ALTITUDEOMICSDB

Thymidylate synthase

AltitudeomicsDB

Protein Official symbol	TYMS
Aliases	TYMS TS OK/SW-cl.29
Chromosomal Location	18
Length	313
Uniprot ID	P04818
EC number	2.1.1.45
Protein family Information(Pfam)	PF00303;
PDB id	1HVY;1HW3;1HW4;1HZW;1I00;1JU6;1JUJ;1YPV;2ONB;2RD8;2RDA;3EAW;3EBU;3ED7;3EDW;3EF9;3EGY;3EHI;3EJL;3GG5;3GH0;3GH2;3H9K;3HB8;3N5E;3N5G;3OB7;4E28;4FGT;4G2O;4G6W;4GD7;4GYH;4H1I;4JEF;4KPW;4O1U;4O1X;4UP1;5HS3;5WRN;5X4W;5X4X;5X4Y;5X5A;5X5D;5X5Q;5X66;5X67;5X69;6OJU;6OJV;6PF3;6PF4;6PF5;6PF6;6QXG;6QXH;6QYQ;6R2E;
InterPro ID	IPR023451;IPR036926;IPR000398;IPR020940;
dbSNP	None

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
RRM2	RRM1	0.999
MCM3	POLA1	0.999
MCM2	MCM5	0.999
CDK1	NDC80	0.999
MCM3	MCM5	0.999
CDK1	UBE2C	0.999
CDK1	KIF11	0.999
CDC20	UBE2C	0.999
CDC45	MCM5	0.999
CDK1	CDC20	0.999
MCM3	MCM2	0.999
CDC20	AURKB	0.999
MCM4	MCM5	0.999
POLA1	MCM2	0.999
DUT	TYMS	0.999
MCM3	MCM4	0.999
RFC4	PRIM1	0.999
MAD2L1	CCNA2	0.999
CDC45	MCM4	0.999
CDK1	MAD2L1	0.999
MCM2	MCM4	0.999
CDC45	MCM2	0.999
CDC20	MAD2L1	0.999
AURKB	NDC80	0.999
CDC20	NDC80	0.999
RFC4	PCNA	0.999
MCM3	CDC45	0.999
POLA1	PRIM1	0.999
MAD2L1	NDC80	0.999
CDK1	CKS2	0.999
CDK1	NCAPG	0.999
CDK1	CCNA2	0.999
CDC20	CCNA2	0.999
DHFR	TYMS	0.999
UBE2C	CCNA2	0.998
AURKB	MAD2L1	0.998
CDC45	CHEK1	0.998
MCM3	RFC4	0.998
POLA1	MCM4	0.998
CDC45	POLA1	0.998
CDK1	AURKB	0.998
CDK1	PCNA	0.997
UBE2C	AURKB	0.997
UBE2C	MAD2L1	0.997
PRIM1	MCM2	0.997
CDC45	PRIM1	0.997
GART	SHMT2	0.997
RFC4	MCM2	0.997
MCM3	PRIM1	0.997
PCNA	PRIM1	0.997
PCNA	MCM4	0.997
TYMS	TK1	0.997
AURKB	NCAPG	0.997
GART	SHMT1	0.997
PCNA	POLA1	0.997
TFDP1	E2F1	0.996
PRIM1	MCM5	0.996
TOP2A	CDK1	0.996
CHEK1	MCM4	0.996
MTHFD2	GART	0.996
GART	MTHFD1	0.996
MCM3	PCNA	0.996
PRIM1	MCM4	0.995
POLA1	MCM5	0.995
CHEK1	MCM2	0.995
CDC20	KIF11	0.995
MAD2L1	KIF11	0.994
CCNA2	MCM2	0.994
DPYD	UMPS	0.994
DUT	DTYMK	0.994
NDC80	KIF11	0.994
MTHFD2	SHMT2	0.993
DCTD	TYMS	0.993
AURKB	KIF11	0.993
MTHFD2L	GART	0.992
TYMS	DTYMK	0.992
MCM3	CHEK1	0.992
CKS2	CCNA2	0.992
MTHFR	TYMS	0.992
TOP2A	UBE2C	0.991
SHMT1	MTHFD1	0.991
MTHFD2	SHMT1	0.991
KIF11	NCAPG	0.991
CDK1	RRM2	0.991
CKS2	CDC20	0.991
CCNA2	MCM4	0.991
DTYMK	TK1	0.991
CDK1	MCM4	0.991
MTHFD2L	SHMT1	0.99
AURKB	CCNA2	0.99
TYMP	DPYD	0.99
DHFR	FPGS	0.99
RFC4	POLA1	0.99
RFC4	MCM4	0.99
MCM3	CCNA2	0.989
CCNA2	KIF11	0.989
SHMT2	AMT	0.989
CCNA2	MCM5	0.989
E2F1	CCNA2	0.989
MTHFR	MTHFD1	0.989
MAD2L1	NCAPG	0.989
DHFR	GART	0.988
CHEK1	RFC4	0.988
MTHFD2L	SHMT2	0.988
SHMT1	AMT	0.988
SHMT1	TYMS	0.988
TOP2A	NCAPG	0.988
MTHFR	SHMT1	0.988
TYMS	MCM2	0.987
NDC80	NCAPG	0.987
DHFRL1	TYMS	0.987
TOP2A	CDC20	0.986
SHMT2	MTHFD1	0.986
CDK1	RFC4	0.986
FPGS	TYMS	0.986
CDK1	TYMS	0.986
SHMT2	TYMS	0.985
TOP2A	KIF11	0.985
RRM1	MCM4	0.984
CHEK1	MCM5	0.984
TYMS	MTHFD1	0.984
TOP2A	CCNA2	0.984
DHFR	SHMT1	0.983
TYMP	UMPS	0.983
CDC45	PCNA	0.982
MCM3	CDK1	0.982
TYMS	RRM1	0.982
MTHFR	SHMT2	0.981
DHFR	SHMT2	0.981
CDK1	MCM2	0.981
CDC20	MCM5	0.981
PCNA	TYMS	0.98
CDK1	E2F1	0.98
MTHFD2L	MTHFD2	0.98
PCNA	RRM1	0.98
PCNA	MCM2	0.98
MTHFD2	AMT	0.979
DHFR	MTHFD1	0.979
TOP2A	AURKB	0.979
PCNA	MCM5	0.978
TYMS	MCM4	0.978
FPGS	MTHFD1	0.978
CKS2	MAD2L1	0.978
DUT	DCTD	0.978
CCNA2	NDC80	0.978
TOP2A	RRM2	0.977
MCM3	RRM1	0.977
RFC4	MCM5	0.977
E2F1	TK1	0.977
DUT	RRM1	0.977
DCTD	DTYMK	0.976
MTHFD2L	AMT	0.976
RRM1	MCM2	0.976
DUT	TK2	0.975
MTHFD2	MTHFR	0.974
RRM2	E2F1	0.974
CDK1	MCM5	0.973
PCNA	UNG	0.973
CDCA7	MCM2	0.972
UBE2C	TYMS	0.972
TYMP	TK1	0.972
MCM4	KIF11	0.972
DHFRL1	FPGS	0.971
RRM2	TYMS	0.97
TOP2A	NDC80	0.97
MTHFD2	TYMS	0.97
CDK1	RRM1	0.97
RRM2	KIF11	0.97
CCNA2	NCAPG	0.969
AMT	MTHFD1	0.969
DTYMK	RRM1	0.969
TYMP	NT5M	0.969
CDC20	RRM2	0.968
DUT	PCNA	0.967
CDC45	NCAPG	0.967
DCTD	TK1	0.967
CDC45	E2F1	0.967
RRM2	DTYMK	0.966
CDC20	MCM2	0.965
CDC20	NCAPG	0.965
DUT	TK1	0.965
PCNA	CDC20	0.964
MTHFD2L	MTHFR	0.964
POLA1	RRM1	0.964
CDK1	DUT	0.963
PCNA	MAD2L1	0.961
RRM2	CCNA2	0.961
RRM1	MCM5	0.96
UBE2C	KIF11	0.959
MTHFR	AMT	0.959
CDC20	MCM4	0.959
CDK1	TFDP1	0.959
PCNA	RRM2	0.959
TYMS	TK2	0.958
TYMP	TK2	0.958
CDCA7	MCM5	0.958
DUT	UNG	0.958
TYMS	NCAPG	0.958
MTHFD2L	TYMS	0.957
TFDP1	CCNA2	0.957
PRIM1	RRM1	0.957
RRM2	UBE2C	0.957
CDCA7	MCM4	0.955
RRM2	MCM4	0.954
DHFRL1	SHMT2	0.954
CHEK1	CCNA2	0.953
