Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

AltitudeomicsDB
Protein Official symbol MCCC1
Aliases MCCC1 MCCA
Chromosomal Location  3
Length 725
Uniprot ID Q96RQ3
EC number 6.4.1.4
Protein family Information(Pfam) PF02785;PF00289;PF00364;PF02786;
PDB id 2EJM;
InterPro ID IPR011761;IPR013815;IPR005481;IPR001882;IPR011764;IPR005482;IPR000089;IPR005479;IPR016185;IPR011054;IPR011053;
dbSNP rs199517715 rs1057520695 rs202197951 rs1229069160 rs748201122 rs757362635 rs186209189 rs727504004 rs773433541 rs754437245 rs746500530 rs1326114075 rs201041864 rs119103212 rs201386261 rs755328329 rs887877405 rs794727036 rs1333357031 rs119103213 rs376289130 rs119103215 rs398124352 rs768785753 rs119103218 rs2270968 rs119103214 rs119103216 rs35219417 rs142867987

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PCCB PCCA 0.997
MCCC2 MCCC1 0.996
IVD MCCC2 0.991
HLCS PC 0.99
HLCS MCCC1 0.99
HLCS PCCA 0.989
PCCA MCCC2 0.98
ACADM EHHADH 0.979
HADHA ACADM 0.977
ECHS1 MCCC2 0.977
PCCB MCCC1 0.975
ACADM ECHS1 0.968
AUH MCCC2 0.963
PCCB PC 0.962
IVD MCCC1 0.962
PCCB HLCS 0.96
PC MCCC2 0.953
IVD ECHS1 0.953
HLCS MCCC2 0.947
IVD HADHA 0.946
ECHS1 MCCC1 0.946
HADHA MCCC2 0.944
PCCB ACADM 0.942
PCCA ACADM 0.939
ACADM MCCC1 0.933
HADHA ECHS1 0.931
HADHA MCCC1 0.93
AUH MCCC1 0.926
IVD EHHADH 0.925
HADHA EHHADH 0.922
PC PCCA 0.921
PC MCCC1 0.921
ECHS1 EHHADH 0.92
ACADM MCCC2 0.919
PCCA MCCC1 0.918
MCCC2 EHHADH 0.918
MCCC1 EHHADH 0.918
PCCB MCCC2 0.916
MCC MCCC1 0.903
MCC MCCC2 0.901
Gene Ontology Semantic Similarity
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# 5096 (PCCB) 64087 (MCCC2) 3712 (IVD) 3141 (HLCS) 5095 (PCCA) 34 (ACADM) 3030 (HADHA) 1892 (ECHS1) 549 (AUH) 5091 (PC) 56922 (MCCC1) 4163 (MCC)
5096 (PCCB) 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 0.28 1.00 1.00 1.00
64087 (MCCC2) 1.00 1.00 0.60 0.60 0.64 0.46 0.42 0.60 0.23 0.80 0.77 0.59
3712 (IVD) 1.00 0.60 1.00 0.53 0.64 0.82 0.47 0.60 0.23 0.66 0.48 0.59
3141 (HLCS) 1.00 0.60 0.53 1.00 0.79 0.44 0.43 0.53 0.24 0.65 0.80 0.51
5095 (PCCA) 1.00 0.64 0.64 0.79 1.00 0.47 0.45 0.64 0.23 0.67 0.74 0.65
34 (ACADM) 0.82 0.46 0.82 0.44 0.47 1.00 0.44 0.46 0.22 0.60 0.40 0.43
3030 (HADHA) 1.00 0.42 0.47 0.43 0.45 0.44 1.00 0.64 0.47 0.49 0.39 0.40
1892 (ECHS1) 1.00 0.60 0.60 0.53 0.64 0.46 0.64 1.00 0.66 0.66 0.48 0.59
549 (AUH) 0.28 0.23 0.23 0.24 0.23 0.22 0.47 0.66 1.00 0.25 0.25 0.20
5091 (PC) 1.00 0.80 0.66 0.65 0.67 0.60 0.49 0.66 0.25 1.00 0.67 0.64
56922 (MCCC1) 1.00 0.77 0.48 0.80 0.74 0.40 0.39 0.48 0.25 0.67 1.00 0.46
4163 (MCC) 1.00 0.59 0.59 0.51 0.65 0.43 0.40 0.59 0.20 0.64 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MCCC1 Toad Heart - 3464 m 33 day downregulated -3.064422719 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
NFYB 4801 MCCC1 56922 proximal_filtered 22955619 TRANSFAC
MAX 4149 MCCC1 56922 proximal_filtered 22955619 TRANSFAC
EBF1 1879 MCCC1 56922 proximal_filtered 22955619 TRANSFAC
USF1 7391 MCCC1 56922 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
56922 GO:0051291 protein heterooligomerization GOTERM_BP_DIRECT
56922 GO:0004075 arylsulfatase activity GOTERM_MF_DIRECT
56922 GO:0006768 biotin metabolic process GOTERM_BP_DIRECT
56922 GO:0009374 electron carrier activity GOTERM_MF_DIRECT
56922 GO:0046872 metal ion binding GOTERM_MF_DIRECT
56922 GO:0004485 malic enzyme activity GOTERM_MF_DIRECT
56922 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
56922 GO:0005829 cytosol GOTERM_CC_DIRECT
56922 GO:0005524 ATP binding GOTERM_MF_DIRECT
56922 GO:0002169 3-methylcrotonyl-CoA carboxylase complex GOTERM_CC_DIRECT
56922 GO:0006552 leucine catabolic process GOTERM_BP_DIRECT
56922 GO:0009083 branched-chain amino acid catabolic process GOTERM_BP_DIRECT
56922 GO:1905202 methylcrotonoyl-CoA carboxylase complex GOTERM_CC_DIRECT
56922 mitochondrial None GOTERM_CC_DIRECT
56922 GO:0005515 protein binding GOTERM_MF_DIRECT
56922 GO:0005739 mitochondrion GOTERM_CC_DIRECT
56922 GO:0005743 mitochondrial inner membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
56922 hsa00280 Valine
56922 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MCCC1 56922 3-methylcrotonyl CoA carboxylase 1 deficiency C0268600 Disease or Syndrome 0.72 0.743 0.276 disease
MCCC1 56922 Hyperammonemia C0220994 Disease or Syndrome 0.4 0.743 0.276 phenotype
MCCC1 56922 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.743 0.276 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types