ALTITUDEOMICSDB

Ribonucleoside-diphosphate reductase subunit

AltitudeomicsDB

Protein Official symbol	RRM2
Aliases	RRM2 RR2
Chromosomal Location	2
Length	389
Uniprot ID	P31350
EC number	1.17.4.1
Protein family Information(Pfam)	PF00268;
PDB id	2UW2;3OLJ;3VPM;3VPN;3VPO;
InterPro ID	IPR009078;IPR012348;IPR033909;IPR030475;IPR000358;
dbSNP	None

Protein Protein Interaction

Download Tab separated file

AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CDK1	KIF11	0.999
MCM4	CDC6	0.999
MCM6	CDC6	0.999
MCM3	MCM7	0.999
MCM7	CDC6	0.999
AURKB	CCNB2	0.999
CDK1	CDC20	0.999
MCM6	MCM4	0.999
MCM3	MCM6	0.999
CDC20	CCNB2	0.999
CDC20	BUB1	0.999
CDC20	CCNA2	0.999
MCM7	MCM2	0.999
CDCA8	AURKB	0.999
RRM2	RRM1	0.999
BUB1	CCNB2	0.999
CDK1	UBE2C	0.999
CDK1	NCAPG	0.999
RFC4	PCNA	0.999
CDCA8	CDC20	0.999
MCM2	MCM4	0.999
CDK1	MAD2L1	0.999
CDC20	UBE2C	0.999
ESPL1	CCNB1	0.999
CDC20	ESPL1	0.999
CDK1	BUB1B	0.999
MCM2	MCM6	0.999
CCNA2	CDC6	0.999
CDK1	CCNB1	0.999
MCM3	MCM2	0.999
KIF20A	MAD2L1	0.999
MAD2L1	CCNA2	0.999
CDCA8	BIRC5	0.999
MAD2L1	BUB1B	0.999
MCM7	MCM4	0.999
CDK1	CCNA2	0.999
CDC20	AURKB	0.999
MCM2	CDC6	0.999
AURKB	BUB1	0.999
MCM7	MCM6	0.999
CDC20	MAD2L1	0.999
BUB1	MAD2L1	0.999
CDK1	CCNB2	0.999
CDC20	BUB1B	0.999
CDK1	BUB1	0.999
MCM3	MCM4	0.999
AURKB	BUB1B	0.999
MCM3	CDC6	0.999
RRM1	RRM2B	0.999
KIF20A	AURKB	0.999
BUB1B	CCNA2	0.999
CCNB2	CCNB1	0.999
KIF2C	AURKB	0.999
BUB1	BUB1B	0.999
CDC20	CCNB1	0.999
CDK1	BIRC5	0.998
CCNA2	CCNB1	0.998
TTK	MAD2L1	0.998
CENPF	BUB1	0.998
CDCA8	MAD2L1	0.998
BUB1	ESPL1	0.998
RFC4	MCM7	0.998
CDCA8	CCNB1	0.998
AURKB	MAD2L1	0.998
MAD2L1	CCNB1	0.998
AURKB	CCNB1	0.998
MCM3	RFC4	0.998
UBE2C	CCNA2	0.998
BUB1B	CCNB1	0.998
BIRC5	MAD2L1	0.998
CDC20	BIRC5	0.998
CDK1	CDCA8	0.998
BUB1B	ESPL1	0.998
CDK1	AURKB	0.998
TTK	BUB1	0.998
KIF2C	BUB1	0.998
AURKB	BIRC5	0.998
CDC20	KIF2C	0.998
MAD2L1	CCNB2	0.998
UBE2C	CCNB1	0.998
RFC4	MCM2	0.997
BUB1	KIF11	0.997
CDC20	TTK	0.997
TOP2A	TPX2	0.997
CDK1	KIF2C	0.997
UBE2C	MAD2L1	0.997
CDK1	PCNA	0.997
CDK1	TPX2	0.997
KIF20A	KIF11	0.997
CDCA8	BUB1B	0.997
AURKB	ESPL1	0.997
KIF2C	BUB1B	0.997
AURKB	NCAPG	0.997
PBK	CDK1	0.997
CDCA8	CCNB2	0.997
UBE2C	BUB1B	0.997
NUSAP1	CDK1	0.997
PCNA	MCM4	0.997
CCNB2	BUB1B	0.997
CDCA8	BUB1	0.997
UBE2C	AURKB	0.997
CDCA8	KIF2C	0.997
PCNA	KIAA0101	0.997
BUB1	CCNB1	0.997
KIF2C	CCNB1	0.996
BIRC5	CCNB1	0.996
TFDP1	E2F1	0.996
BIRC5	BUB1B	0.996
E2F6	TFDP1	0.996
CENPF	BUB1B	0.996
KIF2C	CCNB2	0.996
KIF20A	CDCA8	0.996
BUB1	BIRC5	0.996
TOP2A	CDK1	0.996
CDK1	DLGAP5	0.996
MCM3	PCNA	0.996
PCNA	MCM7	0.996
CDC20	KIF11	0.995
CENPF	CCNB2	0.995
CCNB2	NCAPG	0.995
CDCA8	ESPL1	0.995
KIF2C	ESPL1	0.995
TTK	BUB1B	0.995
UBE2C	ESPL1	0.995
KIF2C	CENPF	0.995
BIRC5	CCNB2	0.995
BUB1	DLGAP5	0.994
MAD2L1	KIF11	0.994
CCNA2	MCM2	0.994
KIF2C	KIF11	0.994
KIF11	DLGAP5	0.994
CDCA8	CENPF	0.994
TPX2	KIF11	0.993
UBE2C	CCNB2	0.993
AURKB	KIF11	0.993
TTK	KIF11	0.993
CDK1	TTK	0.993
KIF20A	KIF2C	0.993
CENPF	CCNB1	0.993
TYMS	DTYMK	0.992
TPX2	DLGAP5	0.992
CENPF	ESPL1	0.992
CDC20	CENPF	0.992
CDK1	CENPF	0.992
NUSAP1	KIF11	0.992
KIF20A	BIRC5	0.992
TTK	NCAPG	0.992
KIF2C	BIRC5	0.992
CDK1	CDC6	0.992
RFC4	CDC6	0.992
TOP2A	UBE2C	0.991
CENPF	AURKB	0.991
CDK1	RRM2	0.991
KIF11	NCAPG	0.991
PBK	TOP2A	0.991
CDK1	KIF20A	0.991
CDK1	MCM4	0.991
CCNB2	KIF11	0.991
BUB1B	KIF11	0.991
KIF2C	MAD2L1	0.991
NUSAP1	CDC20	0.991
CCNA2	MCM4	0.991
E2F1	CDC6	0.991
CDC20	DLGAP5	0.99
TOP2A	BUB1	0.99
CENPF	BIRC5	0.99
NUSAP1	DLGAP5	0.99
RFC4	MCM4	0.99
CCNB1	NCAPG	0.99
BIRC5	ESPL1	0.99
MCM7	CCNA2	0.99
AURKB	CCNA2	0.99
BUB1	CCNA2	0.99
E2F1	CCNA2	0.989
NUSAP1	NCAPG	0.989
CENPF	MAD2L1	0.989
CCNB1	CDC6	0.989
PCNA	MCM6	0.989
CCNA2	MCM6	0.989
MCM3	CCNA2	0.989
MAD2L1	NCAPG	0.989
KIF20A	BUB1	0.989
DTL	CDC6	0.989
CCNA2	KIF11	0.989
CDCA8	TTK	0.988
TOP2A	NCAPG	0.988
TTK	DLGAP5	0.988
CCNB2	MCM2	0.988
NUSAP1	CCNA2	0.988
TYMS	MCM2	0.987
TTK	CCNA2	0.987
BUB1	TPX2	0.987
CCNB1	DLGAP5	0.987
TOP2A	DLGAP5	0.987
TOP2A	CCNB2	0.986
TOP2A	CCNB1	0.986
CCNB2	DLGAP5	0.986
NCAPG	DLGAP5	0.986
CDK1	RFC4	0.986
PBK	MAD2L1	0.986
AURKB	TPX2	0.986
PBK	CCNB1	0.986
TOP2A	CDC20	0.986
KIF11	CCNB1	0.986
CDK1	TYMS	0.986
BUB1	NCAPG	0.985
TOP2A	KIF11	0.985
TOP2A	MKI67	0.984
KIF11	ESPL1	0.984
MAD2L1	ESPL1	0.984
CDCA8	CCNA2	0.984
TTK	ESPL1	0.984
TOP2A	CCNA2	0.984
RRM1	MCM4	0.984
TOP2A	KIF20A	0.984
NUSAP1	TOP2A	0.984
TTK	CCNB2	0.983
CDK1	MCM7	0.983
CDCA8	KIF11	0.983
TOP2A	CENPF	0.983
UBE2C	CDC6	0.983
TOP2A	BUB1B	0.983
CCNB2	ESPL1	0.983
UBE2C	BIRC5	0.983
CDK1	MELK	0.982
PCNA	DTL	0.982
RFC4	DTL	0.982
MCM3	CDK1	0.982
TYMS	RRM1	0.982
CDK1	MCM2	0.981
KIF20A	CCNB1	0.981
NUSAP1	CDCA8	0.981
KIF20A	DLGAP5	0.98
PCNA	RRM1	0.98
CDK1	E2F1	0.98
CCNA2	DLGAP5	0.98
UBE2C	DLGAP5	0.98
TTK	AURKB	0.98
NUSAP1	MKI67	0.98
PCNA	TYMS	0.98
RRM1	MCM6	0.98
PCNA	MCM2	0.98
TOP2A	ESPL1	0.979
CDC20	MELK	0.979
