Ectonucleoside triphosphate diphosphohydrolase 2

AltitudeomicsDB
Protein Official symbol ENTPD2
Aliases ENTPD2 CD39L1
Chromosomal Location  9
Length 495
Uniprot ID Q9Y5L3
EC number 3.6.1.-
Protein family Information(Pfam) PF01150;
PDB id None
InterPro ID IPR000407;
dbSNP rs34618694

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
RRM1 RRM2B 0.999
RRM2 RRM1 0.999
NME2 NME1-NME2 0.977
AK3 NME4 0.974
NME2 NME1 0.972
RRM2 RRM2B 0.972
NME1 NME4 0.952
NME7 RRM1 0.944
PNPT1 NME7 0.94
NME1 NME3 0.939
NME7 AK5 0.938
ENTPD2 AK8 0.937
PNPT1 ENTPD3 0.937
AK1 ENTPD2 0.937
NME1 RRM1 0.935
NME6 AK3 0.934
PNPT1 RRM1 0.934
RRM2B NME4 0.934
PNPT1 ENTPD8 0.933
PKM RRM1 0.933
RRM2 NME1 0.932
NME6 AK5 0.93
NTPCR ENTPD2 0.93
NME6 RRM2B 0.93
AK9 AK3 0.929
AK5 NME4 0.929
PNPT1 RRM2B 0.929
PNPT1 AK2 0.929
AK2 RRM2B 0.929
NME6 PNPT1 0.928
RRM2 PKM 0.928
AK9 PNPT1 0.928
AK5 NME3 0.927
ENTPD1 NTPCR 0.925
PKLR RRM1 0.923
ENTPD2 PKLR 0.923
PNPT1 RRM2 0.923
PNPT1 NME2 0.921
PNPT1 NME1-NME2 0.921
AK3 PKM 0.921
NME7 RRM2B 0.921
RRM2 AK2 0.92
ENTPD8 RRM1 0.92
ENTPD3 RRM1 0.92
PNPT1 NME3 0.92
RRM1 NME3 0.919
AK3 RRM2B 0.919
ENTPD2 NME3 0.919
PNPT1 PKLR 0.918
RRM2B NME3 0.918
NME6 RRM1 0.917
AK2 RRM1 0.917
RRM2 NME4 0.916
NME2 AK3 0.916
AK3 NME3 0.916
NME7 RRM2 0.916
PNPT1 PKM 0.916
RRM1 NME4 0.916
AK3 RRM1 0.915
PNPT1 AK8 0.915
AK4 RRM2B 0.915
RRM1 AK7 0.915
AK1 RRM1 0.915
AK4 RRM1 0.915
RRM1 AK8 0.915
ENTPD8 NTPCR 0.915
NME1-NME2 AK3 0.915
ENTPD8 ENTPD2 0.915
NME1 RRM2B 0.915
AK5 RRM1 0.915
ENTPD3 RRM2B 0.915
ENTPD2 AK2 0.914
PNPT1 NME4 0.914
ENTPD8 RRM2B 0.914
AK3 NME1 0.914
RRM2 NME3 0.914
NME6 RRM2 0.914
PKM RRM2B 0.914
AK5 NME1 0.914
PNPT1 NME1 0.914
AK3 NME7 0.914
NME6 ENTPD2 0.913
ENTPD2 PKM 0.913
AK3 PKLR 0.912
ENTPD2 AK5 0.912
PNPT1 AK3 0.912
PNPT1 AK5 0.911
PNPT1 AK4 0.911
PNPT1 ENTPD2 0.911
PKLR RRM2B 0.911
PNPT1 AK7 0.911
PNPT1 ENTPD1 0.911
PNPT1 AK1 0.911
RRM2 PKLR 0.911
NME6 AK9 0.911
NME2 NTPCR 0.91
AK9 ENTPD2 0.91
ENTPD1 RRM1 0.91
ENTPD2 NME4 0.91
AK1 RRM2 0.909
NME7 ENTPD2 0.909
ENTPD1 ENTPD3 0.909
ENTPD2 RRM1 0.909
ENTPD8 ENTPD3 0.909
AK4 NME4 0.908
AK3 ENTPD8 0.908
ENTPD1 ENTPD2 0.908
ENTPD8 PKLR 0.908
ENTPD2 ENTPD3 0.907
RRM2 ENTPD3 0.907
ENTPD1 PKM 0.907
NME6 NTPCR 0.907
ENTPD8 RRM2 0.907
AK3 ENTPD3 0.906
