Nucleoside diphosphate kinase B

AltitudeomicsDB
Protein Official symbol NME1-NME2
Aliases NME2 NM23B
Chromosomal Location  17
Length 152
Uniprot ID P22392
EC number 2.7.4.6; 2.7.13.3
Protein family Information(Pfam) PF00334;
PDB id 1NSK;1NUE;3BBB;3BBC;3BBF;
InterPro ID IPR034907;IPR036850;IPR001564;IPR023005;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
DUT DTYMK 0.994
ITPA GUK1 0.955
NUDT16 ITPA 0.955
NME1-NME2 CMPK2 0.949
NME1-NME2 DTYMK 0.946
NTPCR ENTPD2 0.93
DCTPP1 CMPK2 0.927
PNPT1 CMPK2 0.927
NME1-NME2 GUK1 0.923
ITPA NUDT2 0.923
PNPT1 NME1-NME2 0.921
NME1-NME2 ITPA 0.919
NME1-NME2 DUT 0.919
HDDC3 GUK1 0.918
PNPT1 GUK1 0.916
NME1-NME2 AK3 0.915
DUT ITPA 0.914
PNPT1 AK3 0.912
PNPT1 ENTPD2 0.911
PNPT1 HDDC3 0.91
NUDT16 NME1-NME2 0.907
AK3 ENTPD2 0.906
NME1-NME2 NUDT2 0.906
HDDC3 NME1-NME2 0.905
PNPT1 NTPCR 0.905
NME1-NME2 DCTPP1 0.903
NME1-NME2 NTPCR 0.902
DTYMK CMPK2 0.902
NME1-NME2 ENTPD2 0.902
AK3 NTPCR 0.901
Gene Ontology Semantic Similarity
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# 1854 (DUT) 3704 (ITPA) 131870 (NUDT16) 4831 (NME1-NME2) 84284 (NTPCR) 79077 (DCTPP1) 87178 (PNPT1) 374659 (HDDC3) 50808 (AK3) 1841 (DTYMK) 2987 (GUK1) 129607 (CMPK2) 954 (ENTPD2) 318 (NUDT2)
1854 (DUT) 1.00 0.69 0.58 0.52 1.00 0.86 0.65 1.00 0.50 0.12 0.12 0.12 0.66 0.60
3704 (ITPA) 0.69 1.00 0.50 0.29 0.30 0.86 0.30 0.82 0.33 0.13 0.14 0.13 0.75 0.61
131870 (NUDT16) 0.58 0.50 1.00 0.43 0.88 0.57 0.44 0.82 0.29 0.10 0.14 0.10 0.75 0.39
4831 (NME1-NME2) 0.52 0.29 0.43 1.00 0.75 0.43 0.56 1.00 0.59 0.47 0.74 0.47 0.15 0.39
84284 (NTPCR) 1.00 0.30 0.88 0.75 1.00 0.37 1.00 0.37 0.37 0.08 0.08 0.08 0.08 0.37
79077 (DCTPP1) 0.86 0.86 0.57 0.43 0.37 1.00 0.42 1.00 0.51 0.13 0.14 0.13 0.75 0.68
87178 (PNPT1) 0.65 0.30 0.44 0.56 1.00 0.42 1.00 1.00 0.47 0.24 0.41 0.24 0.17 0.38
374659 (HDDC3) 1.00 0.82 0.82 1.00 0.37 1.00 1.00 1.00 1.00 0.13 0.12 0.13 0.14 1.00
50808 (AK3) 0.50 0.33 0.29 0.59 0.37 0.51 0.47 1.00 1.00 0.67 0.74 0.64 0.15 0.47
1841 (DTYMK) 0.12 0.13 0.10 0.47 0.08 0.13 0.24 0.13 0.67 1.00 0.82 0.94 0.15 0.12
2987 (GUK1) 0.12 0.14 0.14 0.74 0.08 0.14 0.41 0.12 0.74 0.82 1.00 0.82 0.14 0.12
129607 (CMPK2) 0.12 0.13 0.10 0.47 0.08 0.13 0.24 0.13 0.64 0.94 0.82 1.00 0.15 0.12
954 (ENTPD2) 0.66 0.75 0.75 0.15 0.08 0.75 0.17 0.14 0.15 0.15 0.14 0.15 1.00 0.59
318 (NUDT2) 0.60 0.61 0.39 0.39 0.37 0.68 0.38 1.00 0.47 0.12 0.12 0.12 0.59 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
NME1-NME2 Rat Plasma - 7620 m 6 hours upregulated 1.61 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
NME1-NME2 Rat Plasma - 7620 m 12 hours upregulated 1.89 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
NME1-NME2 Rat Plasma - 7620 m 24 hours upregulated 1.35 2-DE Northern indo-australian plate Sprague-dawley rats 1 Male SD rats weighing 220g 24842778
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
RAD21 5885 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
GABPA 2551 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
EGR1 1958 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
MYC 4609 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
MAX 4149 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
SIN3A 25942 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
CTCF 10664 NME1-NME2 4831 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT036383 hsa-miR-1229-3p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038030 hsa-miR-423-5p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037769 hsa-miR-450b-5p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045749 hsa-miR-125a-5p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046082 hsa-miR-125b-5p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046894 hsa-miR-221-3p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048132 hsa-miR-197-3p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050036 hsa-miR-27a-3p Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052795 hsa-miR-3176 Homo sapiens NME1-NME2 4831 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT472104 hsa-miR-377-5p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472098 hsa-miR-4792 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472103 hsa-miR-6086 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472112 hsa-miR-6511a-5p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472105 hsa-miR-1827 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472111 hsa-miR-4257 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472108 hsa-miR-3160-3p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472109 hsa-miR-1292-3p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472099 hsa-miR-4710 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472106 hsa-miR-4487 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472101 hsa-miR-3612 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472113 hsa-miR-1910-3p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472102 hsa-miR-2467-3p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472100 hsa-miR-650 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472097 hsa-miR-7855-5p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472107 hsa-miR-558 Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT472110 hsa-miR-1247-3p Homo sapiens NME1-NME2 4831 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