KIF20A	CDC20	0.979
BUB1	MCM4	0.979
TOP2A	AURKB	0.979
KIF20A	CCNB2	0.979
PBK	MELK	0.978
NUSAP1	CCNB2	0.978
TYMS	MCM4	0.978
BUB1B	DLGAP5	0.977
MCM3	RRM1	0.977
KIF20A	TPX2	0.977
TOP2A	RRM2	0.977
CCNB2	CCNA2	0.977
KIF2C	TPX2	0.977
UBE2C	TPX2	0.976
MKI67	BUB1	0.976
BUB1	MELK	0.976
NUSAP1	CEP55	0.976
PBK	CDC20	0.976
CDCA8	UBE2C	0.976
RRM1	MCM2	0.976
NUSAP1	MAD2L1	0.976
MCM7	RRM1	0.975
CEP55	KIF11	0.975
RFC4	KIAA0101	0.975
PBK	DLGAP5	0.975
CDC20	CDC6	0.975
CCNB2	CDC6	0.975
RRM2	E2F1	0.974
TOP2A	TTK	0.974
PBK	BIRC5	0.974
NUSAP1	CENPF	0.973
AURKB	DLGAP5	0.973
TPX2	CCNB1	0.972
RFC4	MCM6	0.972
UBE2C	TYMS	0.972
MKI67	KIF11	0.972
RRM2	RRM2B	0.972
MCM4	KIF11	0.972
KIF20A	BUB1B	0.971
RRM2	BUB1B	0.971
CDK1	MCM6	0.971
CDK1	CEP55	0.971
MCM3	BUB1	0.971
PBK	TTK	0.971
UBE2C	BUB1	0.971
CDCA8	DLGAP5	0.971
CDC20	MKI67	0.971
CDK1	RRM1	0.97
RRM2	TYMS	0.97
NUSAP1	UBE2C	0.97
RRM2	KIF11	0.97
MKI67	DLGAP5	0.97
CCNA2	NCAPG	0.969
DTYMK	RRM1	0.969
PBK	BUB1B	0.969
PBK	CCNB2	0.968
MELK	CCNB2	0.968
KIF20A	CCNA2	0.968
CDC20	RRM2	0.968
NUSAP1	TPX2	0.968
PBK	BUB1	0.968
E2F1	CCNB1	0.967
CEP55	CENPF	0.967
BIRC5	KIF11	0.966
RRM2	DTYMK	0.966
CDC20	MCM7	0.966
KIF20A	NCAPG	0.966
MELK	DLGAP5	0.966
KIF20A	CEP55	0.966
NUSAP1	BUB1	0.966
CENPF	KIF11	0.965
CDC20	MCM2	0.965
NUSAP1	KIF20A	0.965
CDC20	NCAPG	0.965
TPX2	MELK	0.965
KIF20A	UBE2C	0.965
BIRC5	CCNA2	0.965
CEP55	DLGAP5	0.965
TOP2A	MELK	0.964
PCNA	CDC20	0.964
MELK	CCNB1	0.964
PBK	KIF11	0.964
TTK	CCNB1	0.964
KIF2C	CCNA2	0.964
NUSAP1	PBK	0.963
TPX2	NCAPG	0.963
CDK1	ESPL1	0.963
PBK	CCNA2	0.963
NUSAP1	TTK	0.963
CENPF	DLGAP5	0.963
CCNA2	ESPL1	0.963
TOP2A	CEP55	0.963
MKI67	CENPF	0.962
NUSAP1	RRM2	0.962
NUSAP1	AURKB	0.962
BIRC5	TPX2	0.962
CEP55	TTK	0.962
TOP2A	KIF2C	0.962
TTK	CENPF	0.962
NUSAP1	BUB1B	0.961
CDCA8	TPX2	0.961
TOP2A	KIAA0101	0.961
TPX2	CCNB2	0.961
CDC20	MCM6	0.961
RRM2	CCNA2	0.961
PBK	KIF20A	0.961
PCNA	MAD2L1	0.961
MELK	CCNA2	0.96
CEP55	BUB1	0.96
RRM2	MELK	0.96
TOP2A	CDCA8	0.96
KIF20A	CENPF	0.96
PBK	UBE2C	0.959
PBK	NCAPG	0.959
PCNA	RRM2	0.959
UBE2C	KIF11	0.959
CDC20	MCM4	0.959
CDK1	TFDP1	0.959
CEP55	MKI67	0.958
RRM2	CCNB2	0.958
TYMS	NCAPG	0.958
BUB1	CDC6	0.957
RRM2	UBE2C	0.957
CDK1	MKI67	0.957
CEP55	UBE2C	0.957
CDC20	TPX2	0.957
TFDP1	CCNA2	0.957
KIAA0101	CCNA2	0.956
MAD2L1	DLGAP5	0.956
TPX2	CCNA2	0.956
CEP55	RRM2	0.956
PBK	CEP55	0.956
KIF2C	DLGAP5	0.956
RRM1	CDC6	0.956
KIF20A	TTK	0.955
MKI67	CCNA2	0.955
CDC20	KIAA0101	0.955
KIF2C	UBE2C	0.955
CENPF	NCAPG	0.955
PBK	RRM2	0.954
CEP55	CCNA2	0.954
E2F8	E2F1	0.954
NUSAP1	BIRC5	0.954
RRM2	CCNB1	0.954
RRM2	MCM4	0.954
CEP55	BUB1B	0.954
CEP55	CCNB1	0.954
MKI67	RRM2	0.953
E2F1	TYMS	0.953
MELK	NCAPG	0.953
CDCA8	NCAPG	0.953
NUSAP1	KIF2C	0.952
PBK	TPX2	0.952
RRM2	MCM2	0.952
DTYMK	RRM2B	0.952
CDK1	KIAA0101	0.952
KIF20A	ESPL1	0.952
KIF2C	TTK	0.951
TTK	MKI67	0.951
MKI67	BUB1B	0.951
TXN	RRM2	0.95
ESPL1	CDC6	0.95
CDC20	CEP55	0.95
PBK	CENPF	0.95
TTK	BIRC5	0.95
TOP2A	BIRC5	0.95
MCM3	CDC20	0.95
NME1	CMPK2	0.95
NME1	DTYMK	0.95
CENPF	CCNA2	0.949
BIRC5	DLGAP5	0.949
RRM2	DLGAP5	0.949
TPX2	BUB1B	0.949
KIF20A	RRM2	0.948
RRM2	BUB1	0.948
CENPF	RRM2	0.948
TFDP1	CCNB1	0.947
MELK	BUB1B	0.947
RFC4	MAD2L1	0.947
CMPK1	NME1	0.947
CDCA8	MELK	0.947
CDCA8	CEP55	0.946
KIF2C	CEP55	0.946
MCM3	TYMS	0.946
UBE2C	KIAA0101	0.945
RRM2	AURKB	0.945
RRM2	NCAPG	0.945
CEP55	NCAPG	0.945
CMPK1	RRM1	0.944
TTK	TPX2	0.944
BIRC5	NCAPG	0.944
CENPF	TPX2	0.944
E2F8	CCNA2	0.944
TOP2A	TYMS	0.943
KIAA0101	CCNB2	0.943
MAD2L1	MCM4	0.943
KIAA0101	KIF11	0.943
TOP2A	MAD2L1	0.943
CEP55	MELK	0.942
TXN	RRM1	0.942
E2F6	E2F1	0.942
TFDP1	CDC6	0.942
RRM1	KIF11	0.942
MCM3	KIF11	0.941
RFC4	RRM1	0.941
PBK	CDCA8	0.941
RRM2	TPX2	0.941
TFDP1	RRM2	0.941
PCNA	TFDP1	0.94
CMPK1	RRM2B	0.94
MELK	KIF11	0.94
RRM1	MAD2L1	0.94
PCNA	E2F1	0.94
PBK	KIF2C	0.94
RRM2	MCM7	0.939
CDCA8	MKI67	0.939
BIRC5	MELK	0.939
MCM7	CCNB2	0.939
MCM7	MAD2L1	0.939
TYMS	MAD2L1	0.939
CDCA8	RRM2	0.939
RRM1	CMPK2	0.938
RRM2	BIRC5	0.938
TTK	RRM2	0.938
UBE2C	MELK	0.937
PCNA	CCNB1	0.937
RRM2	KIAA0101	0.936
MELK	MAD2L1	0.936
MCM3	RRM2	0.936
KIAA0101	BUB1B	0.936
NUSAP1	MELK	0.936
RRM2	MAD2L1	0.936
NME1	RRM1	0.935
KIF2C	RRM2	0.934
MCM2	CCNB1	0.934
ESPL1	NCAPG	0.934
CMPK2	RRM2B	0.934
E2F8	RRM2	0.934
MAD2L1	MCM6	0.934
KIF20A	KIAA0101	0.934
DTL	NCAPG	0.933
KIAA0101	DLGAP5	0.933
E2F8	BUB1B	0.933
NUSAP1	CCNB1	0.933
PKM	RRM1	0.933
CCNB2	MCM4	0.933
NUSAP1	KIAA0101	0.932
E2F8	CDCA8	0.932
RRM2	NME1	0.932
MKI67	BIRC5	0.932
TYMS	AURKB	0.931
RFC4	RRM2	0.931
RRM2	ESPL1	0.931
TXN	RRM2B	0.931
RFC4	TYMS	0.931
MCM3	TOP2A	0.931
TTK	MELK	0.93
AURKB	KIAA0101	0.93
CMPK1	RRM2	0.93
RRM2	MCM6	0.93
ESPL1	DLGAP5	0.93
TOP2A	MCM2	0.929
DTL	RRM1	0.929
KIF20A	MELK	0.929
BUB1	KIAA0101	0.929
KIF20A	MKI67	0.929
MCM4	NCAPG	0.929
CDCA8	KIAA0101	0.928
RRM2	CMPK2	0.928
E2F8	DLGAP5	0.928
RRM2	PKM	0.928