AK1 RRM2B 0.906
AK4 ENTPD2 0.906
AK3 ENTPD2 0.906
PKM ENTPD3 0.906
AK3 ENTPD1 0.906
ENTPD2 AK7 0.906
ENTPD8 ENTPD1 0.906
RRM2 AK8 0.905
PNPT1 NTPCR 0.905
NTPCR AK2 0.905
PKLR ENTPD3 0.905
AK8 RRM2B 0.905
ENTPD2 RRM2B 0.904
ENTPD1 RRM2 0.904
AK4 RRM2 0.904
AK3 RRM2 0.904
AK7 RRM2B 0.904
RRM2 ENTPD2 0.904
NME1-NME2 NME1 0.904
AK9 NME7 0.904
ENTPD1 RRM2B 0.904
AK5 RRM2B 0.904
RRM2 AK5 0.904
RRM2 AK7 0.904
ENTPD8 PKM 0.903
NTPCR PKM 0.903
NTPCR PKLR 0.903
NME1-NME2 ENTPD2 0.902
AK4 NTPCR 0.902
ENTPD2 NME1 0.902
NTPCR ENTPD3 0.902
TAF9 NTPCR 0.902
NTPCR NME3 0.902
ENTPD1 PKLR 0.902
NME1-NME2 NTPCR 0.902
NME2 ENTPD2 0.902
NME7 NTPCR 0.902
TAF9 ENTPD2 0.902
PNPT1 TAF9 0.902
AK3 NTPCR 0.901
AK1 NTPCR 0.901
NTPCR RRM2B 0.901
NTPCR AK7 0.9
NTPCR NME1 0.9
NTPCR RRM1 0.9
NTPCR AK8 0.9
NTPCR RRM2 0.9
AK9 NTPCR 0.9
NTPCR AK5 0.9
NTPCR NME4 0.9
Gene Ontology Semantic Similarity
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# 6240 (RRM1) 6241 (RRM2) 50808 (AK3) 4830 (NME1) 29922 (NME7) 87178 (PNPT1) 954 (ENTPD2) 203 (AK1) 10201 (NME6) 50484 (RRM2B) 5315 (PKM) 84284 (NTPCR) 221264 (AK9) 26289 (AK5) 204 (AK2) 953 (ENTPD1) 5313 (PKLR) 377841 (ENTPD8) 956 (ENTPD3) 205 (AK4) 4831 (NME1-NME2) 158067 (AK8) 122481 (AK7) 102157402 (TAF9) 4833 (NME4) 4832 (NME3) 2167 (FABP4)
6240 (RRM1) 1.00 0.96 0.62 0.49 1.00 0.45 0.15 0.13 0.62 0.96 0.59 0.37 0.14 0.14 0.14 0.54 0.17 0.14 0.54 0.14 0.47 0.44 0.14 0.49 0.57 0.62 0.23
6241 (RRM2) 0.96 1.00 0.57 0.43 1.00 0.41 0.15 0.14 0.57 1.00 0.56 0.37 0.15 0.15 0.14 0.49 0.17 0.15 0.49 0.14 0.42 0.39 0.14 0.43 0.52 0.57 0.22
50808 (AK3) 0.62 0.57 1.00 0.55 1.00 0.47 0.15 0.62 0.90 0.57 0.63 0.37 0.65 0.61 0.74 0.49 0.43 0.15 0.49 0.75 0.59 0.81 0.63 0.75 0.78 0.90 0.22
4830 (NME1) 0.49 0.43 0.55 1.00 1.00 0.63 0.29 0.31 0.58 0.43 0.60 1.00 0.35 0.31 0.74 0.44 0.43 0.15 0.44 0.39 0.71 0.60 0.37 0.71 0.57 0.58 0.22
29922 (NME7) 1.00 1.00 1.00 1.00 1.00 1.00 0.14 0.13 1.00 1.00 1.00 0.37 0.14 0.14 0.12 1.00 0.16 0.14 1.00 0.13 1.00 1.00 0.14 1.00 1.00 1.00 0.30
87178 (PNPT1) 0.45 0.41 0.47 0.63 1.00 1.00 0.17 0.20 0.47 0.41 0.72 1.00 0.23 0.20 0.41 0.39 0.51 0.12 0.39 0.24 0.56 0.46 0.24 0.44 0.45 0.47 0.19