E2F1	TYMS	0.953
TYMS	MCM5	0.953
RRM2	MCM2	0.952
GART	AMT	0.952
DHFR	E2F1	0.952
CDC45	CDK1	0.952
TYMS	AMT	0.951
DUT	MCM5	0.95
MCM3	CDC20	0.95
DUT	MCM4	0.95
TOP2A	CHEK1	0.949
CDC45	KIF11	0.948
CDC45	RFC4	0.948
NT5M	DTYMK	0.947
RFC4	MAD2L1	0.947
CDC45	TYMS	0.946
TYMP	NT5C	0.946
MCM3	TYMS	0.946
DHFRL1	SHMT1	0.946
RRM2	NCAPG	0.945
RRM2	AURKB	0.945
PRIM1	TYMS	0.944
DHFRL1	GART	0.944
DTYMK	TK2	0.943
MAD2L1	MCM4	0.943
TOP2A	TYMS	0.943
TOP2A	MAD2L1	0.943
DPYD	TYMS	0.943
RRM1	KIF11	0.942
RFC4	RRM1	0.941
TFDP1	RRM2	0.941
PRIM1	RNASEH2A	0.941
PCNA	RNASEH2A	0.941
MCM3	KIF11	0.941
CKS2	NCAPG	0.941
PCNA	E2F1	0.94
CHEK1	TYMS	0.94
PCNA	TFDP1	0.94
RRM1	MAD2L1	0.94
TYMS	MAD2L1	0.939
CHEK1	MAD2L1	0.939
DUT	MCM2	0.939
TYMP	NT5E	0.939
MTHFD2	MTHFD1	0.938
DHFR	AMT	0.938
TYMS	NDC80	0.937
CDC45	RRM1	0.937
CDK1	TK1	0.936
RRM2	MAD2L1	0.936
MCM3	RRM2	0.936
DUT	RNASEH2A	0.934
CHEK1	CDC20	0.934
MTHFD2L	MTHFD1	0.934
GART	TYMS	0.933
POLA1	TYMS	0.933
DHFRL1	AMT	0.932
CDC45	CDC20	0.932
CKS2	UBE2C	0.931
RFC4	RRM2	0.931
DCTD	TK2	0.931
TYMS	AURKB	0.931
RFC4	TYMS	0.931
MCM3	TOP2A	0.931
RNASEH2A	MCM5	0.93
NT5E	UMPS	0.93
TOP2A	MCM2	0.929
DUT	NT5E	0.929
CHEK1	CDK1	0.929
MCM4	NCAPG	0.929
DHFRL1	MTHFD1	0.929
CDC45	MAD2L1	0.928
CDC45	AURKB	0.928
TYMS	NT5E	0.928
TK1	TK2	0.927
DUT	POLA1	0.926
TYMS	CDCA7	0.926
TK1	NT5C	0.926
TYMS	UMPS	0.925
MCM3	RNASEH2A	0.925
DTYMK	NT5C	0.925
DUT	NT5C	0.924
TOP2A	TFDP1	0.924
DCTD	NT5E	0.923
POLA1	E2F1	0.923
DCTD	NT5C	0.923
TYMP	TYMS	0.923
TFDP1	TK1	0.922
CDC45	TFDP1	0.922
RRM2	MCM5	0.922
TFDP1	TYMS	0.922
RFC4	NDC80	0.922
PCNA	CCNA2	0.921
CDC45	RRM2	0.92
TYMS	UNG	0.92
UBE2C	NDC80	0.92
DHFR	TFDP1	0.919
RRM2	NDC80	0.919
CDC45	CCNA2	0.919
TYMS	RNASEH2A	0.918
CHEK1	TFDP1	0.918
POLA1	TFDP1	0.917
NT5M	DUT	0.916
NT5M	DCTD	0.916
TYMS	NT5C	0.916
TOP2A	MCM4	0.916
CDC20	TYMS	0.915
MAD2L1	MCM5	0.915
KIF11	MCM5	0.914
RFC4	DUT	0.914
NT5M	TYMS	0.913
TYMS	KIF11	0.912
POLA1	KIF11	0.912
NT5M	NT5E	0.911
AURKB	MCM5	0.91
NT5C	UMPS	0.91
CHEK1	RRM2	0.907
TYMS	CCNA2	0.907
DUT	PRIM1	0.907
MAD2L1	MCM2	0.907
CDC20	RRM1	0.907
CKS2	TYMS	0.907
TOP2A	RRM1	0.905
TK1	MCM5	0.904
TOP2A	CKS2	0.904
MCM2	KIF11	0.903
MCM3	DUT	0.903
UBE2C	NCAPG	0.902
NT5M	UMPS	0.9
DTYMK	NT5E	0.9

Gene Ontology Semantic Similarity

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#	6241 (RRM2)	4172 (MCM3)	4171 (MCM2)	983 (CDK1)	991 (CDC20)	8318 (CDC45)	4173 (MCM4)	5422 (POLA1)	1854 (DUT)	5984 (RFC4)	4085 (MAD2L1)	9212 (AURKB)	1719 (DHFR)	11065 (UBE2C)	5557 (PRIM1)	2618 (GART)	5111 (PCNA)	7298 (TYMS)	7027 (TFDP1)	7153 (TOP2A)	1111 (CHEK1)	10797 (MTHFD2)	890 (CCNA2)	1806 (DPYD)	10403 (NDC80)	1635 (DCTD)	441024 (MTHFD2L)	1164 (CKS2)	4524 (MTHFR)	6470 (SHMT1)	3832 (KIF11)	1841 (DTYMK)	1890 (TYMP)	6472 (SHMT2)	1869 (E2F1)	200895 (DHFRL1)	2356 (FPGS)	6240 (RRM1)	275 (AMT)	56953 (NT5M)	10535 (RNASEH2A)	4907 (NT5E)	7083 (TK1)	30833 (NT5C)	4174 (MCM5)	64151 (NCAPG)	4522 (MTHFD1)	7372 (UMPS)	7084 (TK2)	7374 (UNG)
6241 (RRM2)	1.00	1.00	0.63	0.38	0.75	0.47	0.55	0.49	0.50	0.49	0.73	0.46	0.32	0.54	0.23	0.19	0.54	0.23	0.48	0.54	0.45	0.31	0.50	0.47	0.74	0.64	0.24	0.62	0.40	0.45	0.35	0.14	0.36	0.47	0.40	0.29	0.17	0.96	0.17	0.14	0.15	0.13	0.51	0.21	1.00	1.00	0.44	0.17	0.14	0.50
4172 (MCM3)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.59	1.00	0.33	0.18	1.00	0.29	1.00	1.00	1.00	0.41	1.00	1.00	1.00	1.00	0.16	1.00	0.59	1.00	0.60	0.13	0.61	1.00	1.00	0.30	0.16	1.00	0.16	0.14	0.16	0.13	1.00	0.32	1.00	1.00	1.00	0.16	0.14	1.00
4171 (MCM2)	0.63	1.00	1.00	0.39	0.80	0.72	0.61	0.69	0.66	0.67	0.77	0.49	0.44	0.56	0.55	0.16	0.66	0.41	0.55	0.67	0.47	0.27	0.53	0.48	0.80	0.67	0.14	0.65	0.43	0.54	0.38	0.12	0.36	0.51	0.59	0.41	0.16	0.67	0.16	0.12	0.13	0.13	0.54	0.30	1.00	1.00	0.40	0.14	0.12	0.72
983 (CDK1)	0.38	1.00	0.39	1.00	0.47	0.37	0.37	0.49	0.37	0.35	0.48	0.88	0.27	0.50	0.31	0.24	0.45	0.24	0.39	0.46	0.90	0.23	0.84	0.38	0.44	0.45	0.16	0.44	0.29	0.43	0.28	0.43	0.39	0.44	0.34	0.20	0.18	0.42	0.31	0.14	0.15	0.14	0.61	0.18	1.00	1.00	0.35	0.24	0.43	0.37
991 (CDC20)	0.75	1.00	0.80	0.47	1.00	0.60	0.74	0.58	0.64	0.66	0.89	0.61	0.33	0.69	0.26	0.16	0.66	0.24	0.57	0.64	0.56	0.29	0.62	0.50	0.89	0.77	0.14	0.75	0.42	0.52	0.44	0.12	0.42	0.55	0.48	0.25	0.16	0.76	0.16	0.13	0.13	0.13	0.63	0.24	1.00	1.00	0.49	0.15	0.13	0.64