KIF11	CDC6	0.928
RRM2	CDC6	0.928
KIF2C	MKI67	0.928
E2F6	RRM2	0.927
E2F8	TOP2A	0.927
TOP2A	MCM7	0.925
BUB1B	CDC6	0.925
BUB1B	NCAPG	0.925
CENPF	MELK	0.924
TOP2A	TFDP1	0.924
DTL	RRM2	0.924
CENPF	UBE2C	0.923
KIF2C	NCAPG	0.923
MKI67	ESPL1	0.922
TFDP1	TYMS	0.922
PCNA	CCNA2	0.921
MCM7	CCNB1	0.921
BUB1B	MCM4	0.92
MCM7	KIF11	0.92
MKI67	CCNB2	0.92
TPX2	MAD2L1	0.92
E2F8	KIF11	0.917
TOP2A	MCM4	0.916
CDC20	TYMS	0.915
NME1	RRM2B	0.915
AURKB	CDC6	0.915
MCM4	CCNB1	0.914
CEP55	CCNB2	0.914
RRM1	CCNB1	0.914
NCAPG	CDC6	0.914
PKM	RRM2B	0.914
MKI67	UBE2C	0.912
MKI67	CCNB1	0.912
TYMS	KIF11	0.912
BIRC5	KIAA0101	0.911
KIF2C	MELK	0.911
KIAA0101	CCNB1	0.911
CDK1	DTL	0.91
DTL	MCM2	0.909
MCM3	CCNB1	0.908
CEP55	AURKB	0.907
TYMS	CCNA2	0.907
MAD2L1	MCM2	0.907
BUB1	MCM6	0.907
CDC20	RRM1	0.907
PCNA	CDC6	0.906
TOP2A	RRM1	0.905
TTK	UBE2C	0.905
MCM3	CCNB2	0.905
TTK	KIAA0101	0.904
PBK	AURKB	0.904
CEP55	BIRC5	0.903
MCM2	KIF11	0.903
UBE2C	NCAPG	0.902
DTYMK	CMPK2	0.902
CMPK1	DTYMK	0.901
MCM3	ESPL1	0.901
DTL	CCNA2	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	983 (CDK1)	4173 (MCM4)	4175 (MCM6)	4172 (MCM3)	4176 (MCM7)	9212 (AURKB)	991 (CDC20)	55143 (CDCA8)	6241 (RRM2)	699 (BUB1)	5984 (RFC4)	4171 (MCM2)	9700 (ESPL1)	890 (CCNA2)	10112 (KIF20A)	4085 (MAD2L1)	6240 (RRM1)	701 (BUB1B)	9133 (CCNB2)	11004 (KIF2C)	7272 (TTK)	1063 (CENPF)	11065 (UBE2C)	332 (BIRC5)	7153 (TOP2A)	55872 (PBK)	51203 (NUSAP1)	5111 (PCNA)	7027 (TFDP1)	1876 (E2F6)	3832 (KIF11)	22974 (TPX2)	7298 (TYMS)	1869 (E2F1)	891 (CCNB1)	51514 (DTL)	64151 (NCAPG)	4288 (MKI67)	55165 (CEP55)	1841 (DTYMK)	9833 (MELK)	9768 (KIAA0101)	79733 (E2F8)	7295 (TXN)	4830 (NME1)	51727 (CMPK1)	129607 (CMPK2)	5315 (PKM)	990 (CDC6)	50484 (RRM2B)	9787 (DLGAP5)
983 (CDK1)	1.00	0.37	0.38	1.00	0.37	0.88	0.47	1.00	0.38	0.90	0.35	0.39	0.48	0.84	0.39	0.48	0.42	0.90	0.84	0.36	1.00	0.49	0.50	0.50	0.46	0.90	0.40	0.45	0.39	0.34	0.28	0.41	0.24	0.34	0.80	0.51	1.00	0.43	1.00	0.43	0.85	0.41	0.33	0.39	0.51	0.42	0.43	0.65	0.41	0.38	0.38
4173 (MCM4)	0.37	1.00	0.83	1.00	0.87	0.45	0.74	1.00	0.55	0.56	0.73	0.61	0.47	0.49	0.62	0.72	0.61	0.56	0.47	0.59	1.00	0.68	0.52	0.69	0.63	0.55	0.59	0.54	0.47	0.39	0.53	0.54	0.21	0.39	0.43	0.57	1.00	0.65	1.00	0.12	0.45	0.64	0.38	0.61	0.43	0.12	0.12	0.55	0.56	0.55	0.57
4175 (MCM6)	0.38	0.83	1.00	1.00	0.78	0.46	0.67	1.00	0.53	0.53	0.67	0.58	0.48	0.49	0.59	0.72	0.62	0.53	0.47	0.57	1.00	0.65	0.51	0.69	0.62	0.53	0.57	0.56	0.47	0.41	0.49	0.79	0.25	0.41	0.44	0.54	1.00	0.62	1.00	0.11	0.46	0.59	0.40	0.58	0.64	0.11	0.11	0.54	0.60	0.53	0.54
4172 (MCM3)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.29	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	0.13	0.13	1.00	1.00	1.00	1.00
4176 (MCM7)	0.37	0.87	0.78	1.00	1.00	0.44	0.68	1.00	0.52	0.52	0.74	0.82	0.46	0.48	0.59	0.67	0.57	0.52	0.46	0.64	1.00	0.64	0.50	0.65	0.73	0.51	0.68	0.63	0.50	0.55	0.51	0.54	0.36	0.55	0.42	0.53	1.00	0.73	1.00	0.11	0.44	0.59	0.50	0.72	0.50	0.11	0.11	0.62	0.66	0.52	0.53
9212 (AURKB)	0.88	0.45	0.46	1.00	0.44	1.00	0.61	1.00	0.46	0.87	0.42	0.49	0.49	0.81	0.48	0.59	0.50	0.87	0.80	0.41	1.00	0.58	0.54	0.61	0.53	0.90	0.49	0.52	0.44	0.37	0.38	0.52	0.24	0.38	0.75	0.56	1.00	0.53	1.00	0.38	0.82	0.51	0.37	0.49	0.50	0.37	0.38	0.65	0.55	0.46	0.46
991 (CDC20)	0.47	0.74	0.67	1.00	0.68	0.61	1.00	1.00	0.75	0.75	0.66	0.80	0.61	0.62	0.61	0.89	0.76	0.75	0.61	0.57	1.00	0.82	0.69	0.84	0.64	0.75	0.75	0.66	0.57	0.48	0.44	0.68	0.24	0.48	0.55	0.76	1.00	0.86	1.00	0.12	0.61	0.82	0.47	0.80	0.51	0.12	0.12	0.67	0.73	0.75	0.75
55143 (CDCA8)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.29	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	0.13	0.13	1.00	1.00	1.00	1.00
6241 (RRM2)	0.38	0.55	0.53	1.00	0.52	0.46	0.75	1.00	1.00	0.58	0.49	0.63	0.52	0.50	0.49	0.73	0.96	0.58	0.49	0.45	1.00	0.69	0.54	0.70	0.54	0.57	0.60	0.54	0.48	0.39	0.35	0.55	0.23	0.40	0.44	0.60	1.00	0.67	1.00	0.14	0.46	0.66	0.38	0.63	0.43	0.14	0.14	0.56	0.57	1.00	0.57
699 (BUB1)	0.90	0.56	0.53	1.00	0.52	0.87	0.75	1.00	0.58	1.00	0.49	0.63	0.52	0.81	0.49	0.73	0.63	1.00	0.77	0.46	1.00	0.69	0.61	0.70	0.54	0.95	0.60	0.54	0.48	0.39	0.35	0.55	0.27	0.40	0.72	0.68	1.00	0.66	1.00	0.46	0.82	0.66	0.38	0.63	0.50	0.45	0.46	0.70	0.57	0.58	0.58
5984 (RFC4)	0.35	0.73	0.67	1.00	0.74	0.42	0.66	1.00	0.49	0.49	1.00	0.67	0.46	0.46	0.65	0.65	0.55	0.49	0.45	0.65	1.00	0.63	0.48	0.64	0.68	0.49	0.59	0.57	0.47	0.45	0.58	0.51	0.26	0.46	0.41	0.51	1.00	0.64	1.00	0.12	0.42	0.56	0.43	0.61	0.45	0.12	0.12	0.55	0.57	0.49	0.51
4171 (MCM2)	0.39	0.61	0.58	1.00	0.82	0.49	0.80	1.00	0.63	0.63	0.67	1.00	0.50	0.53	0.51	0.77	0.67	0.63	0.51	0.57	1.00	0.71	0.56	0.73	0.67	0.62	0.80	0.66	0.55	0.59	0.38	0.61	0.41	0.59	0.45	0.64	1.00	0.86	1.00	0.12	0.50	0.71	0.54	0.88	0.53	0.12	0.12	0.70	0.76	0.63	0.63
