Propionyl-CoA carboxylase alpha chain, mitochondrial

AltitudeomicsDB
Protein Official symbol PCCA
Aliases PCCA
Chromosomal Location  13 
Length 728
Uniprot ID P05165
EC number 6.4.1.3
Protein family Information(Pfam) PF02785;PF00289;PF00364;PF02786;PF18140;
PDB id 2CQY;2JKU;
InterPro ID IPR011761;IPR005481;IPR001882;IPR011764;IPR005482;IPR000089;IPR005479;IPR041265;IPR016185;IPR011054;IPR011053;
dbSNP rs794727479 rs141371306 rs202247814 rs202247815 rs375628794 rs121964958 rs794727087 rs1301904623 rs1443858896 rs35719359 rs61749895 rs118169528 rs796052018 rs771438170

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
BCKDHB BCKDHA 0.999
MCCC2 MCCC1 0.999
PCCB PCCA 0.999
DBT BCKDHB 0.998
DBT DLD 0.997
ACADM ACAA2 0.996
BCKDHB DLD 0.995
DBT BCKDHA 0.992
HLCS MCCC1 0.99
HLCS PC 0.99
ACADM HADHB 0.989
HLCS PCCA 0.989
BCKDHA DLD 0.989
PCCA MCCC2 0.988
PCCA BCKDHB 0.986
PCCB MCCC1 0.984
PCCB BCKDHB 0.983
PCCB MCEE 0.982
PCCA MCEE 0.977
ACADM ACAA1 0.975
PCCA BCKDHA 0.963
ALDH6A1 PCCB 0.962
PCCB PC 0.962
PCCA DBT 0.961
ALDH6A1 ACADM 0.96
PCCB HLCS 0.96
ALDH6A1 PCCA 0.957
PC MCCC2 0.953
PCCB BCKDHA 0.952
HLCS MCCC2 0.947
ACSS3 PCCA 0.942
ALDH6A1 DBT 0.942
PCCB ACADM 0.942
PCCA ACADM 0.939
PCCB ACAA1 0.938
PC ACSS2 0.938
PCCB DBT 0.935
ALDH6A1 ACAA1 0.933
ACADM MCCC1 0.933
ACADM DBT 0.931
ACSS3 PCCB 0.93
PCCA HADHB 0.928
PCCB HADHB 0.928
PCCB ACAA2 0.927
ALDH6A1 ACAA2 0.925
PCCA ACSS1 0.925
HADHB ACAA2 0.925
PCCA ACAA2 0.925
PCCA ACAA1 0.924
PCCA DLD 0.923
PC PCCA 0.921
ACSS3 ACSS1 0.921
PC MCCC1 0.921
PCCB ACSS2 0.92
PCCB ACSS1 0.92
ACADM MCCC2 0.919
ACSS3 ACSS2 0.918
PCCA MCCC1 0.918
ALDH6A1 ACSS3 0.916
PCCB DLD 0.916
ALDH6A1 ACSS1 0.916
PCCB MCCC2 0.916
ALDH6A1 ACSS2 0.916
ACADM ACSS2 0.916
ALDH6A1 HADHB 0.916
DBT ACSS1 0.912
PCCA ACSS2 0.912
ACADM ACSS1 0.911
ACSS1 ACSS2 0.91
DBT ACSS2 0.909
ACSS3 DBT 0.909
ACSS3 ACADM 0.906
ACAA2 ACSS2 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 594 (BCKDHB) 64087 (MCCC2) 5096 (PCCB) 1629 (DBT) 34 (ACADM) 3141 (HLCS) 593 (BCKDHA) 5095 (PCCA) 4329 (ALDH6A1) 5091 (PC) 79611 (ACSS3) 3032 (HADHB) 84532 (ACSS1) 10449 (ACAA2) 56922 (MCCC1) 1738 (DLD) 84693 (MCEE) 30 (ACAA1) 55902 (ACSS2)
594 (BCKDHB) 1.00 0.64 1.00 0.40 0.65 0.57 0.87 0.65 0.42 0.69 0.25 0.51 0.63 0.51 0.53 0.65 0.66 0.57 0.21
64087 (MCCC2) 0.64 1.00 1.00 0.36 0.46 0.60 0.56 0.64 0.27 0.80 0.31 0.41 0.65 0.47 0.77 0.51 0.62 0.46 0.23
5096 (PCCB) 1.00 1.00 1.00 0.60 0.82 1.00 1.00 1.00 0.37 1.00 0.14 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.16
1629 (DBT) 0.40 0.36 0.60 1.00 0.30 0.51 0.37 0.59 0.33 0.39 0.18 0.42 0.35 0.55 0.46 0.32 0.38 0.46 0.23
34 (ACADM) 0.65 0.46 0.82 0.30 1.00 0.44 0.58 0.47 0.34 0.60 0.21 0.40 0.45 0.38 0.40 0.50 0.48 0.51 0.18
3141 (HLCS) 0.57 0.60 1.00 0.51 0.44 1.00 0.53 0.79 0.31 0.65 0.36 0.44 0.58 0.48 0.80 0.48 0.55 0.46 0.29
593 (BCKDHA) 0.87 0.56 1.00 0.37 0.58 0.53 1.00 0.57 0.39 0.62 0.25 0.52 0.54 0.47 0.49 0.58 0.59 0.52 0.21
5095 (PCCA) 0.65 0.64 1.00 0.59 0.47 0.79 0.57 1.00 0.31 0.67 0.14 0.46 0.63 0.54 0.74 0.55 0.64 0.50 0.23
4329 (ALDH6A1) 0.42 0.27 0.37 0.33 0.34 0.31 0.39 0.31 1.00 0.29 0.18 0.41 0.26 0.42 0.31 0.45 0.29 0.29 0.22
5091 (PC) 0.69 0.80 1.00 0.39 0.60 0.65 0.62 0.67 0.29 1.00 0.36 0.48 0.71 0.54 0.67 0.57 0.67 0.53 0.24
79611 (ACSS3) 0.25 0.31 0.14 0.18 0.21 0.36 0.25 0.14 0.18 0.36 1.00 0.18 1.00 0.16 0.36 0.17 0.21 0.18 1.00