8318 (CDC45)	0.47	1.00	0.72	0.37	0.60	1.00	0.60	0.73	0.62	0.60	0.60	0.42	0.38	0.47	0.48	0.14	0.66	0.32	0.51	0.71	0.42	0.26	0.46	0.43	0.57	0.54	0.14	0.54	0.43	0.48	0.55	0.11	0.29	0.54	0.55	0.32	0.16	0.52	0.16	0.13	0.14	0.15	0.46	0.27	1.00	1.00	0.37	0.12	0.11	0.61
4173 (MCM4)	0.55	1.00	0.61	0.37	0.74	0.60	1.00	0.48	0.56	0.73	0.72	0.45	0.28	0.52	0.21	0.16	0.54	0.21	0.47	0.63	0.43	0.25	0.49	0.41	0.72	0.63	0.15	0.61	0.35	0.44	0.53	0.12	0.33	0.46	0.39	0.22	0.16	0.61	0.16	0.14	0.14	0.13	0.50	0.21	1.00	1.00	0.37	0.14	0.12	0.50
5422 (POLA1)	0.49	1.00	0.69	0.49	0.58	0.73	0.48	1.00	0.57	0.53	0.57	0.54	0.50	0.52	0.47	0.16	0.67	0.37	0.51	0.72	0.53	0.25	0.57	0.55	0.55	0.52	0.12	0.59	0.52	0.53	0.46	0.19	0.36	0.57	0.57	0.42	0.17	0.51	0.29	0.10	0.12	0.13	0.52	0.40	1.00	1.00	0.41	0.14	0.17	0.60
1854 (DUT)	0.50	1.00	0.66	0.37	0.64	0.62	0.56	0.57	1.00	0.58	0.64	0.43	0.45	0.49	0.35	0.16	0.58	0.39	0.47	0.73	0.43	0.43	0.47	0.45	0.61	0.58	0.16	0.56	0.39	0.59	0.51	0.12	0.31	0.56	0.48	0.39	0.16	0.54	0.16	0.16	0.17	0.19	0.54	0.29	1.00	1.00	0.38	0.14	0.12	0.56
5984 (RFC4)	0.49	1.00	0.67	0.35	0.66	0.60	0.73	0.53	0.58	1.00	0.65	0.42	0.31	0.48	0.32	0.16	0.57	0.26	0.47	0.68	0.41	0.25	0.46	0.40	0.63	0.58	0.16	0.57	0.34	0.45	0.58	0.12	0.31	0.45	0.46	0.26	0.16	0.55	0.16	0.15	0.17	0.14	0.46	0.23	1.00	1.00	0.36	0.14	0.12	0.54
4085 (MAD2L1)	0.73	1.00	0.77	0.48	0.89	0.60	0.72	0.57	0.64	0.65	1.00	0.59	0.33	0.66	0.25	0.15	0.64	0.23	0.57	0.65	0.56	0.28	0.61	0.57	0.93	0.82	0.14	0.72	0.41	0.60	0.40	0.11	0.60	0.59	0.49	0.24	0.16	0.82	0.16	0.12	0.13	0.13	0.68	0.23	1.00	1.00	0.50	0.14	0.12	0.64
9212 (AURKB)	0.46	1.00	0.49	0.88	0.61	0.42	0.45	0.54	0.43	0.42	0.59	1.00	0.28	0.54	0.29	0.21	0.52	0.24	0.44	0.53	0.87	0.24	0.81	0.40	0.55	0.53	0.15	0.57	0.32	0.45	0.38	0.38	0.39	0.47	0.38	0.21	0.16	0.50	0.27	0.13	0.14	0.13	0.61	0.19	1.00	1.00	0.37	0.21	0.37	0.44
1719 (DHFR)	0.32	0.59	0.44	0.27	0.33	0.38	0.28	0.50	0.45	0.31	0.33	0.28	1.00	0.31	0.34	0.14	0.38	0.66	0.30	0.47	0.29	0.41	0.29	0.53	0.32	0.32	0.29	0.31	0.60	0.57	0.27	0.11	0.21	0.46	0.37	0.77	0.20	0.34	0.20	0.11	0.12	0.15	0.30	0.37	0.59	0.59	0.44	0.12	0.11	0.38
11065 (UBE2C)	0.54	1.00	0.56	0.50	0.69	0.47	0.52	0.52	0.49	0.48	0.66	0.54	0.31	1.00	0.29	0.27	0.55	0.28	0.47	0.54	0.57	0.28	0.56	0.45	0.64	0.60	0.19	0.58	0.36	0.49	0.37	0.26	0.47	0.51	0.40	0.24	0.24	0.58	0.40	0.17	0.18	0.19	0.56	0.23	1.00	1.00	0.44	0.27	0.25	0.49
5557 (PRIM1)	0.23	0.33	0.55	0.31	0.26	0.48	0.21	0.47	0.35	0.32	0.25	0.29	0.34	0.29	1.00	0.19	0.31	0.37	0.23	0.34	0.35	0.17	0.28	0.27	0.26	0.26	0.14	0.22	0.27	0.30	0.18	0.28	0.26	0.27	0.35	0.33	0.15	0.24	0.26	0.11	0.12	0.11	0.29	0.24	0.33	0.33	0.20	0.19	0.26	0.39
2618 (GART)	0.19	0.18	0.16	0.24	0.16	0.14	0.16	0.16	0.16	0.16	0.15	0.21	0.14	0.27	0.19	1.00	0.14	0.22	0.15	0.14	0.27	0.19	0.20	0.18	0.17	0.21	0.22	0.14	0.17	0.21	0.15	0.25	0.29	0.24	0.13	0.17	0.60	0.18	0.51	0.19	0.20	0.19	0.20	0.17	0.18	0.18	0.37	0.27	0.25	0.16
5111 (PCNA)	0.54	1.00	0.66	0.45	0.66	0.66	0.54	0.67	0.58	0.57	0.64	0.52	0.38	0.55	0.31	0.14	1.00	0.27	0.53	0.70	0.49	0.26	0.57	0.50	0.62	0.60	0.13	0.61	0.42	0.54	0.48	0.10	0.36	0.58	0.56	0.26	0.16	0.59	0.16	0.12	0.13	0.19	0.54	0.25	1.00	1.00	0.47	0.12	0.10	0.69
7298 (TYMS)	0.23	0.29	0.41	0.24	0.24	0.32	0.21	0.37	0.39	0.26	0.23	0.24	0.66	0.28	0.37	0.22	0.27	1.00	0.20	0.31	0.27	0.22	0.23	0.30	0.24	0.24	0.13	0.21	0.33	0.53	0.19	0.18	0.24	0.40	0.29	0.47	0.17	0.23	0.63	0.10	0.11	0.13	0.24	0.28	0.29	0.29	0.22	0.16	0.15	0.32
7027 (TFDP1)	0.48	1.00	0.55	0.39	0.57	0.51	0.47	0.51	0.47	0.47	0.57	0.44	0.30	0.47	0.23	0.15	0.53	0.20	1.00	0.53	0.46	0.23	0.49	0.42	0.55	0.51	0.13	0.53	0.34	0.44	0.33	0.11	0.29	0.45	0.81	0.21	0.16	0.51	0.16	0.11	0.12	0.13	0.47	0.19	1.00	1.00	0.39	0.13	0.11	0.49
7153 (TOP2A)	0.54	1.00	0.67	0.46	0.64	0.71	0.63	0.72	0.73	0.68	0.65	0.53	0.47	0.54	0.34	0.14	0.70	0.31	0.53	1.00	0.50	0.34	0.55	0.54	0.58	0.58	0.13	0.62	0.42	0.62	0.58	0.10	0.40	0.62	0.59	0.31	0.16	0.56	0.16	0.11	0.13	0.15	0.56	0.27	1.00	1.00	0.48	0.12	0.10	0.63
1111 (CHEK1)	0.45	1.00	0.47	0.90	0.56	0.42	0.43	0.53	0.43	0.41	0.56	0.87	0.29	0.57	0.35	0.27	0.49	0.27	0.46	0.50	1.00	0.26	0.83	0.42	0.52	0.52	0.18	0.51	0.33	0.46	0.32	0.50	0.44	0.48	0.38	0.23	0.24	0.49	0.40	0.16	0.17	0.19	0.68	0.21	1.00	1.00	0.40	0.26	0.49	0.43