9700 (ESPL1)	0.48	0.47	0.48	1.00	0.46	0.49	0.61	1.00	0.52	0.52	0.46	0.50	1.00	0.51	0.52	0.61	0.57	0.52	0.49	0.48	1.00	0.60	0.57	0.61	0.53	0.51	0.50	0.54	0.46	0.39	0.42	0.48	0.28	0.40	0.47	0.58	1.00	0.54	1.00	0.28	0.47	0.52	0.38	0.50	0.47	0.28	0.29	0.54	0.49	0.52	0.56
890 (CCNA2)	0.84	0.49	0.49	1.00	0.48	0.81	0.62	1.00	0.50	0.81	0.46	0.53	0.51	1.00	0.54	0.61	0.54	0.81	0.94	0.45	1.00	0.60	0.56	0.62	0.55	0.77	0.52	0.57	0.49	0.40	0.42	0.58	0.23	0.41	0.90	0.58	1.00	0.56	1.00	0.35	0.73	0.54	0.39	0.53	0.50	0.33	0.36	0.64	0.56	0.50	0.50
10112 (KIF20A)	0.39	0.62	0.59	1.00	0.59	0.48	0.61	1.00	0.49	0.49	0.65	0.51	0.52	0.54	1.00	0.59	0.52	0.49	0.53	0.84	1.00	0.60	0.49	0.69	0.64	0.48	0.62	0.55	0.47	0.41	0.86	0.56	0.20	0.41	0.49	0.51	1.00	0.54	1.00	0.13	0.44	0.52	0.40	0.51	0.44	0.13	0.13	0.51	0.54	0.49	0.51
4085 (MAD2L1)	0.48	0.72	0.72	1.00	0.67	0.59	0.89	1.00	0.73	0.73	0.65	0.77	0.61	0.61	0.59	1.00	0.82	0.73	0.59	0.57	1.00	0.87	0.66	0.82	0.65	0.73	0.73	0.64	0.57	0.49	0.40	0.66	0.23	0.49	0.53	0.74	1.00	0.83	1.00	0.11	0.61	0.79	0.48	0.77	0.56	0.11	0.11	0.66	0.69	0.73	0.73
6240 (RRM1)	0.42	0.61	0.62	1.00	0.57	0.50	0.76	1.00	0.96	0.63	0.55	0.67	0.57	0.54	0.52	0.82	1.00	0.63	0.52	0.49	1.00	0.72	0.58	0.75	0.56	0.62	0.64	0.59	0.51	0.42	0.36	0.58	0.23	0.43	0.47	0.65	1.00	0.69	1.00	0.14	0.51	0.69	0.41	0.67	0.49	0.13	0.13	0.59	0.61	0.96	0.62
701 (BUB1B)	0.90	0.56	0.53	1.00	0.52	0.87	0.75	1.00	0.58	1.00	0.49	0.63	0.52	0.81	0.49	0.73	0.63	1.00	0.77	0.46	1.00	0.69	0.61	0.70	0.54	0.95	0.60	0.54	0.48	0.39	0.35	0.55	0.27	0.40	0.72	0.68	1.00	0.66	1.00	0.46	0.82	0.66	0.38	0.63	0.50	0.45	0.46	0.70	0.57	0.58	0.58
9133 (CCNB2)	0.84	0.47	0.47	1.00	0.46	0.80	0.61	1.00	0.49	0.77	0.45	0.51	0.49	0.94	0.53	0.59	0.52	0.77	1.00	0.43	1.00	0.59	0.54	0.61	0.54	0.76	0.51	0.56	0.45	0.39	0.41	0.56	0.23	0.40	0.91	0.55	1.00	0.54	1.00	0.34	0.72	0.52	0.38	0.51	0.49	0.32	0.35	0.68	0.54	0.49	0.49
11004 (KIF2C)	0.36	0.59	0.57	1.00	0.64	0.41	0.57	1.00	0.45	0.46	0.65	0.57	0.48	0.45	0.84	0.57	0.49	0.46	0.43	1.00	1.00	0.59	0.46	0.70	0.65	0.45	0.68	0.56	0.49	0.48	0.82	0.48	0.23	0.48	0.41	0.47	1.00	0.56	1.00	0.11	0.41	0.50	0.47	0.53	0.45	0.11	0.11	0.52	0.59	0.45	0.48
7272 (TTK)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.29	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	0.13	0.13	1.00	1.00	1.00	1.00
1063 (CENPF)	0.49	0.68	0.65	1.00	0.64	0.58	0.82	1.00	0.69	0.69	0.63	0.71	0.60	0.60	0.60	0.87	0.72	0.69	0.59	0.59	1.00	1.00	0.64	0.76	0.69	0.68	0.71	0.67	0.60	0.52	0.48	0.64	0.23	0.52	0.53	0.69	1.00	0.77	1.00	0.11	0.59	0.86	0.51	0.71	0.55	0.11	0.11	0.65	0.66	0.69	0.69
11065 (UBE2C)	0.50	0.52	0.51	1.00	0.50	0.54	0.69	1.00	0.54	0.61	0.48	0.56	0.57	0.56	0.49	0.66	0.58	0.61	0.54	0.46	1.00	0.64	1.00	0.66	0.54	0.60	0.56	0.55	0.47	0.40	0.37	0.53	0.28	0.40	0.55	0.91	1.00	0.60	1.00	0.26	0.53	0.58	0.39	0.56	0.47	0.26	0.26	0.60	0.54	0.54	0.54
332 (BIRC5)	0.50	0.69	0.69	1.00	0.65	0.61	0.84	1.00	0.70	0.70	0.64	0.73	0.61	0.62	0.69	0.82	0.75	0.70	0.61	0.70	1.00	0.76	0.66	1.00	0.63	0.70	0.81	0.68	0.58	0.50	0.53	0.66	0.22	0.51	0.56	0.70	1.00	0.74	1.00	0.11	0.61	0.74	0.49	0.73	0.56	0.11	0.11	0.66	0.69	0.70	0.70
7153 (TOP2A)	0.46	0.63	0.62	1.00	0.73	0.53	0.64	1.00	0.54	0.54	0.68	0.67	0.53	0.55	0.64	0.65	0.56	0.54	0.54	0.65	1.00	0.69	0.54	0.63	1.00	0.54	0.65	0.70	0.53	0.58	0.58	0.57	0.31	0.59	0.52	0.55	1.00	0.69	1.00	0.10	0.55	0.62	0.55	0.66	0.65	0.10	0.10	0.63	0.63	0.54	0.55
55872 (PBK)	0.90	0.55	0.53	1.00	0.51	0.90	0.75	1.00	0.57	0.95	0.49	0.62	0.51	0.77	0.48	0.73	0.62	0.95	0.76	0.45	1.00	0.68	0.60	0.70	0.54	1.00	0.60	0.54	0.48	0.39	0.35	0.55	0.26	0.40	0.69	0.66	1.00	0.66	1.00	0.41	0.84	0.65	0.38	0.62	0.49	0.40	0.40	0.68	0.57	0.57	0.57
51203 (NUSAP1)	0.40	0.59	0.57	1.00	0.68	0.49	0.75	1.00	0.60	0.60	0.59	0.80	0.50	0.52	0.62	0.73	0.64	0.60	0.51	0.68	1.00	0.71	0.56	0.81	0.65	0.60	1.00	0.62	0.52	0.52	0.50	0.60	0.42	0.52	0.46	0.61	1.00	0.89	1.00	0.11	0.50	0.67	0.48	0.90	0.57	0.11	0.11	0.74	0.67	0.60	0.60
5111 (PCNA)	0.45	0.54	0.56	1.00	0.63	0.52	0.66	1.00	0.54	0.54	0.57	0.66	0.54	0.57	0.55	0.64	0.59	0.54	0.56	0.56	1.00	0.67	0.55	0.68	0.70	0.54	0.62	1.00	0.53	0.55	0.48	0.57	0.27	0.56	0.55	0.55	1.00	0.63	1.00	0.10	0.50	0.64	0.52	0.62	0.56	0.10	0.10	0.59	0.63	0.54	0.56
7027 (TFDP1)	0.39	0.47	0.47	1.00	0.50	0.44	0.57	1.00	0.48	0.48	0.47	0.55	0.46	0.49	0.47	0.57	0.51	0.48	0.45	0.49	1.00	0.60	0.47	0.58	0.53	0.48	0.52	0.53	1.00	0.84	0.33	0.49	0.20	0.81	0.43	0.48	1.00	0.55	1.00	0.11	0.44	0.51	0.86	0.52	0.43	0.11	0.11	0.51	0.56	0.48	0.48
1876 (E2F6)	0.34	0.39	0.41	1.00	0.55	0.37	0.48	1.00	0.39	0.39	0.45	0.59	0.39	0.40	0.41	0.49	0.42	0.39	0.39	0.48	1.00	0.52	0.40	0.50	0.58	0.39	0.52	0.55	0.84	1.00	0.30	0.43	0.28	0.93	0.38	0.39	1.00	0.54	1.00	0.10	0.37	0.42	0.95	0.52	0.45	0.09	0.10	0.50	0.54	0.39	0.39
