CO2 0.999
COX6C COX5A 0.999
COX6C MT-CO2 0.999
COX4I1 COX6C 0.999
COX6C COX7C 0.999
MT-CO3 MT-CO1 0.999
MT-CO2 COX5A 0.999
COX6C COX6B1 0.999
MT-CO2 COX5B 0.999
COX4I1 MT-CO2 0.999
COX7C COX5A 0.999
MT-CO2 COX6B1 0.999
COX6C COX5B 0.999
COX4I1 COX5B 0.999
MT-CO3 MT-CYB 0.999
MT-CO2 MT-CYB 0.999
COX4I1 COX5A 0.999
COX5B COX6B1 0.999
COX7C MT-CO2 0.999
MT-CYB MT-CO1 0.999
COX5A COX6B1 0.999
MT-CO2 MT-CO1 0.999
COX7A2 MT-CO2 0.998
COX7C COX6B1 0.998
MT-CO3 COX5A 0.997
MT-CO1 COX5A 0.996
COX4I1 COX6B1 0.996
COX4I1 COX7C 0.996
COX7C COX7A2 0.995
MT-CO1 COX5B 0.994
COX4I1 MT-CO1 0.992
MT-CO3 COX5B 0.992
COX4I1 MT-CO3 0.989
COX7C MT-CO3 0.989
COX7C MT-CO1 0.987
COX6C COX7A2 0.986
COX6C MT-CO3 0.979
MT-CO3 COX6B1 0.977
MT-CO1 COX6B1 0.967
COX7A2 COX5B 0.952
COX6C MT-CO1 0.951
MT-CYB COX5B 0.949
COX4I1 MT-CYB 0.946
MT-CYB COX5A 0.929
COX7A2 COX5A 0.921
COX7C MT-CYB 0.907
COX7A2 COX6B1 0.904
COX4I1 COX7A2 0.871
COX6C MT-CYB 0.798
MT-CYB COX6B1 0.581
COX7A2 MT-CYB 0.466
COX7A2 MT-CO3 0.414
Gene Ontology Semantic Similarity
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# 9377 (COX5A) 1350 (COX7C) 4514 (MT-CO3) 1327 (COX4I1) 4513 (MT-CO2) 1329 (COX5B) 4519 (MT-CYB) 4512 (MT-CO1) 1340 (COX6B1)
9377 (COX5A) 1.00 1.00 0.89 0.87 0.87 0.87 0.61 0.87 0.87
1350 (COX7C) 1.00 1.00 1.00 1.00 1.00 1.00 0.61 1.00 1.00
4514 (MT-CO3) 0.89 1.00 1.00 0.75 0.75 0.75 0.61 0.75 0.75
1327 (COX4I1) 0.87 1.00 0.75 1.00 1.00 1.00 0.61 1.00 1.00
4513 (MT-CO2) 0.87 1.00 0.75 1.00 1.00 1.00 0.61 1.00 1.00
1329 (COX5B) 0.87 1.00 0.75 1.00 1.00 1.00 0.61 1.00 1.00
4519 (MT-CYB) 0.61 0.61 0.61 0.61 0.61 0.61 1.00 0.61 0.61
4512 (MT-CO1) 0.87 1.00 0.75 1.00 1.00 1.00 0.61 1.00 1.00
1340 (COX6B1) 0.87 1.00 0.75 1.00 1.00 1.00 0.61 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MT-CO2 Human Blood - 3250 m 4 day upregulated –2.0502 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT003965 hsa-miR-101-3p Homo sapiens MT-CO2 4513 Homo sapiens Microarray Functional MTI (Weak) 17875710
MIRT003964 hsa-miR-143-3p Homo sapiens MT-CO2 4513 Homo sapiens Microarray Functional MTI (Weak) 17875710
MIRT003965 hsa-miR-101-3p Homo sapiens MT-CO2 4513 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 23608225
MIRT035810 hsa-miR-1908-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037539 hsa-miR-744-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038368 hsa-miR-296-3p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039467 hsa-miR-652-3p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044807 hsa-miR-320a Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048680 hsa-miR-99a-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048596 hsa-miR-100-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050864 hsa-miR-17-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051845 hsa-let-7c-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052290 hsa-let-7b-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052383 hsa-let-7a-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052894 hsa-miR-3934-5p Homo sapiens MT-CO2 4513 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT053759 hsa-miR-143-5p Homo sapiens MT-CO2 4513 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24616567
MIRT437978 hsa-miR-137 Homo sapiens MT-CO2 4513 Homo sapiens FACS//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25064845
MIRT438527 hsa-miR-146a-5p Homo sapiens MT-CO2 4513 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 25047043
MIRT438527 hsa-miR-146a-5p Homo sapiens MT-CO2 4513 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25767384
MIRT731141 hsa-miR-26b-5p Homo sapiens MT-CO2 4513 Homo sapiens qRT-PCR//Luciferase reporter assay//Western blot Functional MTI 25483152
MIRT732845 hsa-miR-26b-3p Homo sapiens MT-CO2 4513 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 28255114
MIRT732933 hsa-miR-21-5p Homo sapiens MT-CO2 4513 Homo sapiens Flow//qRT-PCR//Western blot Functional MTI 26604791
Gene Ontology
ID GO ID GO Term GO Type
4513 GO:0016020 membrane GOTERM_CC_DIRECT
4513 GO:0005743 mitochondrial inner membrane GOTERM_CC_DIRECT
4513 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
4513 GO:0045277 respiratory chain complex IV GOTERM_CC_DIRECT
4513 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
4513 GO:0070469 respiratory chain GOTERM_CC_DIRECT
4513 GO:0007595 lactation GOTERM_BP_DIRECT
4513 GO:0005507 iron ion binding GOTERM_MF_DIRECT
4513 GO:0005739 mitochondrion GOTERM_CC_DIRECT
4513 GO:0009409 response to cold GOTERM_BP_DIRECT
4513 GO:0006123 mitochondrial electron transport GOTERM_BP_DIRECT
4513 GO:0004129 cytochrome-c oxidase activity GOTERM_MF_DIRECT
4513 GO:0022900 electron transport chain GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4513 hsa00190 Oxidative phosphorylation
4513 hsa01100 Metabolic pathways
4513 hsa04260 Cardiac muscle contraction
4513 hsa04932 Non-alcoholic fatty liver disease
4513 hsa05012 Parkinson's disease
4513 hsa05016 Huntington's disease
4513 hsa05010 Alzheimer's disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
COX2 4513 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.397 0.862 disease
COX2 4513 Neuroblastoma C0027819 Neoplastic Process 0.33 0.397 0.862 group
COX2 4513 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.397 0.862 disease
COX2 4513 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.397 0.862 disease
COX2 4513 MELAS Syndrome C0162671 Disease or Syndrome 0.51 0.397 0.862 disease
COX2 4513 Cytochrome-c Oxidase Deficiency C0268237 Congenital Abnormality; Disease or Syndrome 0.54 0.397 0.862 disease
COX2 4513 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.44 0.397 0.862 disease
COX2 4513 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.33 0.397 0.862 disease
COX2 4513 Colorectal Cancer C1527249 Neoplastic Process 0.4 0.397 0.862 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types