10797 (MTHFD2)	0.31	0.41	0.27	0.23	0.29	0.26	0.25	0.25	0.43	0.25	0.28	0.24	0.41	0.28	0.17	0.19	0.26	0.22	0.23	0.34	0.26	1.00	0.25	0.33	0.28	0.39	0.77	0.25	0.48	0.38	0.25	0.14	0.23	0.41	0.21	0.39	0.20	0.32	0.20	0.18	0.19	0.22	0.32	0.21	0.41	0.41	0.74	0.17	0.14	0.27
890 (CCNA2)	0.50	1.00	0.53	0.84	0.62	0.46	0.49	0.57	0.47	0.46	0.61	0.81	0.29	0.56	0.28	0.20	0.57	0.23	0.49	0.55	0.83	0.25	1.00	0.43	0.58	0.55	0.15	0.72	0.34	0.47	0.42	0.35	0.39	0.49	0.41	0.21	0.18	0.54	0.31	0.13	0.14	0.14	0.62	0.20	1.00	1.00	0.41	0.19	0.32	0.47
1806 (DPYD)	0.47	1.00	0.48	0.38	0.50	0.43	0.41	0.55	0.45	0.40	0.57	0.40	0.53	0.45	0.27	0.18	0.50	0.30	0.42	0.54	0.42	0.33	0.43	1.00	0.49	0.48	0.22	0.47	0.58	0.53	0.33	0.14	0.39	0.50	0.40	0.48	0.24	0.51	0.24	0.13	0.15	0.19	0.44	0.35	1.00	1.00	0.44	0.15	0.13	0.43
10403 (NDC80)	0.74	1.00	0.80	0.44	0.89	0.57	0.72	0.55	0.61	0.63	0.93	0.55	0.32	0.64	0.26	0.17	0.62	0.24	0.55	0.58	0.52	0.28	0.58	0.49	1.00	0.83	0.15	0.72	0.41	0.54	0.39	0.12	0.49	0.56	0.45	0.25	0.16	0.83	0.16	0.13	0.14	0.13	0.65	0.23	1.00	1.00	0.45	0.15	0.13	0.61
1635 (DCTD)	0.64	1.00	0.67	0.45	0.77	0.54	0.63	0.52	0.58	0.58	0.82	0.53	0.32	0.60	0.26	0.21	0.60	0.24	0.51	0.58	0.52	0.39	0.55	0.48	0.83	1.00	0.32	0.65	0.39	0.52	0.42	0.17	0.47	0.54	0.43	0.26	0.22	0.73	0.22	0.23	0.24	0.27	0.61	0.29	1.00	1.00	0.55	0.19	0.17	0.59
441024 (MTHFD2L)	0.24	0.16	0.14	0.16	0.14	0.14	0.15	0.12	0.16	0.16	0.14	0.15	0.29	0.19	0.14	0.22	0.13	0.13	0.13	0.13	0.18	0.77	0.15	0.22	0.15	0.32	1.00	0.12	0.35	0.12	0.16	0.16	0.20	0.13	0.12	0.42	0.20	0.22	0.20	0.22	0.23	0.22	0.15	0.19	0.16	0.16	0.79	0.20	0.17	0.16
1164 (CKS2)	0.62	1.00	0.65	0.44	0.75	0.54	0.61	0.59	0.56	0.57	0.72	0.57	0.31	0.58	0.22	0.14	0.61	0.21	0.53	0.62	0.51	0.25	0.72	0.47	0.72	0.65	0.12	1.00	0.37	0.49	0.46	0.11	0.36	0.51	0.46	0.21	0.16	0.65	0.16	0.11	0.11	0.13	0.56	0.20	1.00	1.00	0.46	0.12	0.11	0.56
4524 (MTHFR)	0.40	0.59	0.43	0.29	0.42	0.43	0.35	0.52	0.39	0.34	0.41	0.32	0.60	0.36	0.27	0.17	0.42	0.33	0.34	0.42	0.33	0.48	0.34	0.58	0.41	0.39	0.35	0.37	1.00	0.43	0.41	0.13	0.26	0.50	0.33	0.57	0.20	0.41	0.20	0.13	0.14	0.15	0.35	0.37	0.59	0.59	0.50	0.15	0.13	0.42
6470 (SHMT1)	0.45	1.00	0.54	0.43	0.52	0.48	0.44	0.53	0.59	0.45	0.60	0.45	0.57	0.49	0.30	0.21	0.54	0.53	0.44	0.62	0.46	0.38	0.47	0.53	0.54	0.52	0.12	0.49	0.43	1.00	0.34	0.14	0.41	0.90	0.45	0.36	0.20	0.51	0.51	0.10	0.11	0.15	0.62	0.26	1.00	1.00	0.40	0.14	0.13	0.48
3832 (KIF11)	0.35	0.60	0.38	0.28	0.44	0.55	0.53	0.46	0.51	0.58	0.40	0.38	0.27	0.37	0.18	0.15	0.48	0.19	0.33	0.58	0.32	0.25	0.42	0.33	0.39	0.42	0.16	0.46	0.41	0.34	1.00	0.11	0.25	0.39	0.31	0.19	0.16	0.36	0.16	0.16	0.18	0.19	0.34	0.22	0.60	0.60	0.31	0.13	0.11	0.41
1841 (DTYMK)	0.14	0.13	0.12	0.43	0.12	0.11	0.12	0.19	0.12	0.12	0.11	0.38	0.11	0.26	0.28	0.25	0.10	0.18	0.11	0.10	0.50	0.14	0.35	0.14	0.12	0.17	0.16	0.11	0.13	0.14	0.11	1.00	0.28	0.16	0.10	0.14	0.17	0.14	0.28	0.14	0.15	0.13	0.46	0.13	0.13	0.13	0.17	0.26	0.66	0.12
1890 (TYMP)	0.36	0.61	0.36	0.39	0.42	0.29	0.33	0.36	0.31	0.31	0.60	0.39	0.21	0.47	0.26	0.29	0.36	0.24	0.29	0.40	0.44	0.23	0.39	0.39	0.49	0.47	0.20	0.36	0.26	0.41	0.25	0.28	1.00	0.37	0.25	0.20	0.24	0.45	0.40	0.17	0.18	0.19	0.45	0.20	0.61	0.61	0.32	0.56	0.28	0.31
6472 (SHMT2)	0.47	1.00	0.51	0.44	0.55	0.54	0.46	0.57	0.56	0.45	0.59	0.47	0.46	0.51	0.27	0.24	0.58	0.40	0.45	0.62	0.48	0.41	0.49	0.50	0.56	0.54	0.13	0.51	0.50	0.90	0.39	0.16	0.37	1.00	0.43	0.28	0.20	0.53	0.51	0.11	0.12	0.15	0.65	0.26	1.00	1.00	0.40	0.15	0.14	0.49
1869 (E2F1)	0.40	1.00	0.59	0.34	0.48	0.55	0.39	0.57	0.48	0.46	0.49	0.38	0.37	0.40	0.35	0.13	0.56	0.29	0.81	0.59	0.38	0.21	0.41	0.40	0.45	0.43	0.12	0.46	0.33	0.45	0.31	0.10	0.25	0.43	1.00	0.28	0.16	0.43	0.16	0.10	0.11	0.13	0.40	0.22	1.00	1.00	0.34	0.11	0.10	0.52
200895 (DHFRL1)	0.29	0.30	0.41	0.20	0.25	0.32	0.22	0.42	0.39	0.26	0.24	0.21	0.77	0.24	0.33	0.17	0.26	0.47	0.21	0.31	0.23	0.39	0.21	0.48	0.25	0.26	0.42	0.21	0.57	0.36	0.19	0.14	0.20	0.28	0.28	1.00	0.20	0.28	0.20	0.13	0.13	0.15	0.22	0.38	0.30	0.30	0.47	0.15	0.13	0.31