3832 (KIF11)	0.28	0.53	0.49	0.60	0.51	0.38	0.44	0.60	0.35	0.35	0.58	0.38	0.42	0.42	0.86	0.40	0.36	0.35	0.41	0.82	0.60	0.48	0.37	0.53	0.58	0.35	0.50	0.48	0.33	0.30	1.00	0.44	0.19	0.31	0.38	0.37	0.60	0.39	0.60	0.11	0.33	0.46	0.30	0.38	0.38	0.11	0.11	0.38	0.44	0.35	0.39
22974 (TPX2)	0.41	0.54	0.79	1.00	0.54	0.52	0.68	1.00	0.55	0.55	0.51	0.61	0.48	0.58	0.56	0.66	0.58	0.55	0.56	0.48	1.00	0.64	0.53	0.66	0.57	0.55	0.60	0.57	0.49	0.43	0.44	1.00	0.27	0.44	0.51	0.56	1.00	0.64	1.00	0.10	0.48	0.60	0.42	0.61	0.69	0.10	0.10	0.56	0.69	0.55	0.55
7298 (TYMS)	0.24	0.21	0.25	0.29	0.36	0.24	0.24	0.29	0.23	0.27	0.26	0.41	0.28	0.23	0.20	0.23	0.23	0.27	0.23	0.23	0.29	0.23	0.28	0.22	0.31	0.26	0.42	0.27	0.20	0.28	0.19	0.27	1.00	0.29	0.21	0.29	0.29	0.43	0.29	0.18	0.24	0.24	0.25	0.46	0.36	0.17	0.18	0.40	0.34	0.23	0.23
1869 (E2F1)	0.34	0.39	0.41	1.00	0.55	0.38	0.48	1.00	0.40	0.40	0.46	0.59	0.40	0.41	0.41	0.49	0.43	0.40	0.40	0.48	1.00	0.52	0.40	0.51	0.59	0.40	0.52	0.56	0.81	0.93	0.31	0.44	0.29	1.00	0.38	0.40	1.00	0.55	1.00	0.10	0.37	0.43	0.94	0.52	0.45	0.10	0.10	0.51	0.55	0.40	0.40
891 (CCNB1)	0.80	0.43	0.44	1.00	0.42	0.75	0.55	1.00	0.44	0.72	0.41	0.45	0.47	0.90	0.49	0.53	0.47	0.72	0.91	0.41	1.00	0.53	0.55	0.56	0.52	0.69	0.46	0.55	0.43	0.38	0.38	0.51	0.21	0.38	1.00	0.50	1.00	0.48	1.00	0.31	0.68	0.46	0.37	0.45	0.48	0.29	0.32	0.59	0.49	0.44	0.44
51514 (DTL)	0.51	0.57	0.54	1.00	0.53	0.56	0.76	1.00	0.60	0.68	0.51	0.64	0.58	0.58	0.51	0.74	0.65	0.68	0.55	0.47	1.00	0.69	0.91	0.70	0.55	0.66	0.61	0.55	0.48	0.39	0.37	0.56	0.29	0.40	0.50	1.00	1.00	0.67	1.00	0.29	0.55	0.67	0.38	0.64	0.47	0.29	0.29	0.63	0.58	0.60	0.60
64151 (NCAPG)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.29	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	0.13	0.13	1.00	1.00	1.00	1.00
4288 (MKI67)	0.43	0.65	0.62	1.00	0.73	0.53	0.86	1.00	0.67	0.66	0.64	0.86	0.54	0.56	0.54	0.83	0.69	0.66	0.54	0.56	1.00	0.77	0.60	0.74	0.69	0.66	0.89	0.63	0.55	0.54	0.39	0.64	0.43	0.55	0.48	0.67	1.00	1.00	1.00	0.12	0.54	0.73	0.51	0.96	0.60	0.12	0.12	0.77	0.72	0.67	0.67
55165 (CEP55)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.29	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	0.13	0.13	1.00	1.00	1.00	1.00
1841 (DTYMK)	0.43	0.12	0.11	0.13	0.11	0.38	0.12	0.13	0.14	0.46	0.12	0.12	0.28	0.35	0.13	0.11	0.14	0.46	0.34	0.11	0.13	0.11	0.26	0.11	0.10	0.41	0.11	0.10	0.11	0.10	0.11	0.10	0.18	0.10	0.31	0.29	0.13	0.12	0.13	1.00	0.37	0.12	0.10	0.12	0.39	0.87	0.94	0.27	0.11	0.14	0.14
9833 (MELK)	0.85	0.45	0.46	1.00	0.44	0.82	0.61	1.00	0.46	0.82	0.42	0.50	0.47	0.73	0.44	0.61	0.51	0.82	0.72	0.41	1.00	0.59	0.53	0.61	0.55	0.84	0.50	0.50	0.44	0.37	0.33	0.48	0.24	0.37	0.68	0.55	1.00	0.54	1.00	0.37	1.00	0.51	0.36	0.50	0.53	0.36	0.37	0.63	0.49	0.46	0.46
9768 (KIAA0101)	0.41	0.64	0.59	1.00	0.59	0.51	0.82	1.00	0.66	0.66	0.56	0.71	0.52	0.54	0.52	0.79	0.69	0.66	0.52	0.50	1.00	0.86	0.58	0.74	0.62	0.65	0.67	0.64	0.51	0.42	0.46	0.60	0.24	0.43	0.46	0.67	1.00	0.73	1.00	0.12	0.51	1.00	0.41	0.71	0.48	0.12	0.12	0.60	0.63	0.66	0.66
79733 (E2F8)	0.33	0.38	0.40	1.00	0.50	0.37	0.47	1.00	0.38	0.38	0.43	0.54	0.38	0.39	0.40	0.48	0.41	0.38	0.38	0.47	1.00	0.51	0.39	0.49	0.55	0.38	0.48	0.52	0.86	0.95	0.30	0.42	0.25	0.94	0.37	0.38	1.00	0.51	1.00	0.10	0.36	0.41	1.00	0.48	0.42	0.09	0.10	0.48	0.53	0.38	0.38
7295 (TXN)	0.39	0.61	0.58	1.00	0.72	0.49	0.80	1.00	0.63	0.63	0.61	0.88	0.50	0.53	0.51	0.77	0.67	0.63	0.51	0.53	1.00	0.71	0.56	0.73	0.66	0.62	0.90	0.62	0.52	0.52	0.38	0.61	0.46	0.52	0.45	0.64	1.00	0.96	1.00	0.12	0.50	0.71	0.48	1.00	0.58	0.12	0.12	0.77	0.70	0.63	0.63
4830 (NME1)	0.51	0.43	0.64	1.00	0.50	0.50	0.51	1.00	0.43	0.50	0.45	0.53	0.47	0.50	0.44	0.56	0.49	0.50	0.49	0.45	1.00	0.55	0.47	0.56	0.65	0.49	0.57	0.56	0.43	0.45	0.38	0.69	0.36	0.45	0.48	0.47	1.00	0.60	1.00	0.39	0.53	0.48	0.42	0.58	1.00	0.35	0.39	0.60	0.54	0.43	0.48
51727 (CMPK1)	0.42	0.12	0.11	0.13	0.11	0.37	0.12	0.13	0.14	0.45	0.12	0.12	0.28	0.33	0.13	0.11	0.13	0.45	0.32	0.11	0.13	0.11	0.26	0.11	0.10	0.40	0.11	0.10	0.11	0.09	0.11	0.10	0.17	0.10	0.29	0.29	0.13	0.12	0.13	0.87	0.36	0.12	0.09	0.12	0.35	1.00	0.77	0.26	0.11	0.14	0.14
129607 (CMPK2)	0.43	0.12	0.11	0.13	0.11	0.38	0.12	0.13	0.14	0.46	0.12	0.12	0.29	0.36	0.13	0.11	0.13	0.46	0.35	0.11	0.13	0.11	0.26	0.11	0.10	0.40	0.11	0.10	0.11	0.10	0.11	0.10	0.18	0.10	0.32	0.29	0.13	0.12	0.13	0.94	0.37	0.12	0.10	0.12	0.39	0.77	1.00	0.28	0.11	0.14	0.14
5315 (PKM)	0.65	0.55	0.54	1.00	0.62	0.65	0.67	1.00	0.56	0.70	0.55	0.70	0.54	0.64	0.51	0.66	0.59	0.70	0.68	0.52	1.00	0.65	0.60	0.66	0.63	0.68	0.74	0.59	0.51	0.50	0.38	0.56	0.40	0.51	0.59	0.63	1.00	0.77	1.00	0.27	0.63	0.60	0.48	0.77	0.60	0.26	0.28	1.00	0.62	0.56	0.56