Gene Ontology
ID GO ID GO Term GO Type
4831 GO:0006165 nucleoside diphosphate phosphorylation GOTERM_BP_DIRECT
4831 GO:0006241 CTP biosynthetic process GOTERM_BP_DIRECT
4831 GO:0007229 integrin-mediated signaling pathway GOTERM_BP_DIRECT
4831 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4831 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
4831 GO:0006351 transcription GOTERM_BP_DIRECT
4831 GO:0046777 protein autophosphorylation GOTERM_BP_DIRECT
4831 GO:0051259 protein oligomerization GOTERM_BP_DIRECT
4831 GO:0003677 DNA binding GOTERM_MF_DIRECT
4831 GO:0005524 ATP binding GOTERM_MF_DIRECT
4831 GO:0008144 poly GOTERM_MF_DIRECT
4831 GO:0005634 nucleus GOTERM_CC_DIRECT
4831 GO:0004674 protein serine/threonine kinase activity GOTERM_MF_DIRECT
4831 GO:0006355 regulation of transcription GOTERM_BP_DIRECT
4831 GO:0001726 ruffle GOTERM_CC_DIRECT
4831 GO:0050679 positive regulation of epithelial cell proliferation GOTERM_BP_DIRECT
4831 GO:0007155 cell adhesion GOTERM_BP_DIRECT
4831 GO:0010976 positive regulation of neuron projection development GOTERM_BP_DIRECT
4831 GO:0031966 mitochondrial membrane GOTERM_CC_DIRECT
4831 GO:0030819 positive regulation of cAMP biosynthetic process GOTERM_BP_DIRECT
4831 GO:0005882 intermediate filament GOTERM_CC_DIRECT
4831 GO:0006163 purine nucleotide metabolic process GOTERM_BP_DIRECT
4831 GO:0045682 regulation of epidermis development GOTERM_BP_DIRECT
4831 GO:0005925 focal adhesion GOTERM_CC_DIRECT
4831 GO:0030027 lamellipodium GOTERM_CC_DIRECT
4831 GO:0071398 cellular response to fatty acid GOTERM_BP_DIRECT
4831 GO:0003700 transcription factor activity GOTERM_MF_DIRECT
4831 GO:0005829 cytosol GOTERM_CC_DIRECT
4831 GO:0015949 nucleobase-containing small molecule interconversion GOTERM_BP_DIRECT
4831 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
4831 GO:0060416 response to growth hormone GOTERM_BP_DIRECT
4831 GO:0004673 protein kinase activity GOTERM_MF_DIRECT
4831 GO:0005504 retinoid binding GOTERM_MF_DIRECT
4831 GO:0009142 nucleoside triphosphate biosynthetic process GOTERM_BP_DIRECT
4831 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
4831 GO:0004550 deoxyribonuclease activity GOTERM_MF_DIRECT
4831 GO:0019899 enzyme binding GOTERM_MF_DIRECT
4831 GO:0046872 metal ion binding GOTERM_MF_DIRECT
4831 GO:0071944 cell periphery GOTERM_CC_DIRECT
4831 GO:0006220 pyrimidine nucleotide metabolic process GOTERM_BP_DIRECT
4831 GO:0034599 cellular response to oxidative stress GOTERM_BP_DIRECT
4831 GO:0002762 negative regulation of myeloid leukocyte differentiation GOTERM_BP_DIRECT
4831 GO:0045618 positive regulation of keratinocyte differentiation GOTERM_BP_DIRECT
4831 GO:0071333 cellular response to glucose stimulus GOTERM_BP_DIRECT
4831 GO:0043209 myelin sheath GOTERM_CC_DIRECT
4831 GO:0019215 glyoxalase III activity GOTERM_MF_DIRECT
4831 GO:0006183 GTP biosynthetic process GOTERM_BP_DIRECT
4831 GO:0006228 UTP biosynthetic process GOTERM_BP_DIRECT
4831 GO:0018106 peptidyl-histidine phosphorylation GOTERM_BP_DIRECT
4831 GO:0005515 protein binding GOTERM_MF_DIRECT
4831 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4831 hsa00240 Pyrimidine metabolism
4831 hsa00230 Purine metabolism
4831 hsa01130 Biosynthesis of antibiotics
4831 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
NME2 4831 Degenerative polyarthritis C0029408 Disease or Syndrome 0.3 0.604 0.552 disease
NME2 4831 ovarian neoplasm C0919267 Neoplastic Process 0.31 0.604 0.552 disease
NME2 4831 Colorectal Carcinoma C0009402 Neoplastic Process 0.31 0.604 0.552 disease
NME2 4831 Colorectal Cancer C1527249 Neoplastic Process 0.31 0.604 0.552 disease
NME2 4831 Mesothelioma C0025500 Neoplastic Process 0.3 0.604 0.552 disease
NME2 4831 Osteoarthrosis Deformans C0086743 Disease or Syndrome 0.3 0.604 0.552 disease
NME2 4831 Colorectal Neoplasms C0009404 Neoplastic Process 0.3 0.604 0.552 group
NME2 4831 Malignant neoplasm of ovary C1140680 Neoplastic Process 0.32 0.604 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
NME2 4831 PROGESTERONE PROGESTERONE CHEMBL103 None