2356 (FPGS)	0.17	0.16	0.16	0.18	0.16	0.16	0.16	0.17	0.16	0.16	0.16	0.16	0.20	0.24	0.15	0.60	0.16	0.17	0.16	0.16	0.24	0.20	0.18	0.24	0.16	0.22	0.20	0.16	0.20	0.20	0.16	0.17	0.24	0.20	0.16	0.20	1.00	0.17	0.20	0.17	0.20	0.15	0.17	0.17	0.16	0.16	0.60	0.20	0.17	0.16
6240 (RRM1)	0.96	1.00	0.67	0.42	0.76	0.52	0.61	0.51	0.54	0.55	0.82	0.50	0.34	0.58	0.24	0.18	0.59	0.23	0.51	0.56	0.49	0.32	0.54	0.51	0.83	0.73	0.22	0.65	0.41	0.51	0.36	0.14	0.45	0.53	0.43	0.28	0.17	1.00	0.17	0.14	0.15	0.13	0.59	0.22	1.00	1.00	0.48	0.16	0.14	0.55
275 (AMT)	0.17	0.16	0.16	0.31	0.16	0.16	0.16	0.29	0.16	0.16	0.16	0.27	0.20	0.40	0.26	0.51	0.16	0.63	0.16	0.16	0.40	0.20	0.31	0.24	0.16	0.22	0.20	0.16	0.20	0.51	0.16	0.28	0.40	0.51	0.16	0.20	0.20	0.17	1.00	0.17	0.20	0.15	0.29	0.17	0.16	0.16	0.24	0.34	0.29	0.16
56953 (NT5M)	0.14	0.14	0.12	0.14	0.13	0.13	0.14	0.10	0.16	0.15	0.12	0.13	0.11	0.17	0.11	0.19	0.12	0.10	0.11	0.11	0.16	0.18	0.13	0.13	0.13	0.23	0.22	0.11	0.13	0.10	0.16	0.14	0.17	0.11	0.10	0.13	0.17	0.14	0.17	1.00	0.39	1.00	0.12	0.82	0.14	0.14	0.20	0.17	0.14	0.16
10535 (RNASEH2A)	0.15	0.16	0.13	0.15	0.13	0.14	0.14	0.12	0.17	0.17	0.13	0.14	0.12	0.18	0.12	0.20	0.13	0.11	0.12	0.13	0.17	0.19	0.14	0.15	0.14	0.24	0.23	0.11	0.14	0.11	0.18	0.15	0.18	0.12	0.11	0.13	0.20	0.15	0.20	0.39	1.00	0.40	0.14	0.33	0.16	0.16	0.22	0.18	0.15	0.17
4907 (NT5E)	0.13	0.13	0.13	0.14	0.13	0.15	0.13	0.13	0.19	0.14	0.13	0.13	0.15	0.19	0.11	0.19	0.19	0.13	0.13	0.15	0.19	0.22	0.14	0.19	0.13	0.27	0.22	0.13	0.15	0.15	0.19	0.13	0.19	0.15	0.13	0.15	0.15	0.13	0.15	1.00	0.40	1.00	0.13	1.00	0.13	0.13	0.22	0.15	0.13	0.19
7083 (TK1)	0.51	1.00	0.54	0.61	0.63	0.46	0.50	0.52	0.54	0.46	0.68	0.61	0.30	0.56	0.29	0.20	0.54	0.24	0.47	0.56	0.68	0.32	0.62	0.44	0.65	0.61	0.15	0.56	0.35	0.62	0.34	0.46	0.45	0.65	0.40	0.22	0.17	0.59	0.29	0.12	0.14	0.13	1.00	0.20	1.00	1.00	0.40	0.19	0.58	0.47
30833 (NT5C)	0.21	0.32	0.30	0.18	0.24	0.27	0.21	0.40	0.29	0.23	0.23	0.19	0.37	0.23	0.24	0.17	0.25	0.28	0.19	0.27	0.21	0.21	0.20	0.35	0.23	0.29	0.19	0.20	0.37	0.26	0.22	0.13	0.20	0.26	0.22	0.38	0.17	0.22	0.17	0.82	0.33	1.00	0.20	1.00	0.32	0.32	0.23	0.15	0.13	0.28
4174 (MCM5)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.59	1.00	0.33	0.18	1.00	0.29	1.00	1.00	1.00	0.41	1.00	1.00	1.00	1.00	0.16	1.00	0.59	1.00	0.60	0.13	0.61	1.00	1.00	0.30	0.16	1.00	0.16	0.14	0.16	0.13	1.00	0.32	1.00	1.00	1.00	0.16	0.14	1.00
64151 (NCAPG)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.59	1.00	0.33	0.18	1.00	0.29	1.00	1.00	1.00	0.41	1.00	1.00	1.00	1.00	0.16	1.00	0.59	1.00	0.60	0.13	0.61	1.00	1.00	0.30	0.16	1.00	0.16	0.14	0.16	0.13	1.00	0.32	1.00	1.00	1.00	0.16	0.14	1.00
4522 (MTHFD1)	0.44	1.00	0.40	0.35	0.49	0.37	0.37	0.41	0.38	0.36	0.50	0.37	0.44	0.44	0.20	0.37	0.47	0.22	0.39	0.48	0.40	0.74	0.41	0.44	0.45	0.55	0.79	0.46	0.50	0.40	0.31	0.17	0.32	0.40	0.34	0.47	0.60	0.48	0.24	0.20	0.22	0.22	0.40	0.23	1.00	1.00	1.00	0.21	0.18	0.38
7372 (UMPS)	0.17	0.16	0.14	0.24	0.15	0.12	0.14	0.14	0.14	0.14	0.14	0.21	0.12	0.27	0.19	0.27	0.12	0.16	0.13	0.12	0.26	0.17	0.19	0.15	0.15	0.19	0.20	0.12	0.15	0.14	0.13	0.26	0.56	0.15	0.11	0.15	0.20	0.16	0.34	0.17	0.18	0.15	0.19	0.15	0.16	0.16	0.21	1.00	0.26	0.14
7084 (TK2)	0.14	0.14	0.12	0.43	0.13	0.11	0.12	0.17	0.12	0.12	0.12	0.37	0.11	0.25	0.26	0.25	0.10	0.15	0.11	0.10	0.49	0.14	0.32	0.13	0.13	0.17	0.17	0.11	0.13	0.13	0.11	0.66	0.28	0.14	0.10	0.13	0.17	0.14	0.29	0.14	0.15	0.13	0.58	0.13	0.14	0.14	0.18	0.26	1.00	0.12
7374 (UNG)	0.50	1.00	0.72	0.37	0.64	0.61	0.50	0.60	0.56	0.54	0.64	0.44	0.38	0.49	0.39	0.16	0.69	0.32	0.49	0.63	0.43	0.27	0.47	0.43	0.61	0.59	0.16	0.56	0.42	0.48	0.41	0.12	0.31	0.49	0.52	0.31	0.16	0.55	0.16	0.16	0.17	0.19	0.47	0.28	1.00	1.00	0.38	0.14	0.12	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
TYMS	Toad	Brain	-	3464 m	33 day	downregulated	-2.47742427	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
E2F1	1869	TYMS	7298	proximal_filtered	22955619	TRANSFAC
ESR1	2099	TYMS	7298	Repression	22510021	TRUSST
TFCP2	7024	TYMS	7298	Activation	14630715	TRUSST
SP1	6667	TYMS	7298	Activation	16854221	TRUSST
TFDP1	7027	TYMS	7298	Activation	17614769	TRUSST
USF1	7391	TYMS	7298	Unknown	15229244	TRUSST
CHD8	57680	TYMS	7298	Activation	14630715	TRUSST
YBX1	4904	TYMS	7298	Unknown	15229244	TRUSST