990 (CDC6)	0.41	0.56	0.60	1.00	0.66	0.55	0.73	1.00	0.57	0.57	0.57	0.76	0.49	0.56	0.54	0.69	0.61	0.57	0.54	0.59	1.00	0.66	0.54	0.69	0.63	0.57	0.67	0.63	0.56	0.54	0.44	0.69	0.34	0.55	0.49	0.58	1.00	0.72	1.00	0.11	0.49	0.63	0.53	0.70	0.54	0.11	0.11	0.62	1.00	0.57	0.57
50484 (RRM2B)	0.38	0.55	0.53	1.00	0.52	0.46	0.75	1.00	1.00	0.58	0.49	0.63	0.52	0.50	0.49	0.73	0.96	0.58	0.49	0.45	1.00	0.69	0.54	0.70	0.54	0.57	0.60	0.54	0.48	0.39	0.35	0.55	0.23	0.40	0.44	0.60	1.00	0.67	1.00	0.14	0.46	0.66	0.38	0.63	0.43	0.14	0.14	0.56	0.57	1.00	0.57
9787 (DLGAP5)	0.38	0.57	0.54	1.00	0.53	0.46	0.75	1.00	0.57	0.58	0.51	0.63	0.56	0.50	0.51	0.73	0.62	0.58	0.49	0.48	1.00	0.69	0.54	0.70	0.55	0.57	0.60	0.56	0.48	0.39	0.39	0.55	0.23	0.40	0.44	0.60	1.00	0.67	1.00	0.14	0.46	0.66	0.38	0.63	0.48	0.14	0.14	0.56	0.57	0.57	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
RRM2	Toad	Brain	-	3464 m	33 day	downregulated	-4.327025041	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
NFYA	4800	RRM2	6241	proximal_filtered	22955619	TRANSFAC
E2F1	1869	RRM2	6241	proximal_filtered	22955619	TRANSFAC
NFYB	4801	RRM2	6241	proximal_filtered	22955619	TRANSFAC
E2F4	1874	RRM2	6241	proximal_filtered	22955619	TRANSFAC
SIN3A	25942	RRM2	6241	proximal_filtered	22955619	TRANSFAC
ZBTB7A	51341	RRM2	6241	proximal_filtered	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT005050	hsa-let-7b-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT005050	hsa-let-7b-5p	Homo sapiens	RRM2	6241	Homo sapiens	Proteomics	Functional MTI (Weak)	18668040
MIRT005050	hsa-let-7b-5p	Homo sapiens	RRM2	6241	Homo sapiens	Microarray	Functional MTI (Weak)	17699775
MIRT016281	hsa-miR-193b-3p	Homo sapiens	RRM2	6241	Homo sapiens	Microarray	Functional MTI (Weak)	20304954
MIRT016281	hsa-miR-193b-3p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT020622	hsa-miR-155-5p	Homo sapiens	RRM2	6241	Homo sapiens	Proteomics	Functional MTI (Weak)	18668040
MIRT025270	hsa-miR-34a-5p	Homo sapiens	RRM2	6241	Homo sapiens	Proteomics	Functional MTI (Weak)	21566225
MIRT028473	hsa-miR-30a-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT028473	hsa-miR-30a-5p	Homo sapiens	RRM2	6241	Homo sapiens	Proteomics	Functional MTI (Weak)	18668040
MIRT028473	hsa-miR-30a-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT030469	hsa-miR-24-3p	Homo sapiens	RRM2	6241	Homo sapiens	qRT-PCR;Microarray	Functional MTI (Weak)	19748357
MIRT039342	hsa-miR-425-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT041980	hsa-miR-484	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT043700	hsa-miR-342-3p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT045271	hsa-miR-186-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT046565	hsa-let-7g-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT046565	hsa-let-7g-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT047887	hsa-miR-30c-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT047887	hsa-miR-30c-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT047887	hsa-miR-30c-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT048497	hsa-miR-100-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT050154	hsa-miR-26a-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT052385	hsa-let-7a-5p	Homo sapiens	RRM2	6241	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT052385	hsa-let-7a-5p	Homo sapiens	RRM2	6241	Homo sapiens	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	23335963
MIRT052385	hsa-let-7a-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT054803	hsa-miR-211-5p	Homo sapiens	RRM2	6241	Homo sapiens	qRT-PCR	Functional MTI (Weak)	24940696
MIRT084344	hsa-miR-20a-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT084349	hsa-miR-20b-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084347	hsa-miR-106b-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084343	hsa-miR-17-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT084370	hsa-miR-4672	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT084343	hsa-miR-17-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084345	hsa-miR-93-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT084351	hsa-miR-519d-3p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT084352	hsa-miR-4755-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084354	hsa-miR-6083	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084344	hsa-miR-20a-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084349	hsa-miR-20b-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT084346	hsa-miR-106a-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084351	hsa-miR-519d-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084353	hsa-miR-5006-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084345	hsa-miR-93-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT084347	hsa-miR-106b-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT084350	