3032 (HADHB) 0.51 0.41 1.00 0.42 0.40 0.44 0.52 0.46 0.41 0.48 0.18 1.00 0.40 0.72 0.41 0.41 0.44 0.56 0.19
84532 (ACSS1) 0.63 0.65 1.00 0.35 0.45 0.58 0.54 0.63 0.26 0.71 1.00 0.40 1.00 0.47 0.54 0.50 0.61 0.45 0.58
10449 (ACAA2) 0.51 0.47 1.00 0.55 0.38 0.48 0.47 0.54 0.42 0.54 0.16 0.72 0.47 1.00 0.43 0.42 0.49 0.69 0.18
56922 (MCCC1) 0.53 0.77 1.00 0.46 0.40 0.80 0.49 0.74 0.31 0.67 0.36 0.41 0.54 0.43 1.00 0.43 0.50 0.41 0.32
1738 (DLD) 0.65 0.51 1.00 0.32 0.50 0.48 0.58 0.55 0.45 0.57 0.17 0.41 0.50 0.42 0.43 1.00 0.52 0.45 0.16
84693 (MCEE) 0.66 0.62 1.00 0.38 0.48 0.55 0.59 0.64 0.29 0.67 0.21 0.44 0.61 0.49 0.50 0.52 1.00 0.48 0.19
30 (ACAA1) 0.57 0.46 1.00 0.46 0.51 0.46 0.52 0.50 0.29 0.53 0.18 0.56 0.45 0.69 0.41 0.45 0.48 1.00 0.17
55902 (ACSS2) 0.21 0.23 0.16 0.23 0.18 0.29 0.21 0.23 0.22 0.24 1.00 0.19 0.58 0.18 0.32 0.16 0.19 0.17 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PCCA Toad Heart - 3464 m 33 day downregulated -2.407791852 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT029589 hsa-miR-26b-5p Homo sapiens PCCA 5095 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT040742 hsa-miR-455-5p Homo sapiens PCCA 5095 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT445554 hsa-miR-155-5p Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445558 hsa-miR-486-5p Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445552 hsa-miR-568 Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445556 hsa-miR-15b-3p Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445551 hsa-miR-7152-5p Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445555 hsa-miR-4326 Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445553 hsa-miR-1273e Homo sapiens PCCA 5095 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
Gene Ontology
ID GO ID GO Term GO Type
5095 GO:0019836 hemolysis by symbiont of host erythrocytes GOTERM_BP_DIRECT
5095 GO:0004075 L-aspartate:2-oxoglutarate aminotransferase activity GOTERM_MF_DIRECT
5095 GO:0005576 extracellular region GOTERM_CC_DIRECT
5095 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
5095 GO:0009374 electron carrier activity GOTERM_MF_DIRECT
5095 GO:0046872 metal ion binding GOTERM_MF_DIRECT
5095 GO:0005829 cytosol GOTERM_CC_DIRECT
5095 GO:0005524 ATP binding GOTERM_MF_DIRECT
5095 GO:0019899 enzyme binding GOTERM_MF_DIRECT
5095 GO:0006768 biotin metabolic process GOTERM_BP_DIRECT
5095 GO:0019626 short-chain fatty acid catabolic process GOTERM_BP_DIRECT
5095 GO:0004658 phosphopyruvate hydratase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5095 hsa00280 Valine
5095 hsa00630 Glyoxylate and dicarboxylate metabolism
5095 hsa01130 Biosynthesis of antibiotics
5095 hsa01100 Metabolic pathways
5095 hsa00640 Propanoate metabolism
5095 hsa01200 Carbon metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PCCA 5095 Propionicaciduria C2717876 Disease or Syndrome 0.5 0.672 0.448 disease
PCCA 5095 Propionic acidemia C0268579 Disease or Syndrome 0.8 0.672 0.448 disease
PCCA 5095 Hyperammonemia C0220994 Disease or Syndrome 0.4 0.672 0.448 phenotype
PCCA 5095 Ketotic hypoglycemia C0271713 Disease or Syndrome 0.3 0.672 0.448 phenotype
PCCA 5095 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.672 0.448 group
PCCA 5095 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.672 0.448 disease
PCCA 5095 Propionic acidemia, type II C0311298 Disease or Syndrome 0.3 0.672 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types