TP53	7157	TYMS	7298	Unknown	19494806	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT001582	hsa-let-7b-5p	Homo sapiens	TYMS	7298	Homo sapiens	pSILAC//Proteomics;Other	Functional MTI (Weak)	18668040
MIRT016485	hsa-miR-193b-3p	Homo sapiens	TYMS	7298	Homo sapiens	Microarray	Functional MTI (Weak)	20304954
MIRT025487	hsa-miR-34a-5p	Homo sapiens	TYMS	7298	Homo sapiens	Proteomics	Functional MTI (Weak)	21566225
MIRT029608	hsa-miR-26b-5p	Homo sapiens	TYMS	7298	Homo sapiens	Microarray	Functional MTI (Weak)	19088304
MIRT040293	hsa-miR-615-3p	Homo sapiens	TYMS	7298	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT040968	hsa-miR-18a-3p	Homo sapiens	TYMS	7298	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT042289	hsa-miR-484	Homo sapiens	TYMS	7298	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT044879	hsa-miR-194-5p	Homo sapiens	TYMS	7298	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT048693	hsa-miR-99a-5p	Homo sapiens	TYMS	7298	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT199238	hsa-miR-203a-3p	Homo sapiens	TYMS	7298	Homo sapiens	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	25482885
MIRT437980	hsa-miR-196a-5p	Homo sapiens	TYMS	7298	Homo sapiens	Luciferase reporter assay	Functional MTI	24681820
MIRT438242	hsa-miR-433-3p	Homo sapiens	TYMS	7298	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	23915286
MIRT733936	hsa-miR-193a-3p	Homo sapiens	TYMS	7298	Homo sapiens	qRT-PCR//Western blot	Functional MTI	26125439

Gene Ontology

ID	GO ID	GO Term	GO Type
7298	GO:0000166	nucleotide binding	GOTERM_MF_DIRECT
7298	GO:0003729	mRNA binding	GOTERM_MF_DIRECT
7298	GO:0004799	superoxide dismutase activity	GOTERM_MF_DIRECT
7298	GO:0033189	response to vitamin A	GOTERM_BP_DIRECT
7298	GO:0042493	response to drug	GOTERM_BP_DIRECT
7298	GO:0051384	response to glucocorticoid	GOTERM_BP_DIRECT
7298	GO:0005634	nucleus	GOTERM_CC_DIRECT
7298	GO:0006231	dTMP biosynthetic process	GOTERM_BP_DIRECT
7298	GO:0032570	response to progesterone	GOTERM_BP_DIRECT
7298	GO:0048037	cofactor binding	GOTERM_MF_DIRECT
7298	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
7298	GO:0035999	tetrahydrofolate interconversion	GOTERM_BP_DIRECT
7298	GO:0045471	response to ethanol	GOTERM_BP_DIRECT
7298	GO:0046078	dUMP metabolic process	GOTERM_BP_DIRECT
7298	GO:0071897	DNA biosynthetic process	GOTERM_BP_DIRECT
7298	GO:0005829	cytosol	GOTERM_CC_DIRECT
7298	GO:0007568	aging	GOTERM_BP_DIRECT
7298	GO:0019860	uracil metabolic process	GOTERM_BP_DIRECT
7298	GO:0060574	intestinal epithelial cell maturation	GOTERM_BP_DIRECT
7298	GO:0032259	methylation	GOTERM_BP_DIRECT
7298	GO:0034097	response to cytokine	GOTERM_BP_DIRECT
7298	GO:0046134	pyrimidine nucleoside biosynthetic process	GOTERM_BP_DIRECT
7298	GO:0048589	developmental growth	GOTERM_BP_DIRECT
7298	GO:0042803	protein homodimerization activity	GOTERM_MF_DIRECT
7298	GO:0046683	response to organophosphorus	GOTERM_BP_DIRECT
7298	GO:0008144	drug binding	GOTERM_MF_DIRECT
7298	GO:0006417	regulation of translation	GOTERM_BP_DIRECT
7298	GO:0016049	cell growth	GOTERM_BP_DIRECT
7298	GO:0005739	mitochondrion	GOTERM_CC_DIRECT
7298	GO:0005743	mitochondrial inner membrane	GOTERM_CC_DIRECT
7298	GO:0006139	nucleobase-containing compound metabolic process	GOTERM_BP_DIRECT
7298	GO:0008283	cell proliferation	GOTERM_BP_DIRECT
7298	GO:0046653	tetrahydrofolate metabolic process	GOTERM_BP_DIRECT
7298	GO:0051593	response to folic acid	GOTERM_BP_DIRECT
7298	GO:0097421	liver regeneration	GOTERM_BP_DIRECT
7298	GO:0005542	glucose binding	GOTERM_MF_DIRECT
7298	GO:0005730	nucleolus	GOTERM_CC_DIRECT
7298	GO:0000082	G1/S transition of mitotic cell cycle	GOTERM_BP_DIRECT
7298	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	GOTERM_BP_DIRECT
7298	GO:0006235	dTTP biosynthetic process	GOTERM_BP_DIRECT
7298	GO:0007623	circadian rhythm	GOTERM_BP_DIRECT
7298	GO:0019088	immortalization of host cell by virus	GOTERM_BP_DIRECT
7298	GO:0051216	cartilage development	GOTERM_BP_DIRECT
7298	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
7298	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	GOTERM_BP_DIRECT
7298	GO:0009636	response to toxic substance	GOTERM_BP_DIRECT
7298	GO:0005759	mitochondrial matrix	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