hsa-miR-526b-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT118914	hsa-miR-4768-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT118914	hsa-miR-4768-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT154956	hsa-miR-30e-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT154970	hsa-miR-3064-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT154967	hsa-miR-4520-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT154974	hsa-miR-6504-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT154952	hsa-miR-30b-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT154952	hsa-miR-30b-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT154956	hsa-miR-30e-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT154963	hsa-miR-3169	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT154964	hsa-miR-4316	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT154968	hsa-miR-4668-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT154965	hsa-miR-4515	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT154950	hsa-miR-33a-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT154951	hsa-miR-30d-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT154951	hsa-miR-30d-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT297014	hsa-let-7f-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297022	hsa-miR-4458	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297019	hsa-miR-1294	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297031	hsa-miR-219b-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297012	hsa-let-7d-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297020	hsa-miR-4328	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297031	hsa-miR-219b-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT297015	hsa-miR-98-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297013	hsa-let-7e-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297023	hsa-miR-4500	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297011	hsa-let-7c-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297024	hsa-miR-6768-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT297017	hsa-let-7i-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468829	hsa-miR-1273e	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468829	hsa-miR-1273e	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468830	hsa-miR-6807-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468836	hsa-miR-8082	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468841	hsa-miR-6888-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468834	hsa-miR-3689d	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468839	hsa-miR-665	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468841	hsa-miR-6888-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468844	hsa-miR-7843-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468845	hsa-miR-8068	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468833	hsa-miR-6851-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468840	hsa-miR-4802-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468838	hsa-miR-6840-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468842	hsa-miR-302f	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468843	hsa-miR-127-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468847	hsa-miR-548ah-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468839	hsa-miR-665	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468848	hsa-miR-3609	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468831	hsa-miR-582-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468832	hsa-miR-101-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468837	hsa-miR-655-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468842	hsa-miR-302f	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468835	hsa-miR-4534	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468838	hsa-miR-6840-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468836	hsa-miR-8082	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468840	hsa-miR-4802-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT468846	hsa-miR-4796-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23592263