954 (ENTPD2) 0.15 0.15 0.15 0.29 0.14 0.17 1.00 0.15 0.15 0.15 0.17 0.08 0.15 0.15 0.14 1.00 0.17 1.00 1.00 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.08
203 (AK1) 0.13 0.14 0.62 0.31 0.13 0.20 0.15 1.00 0.72 0.14 0.23 0.08 0.85 0.86 1.00 0.14 0.43 0.14 0.14 0.94 0.40 0.79 0.90 0.63 0.59 0.72 0.07
10201 (NME6) 0.62 0.57 0.90 0.58 1.00 0.47 0.15 0.72 1.00 0.57 0.63 0.37 0.73 0.71 0.74 0.49 0.43 0.15 0.49 0.75 0.64 0.86 0.70 0.75 0.86 1.00 0.22
50484 (RRM2B) 0.96 1.00 0.57 0.43 1.00 0.41 0.15 0.14 0.57 1.00 0.56 0.37 0.15 0.15 0.14 0.49 0.17 0.15 0.49 0.14 0.42 0.39 0.14 0.43 0.52 0.57 0.22
5315 (PKM) 0.59 0.56 0.63 0.60 1.00 0.72 0.17 0.23 0.63 0.56 1.00 1.00 0.27 0.24 0.41 0.51 1.00 0.13 0.51 0.28 0.61 0.57 0.28 0.56 0.59 0.63 0.22
84284 (NTPCR) 0.37 0.37 0.37 1.00 0.37 1.00 0.08 0.08 0.37 0.37 1.00 1.00 0.08 0.08 0.08 0.37 0.10 0.08 0.37 0.08 0.75 0.37 0.08 0.37 0.37 0.37 0.20
221264 (AK9) 0.14 0.15 0.65 0.35 0.14 0.23 0.15 0.85 0.73 0.15 0.27 0.08 1.00 0.96 0.74 0.15 0.45 0.15 0.15 0.89 0.44 0.79 0.89 0.63 0.62 0.73 0.07
26289 (AK5) 0.14 0.15 0.61 0.31 0.14 0.20 0.15 0.86 0.71 0.15 0.24 0.08 0.96 1.00 0.74 0.15 0.45 0.15 0.15 0.84 0.40 0.79 0.90 0.54 0.58 0.71 0.07
204 (AK2) 0.14 0.14 0.74 0.74 0.12 0.41 0.14 1.00 0.74 0.14 0.41 0.08 0.74 0.74 1.00 0.14 0.41 0.14 0.14 1.00 0.74 1.00 1.00 1.00 0.74 0.74 0.07
953 (ENTPD1) 0.54 0.49 0.49 0.44 1.00 0.39 1.00 0.14 0.49 0.49 0.51 0.37 0.15 0.15 0.14 1.00 0.17 0.83 1.00 0.14 0.39 0.36 0.14 0.39 0.46 0.49 0.20
5313 (PKLR) 0.17 0.17 0.43 0.43 0.16 0.51 0.17 0.43 0.43 0.17 1.00 0.10 0.45 0.45 0.41 0.17 1.00 0.17 0.17 0.43 0.43 0.45 0.45 0.43 0.43 0.43 0.09
377841 (ENTPD8) 0.14 0.15 0.15 0.15 0.14 0.12 1.00 0.14 0.15 0.15 0.13 0.08 0.15 0.15 0.14 0.83 0.17 1.00 0.83 0.15 0.11 0.14 0.14 0.13 0.13 0.15 0.08
956 (ENTPD3) 0.54 0.49 0.49 0.44 1.00 0.39 1.00 0.14 0.49 0.49 0.51 0.37 0.15 0.15 0.14 1.00 0.17 0.83 1.00 0.14 0.39 0.36 0.14 0.39 0.46 0.49 0.20
205 (AK4) 0.14 0.14 0.75 0.39 0.13 0.24 0.15 0.94 0.75 0.14 0.28 0.08 0.89 0.84 1.00 0.14 0.43 0.15 0.14 1.00 0.48 0.79 0.88 0.72 0.65 0.75 0.07
4831 (NME1-NME2) 0.47 0.42 0.59 0.71 1.00 0.56 0.15 0.40 0.64 0.42 0.61 0.75 0.44 0.40 0.74 0.39 0.43 0.11 0.39 0.48 1.00 0.65 0.45 0.68 0.61 0.64 0.22