7298	hsa00240	Pyrimidine metabolism
7298	hsa00670	One carbon pool by folate
7298	hsa01100	Metabolic pathways

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
TYMS	7298	Prostatic Neoplasms	C0033578	Neoplastic Process	0.31	0.457	0.759	group
TYMS	7298	Encephalopathies	C0085584	Disease or Syndrome	0.3	0.457	0.759	group
TYMS	7298	Cancer of Digestive System	C0751075	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Cleft palate, isolated	C1837218	Congenital Abnormality	0.3	0.457	0.759	disease
TYMS	7298	Lymphoma, Follicular, Grade 1	C1956130	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Cancer of Neck	C0746787	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Brain Diseases	C0006111	Disease or Syndrome	0.3	0.457	0.759	group
TYMS	7298	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Rectal Neoplasms	C0034885	Neoplastic Process	0.33	0.457	0.759	group
TYMS	7298	Reticulosarcoma	C0024302	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Lymphoma, Mixed-Cell	C0024304	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	nervous system disorder	C0027765	Disease or Syndrome	0.3	0.457	0.759	group
TYMS	7298	Stomach Neoplasms	C0038356	Neoplastic Process	0.37	0.457	0.759	group
TYMS	7298	High Grade Lymphoma (neoplasm)	C0079740	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Lymphoma, Diffuse	C3714542	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Cleft upper lip	C0008924	Congenital Abnormality	0.31	0.457	0.759	disease
TYMS	7298	Colorectal Neoplasms	C0009404	Neoplastic Process	0.4	0.457	0.759	group
TYMS	7298	Head and Neck Neoplasms	C0018671	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Breast Carcinoma	C0678222	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Cancer of Head	C0751177	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Malignant neoplasm of ovary	C1140680	Neoplastic Process	0.34	0.457	0.759	disease
TYMS	7298	Mammary Neoplasms	C1458155	Neoplastic Process	0.36	0.457	0.759	group
TYMS	7298	Liver carcinoma	C2239176	Neoplastic Process	0.36	0.457	0.759	disease
TYMS	7298	Cleft Palate	C0008925	Congenital Abnormality	0.31	0.457	0.759	disease
TYMS	7298	Head Neoplasms	C0018675	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Malignant Head and Neck Neoplasm	C0278996	Neoplastic Process	0.31	0.457	0.759	disease
TYMS	7298	Mammary Neoplasms, Human	C1257931	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Neoplasm Recurrence, Local	C0027643	Neoplastic Process	0.3	0.457	0.759	phenotype
TYMS	7298	Neuroendocrine Tumors	C0206754	Neoplastic Process	0.32	0.457	0.759	group
TYMS	7298	Colorectal Cancer	C1527249	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Squamous cell carcinoma	C0007137	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Colonic Neoplasms	C0009375	Neoplastic Process	0.4	0.457	0.759	group
TYMS	7298	Pancreatic Neoplasm	C0030297	Neoplastic Process	0.31	0.457	0.759	disease
TYMS	7298	Adverse reaction to drug	C0041755	Pathologic Function	0.3	0.457	0.759	group
TYMS	7298	Malignant neoplasm of tongue	C0153349	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Digestive System Neoplasms	C0012243	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Lymphoma, Small Cleaved-Cell, Follicular	C0079765	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Lymphoma, Intermediate-Grade	C0079741	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Lymphoma, Mixed-Cell, Follicular	C0079758	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Rectal Carcinoma	C0007113	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Lymphoma, Non-Hodgkin	C0024305	Neoplastic Process	0.37	0.457	0.759	disease
TYMS	7298	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Lymphoma, Large-Cell, Follicular	C0079745	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Low Grade Lymphoma (neoplasm)	C0079747	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Upper Aerodigestive Tract Neoplasms	C0887900	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Malignant tumor of colon	C0007102	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Drug toxicity	C0013221	Injury or Poisoning	0.3	0.457	0.759	group