MIRT468835	hsa-miR-4534	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT546643	hsa-miR-410-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT546644	hsa-miR-323b-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT546642	hsa-miR-494-5p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT546645	hsa-miR-202-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT546646	hsa-miR-4700-3p	Homo sapiens	RRM2	6241	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT722670	hsa-miR-4728-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722677	hsa-miR-6129	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722673	hsa-miR-423-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722675	hsa-miR-6133	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722672	hsa-miR-6778-3p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722671	hsa-miR-149-3p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722674	hsa-miR-3184-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722669	hsa-miR-6785-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722676	hsa-miR-6130	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722667	hsa-miR-6826-3p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722668	hsa-miR-6883-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722683	hsa-miR-4794	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722678	hsa-miR-6127	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722680	hsa-miR-4419a	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722688	hsa-miR-4739	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722681	hsa-miR-149-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722685	hsa-miR-6795-3p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722690	hsa-miR-6873-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722686	hsa-miR-6887-3p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722687	hsa-miR-4756-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722682	hsa-miR-664a-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722684	hsa-miR-2276-5p	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722689	hsa-miR-1321	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157
MIRT722679	hsa-miR-4510	Homo sapiens	RRM2	6241	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	19536157

Gene Ontology

ID	GO ID	GO Term	GO Type
6241	GO:0005634	nucleus	GOTERM_CC_DIRECT
6241	GO:0016491	oxidoreductase activity	GOTERM_MF_DIRECT
6241	GO:0015949	nucleobase-containing small molecule interconversion	GOTERM_BP_DIRECT
6241	GO:0009263	deoxyribonucleotide biosynthetic process	GOTERM_BP_DIRECT
6241	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
6241	GO:0000082	G1/S transition of mitotic cell cycle	GOTERM_BP_DIRECT
6241	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
6241	GO:0051290	protein heterotetramerization	GOTERM_BP_DIRECT
6241	GO:0005515	protein binding	GOTERM_MF_DIRECT
6241	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
6241	GO:0009186	deoxyribonucleoside diphosphate metabolic process	GOTERM_BP_DIRECT
6241	GO:0005829	cytosol	GOTERM_CC_DIRECT
6241	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	GOTERM_BP_DIRECT
6241	GO:0055114	oxidation-reduction process	GOTERM_BP_DIRECT
6241	GO:0004748	retinol dehydrogenase activity	GOTERM_MF_DIRECT
6241	GO:0006260	DNA replication	GOTERM_BP_DIRECT
6241	GO:0005971	ribonucleoside-diphosphate reductase complex	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
6241	hsa00240	Pyrimidine metabolism
6241	hsa00230	Purine metabolism
6241	hsa00480	Glutathione metabolism
6241	hsa01100	Metabolic pathways
6241	hsa04115	p53 signaling pathway

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
RRM2	6241	Polycystic Ovary Syndrome	C0032460	Disease or Syndrome	0.3	0.604	0.552	disease
RRM2	6241	Adenocarcinoma of lung (disorder)	C0152013	Neoplastic Process	0.31	0.604	0.552	disease
RRM2	6241	Liver carcinoma	C2239176	Neoplastic Process	0.32	0.604	0.552	disease
RRM2	6241	Sclerocystic Ovaries	C1136382	Disease or Syndrome	0.3	0.604	0.552	disease
RRM2	6241	Colorectal Carcinoma	C0009402	Neoplastic Process	0.31	0.604	0.552	disease
RRM2	6241	Colorectal Neoplasms	C0009404	Neoplastic Process	0.3	0.604	0.552	group
RRM2	6241	Colorectal Cancer	C1527249	Neoplastic Process	0.33	0.604	0.552	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
RRM2	6241	CLOFARABINE	CLOFARABINE	CHEMBL1750	inhibitor
RRM2	6241	CLOFARABINE	CLOFARABINE	CHEMBL1750	inhibitor
RRM2	6241	FLUDARABINE	FLUDARABINE	CHEMBL1568	inhibitor
RRM2	6241	FLUDARABINE PHOSPHATE	FLUDARABINE PHOSPHATE	CHEMBL1096882	inhibitor
RRM2	6241	GALLIUM NITRATE	GALLIUM NITRATE	CHEMBL1200983	inhibitor
RRM2	6241	GEMCITABINE HYDROCHLORIDE	GEMCITABINE HYDROCHLORIDE	CHEMBL1637	inhibitor
RRM2	6241	GEMCITABINE	GEMCITABINE	CHEMBL888	None
RRM2	6241	GEMCITABINE	GEMCITABINE	CHEMBL888	inhibitor
RRM2	6241	HYDROXYUREA	HYDROXYUREA	CHEMBL467	inhibitor
RRM2	6241	HYDROXYUREA	HYDROXYUREA	CHEMBL467	inhibitor
RRM2	6241	LOR-2040	None	None	None
RRM2	6241	MOTEXAFIN GADOLINIUM	MOTEXAFIN GADOLINIUM	CHEMBL3544910	inhibitor
RRM2	6241	MOTEXAFIN GADOLINIUM	MOTEXAFIN GADOLINIUM	CHEMBL3544910	None
RRM2	6241	TEZACITABINE	TEZACITABINE	CHEMBL2105467	inhibitor
RRM2	6241	TRIAPINE	TRIAPINE	CHEMBL231616	None