158067 (AK8) 0.44 0.39 0.81 0.60 1.00 0.46 0.15 0.79 0.86 0.39 0.57 0.37 0.79 0.79 1.00 0.36 0.45 0.14 0.36 0.79 0.65 1.00 0.91 0.80 0.79 0.86 0.17
122481 (AK7) 0.14 0.14 0.63 0.37 0.14 0.24 0.15 0.90 0.70 0.14 0.28 0.08 0.89 0.90 1.00 0.14 0.45 0.14 0.14 0.88 0.45 0.91 1.00 0.65 0.61 0.70 0.07
102157402 (TAF9) 0.49 0.43 0.75 0.71 1.00 0.44 0.15 0.63 0.75 0.43 0.56 0.37 0.63 0.54 1.00 0.39 0.43 0.13 0.39 0.72 0.68 0.80 0.65 1.00 0.70 0.75 0.21
4833 (NME4) 0.57 0.52 0.78 0.57 1.00 0.45 0.15 0.59 0.86 0.52 0.59 0.37 0.62 0.58 0.74 0.46 0.43 0.13 0.46 0.65 0.61 0.79 0.61 0.70 1.00 0.86 0.31
4832 (NME3) 0.62 0.57 0.90 0.58 1.00 0.47 0.15 0.72 1.00 0.57 0.63 0.37 0.73 0.71 0.74 0.49 0.43 0.15 0.49 0.75 0.64 0.86 0.70 0.75 0.86 1.00 0.22
2167 (FABP4) 0.23 0.22 0.22 0.22 0.30 0.19 0.08 0.07 0.22 0.22 0.22 0.20 0.07 0.07 0.07 0.20 0.09 0.08 0.20 0.07 0.22 0.17 0.07 0.21 0.31 0.22 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ENTPD2 Toad Liver - 3464 m 33 day downregulated -2.565908024 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 ENTPD2 954 distal 22955619 TRANSFAC
NR3C1 2908 ENTPD2 954 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
954 GO:0009181 purine ribonucleoside diphosphate catabolic process GOTERM_BP_DIRECT
954 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
954 GO:0017110 sodium channel regulator activity GOTERM_MF_DIRECT
954 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
954 GO:0007186 G-protein coupled receptor signaling pathway GOTERM_BP_DIRECT
954 GO:0017111 sulfonylurea receptor binding GOTERM_MF_DIRECT
954 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
954 GO:0030168 platelet activation GOTERM_BP_DIRECT
954 GO:0005524 ATP binding GOTERM_MF_DIRECT
954 GO:0005886 plasma membrane GOTERM_CC_DIRECT
954 GO:0005605 basal lamina GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
954 hsa00230 Purine metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ENTPD2 954 Primary biliary cirrhosis C0008312 Disease or Syndrome 0.3 0.785 0.103 disease
ENTPD2 954 Biliary Cirrhosis, Secondary C0238065 Disease or Syndrome 0.3 0.785 0.103 disease
ENTPD2 954 Biliary cirrhosis C0023892 Disease or Syndrome 0.31 0.785 0.103 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ENTPD2 954 PSB-6426 CHEMBL469212 CHEMBL469212 inhibitor