TYMS	7298	Lymphoma, Follicular	C0024301	Neoplastic Process	0.32	0.457	0.759	disease
TYMS	7298	Lymphoma, Small Noncleaved-Cell	C0079770	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Malignant neoplasm of pancreas	C0346647	Neoplastic Process	0.36	0.457	0.759	disease
TYMS	7298	Colorectal Carcinoma	C0009402	Neoplastic Process	0.4	0.457	0.759	disease
TYMS	7298	Tongue Neoplasms	C0040411	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Diffuse Mixed-Cell Lymphoma	C0079757	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Hyperammonemia	C0220994	Disease or Syndrome	0.3	0.457	0.759	phenotype
TYMS	7298	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.31	0.457	0.759	disease
TYMS	7298	Lymphoma, Follicular, Grade 2	C1956132	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Anemia	C0002871	Disease or Syndrome	0.32	0.457	0.759	disease
TYMS	7298	Lung Neoplasms	C0024121	Neoplastic Process	0.32	0.457	0.759	group
TYMS	7298	Adenocarcinoma of lung (disorder)	C0152013	Neoplastic Process	0.38	0.457	0.759	disease
TYMS	7298	Lymphoma, Follicular, Grade 3	C1956131	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	Lymphoma, Undifferentiated	C0024306	Neoplastic Process	0.3	0.457	0.759	disease
TYMS	7298	ovarian neoplasm	C0919267	Neoplastic Process	0.31	0.457	0.759	disease
TYMS	7298	Neck Neoplasms	C0027533	Neoplastic Process	0.3	0.457	0.759	group
TYMS	7298	Poisoning by fluorouracil	C0274576	Injury or Poisoning	0.3	0.457	0.759	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
TYMS	7298	5-FLUOROURACIL	FLUOROURACIL	CHEMBL185	None
TYMS	7298	5-FLUOROURACIL	FLUOROURACIL	CHEMBL185	None
TYMS	7298	9-AC	ANTHRACENE-9-CARBOXYLIC ACID	CHEMBL1513985	None
TYMS	7298	9-AMINOCAMPTOTHECIN	None	None	None
TYMS	7298	ANTIFOLATES	None	None	None
TYMS	7298	CAPECITABINE	CAPECITABINE	CHEMBL1773	None
TYMS	7298	CAPECITABINE	CAPECITABINE	CHEMBL1773	inhibitor
TYMS	7298	CARBOGEN	None	None	None
TYMS	7298	CAPECITABINE	CAPECITABINE	CHEMBL1773	None
TYMS	7298	CAPECITABINE	CAPECITABINE	CHEMBL1773	inhibitor
TYMS	7298	CISPLATIN	None	None	None
TYMS	7298	DAUNOMYCIN	DAUNORUBICIN	CHEMBL178	None
TYMS	7298	DEXAMETHASONE	DEXAMETHASONE	CHEMBL384467	None
TYMS	7298	DOXIFLURIDINE	DOXIFLURIDINE	CHEMBL1130	None
TYMS	7298	ENILURACIL	ENILURACIL	CHEMBL355200	None
TYMS	7298	FLOXURIDINE	FLOXURIDINE	CHEMBL917	None
TYMS	7298	FLUOROURACIL	FLUOROURACIL	CHEMBL185	inhibitor
TYMS	7298	FLOXURIDINE	FLOXURIDINE	CHEMBL917	None
TYMS	7298	FLOXURIDINE	FLOXURIDINE	CHEMBL917	inhibitor
TYMS	7298	FLOXURIDINE	FLOXURIDINE	CHEMBL917	None
TYMS	7298	FLUOROURACIL	FLUOROURACIL	CHEMBL185	None
TYMS	7298	HYDROCORTISONE	HYDROCORTISONE	CHEMBL389621	None
TYMS	7298	INDOMETHACIN	INDOMETHACIN	CHEMBL6	None
TYMS	7298	INTERFERON GAMMA	INTERFERON GAMA-1B	CHEMBL1201564	None
TYMS	7298	IRINOTECAN	IRINOTECAN	CHEMBL481	None
TYMS	7298	LEUCOVORIN	LEUCOVORIN	CHEMBL1679	None
TYMS	7298	LEUCOVORIN	LEUCOVORIN	CHEMBL1679	None
TYMS	7298	METHOTREXATE	METHOTREXATE	CHEMBL34259	None
TYMS	7298	MITOMYCIN C	MITOMYCIN	CHEMBL105	None
TYMS	7298	MLS003106905	None	None	None
TYMS	7298	MODUFOLIN	None	None	None
TYMS	7298	NB-1011	None	None	None
TYMS	7298	OSI-7904L	CHEMBL169896	CHEMBL169896	None
TYMS	7298	ONX 0801	None	None	None
TYMS	7298	PEMETREXED	PEMETREXED (CHEMBL1201258)	CHEMBL1201258	inhibitor
TYMS	7298	PEMETREXED	PEMETREXED (CHEMBL1201258)	CHEMBL1201258	None
TYMS	7298	PEMETREXED DISODIUM	PEMETREXED DISODIUM	CHEMBL1200373	inhibitor
TYMS	7298	PEMETREXED	PEMETREXED (CHEMBL1201258)	CHEMBL1201258	None
TYMS	7298	PEMETREXED	PEMETREXED (CHEMBL1201258)	CHEMBL1201258	None
TYMS	7298	PEMETREXED	PEMETREXED (CHEMBL1201258)	CHEMBL1201258	None
TYMS	7298	PHENTOLAMINE	PHENTOLAMINE	CHEMBL597	None
TYMS	7298	RALTITREXED	RALTITREXED	CHEMBL225071	None
TYMS	7298	RALTITREXED	RALTITREXED	CHEMBL225071	inhibitor
TYMS	7298	RALTITREXED	RALTITREXED	CHEMBL225071	None
TYMS	7298	RESERPINE	RESERPINE	CHEMBL772	None
TYMS	7298	TAMOXIFEN	TAMOXIFEN	CHEMBL83	None
TYMS	7298	TEGAFUR	TEGAFUR	CHEMBL20883	None
TYMS	7298	TOPOTECAN	TOPOTECAN	CHEMBL84	None
TYMS	7298	TPN	SODIUM beta-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE	CHEMBL295069	None
TYMS	7298	VERAPAMIL	VERAPAMIL	CHEMBL6966	None
TYMS	7298	VINCRISTINE	VINCRISTINE	CHEMBL90555	None